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自体同侧旋转式穿透性角膜移植术:一种预防peter异常症中严重不可逆弱视的早期手术方法(德)

世界核心医学期刊文摘（眼科学分册） 2005年第7期1卷 33-33页

作者： Grü nauer- Kloevekorn c. Bau V. Weidlich R. Duncker G. 韩静 Universitatsaugenklin. mit Poliklin. Martin- Luther- Univ. Halle- Witten- berg Ernst- Grube- Straé 40 06097 Halle Germany

Puprose: It is a challenge to prevent irreversible amblyopia in infants suffering from peters anomaly. In some cases of centrally located corneal opacifications an optical sector iridectomy can not lead to a clear optical axis. The homologous penetrating keratoplasty as early surgical procedure has shown an extremely poor outcome with a high risk of irreversible graft failure. We report on the autologous ipsilateral rotating penetrating keratoplasty in an eight- week- old infant suffering from peters anomaly. Patients: An autologous ipsilateral rotating penetrating keratoplasty was performed in an eight- week- old infant suffering from peters anomaly to prevent irreversible amblyopia. Results: After a follow- up time of 8 months we saw a clear graft within the optical axis without any complications in wound healing. We removed the single sutures two months after keratoplasty. Postoperative astigmatism could be corrected first by fitting a special nursery contact lens and after reduction of astigmatismbecause of suture removalwe fitted special nursery glasses. The intraocular pressure remained within the normal range during the follow- up period. conclusion: The autologous ipsilateral rotating penetrating keratoplasty should be considered superior to homologous keratoplasty in infants withpeters anomaly if sector iridectomy is not advisable because of a central corneal opacification. Resulting high refractive errors can be successfully corrected by special contact lens fitting or by nursery glasses.

关键词： peter 体同植片扇形虹膜切除术全层角膜移植术角膜中央婴儿行视轴屈光不正不可逆性

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原发性神经炎性麻风患者随访过程中出现皮损

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世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 54-54页

作者： Suneetha S. Sigamoni A. Kurian N. chacko c.J.G. 牛新武 LEPRA India Blue Peter Research Center Near TEC Building Cherlapally Hyderabad 501 301 India Dr.

Background: Primary neuritic leprosy (PNL) is a rare form of leprosy where the characteristic skin lesions are absent. Investigations of apparently normal skin from the areas of sensory change have revealed microscopic evidence of nerve involvement. clinical studies have found that a proportion of patients develop visible skin lesions during follow- up. The aim of the study was to perform a clinical and histological analysis of PNL patients who developed visible skin lesions during treatment and follow- up, to gain insight into the pathogenesis of the disease. Methods: Twenty- nine individuals in a series of 182 PNL patients developed visible skin lesions during follow- up. Analysis of the number, location, histology and time of onset of the new skin lesions in relation to the type and regularity of the treatment regimen were noted. A biopsy from the new skin lesion when available was compared with the nerve biopsy findings at the time of initial diagnosis. Results: Thirty- eight per cent of patients developed a single patch and 28% developed two patches. Over three- quarters of these were on the lower limb (47% ) or the upper limb (29% ). Sixty- two per cent of patients developed the lesions within 2 years of the onset of symptoms. Patients on regular treatment developed patches earlier than those on irregular treatment or no treatment. A skin biopsy from the new patch revealed borderline tuberculoid leprosy histology in 47% of the patients. conclusions: The findings suggest that leprosy primarily affects the nerve and that a neuritic phase precedes the development of visible cutaneous lesions.

关键词：麻风患者随访过程神经活检皮损数目组织学特征治疗规律活检标本规律治疗感觉异常治疗者

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脑神经科学与教育:中英语文教学研究计划综合报告(英文)

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教育生物学杂志 2013年第1期1卷 28-40页

作者：杜祖贻关定辉霍泰辉陈瑞燕陈和晏陈宇亮周伟立冯国培冯戬云孔宪辉李学铭麦继强苏廷弼香港中文大学香港大学香港理工大学香港城市大学

《应用脑神经及认知科学提高香港语文教育成效研究计划报告》全文600余页。报告分三部分,第一部分是综合报告,它是第二部分的导言;第二部分为研究报告,由十一节组成;第三部分为附录,包括研究工具和程序等。文章是《应用脑神经及认知科... 详细信息

《应用脑神经及认知科学提高香港语文教育成效研究计划报告》全文600余页。报告分三部分,第一部分是综合报告,它是第二部分的导言;第二部分为研究报告,由十一节组成;第三部分为附录,包括研究工具和程序等。文章是《应用脑神经及认知科学提高得港语文教育的成效研究计划报告》的综合报告,记录3年(2000—2003)研究的全部结果,并论述本计划对教育研究与教学实践的意义。本计划中香港特别行政区政府资助,为香港近年各大学大规模跨学科合作科研项目。本合作研究计划的目的,是要为香港教师和学童寻求以科学为依据、并具有高效率的语文教学途径和方法。除了设有课堂实验外,本计划同时研究脑部结构及在学习时的运作与活动。本计划要将经过验证的新知识应用于改善教育的工作。

关键词：神经认知语言中文学童教学功能性磁共振成像脑电图

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新研究确定了与肝病和脂肪代谢有关的肝细胞突变

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中西医结合肝病杂志 2021年第11期31卷 1011-1011页

作者： Stanley W. K. Ng Foad J. Rouhani Simon F. Brunner Natalia Brzozowska Federico Abascal Luiza Moore Lia chappell Daniel Leongamornlert Aleksandra Ivovic Philip Robinson Timothy Butler Mathijs A. Sanders Nicholas Williams Tim H. H. coorens Jon Teague Keiran Raine Adam P. Butler Yvette Hooks Beverley Wilson Natalie Birtchnell Michael R. Stratton Iñigo Martincorena Raheleh Rahbari peter J. campbell Foad J. Rouhani & Huw Naylor Sarah J. Aitken & Matthew Hoare Sarah J. Aitken & Susan E. Davies Sarah J. Aitken Ming Yang Efterpi Nikitopoulou christian Frezza Matthew Hoare cancer Genome Project Wellcome Sanger Institute Hinxton UK Department of Hematology Erasmus University Medical Center Rotterdam The Netherlands Stem cell Institute University of Cambridge Cambridge UK Department of Surgery Addenbrooke’s Hospital Cambridge UK cRUK cambridge Institute Cambridge UK Department of Pathology Addenbrooke’s Hospital Cambridge UK MRc Toxicology Unit University of Cambridge Cambridge UK MRc cancer Unit University of Cambridge Cambridge UK Department of Medicine University of Cambridge Addenbrooke’s Hospital Cambridge UK

一项来自英国韦尔科姆基金会桑格研究所和剑桥大学等研究机构的研究人员的新研究分析了来自34例患者肝脏样本的1590个基因组,包括健康对照、酒精相关肝病和非酒精性脂肪肝疾病患者的肝脏样本,结果发现AcVR2A、TNRc6B、NEAT1、FOXO1和GP... 详细信息

一项来自英国韦尔科姆基金会桑格研究所和剑桥大学等研究机构的研究人员的新研究分析了来自34例患者肝脏样本的1590个基因组,包括健康对照、酒精相关肝病和非酒精性脂肪肝疾病患者的肝脏样本,结果发现AcVR2A、TNRc6B、NEAT1、FOXO1和GPAM 五个基因在肝病患者的肝细胞中发生了突变,过程如图a所示。而其中的FOXO1、cIDEB、GPAM三个基因是对肝细胞如何代谢脂肪和对胰岛素作出反应有直接影响的基因。

关键词： FOXO1 肝病患者细胞突变肝细胞脂肪代谢胰岛素 GPA 剑桥大学

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Abstracts from the 15th International Myopia conference

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Eye and Vision 2016年第1期3卷 211-221页

作者： Alexandra Benavente-Perez Ann Nour Tobin Ansel Kathleen Abarr Luying Yan Keisha Roden David Troilo chanyi Lu Miaozhen Pan Min Zheng Jia Qu Xiangtian Zhou christine F. Wildsoet Fan Lu Jie chen Jinhua Bao Liang Hu Qinmei Wang Zibing Jin Frances Rucker Stephanie Britton Stephan Hanowsky Molly Spatcher Hui-Ying Kuo ching-Hsiu Ke I-Hsin Kuo chien-chun Peng Han-Yin Sun Ian G. Morgan Jeremy A. Guggenheim Rupal L. Shah cathy Williams Jinglei Yang peter S. Reinach Sen Zhang Wenfeng Sun Bo Liu Fen Li Xiaoqing Li Aihua Zhao Tianlu chen Wei Jia Jun Jiang Haoran Wu Kazuo Tsubota Hiroko Ozawa Hidemasa Torii Shigemasa Takamizawa Toshihide Kurihara Kazuno Negishi Klaus Graef Daniel Rathbun Frank Schaeffel Ladan Ghodsi William K. Stell Machelle T. Pardue Ranjay chakraborty Han na Park curran S. Sidhu P. Michael Iuvone Michael J collins Nethrajeith Srinvasalu Sally A. McFadden Paul N. Baird Pablo Artal Pauline cho SW cheung Pei-chang Wu Quan V. Hoang Duk c. Lee Erica G. Landis Michael A. Bergen curran Sidhu Samer Hattar Richard A. Stone Ravi Metlapally Ruiqin Li Qinglin Xu Hong Zhong chenglin Pan Weizhong Lan Xiaoning Li Ling chen Zhikuan Yang Scott A. Read Seang-Mei Saw Shi-Jun Weng Xiao-Hua Wu Kang-Wei Qian Yun-Yun Li Guo-Zhong Xu Furong Huang Xiong-Li Yang Yong-Mei Zhong Earl L Smith, III Baskar Arumugam Li-Fang Hung Lisa A. Ostrin Klaus Trier Monica Jong Brien A. Holden Thomas chuen Lam Samantha Shan Bing Zuo Dennis Yan-yin Tse Jingfang Bian King-Kit Li Quan Liu chi-ho To Timothy J. Gawne John T. Siegwart, Jr. Alexander H. Ward Thomas T. Norton Yan Zhang Yue Liu carol Ho Eileen Phan Abraham Hang Emily Eng christine Wildsoet Department of Biological Sciences SUNY College of Optometry New York NY 10036 USA School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China center for Eye Disease & Development School of Optometry & Vision Science Program University of California Berkeley Berkeley CA 94720-2020 USA Wenzhou Medical University Wenzhou Zhejiang 325027 China Biomedical Science and Disease New England College of Optom Boston MA USA School of Optometry Chung Shan Medical University Taichung City 402 Taiwan Institute of Medicine Chung Shan Medical University Taichung City 402 Taiwan Division of Biochemistry and Molecular Biology Research School of Biology Australian National University Canberra Australia State Key Laboratory of Ophthalmology and Division of Preventive Ophthalmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China School of Optometry & Vision Sciences Cardiff University Cardiff UK School of Social and community Medicine University of Bristol Bristol UK School of and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China State Key Laboratory cultivation Base and Key Laboratory of Vision Science Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Zhejiang 325027 People’s Republic of China Shanghai Key Laboratory of Diabetes Mellitus and center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233 China Eye Hospital of Wenzhou Medical University Wenzhou Zhejiang 325027 China Department of Ophthalmology Keio University School of Medicine Shinjuku-ku Tokyo 160-8582 Japan General Medicine Ichikawa Medical Center Urayasu City Chiba 279-0001 Japan Ophthalmic Research Institute University of Tuebingen 72076 Tuebingen Germany Bernstein center for computational Neuroscience Tuebingen 72076 Tuebingen Germany Werner Reichardt centre for Integrative Neuroscience Otfried-Mueller-Straße 25 Tueb

To assess the peripheral refractive changes that occur when eye growth decelerates in *** We measured peripheral refraction and on-axis vitreous chamber depth on a total of 53 marmosets;36 treated monocularly for 12 weeks 9 hrs/day(26 with-5 D contact lenses,10 with+5 D)and 17 untreated *** the 26 marmosets treated with-5 D,10 wore contact lenses 9 hrs/day without interruptions and were mea-sured at the end of 10 weeks of treatment(T10)and after 4 weeks of recovery(R14).Eight had both contact lenses removed for 30 mins twice/day(mid-morning and mid-afternoon)during the first four weeks of treatment(early interruption group)and eight had the lenses removed during the second four weeks of treatment(late interruption group).The two interruption groups were measured after 4,8 and 12 weeks of treatment only(T4,T8,T12).

关键词： removed treatment untreated

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