检索结果-南通市图书馆

biomaterials for stem cell engineering and biomanufacturing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

bioactive Materials 2019年第1期4卷 366-379页

作者： Yibo Xu Chuanxin Chen peter b.Hellwarth Xiaoping bao Davidson School of Chemical Engineering Purdue UniversityWest LafayetteWest LafayetteIN47907USA

Recent years have witnessed the expansion of tissue failures and *** uprising of regenerative medicine converges the sight onto stem cell-biomaterial based *** engineering and regenerative medicine proposes the strategy of constructing spatially,mechanically,chemically and biologically designed biomaterials for stem cells to grow and ***,this paper summarized the basic properties of embryonic stem cells(ESCs),induced pluripotent stem cells(iPSCs)and adult stem *** properties of frequently used biomaterials were also described in terms of natural and synthetic ***,the combination of stem cells and biomaterials for tissue repair applications was reviewed in terms of nervous,cardiovascular,pancreatic,hematopoietic and musculoskeletal ***,stem-cell-related biomanufacturing was envisioned and the novel biofabrication technologies were discussed,enlightening a promising route for the future advancement of large-scale stem cell-biomaterial based therapeutic manufacturing.

关键词： Stem cells biomaterial Regenerative medicine biofabrication biomanufacturing

Application of Generalized Standard Addition Method and Ultraviolet Spectroscopy to Quantify Electrolytic Depolymerization of Lignin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Analysis and Testing 2020年第1期4卷 35-44页

作者： Zewei Chen Mahtab NaderiNasrabadi John A.Staser peter b.Harrington Department of Chemistry and biochemistry Clippinger LaboratoriesOhio UniversityAthensOH 45701USA Department of Chemical and biomolecular Engineering Center for Electrochemical Engineering ResearchOhio UniversityAthensOH 45701USA

Industrial lignin waste is an important byproduct of bio-refineries and the paper *** of industrial lignin could generate useful aromatic *** group has focused on electrolytic decomposition of biorefinery *** quantify electrolytic decomposition of the lignin in a highly caustic solution,ultraviolet(UV)spectroscopy provides a useful *** conversion of the neat lignin to the oxidized products achieved by the electrolytic reactor may be measured by quantifying the amount of unreacted neat lignin that remains in the *** the properties of electrolytic decomposition products are largely unknown,a useful approach to quantify decomposition of the neat lignin is to use a multivariate calibration method referred to as the generalized standard addition method(GSAM).In this approach,the electrolytic decomposition products represent a background interference and the neat lignin that remains can be *** approach allows the conversion of the neat lignin to be calculated in a solution that is a complex mixture.

关键词： GSAM Lignin depolymerization Electrolytic reactor UV spectroscopy best linear unbiased estimator(bLUE)

Cellular senescence:from anti-cancer weapon to anti-aging target

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2020年第3期63卷 332-342页

作者： Lifeng Yuan peter bAlexander Xiao-Fan Wang Program in Cellular and Molecular Medicine Boston Children’s HospitalBostonMA 02115USA Department of Genetics Harvard Medical SchoolBostonMA 02115USA Duke University Medical Center DurhamNC 27710USA

Cellular senescence(CS)is a state of stable cell cycle arrest characterized by the production and secretion of inflammatory *** studies described oncogene-induced senescence(OIS)as a barrier to tumorigenesis,such that the therapeutic induction of CS might represent a rational anti-cancer ***,the validity of this approach has been borne out by the development and approval of the cyclin-dependent kinase(CDK)inhibitor palbociclib for the treatment of breast *** from tumors,senescent cells have also been shown to accumulate during natural mammalian aging,where they produce detrimental effects on the physiology of surrounding ***,pharmacological senescent cell depletion has been proposed as an approach to delay age-related functional decline;this has been formally demonstrated in animal *** this review article,we describe the current mechanistic understanding of cellular senescence at the molecular level and how it informs the development of new therapeutic strategies to combat cancer and aging.

关键词： cellular senescence cancer healthy aging pro-senescence cancer therapy senolytic therapies

Spectral Representation of Proton NMR Spectroscopy for the Pattern Recognition of Complex Materials

在线全文

学校读者我要写书评

暂无评论

Journal of Analysis and Testing 2017年第2期1卷 1-11页

作者： peter de b.Harrington Xinyi Wang Clippinger Laboratories Department of Chemistry and BiochemistryCenter for Intelligent Chemical InstrumentationOhio UniversityAthensOH 45701-2979USA

Proton nuclear magnetic resonance(NMR)spectroscopy provides a powerful tool for chemical profiling,also known as spectral fingerprinting,because of its inherent *** is now increasing in use for authentication of complex ***,the absorbance spectrum is used that is obtained as the phase-corrected real component of the Fourier transform(FT)of the free induction decay(FID).However,the practice discards half the information that is available in the dispersion spectrum obtained as the imaginary component from the *** qualitative analysis or quantitative analysis of small sets of absorbance peaks,the symmetric and sharp peaks of the real spectra work ***,for pattern recognition of entire spectra,trading peak resolution for peak reproducibility is *** absolute value of the complex spectrum gives the length or magnitude of magnetization vector in the complex plane;therefore,the magnitude relates directly to the signal(i.e.,induced magnetization).The magnitude spectrum is obtained as the absolute value from the real and imaginary spectral components after the FT of the *** breaking with tradition and using the magnitude spectrum the reproducibility of the spectra and consequent recognition rates can be *** study used a 500-MHz 1H NMR instrument to obtain spectra from 4 diverse datasets;12 tea extracts,8 liquor samples,9 hops extracts,and 25 Cannabis *** classifiers were statistically evaluated using 100 bootstrapped Latin *** classifiers were a fuzzy rule-building expert system(FuRES)tree,support vector machine trees(SVMTreeG and SVMTreeH),a regularized linear discriminant analysis(LDA),super partial least squares discriminant analysis(sPLS-DA),and a one against all support vector machine(SVM).All classifiers gave better or equivalent results for the magnitude spectral representation than for the real spectra,except for one case of the 24 *** addition,the enhanced reproducibilit

关键词： Cannabis Tea Hops Liquor HumulusNMR fingerprinting Magnitude spectrum Absolute value spectrum Pattern recognition Classification

A systematic literature review on the effectiveness of eurythmy therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2015年第4期13卷 217-230页

作者： Désirée Lotzke peter Heusser Arndt büssing Quality of Life Spirituality and Coping Institute of Integrative Medicine University of Witten/Herdecke Theory of Medicine Integrative and Anthroposophic Medicine Institute of Integrative MedicineUniversity of Witten/Herdecke

bACKGROUND：Eurythmy therapy is a movement therapy of anthroposophic medicine that can have effects on a person’s physical body,spirit,and ***：The aim of this publication was to update and summarize the relevant literature on the effectiveness of eurythmy in a therapeutic context since *** STRATEGY：Different databases like Pub Med,MEDPILOT,Research Gate,The Cochrane Library,DIMDI,Arthe and also the journal databases Der Merkurstab and the European Journal of Integrative Medicine were searched for prospective and retrospective clinical trials in German or English *** CRITERIA：There were no limitations for indication,considered outcome or age of *** EXTRACTION AND ANALYSIS：Studies were evaluated with regard to their description of the assembly process and treatment,adequate reporting of follow-ups,and equality of comparison groups in controlled ***：Eleven studies met the inclusion *** included two single-arm,non-controlled pilot studies,two publications on the same non-randomized controlled trial and one case study;six further studies referred to a prospective cohort study,the Anthroposophic Medicine Outcome *** of these studies described positives treatment effects with varying effect *** studies were heterogynous according to the indications,age groups,study design and measured *** methodological quality of the studies varied *** were no clear improvements since 2008,when the recommendations were published in the fi rst ***：Eurythmy seems to be a benefi cial add-on in a therapeutic context that can improve the health conditions of affected *** methodologically sound studies are needed to substantiate this positive impression.

关键词： eurythmy therapy mind-body and relaxation techniques anthroposophy review

The Evolution of Ultrafine Grained Structure Formation Through Isothermal Static Phase Transformation

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2011年第S1期18卷 218-222页

作者： HOSSEIN beladi ILANA b Timokhina SUbRATA Mukherjee peter D Hodgson Centre for Material and Fibre Innovation Deakin UniversityGeelongAustraliaVic 3216

In the current study,a 0.3C-2Si-2Mn-0.28Mo (in wt%) steel with high hardenability was deformed at a relatively low temperature followed by isothermal static phase *** novel thermomechanical processing made it possible to successfully produce an ultrafine ferrite grained structure (～2 μm) in the absence of both dynamic phase transformation and controlled *** use of a model Ni-30Fe austenitic alloy showed that the low temperature deformation induced very fine intragranular defects throughout the microstructure,which would then act as fine spaced ferrite nucleation sites at an early stage of phase *** a result,the coarsening of ferrite was extremely limited during isothermal phase transformation,resulting a very fine ferrite grained structure;even nanoscale in the region of the prior austenite grain boundary.

关键词： ultrafine ferrite warm deformation isothermal phase transformation substructure

Clinical and dietary predictors of common carotid artery intima media thickness in a population with type 1 and type 2 diabetes: A cross-sectional study

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2017年第1期8卷 18-27页

作者： Kristina S petersen Jennifer b Keogh peter J Meikle Manohar L Garg peter M Clifton School of Pharmacy and Medical Sciences University of South Australia baker IDI Heart and Diabetes Institute Nutraceuticals Research Group University of NewcastleCallaghan

AIM To determine the clinical and dietary predictors of common carotid artery intima media thickness(CCA IMT) in a cohort of subjects with type 1 and type 2 diabetes. METHODS Participants with type 1(n = 23) and type 2 diabetes(n = 127) had mean and mean maximum CCA IMT measured using b mode ultrasound. Dietary intake was measured using a food frequency questionnaire. Clinical and dietary predictors of mean and mean maximum CCA IMT were determined using linear regression analysis adjusted for potential confounders. RESULTS The main predictors of mean and mean maximum CCA IMT were age and weight. After multivariate adjustment there were no dietary predictors of CCA IMT. However,in subjects that were not prescribed a lipid lowering medication alcohol consumption was positively associated with CCA IMT after multivariate adjustment. No difference existed in CCA IMT between subjects with type 1 or type 2 diabetes once age was adjusted for. CONCLUSION CCA IMT was predominantly predicted by age and weight in these subjects with diabetes. The finding that CCA IMT was not different between people with type 1 and type 2 diabetes warrants further investigation in a larger cohort.

关键词： Diabetes Carotid intima media thickness Arterial structure Diet Lipidomics Carotenoids

Radial basis Function Networks Applied in bacterial Classification based on MALDI-TOF-MS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2002年第4期18卷 453-457页

作者： HARRINGTON peter de b. VOORHEES Kent J. REES Jon Ohio University Center for Intelligent Chemical Instrumentation Department of Chemistry and Biochemistry Ohio UniversityDepartment of Chemistry and Geochemistry Colorado School of MinesDepartment of Chemistry and Geochemistry Colorado School of Mines Athens Ohio 45701-2979 USA Golden CO 80401 USAGolden CO 80401 USA

The radial basis function networks were applied to bacterial classification based on the matrix-assisted laser desorption/ionization time-of-flight mass spectrometric (MALDI-TOF-MS) data. The classification of bacteria cultured at different time was discussed and the effect of the network parameters on the classification was investigated. The cross-validation method was used to test the trained networks. The correctness of the classification of different bacteria investigated changes in a wide range from 61.5% to 92.8%. Owing to the complexity of biological effects in bacterial growth, the more rigid control of bacterial culture conditions seems to be a critical factor for improving the rate of correctness for bacterial classification.

关键词： Radial basis function network Matrix-assisted laser desorption/ionization Time-of-flight mass spectrometry bacterium Classification

单样本学习下时序约束稀疏表示的物体识别方法

在线全文

学校读者我要写书评

暂无评论

中国科学：信息科学 2024年第1期54卷 191-209页

作者：童小宝熊鹏文宋爱国刘小平中南大学自动化学院长沙410083 南昌大学先进制造学院南昌330031 中国科学技术大学自动化系合肥230026 东南大学仪器科学与工程学院南京210096 Department of Systems and Computer Engineering Carleton UniversityOttawa K1S5B6Canada

非接触式传感器相比接触式触觉传感器可以避免与物体直接接触过程中产生的噪声,因而能够获取更有价值的原始数据表征物体内在属性;然而针对非接触式传感器感知的物体属性数据而言,现有算法难以实现单样本学习下的物体准确识别.为解决这... 详细信息

非接触式传感器相比接触式触觉传感器可以避免与物体直接接触过程中产生的噪声,因而能够获取更有价值的原始数据表征物体内在属性;然而针对非接触式传感器感知的物体属性数据而言,现有算法难以实现单样本学习下的物体准确识别.为解决这一问题,本文提出一种新颖的单样本学习下时序约束稀疏表示方法(one-shot learning with temporally constrained sparse representation,OSLTCSR)用于识别5种不同材料下的50个物体类别.首先将两种原始数据(Lumini光谱和SCiO光谱)并行投影至共享子空间,并且使用聚类典型关联分析法(cluster canonical correlation analysis,C-CCA)计算两种原始数据的聚类相关性特征;其次通过稀疏表示分别计算得到聚类相关性特征数据以及原始数据的编码向量,并利用原始数据的编码向量对相关性特征数据的编码向量进行二次投影映射;然后将两次映射后的原始数据和相关性特征数据进行重构,以充分耦合化两种光谱数据,解决了单样本学习下的数据稀缺问题;进一步地,设计新颖的时序约束稀疏表示方法计算重构后的原始数据和相关性特征数据,以充分考虑每个光谱序列的时序特征;最后与最新的物体识别方法进行实验对比,结果表明提出的OSL-TCSR方法提高了单样本学习情况下的物体识别结果.此外,OSL-TCSR还可灵活迁移至多种应用场景,比如材料识别或纹理识别等.

关键词：物体识别聚类相关性特征单样本学习时序约束正则化