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Circadian dysregulation and Alzheimer's disease:A comprehensive review

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Brain Science Advances 2022年第4期8卷 221-257页

作者： peter Iacobelli Departmentof arts and Sciences University of South CarolinaColumbiaUSA

Alzheimer’s disease(AD),the foremost variant of dementia,has been associated with a menagerie of risk factors,many of which are considered to be *** these modifiable risk factors is circadian rhythm,the chronobiological system that regulates sleep-wake cycles,food consumption timing,hydration timing,and immune responses amongst many other necessary physiological *** rhythm at the level of the suprachiasmatic nucleus(SCN),is tightly regulated in the human body by a host of biomolecular substances,principally the hormones melatonin,cortisol,and *** addition,photic information projected along afferent pathways to the SCN and peripheral oscillators regulates the synthesis of these hormones and mediates the manner in which they act on the SCN and its *** of this cycle,whether induced by environmental changes involving irregular exposure to light,or through endogenous pathology,will have a negative impact on immune system optimization and will heighten the deposition of Aβand the hyperphosphorylation of the tau *** these correlations,it appears that there is a physiologic association between circadian rhythm dysregulation and *** review will explore the physiology of circadian dysregulation in the AD brain,and will propose a basic model for its role in AD-typical pathology,derived from the literature compiled and referenced throughout.

关键词： Alzheimer’s disease circadian pathology amyloid tau

Sports： Martial arts--Let＇s Learn TAEKWONDO!

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空中英语教室（初级版．大家说英语） 2015年第9期 11-14,49页

作者： peter Smith

Not yet IDEAL?-evidence and learning curves of minimally invasive pancreaticoduodenectomy

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Hepatobiliary Surgery and Nutrition 2020年第6期9卷 812-814页

作者： Felix Nickel Caelán Max Haney Beat-peter Müller-Stich Thilo Hackert Department of General Visceraland Transplantation SurgeryHeidelberg UniversityHospital HeidelbergHeidelbergGermany

In response to“What’s the next step in evaluating laparoscopic pancreaticoduodenectomy?”(http://***/article/view/29682/25710)by Fernando Burdío,Luís Grand and Ignasi *** and foremost,we would like to express our sincere condolences on the passing of Professor Ignasi *** were deeply saddened to hear of this and wish his family,friends and colleagues strength in these difficult times of grieving.

关键词： IDEAL learning Grand

Geolocator study reveals east African migration route of Central European Common Terns

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Avian Research 2020年第1期11卷 34-44页

作者： Jelena Kralj Milos Martinovic Luka Jurinovic peter Szinai Szandra Suto Balint Preiszner Institute of Ornithology Croatian Academy of Sciences and ArtsGunduliceva 2410000 ZagrebCroatia Poultry Centre Croatian Veterinary InstituteHeinzelova 5510000 ZagrebCroatia Balaton-felvideki National Park Directorate Csopak 8229Hungary Department of Limnology University of PannoniaVeszprem 8200Hungary Balaton Limnological Institute MTA Centre for Ecological ResearchTihany 8237Hungary

Background: The majority of European Common Terns(Sterna hirundo) migrate south along the western coast of Europe and Africa, while birds from eastern regions are known to cross the Mediterranean Sea from east to west or migrate along the eastern African coast. The migration route of north European terns wintering along the coast of western Africa was already described using geolocator data, while knowledge about movements of the European inland populations is based only on relatively scarce recoveries of ringed ***: We used light-level geolocators in inland Common Tern colonies in Hungary and Croatia to study their migration route and to identify wintering areas along with stopover sites. Results revealed by geolocators were compared with recoveries of ringed ***: All tracked birds used the east African migration route with autumn stopovers at Lower Nile and in the southern part of the Red Sea, and short spring stopover in Israel. Terns wintered along Kenyan coasts and in the southern Mozambique Channel. Autumn migration lasted four times longer than spring ***: This is the first geolocator study that describes the east African migration route of the Common Tern. Important stopover sites were identified. More studies of inland populations are needed to better elucidate tern winter movements.

关键词： Inland population Light-level geolocators Mozambique Channel Red Sea Sterna hirundo Stopover sites Wintering area

Analysis and Dynamics of Fractional Order Mathematical Model of COVID-19in Nigeria Using Atangana-Baleanu Operator

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Computers, Materials & Continua 2021年第2期66卷 1823-1848页

作者： Olumuyiwa J.peter Amjad S.Shaikh Mohammed O.Ibrahim Kottakkaran Sooppy Nisar Dumitru Baleanu Ilyas Khan Adesoye I.Abioye Department of Mathematics University of IlorinIlorinKwaraNigeria Department of Mathematics AKI’s Poona College of ArtsScience and CommerceCampPuneIndia Department of Mathematics College of Arts and SciencesPrince Sattam bin Abdulaziz UniversityWadi AldawaserSaudi Arabia Department of Mathematics Cankaya UniversityAnkara06790Turkey Institute of Space Sciences Magurele-Bucharest077125Romania Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung40447Taiwan Faculty of Mathematics and Statistics Ton Duc Thang UniversityHo Chi Minh CityVietnam

We propose a mathematical model of the coronavirus disease 2019(COVID-19)to investigate the transmission and control mechanism of the disease in the community of *** stability theory of differential equations,the qualitative behavior of model is *** pandemic indicator represented by basic reproductive number R0 is obtained from the largest eigenvalue of the next-generation *** as well as global asymptotic stability conditions for the disease-free and pandemic equilibrium are obtained which determines the conditions to stabilize the exponential spread of the ***,we examined this model by using Atangana–Baleanu fractional derivative operator and existence criteria of solution for the operator is *** consider the data of reported infection cases from April 1,2020,till April 30,2020,and parameterized the *** have used one of the reliable and efficient method known as iterative Laplace transform to obtain numerical *** impacts of various biological parameters on transmission dynamics of COVID-19 is *** results are based on different values of the fractional parameter and serve as a control parameter to identify the significant strategies for the control of the *** the end,the obtained results are demonstrated graphically to justify our theoretical findings.

关键词： Mathematical model COVID-19 Atangana-Baleanu fractional operator existence of solutions stability analysis numerical simulation

Intraprocedural gastric juice analysis as compared to rapid urease test for real-time detection of Helicobacter pylori

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World Journal of Gastroenterology 2023年第10期29卷 1638-1647页

作者： Riccardo Vasapolli Florent Ailloud Sebastian Suerbaum Jens Neumann Nadine Koch Lukas Macke Jörg Schirra Julia Mayerle peter Malfertheiner Christian Schulz Medical DepartmentⅡ University Hospital LMU MunichMunich 81377Germany Deutsches Zentrum für Infektionsforschung Partner Site MunichMunich 81377Germany Max von Pettenkofer Institute Faculty of MedicineLudwig-Maximilians University of MunichMunich 80336Germany National Reference Center for Helicobacter pylori Munich 81377Germany Institute of Pathology Faculty of MedicineLudwig-Maximilians-University of MunichMunich 81377Germany

BACKGROUND Endofaster is an innovative technology that can be combined with upper gastrointestinal endoscopy(UGE)to perform gastric juice analysis and real-time detection of Helicobacter pylori(***).AIM To assess the diagnostic performance of this technology and its impact on the management of *** in the real-life clinical *** Patients undergoing routine UGE were prospectively *** were taken to assess gastric histology according to the updated Sydney system and for rapid urease test(RUT).Gastric juice sampling and analysis was performed using the Endofaster,and the diagnosis of *** was based on real-time ammonium *** detection of *** served as the diagnostic gold standard for comparing Endofaster-based *** diagnosis with RUT-based *** *** A total of 198 patients were prospectively enrolled in an *** diagnostic study by Endofasterbased gastric juice analysis(EGJA)during the *** for RUT and histological assessment were performed on 161 patients(82 men and 79 women,mean age 54.8±19.2 years).*** infection was detected by histology in 47(29.2%)***,the sensitivity,specificity,accuracy,positive predictive value,and negative predictive value(NPV)for *** diagnosis by EGJA were 91.5%,93.0%,92.6%,84.3%,and 96.4%,*** patients on treatment with proton pump inhibitors,diagnostic sensitivity was reduced by 27.3%,while specificity and NPV were *** and RUT were comparable in diagnostic performance and highly concordant in *** detection(κ-value=0.85).CONCLUSION Endofaster allows for rapid and highly accurate detection of *** during *** may guide taking additional biopsies for antibiotic susceptibility testing during the same procedure and then selecting an individually tailored eradication regimen.

关键词： Helicobacter pylori diagnostic Chronic gastritis Gastric juice Endofaster Rapid urease test Antimicrobial susceptibility testing

Optical properties of excitons in strained Ga_x In_1-x As/GaAs quantum dot: effect of geometrical confinement on exciton g-factor

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Chinese Optics Letters 2013年第8期11卷 80-86页

作者： N. R. Senthil Kumar A. John peter Chang Woo Lee Department of Physics RVS School of Engineering College Department of Physics Govt.Arts College Department of Chemical Engineering and Green Energy Center College of EngineeringKyung Hee University

Taking into account anisotropy, nonparabolicity of the conduction band, and geometrical confinement, we discuss the heavy-hole excitonic states in a strained GaxIn1-xAs/GaAs quantum dot for various Ga alloy contents. The strained quantum dot is considered as a spherical InAs dot surrounded by a GaAs barrier material. The dependence of the effective excitonic g-factor as a function of dot radius and Ga ion content is numerically measured. Interband optical energy with and without the parabolic effect is computed using structural confinement. The interband matrix element for different Ga concentrations is also calculated. The oscillator strength of interband transitions on the dot radius is studied at different Ga concentrations in the GaxIn1-xAs/GaAs quantum dot. Heavy-hole excitonic absorption spectra are recorded for various Ga alloy contents in the GaxIn1-xAs/GaAs quantum dot. Results show that oscillator strength diminishes when dot size decreases because of the dominance of the quantum size effect. Furthermore, exchange enhancement and exchange sDlitting increase as exciton confinement inereases.

关键词： GaAs effect of geometrical confinement on exciton g-factor Optical properties of excitons in strained Gax In1-x As/GaAs quantum dot

A flexible protruding microelectrode array for neural interfacing in bioelectronic medicine

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Microsystems & Nanoengineering 2022年第6期8卷 165-179页

作者： Helen Steins Michael Mierzejewski Lisa Brauns Angelika Stumpf Alina Kohler Gerhard Heusel Andrea Corna Thoralf Herrmann peter D.Jones Günther Zeck Rene von Metzen Thomas Stieglitz NMI Natural and Medical Sciences Institute at the University of Tübingen ReutlingenGermany Laboratory for Biomedical Microtechnology Department of Microsystems EngineeringUniversity of FreiburgFreiburgGermany Institute of Biomedical Electronics TU WienViennaAustria Bernstein Center Freiburg University of FreiburgFreiburgGermany BrainLinks-BrainTools University of FreiburgFreiburgGermany

Recording neural signals from delicate autonomic nerves is a challenging task that requires the development of a lowinvasive neural interface with highly selective,micrometer-sized *** paper reports on the development of a three-dimensional(3D)protruding thin-film microelectrode array(MEA),which is intended to be used for recording low-amplitude neural signals from pelvic nervous structures by penetrating the nerves transversely to reduce the distance to the *** gold pillars(O 20 or 50μm,~60μm height)were fabricated on a micromachined polyimide substrate in an electroplating *** sidewalls were insulated with parylene C,and their tips were optionally modified by wet etching and/or the application of a titanium nitride(TiN)*** microelectrodes modified by these combined techniques exhibited low impedances(~7 kΩ at 1 kHz for ∅ 50μm microelectrode with the exposed surface area of~5000μm^(2))and low intrinsic noise *** functionalities were evaluated in an ex vivo pilot study with mouse retinae,in which spontaneous neuronal spikes were recorded with amplitudes of up to 66μ*** novel process strategy for fabricating flexible,3D neural interfaces with low-impedance microelectrodes has the potential to selectively record neural signals from not only delicate structures such as retinal cells but also autonomic nerves with improved signal quality to study neural circuits and develop stimulation strategies in bioelectronic medicine,e.g.,for the control of vital digestive functions.

关键词： neural microelectrode electronic

User-Level Device Drivers： Achieved Performance

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Journal of Computer Science & Technology 2005年第5期20卷 654-664页

作者： Ben Leslie peter Chubb Nicholas Fitzroy-Dale Stefan Gotz Charles Gray Luke Macpherson Daniel Potts Yue-Ting Shen Kevin Elphinstone Gernot Heiser National ICT Australia and School of Computer Science and Engineering University of New South Wales Sydney 2052 Australia Wilhelm-Schickard-Institute for Computer Science University of Tǖbingen D-72076 Tǖbingen Germany

Running device drivers as unprivileged user-level code, encapsulated into their own process, has often been proposed as a technique for increasing system robustness. However, in the past, systems based on user-level drivers have generally exhibited poor I/O performance. Consequently, user-level device drivers have never caught on to any significant degree. In this paper we demonstrate that it is possible to build systems which employ user-level device drivers, without significant performance degradation, even for high-bandwidth devices such as Gigabit Ethernet.

关键词： device drivers operating systems performance reliability