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Benchmark experiment on slab^(238)U with D-t neutrons for validation of evaluated nuclear data

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Nuclear Science and techniques 2024年第2期35卷 145-159页

作者： Yan-Yan Ding Yang-Bo Nie Yue Zhang Zhi-Jie Hu Qi Zhao Huan-Yu Zhang Kuo-Zhi Xu Shi-Yu Zhang Xin-Yi Pan chang-Lin Lan Jie Ren Xi-chao Ruan Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Nuclear Science and technology Lanzhou UniversityLanzhou 730000China Institute of Fluid Physics China Academy of Engineering PhysicsMianyang 62100China

A benchmark experiment on^(238)U slab samples was conducted using a deuterium-tritium neutron source at the china Institute of Atomic *** leakage neutron spectra within energy levels of 0.8-16 MeV at 60°and 120°were measured using the time-of-flight *** samples were prepared as rectangular slabs with a 30 cm square base and thicknesses of 3,6,and 9 *** leakage neutron spectra were also calculated using the McNP-4c program based on the latest evaluated files of^(238)U evaluated neutron data from cENDL-3.2,ENDF/B-Ⅷ.0,JENDL-5.0,and *** on the comparison,the deficiencies and improvements in^(238)U evaluated nuclear data were *** results showed the following.(1)the calculated results for cENDL-3.2 significantly overestimated the measurements in the energy interval of elastic scattering at 60°and 120°.(2)the calculated results of cENDL-3.2 overestimated the measurements in the energy interval of inelastic scattering at 120°.(3)the calculated results for cENDL-3.2 significantly overestimated the measurements in the 3-8.5 MeV energy interval at 60°and 120°.(4)the calculated results with JENDL-5.0 were generally consistent with the measurement results.

关键词： Leakage neutron spectra Uranium D-t neutron source Evaluated nuclear data

Adjuvant camrelizumab plus apatinib in resected hepatocellular carcinoma with microvascular invasion:a multi-center real world study

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 616-631,I0022-I0024页

作者： Jingzhong Ouyang Yi Yang Yanzhao Zhou Xu chang Zhengzheng Wang Qingjun Li Yu tang Jianqiang cai Jinxue Zhou Zhen Huang Hong Zhao Department of Hepatobiliary and Pancreatic Surgery The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhouChina Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Key Laboratory of Gene Editing Screening and Research and Development(R&D)of Digestive System tumor Drugs Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Interventional therapy II Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinanChina clinical trials center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background:It is well known that laparoscopic liver surgery can offer advantages over open liver surgery in selected ***,what type of procedures can benefit most from a laparoscopic approach has been investigated poorly thus *** aim of this study is thus to define the extent of advantages of laparoscopic over open liver surgery for lesions in the anterolateral(AL)and posterosuperior(PS)***:In this international multicentre retrospective cohort study,laparoscopic and open minor liver resections for lesions in the AL and PS segments were compared after propensity score *** differential benefit of laparoscopy over open liver surgery,calculated using bootstrap sampling,was compared between AL and PS resections and expressed as a Delta of the ***:After matching,3,040 AL and 2,336 PS resections were compared,encompassing open and laparoscopic procedures in a 1:1 *** and PS laparoscopic liver resections were more advantageous in comparison to open in terms of blood loss,transfusion rate,complications,and length of ***,AL resections benefitted more from laparoscopy than PS in terms of overall and severe complications(D-difference were 4.8%,P=0.046 and 3%,P=0.046)and blood loss(D-difference was 195 mL,Pts were observed in the subset for high-volume centres,while in recent years no significant differences were found in the differential benefit between AL and PS ***:the advantage of laparoscopic over open liver surgery is greater in the AL segments than in the PS segments.

关键词： Liver neoplasms hepatectomy laparoscopic liver resection open liver resection

Melittin analog p5RHH enhances recombinant adeno-associated virus transduction efficiency

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Journal of Integrative Medicine 2024年第1期22卷 72-82页

作者： Jing-shun Meng Yun He Heng-bin Yang Li-ping Zhou Si-yuan Wang Xi-lin Feng Omar Yahya Al-shargi Xiao-min Yu Li-qing Zhu chang-quan Ling Shanghai University of traditional chinese Medicine Shanghai 201203China Oncology Department of traditional chinese Medicine Changhai HospitalNaval Medical UniversityShanghai 200433China Faculty of traditional chinese Medicine Naval Medical UniversityShanghai 200043China State Key Laboratory of Genetic Engineering and Engineering Research center of Gene technology(Ministry of Education) School of Life SciencesZhongshan HospitalFudan UniversityShanghai 200438China Yantai Fuheng Biological technology co. Ltd.YantaiShandong Province 264006China. Department of clinical Laboratory the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

Objective Melittin and its derivatives have been characterized to establish effective gene delivery *** capability of facilitating endosomal release enhances the nanoparticles-based gene ***,little investigation has been conducted to explore its potential application in the context of viral *** Various melittin-derived peptides were inserted into the loop VIII of the capsid proteins of recombinant adeno-associated virus *** vectors carrying either gfp or fluc genes were subjected to qPcR assays and transduction assays of HEK293t cells to investigate the efficiency of vector production and gene *** addition,the ability of a specific p5RHH-rAAV vector to deliver genes was examined through in vitro transduction of different cultured cells and in vivo tail vein administration to c57BL/6 ***,the intricate details of the vector-mediated transduction mechanisms were revealed by specific pharmacological inhibitors of every stage of the rAAV2 intracellular life *** A total of 76 melittin-related peptides were compiled from existing *** them,cMA2,Melt13,p5RHH and aAR3 were found to significantly enhance the gene delivery efficiency of rAAV2 *** p5RHH-rAAV2 vectors efficiently transduced not only rAAV-potent cell lines but also cell lines previously considered resistant to ***,bafilomycin A1,a vacuolar endosome acidification inhibitor,completely inhibited the transgene expression mediated by the p5RHH-rAAV2 *** importantly,p5RHH-rAAV8 vectors also demonstrated increased hepatic transduction in vivo in c57BL/6 *** the incorporation of melittin analogues into the rAAV capsids results in a significant improvement in rAAV-mediated transgene *** further modifications remain an area of interest,our studies have substantially broadened the pharmacological prospects of melittin in the context of viral vector-mediated gene delivery.

关键词： Melittin Recombinant adeno-associated virus capsid engineering transduction efficiency

South　china　Sea　Warm　Pool　in　Boreal　Spring

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Advances in Atmospheric Sciences 1997年第2期14卷 72-83页

作者： peter c. chu c. P. chang Naval Postgraduate School Monterey USA

During the boreal spring of 1966, a warm-core eddy is identified in the upper South china Sea (ScS) west of the Philippines through an analysis of the U.S. Navy′s Master Oceanographic Observation Data Set. this eddy occurred before the development of the northern summer monsoon and disappeared afterward. We propose that this eddy is a result of the radiative warming during spring and the downwelling due to the anticyclonic forcing at the surface. Our hypothesis suggests an air-sea feedback scenario that may explain the development and withdrawal of the summer monsoon over the ScS. the development phase of the warm-core eddy in this hypothesis is tested by using the Princeton Ocean model.

关键词： Warm-core eddy Summer monsoon Downwelling South china Sea

Permian ridge subduction-related magmatism in the chinese Altai: Insights from geochronology and geochemistry of the Jiangjunshan pluton

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Journal of Earth Science 2024年

作者： Shi-Heng Bai Ru-Xiong Lei Matthew J.Brzozowski Zhenhua Wang Wei Wang chang-Zhi Wu Laboratory of Mineralization and Dynamics， School of Earth Science and Resources， chang'an University Xinjiang Natural Resources and Ecological Environment Research center

the chinese Altai is an important constituent of the central Asian Orogenic Belt， a prominent Phanerozoic accretionary orogenic belt. Oceanic-continental subduction processes during the cambrian–carboniferous and intracontinental extension from the triassic onwards have been well constrained in the chinese Altai， the southwestern portion of the cAOB. characterizing the petrogenetic evolution of the chinese Altai during the Permian has， therefore， been considered critical to enhancing our understanding of the tectonic transformations that occurred in this region. Despite this， the tectonic environment of the chinese Altai during this period remains equivocal. to address this deficiency， this contribution characterizes the age of formation and geochemical composition of the Jiangjunshan pluton located in the southern portion of the chinese Altai. Zircon U-Pb geochronology demonstrates that the gabbro and two-mica alkali feldspar granite， which comprise the main body of the Jiangjunshan pluton， formed at ca. 272 ± 3.5 and 272 ± 1.6 Ma， respectively. Geochemically， the gabbro is depleted in light rare earth elements （LREE）， has low Nb/Yb （0.39–0.46） and ti/V （23.7–25.3） ratios， exhibits trace-element characteristics resembling normal mid-ocean ridge basalts （N-MORB）， but is depleted in Nb and ta similar to island arc basalts. the depleted Hf and Nd isotope compositions (εHf（t） = +0.60 to +4.63， εNd（t） = +6.32 to +7.80) of the gabbro， coupled with the weak correlation between εNd（t） values and SiO2contents， suggest that the magma from which it crystallized was slightly contaminated by crustal material during its evolution. Based on the Sm， Yb， and La contents， it is inferred that the melt from which the gabbro crystallized originated from approximately 8–20% partial melting of spinel lherzolite mantle. the depleted Hf and Nd isotope compositions (εHf（t） = +6.81 to +9.10， εNd（t） = +0.79 to +1.45) of the granite， combined with petrographic observations （e.g.， absent of the

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Laguerre expansion on the Heisenberg group and Fourier-Bessel transform on c^n Dedicated to Professor Sheng GONG on the occasion of his 75th birthday

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Science china Mathematics 2006年第11期49卷 1722-1739页

作者： chang Der-chen GRIENER peter Department of Mathematics Georgetown University Washington DC 20057USA Department of Mathematics University of toronto TorontoON M5S 3G3Canada

Given a principal value convolution on the Heisenberg group Hn = cn × R, we study the relation between its Laguerre expansion and the Fourier-Bessel expansion of its limit on cn. We also calculate the Dirichlet kerne... 详细信息

关键词： Heisenberg group, Fourier transform, Laguerre expansion, Bessel functions,Poisson sum, Dirichlet kernel.

Bonding enhancement of cold rolling tA1 P-ti/AA6061 composite plates via surface oxidation treatment

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transactions of Nonferrous Metals Society of china 2024年第9期34卷 2864-2880页

作者： Lun FU Bin YANG Yun-chang GUO chao YU Hong XIAO National Engineering Research center for Equipment and technology of cold Strip Rolling Yanshan UniversityQinhuangdao 066004China college of Mechanical Engineering Yanshan UniversityQinhuangdao 066004China

tA1 P-ti/AA6061 composite plate was produced by oxidizing the surface of the titanium plate and adopting a cold roll bonding *** results revealed that the oxide film(ti6O)prepared on the surface of tA1 pure titanium was easy to crack during the cold roll bonding,thereby promoting the formation of an effective mechanical interlock at the interface,which can effectively reduce the minimum reduction rate of the composite plates produced by cold rolling of titanium and aluminium ***,the composite plate subjected to oxidation treatment exhibited high shear strength,particularly at a 43%reduction rate,achieving a commendable value of 117 *** on oxidation treatment and different reduction rates,the annealed composite plates at temperatures of 400,450,and 500°c displayed favorable resistance to interface delamination,highlighting their remarkable strength-plasticity compatibility as evidenced by a maximum elongation of 31.845%.

关键词： tA1 P-ti/AA6061 composite plate oxidation treatment annealing treatment cold roll bonding

Superior antibody and membrane protein‑specific t‑cell responses to coronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.cheng carolyn A.cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet chung tsun Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo c.H.tsang Sara chaothai tsz chun Kwan John K.c.Li Karl c.K.chan Leo L.H.Luk Jenson c.H.Ho Wing Yan Li Amos M.t.Lee Jennifer H.Y.Lam Sau Man chan Wilfred H.S.Wong Issan Y.S.tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei tu Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia center for Immunology and Infection c2i Hong KongChina

Background Optimising the immunogenicity of cOVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-coV-2)at the full dose is *** study(Nct04800133)investigated the superiority of antibody and t-cell responses of full-dose coronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-cc versus ID-cc)and post-dose 3(IMccc versus ID-ccc).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+cD4^(+),SNM-specific IL-2^(+)cD8^(+),S-specific IL-2^(+)cD8^(+),N-specific IL-2^(+)cD4^(+),N-specific IL-2^(+)cD8^(+)and M-specific IL-2^(+)cD4^(+)responses fulfilled the superior and non-inferior criteria for ID-cc compared to IM-cc,whereas IgG avidity was *** ID-ccc,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNt90),PRNt50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)cD4^(+),interferon-γ+cD8^(+)and IL-2^(+)cD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-cc,ID-cc,IM-ccc and ID-ccc,*** ID groups reported more local,mild adverse *** this is the first study to demonstrate superior antibody and M-specific t-cell responses by ID inactivated SARScoV-2 vaccination and serves as the basis for future research to improve the

关键词： coronaVac coronavirus disease 2019 Immunity Intradermal Vaccine

Inhibition of Bcl-6 Expression Ameliorates Asthmatic characteristics in Mice

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current Medical Science 2024年第1期44卷 110-120页

作者： chang-zhi ZHOU Xiong XIONG Wei-jun tAN Ya-fei WANG Zhen YANG Xue-ying LI Xiu-wen YANG Xiao-fan LIU Sun-feng YU Liang-chao WANG Shuang GENG Department of Respiratory and critical care Medicine The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China Department of General Surgery Wuhan Wuchang HospitalWuhan University of Science and TechnologyWuhan 430063China

Objective the function of Bcl-6 in t follicular helper(tfh)cell maturation is indispensable,and tfh cells play a pivotal role in *** study investigated the impact of Bcl-6 on asthmatic *** the microscopic pathological alterations,airway resistance(AR),and lung compliance(Lc)were determined in asthmatic mice and Bcl-6 interference *** surface molecular markers of tfh cells and the Bcl-6 mRNA and protein expression were determined by flow cytometry,Rt-qPcR,and Western blotting,*** relationships between the tfh cell ratio and the IgE and IgG1 concentrations in peripheral blood mononuclear cells(PBMcs)and bronchoalveolar lavage fluid(BALF)were *** Asthmatic inflammatory changes were observed in the lung tissue and were attenuated by Bcl-6 siRNA and dexamethasone(DXM).Asthmatic mice exhibited an increased AR and a decreased Lc,while Bcl-6 siRNA or DXM mitigated these *** percentages of tfh cells and eosinophils were significantly increased in the asthmatic mice,and they significantly decreased after Bcl-6 inhibition or DXM ***-qPcR and Western blotting analyses revealed that the Bcl-6 expression level in PBMcs was significantly higher in asthmatic mice,and it decreased following Bcl-6 inhibition or DXM *** IgE expression in the serum and BALF and the B cell expression in PBMcs exhibited a similar *** asthmatic mice,the ratio of tfh cells in the peripheral blood showed a strong positive correlation with the IgE levels in the serum and BALF,but not with the IgG1 *** the amelioration of airway inflammation and airway hyper-responsiveness is achieved through Bcl-6 suppression,which effectively hinders tfh cell differentiation,ultimately resulting in a concurrent reduction in IgE production.

关键词： Bcl-6 tfh asthma airway hyper-responsiveness mouse model