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Protective and Regenerative Efficacy of a Plant Oil-Based Day and Night Cream: Investigated by a Novel Approach to Reveal the Impact of Blue Light Irradiation on Epidermal Barrier Integrity and Lipid Matrix

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Journal of Cosmetics, Dermatological Sciences and Applications 2024年第3期14卷 227-241页

作者： Dorothee Dähnhardt Stephan Dähnhardt-Pfeiffer Isabel Simon Dana Ditgen Inge Holland Dörte Segger peter staib Microscopy Services Dhnhardt GmbH Flintbek Germany Research & Development and Regulatory Affairs Kneipp GmbH Wuerzburg Germany SGS INSTITUT FRESENIUS GmbH Hamburg Germany

In recent years, the harmful effects of blue light (400 - 500 nm) as a component of visible light (400 - 700 nm) have increasingly gained attention of science, industry, and consumers. To date, only a few in vivo test methods for measuring the effects of blue light on the skin have been described. A direct measurement method that can detect the immediate effects of blue light on the epidermal permeability barrier (EPB) is still lacking. In this study, we present a new methodological approach that can be used to investigate both the protective and regenerative effects of cosmetic products on the EPB after blue light irradiation. In a study with 14 female volunteers, it was investigated whether the regular application of an O/W emulsion (day cream) can strengthen and protect the epidermal barrier against damaging blue light radiation of 60 J/cm2 (protective study design) and also whether a disruption of the epidermal barrier caused by blue light radiation is restored faster and better by the regular application of another O/W emulsion (night cream) than in product-untreated skin (regenerative study design). The two O/W emulsions are different in plant oil, active ingredient composition and texture. The seven-day treatment with the day cream initially led to a significant increase in the normalized lipid lamellae length in the intercellular space, whereas the irradiation with blue light after 24 hours led to a significant decrease in the lipid lamellae length in the untreated test area, but not in the area previously treated with the product. Regarding the regenerative study design, a two-day treatment with the night cream was able to restore a blue-light-induced decrease in lipid lamellae length in the intercellular space. In summary, with the study designs presented here, the protective and regenerative effect of two cosmetic products could be demonstrated for the first time on the integrity of the EPB after blue light irradiation and the data showed that the Lipbarv

关键词： Skin Care Blue Light Irradiation Skin Barrier Intercellular Lipid Lamellae Electron Microscopy

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Consumer Panel Size in Sensory Cosmetic Product Evaluation: A Pilot Study from a Statistical Point of View

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Journal of Cosmetics, Dermatological Sciences and Applications 2018年第3期8卷 97-109页

作者： Jurgen Blaak Daniela Keller Isabel Simon Marina SchleiBinger Nanna Y.Schurer peter staib Research&Development and Regulatory Affairs Kneipp GmbHWurzburgGermany Statistik&Beratung Daniela Keller KurnachGermany Department of Dermatology Environmental Medicine and Health TheoryUniversity of OsnabruckGermany

Subjective evaluations are nowadays applied more commonly in cosmetic product assessment. They are used in quality control, product development steps and efficacy studies for claim support. Several studies have been published to determine the adequate number of panelists, but recommendations and guidelines dealing with this topic are rare in the cosmetic sector. The aim of the present pilot study was to recommend a suitable study plan and define the adequate consumer panel size for cosmetic consumer assessment. A questionnaire-based product evaluation study, with three different cosmetic products, was organized as a consumer test using a seven-point scale. As a last step, a specific statistical calculation was performed to define the minimum sample size. It showed that the minimum sample size, besides the obvious statistical parameters of standard deviation and confidence interval, also depends on age and gender of the panelists and product assessment item. Utilizing a CI of 95% a minimum of 60 panelists seems to be sufficient for home-use-test (HUT) with a given seven-point scale. A minimum of 101 panelists are shown to be sufficient utilizing a CI of 99%.

关键词： Claim Substantiation Consumer Panel Size Product Evaluation Sample Size Calculation

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A Commercially Available Skin Care Lotion with a pH of 4.5 and 10% Urea Improves Skin Surface pH, Stratum Corneum Hydration and Epidermal Barrier Function in Subjects with Dry Skin and Atopic Diathesis

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Journal of Cosmetics, Dermatological Sciences and Applications 2020年第3期10卷 116-133页

作者： Jürgen Blaak Christiane Theiss Marina Schleißinger Isabel Simon Nanna Y. Schürer peter staib Department of Research & Development and Regulatory Affairs Kneipp GmbH Würzburg Germany Department of Dermatology Environmental Medicine and Health Theory University of Osnabrück Osnabrück Germany

OBJECTIVE: The physiological skin surface pH is crucial for several epidermal barrier functions, like stratum corneum integrity, cohesion and restoration. Alterations of the “normal” acidic nature of the skin surface have been shown to correlate with specific skin conditions like aged or inflamed skin and are leading to impaired skin barrier function and formation. It is previously demonstrated that topical acidification in atopic dermatitis improves stratum corneum function, skin barrier structure and clinical signs in dermatitis. Against this background, we examined the impact of a slightly acidic skin care product containing urea on stratum corneum hydration, skin surface pH and epidermal barrier function in subjects with dry skin and atopic diathesis. METHODS: Stratum corneum hydration, skin surface pH and transepidermal water loss were biophysically measured before and after a 4-week treatment period with the test product (pH 4.5, 10% urea) compared to the reference product in 25 volunteers. In addition, dynamic epidermal barrier parameters like stratum corneum integrity, cohesion and recovery were investigated by using a previously described tape stripping approach. RESULTS: It was shown that the test product (pH 4.5, 10% urea) significantly elevated stratum corneum hydration and improved the acidic nature of the skin surface by lowering the skin surface pH to a greater extent compared to the reference product. After the 4-week treatment period a significant faster barrier restoration was detected on the test site treated with the test product compared to the reference product. Moreover, the test product strengthens the skin barrier integrity and cohesion.

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Protective and Regenerative Anti-Pollution Efficacy of a Plant Oil-Based Day and Night Cream: Investigated by a Novel Approach to Reveal the Impact of Pollutants on Epidermal Barrier Integrity and Lipid Matrix

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Journal of Cosmetics, Dermatological Sciences and Applications 2023年第4期13卷 302-321页

作者： Dorothee Dähnhardt Stephan Dähnhardt-Pfeiffer Isabel Simon Dana Ditgen Inge Holland Dörte Segger Jürgen Blaak peter staib Microscopy Services Dä hnhardt GmbH Flintbek Germany Research & Development and Regulatory Affairs Kneipp GmbH Wuerzburg Germany SGS INSTITUT FRESENIUS GmbH Hamburg Germany

In the wake of ever-increasing environmental pollution, human skin in the modern urban world is exposed to increased levels of harmful environmental pollutants. Many studies have shown that these pollutants can weaken the epidermal skin barrier and thus facilitate the penetration of these substances into the skin. An important goal of modern skin care against harmful environmental influences should therefore be to protect and strengthen the epidermal barrier and to repair occurring damage quickly and efficiently. With this in mind, in the present study we investigated what damage cigarette smoke causes to the epidermal barrier and 1) whether the regular application of a O/W emulsion (Day Cream) can protectively strengthen the epidermal barrier against environmental damage and 2) whether a cigarette smoke-induced disruption of the epidermal barrier is restored faster and better by the regular application of a another O/W emulsion (Night Cream) than in product-untreated skin. The two products are slightly different in plant-oil, active ingredient composition and texture. Firstly, the study has shown that the Lipbarvis? method is suitable for measuring the effect of cigarette smoke, in contrast to conventional biophysical measurement methods (transepidermal water loss, skin hydration). Secondly, both products were able to improve skin barrier function in the corresponding test scenario. This was demonstrated for both test products by a significantly reduced TEWL, significantly increased skin hydration and significantly improved length of the lipid lamellae in the intercellular space, as well as the protective effect of the day cream on the epidermal skin barrier and the regenerative properties of the tested night cream. .

关键词： Skin Care Anti-Pollution Skin Barrier Intercellular Lipid Lamellae Cigarette Smoke

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Genetics of hepatocellular carcinoma

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World Journal of Gastroenterology 2007年第16期13卷 2271-2282页

作者： Andreas Teufel Frank staib Stephan Kanzler Arndt Weinmann Henning Schulze-Bergkamen peter R Galle Department of Medicine Johannes Gutenberg University Mainz Germany

The completely assembled human genome has made it possible for modern medicine to step into an era rich in genetic information and high-throughput genomic analysis. These novel and readily available genetic resources and analytical tools may be the key to unravel the molecular basis of hepatocellular carcinoma (HCC). Moreover, since an efficient treatment for this disease is lacking, further understanding of the genetic background of HCC will be crucial in order to develop new therapies aimed at selected targets. We report on the current status and recent developments in HCC genetics. Special emphasis is given to the genetics and regulation of major signalling pathways involved in HCC such as p53, Wnt- signalling, TGFβ, Ras, and Rb pathways. Furthermore, we describe the influence of chromosomal aberrations as well as of DNA methylation. Finally, we report on the rapidly developing field of genomic expression profiling in HCC, mainly by microarray analysis.

关键词： Hepatocellular carcinoma Liver cancer Genetics Genomics Chromosome Mutation Pathway

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Journal of Cosmetics, Dermatological Sciences and Applications（化妆品、皮肤病及应用期刊） 2023年第4期

作者： Dorothee Dähnhardt Stephan Dähnhardt-Pfeiffer Isabel Simon Dana Ditgen Inge Holland Dörte Segger Jürgen Blaak peter staib

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Patient-centered developments in colon-and rectal cancer with a multidisciplinary international team:From translational research to national guidelines

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World Journal of Gastrointestinal Surgery 2021年第12期13卷 1597-1614页

作者： Karl-Heinrich Link Marko Kornmann Ludger staib Ernst-Dietrich Kreuser Wilhelm Gaus Erwin Röttinger peter Suhr Catharina Maulbecker-Armstrong peter Danenberg Kathleen Danenberg Miriam Schatz Silvia Sander Zhen-Ling Ji Jiang-Tao Li Shu-You Peng Reinhard Bittner Hans Günther Beger Benno Traub Asklepios Tumor Center(ATC)and Surgical Center Asklepios Paulinen KlinikWiesbaden 65197Germany FOGT(Multidisciplinary Study Group on Oncology of Gastrointestinal Tumors) University of UlmUlm 89081Germany Department of General and Visceral Surgery University of UlmUlm 89081Germany Department of Biometry and Medical Documentation University of UlmUlm 89081Germany Department of Radiotherapy University of UlmUlm 89081Germany Fachbereich Gesundheit Medizinisches ManagementSozialversicherungssystemeInternationales Versorgungsmanagemente-HealthTechnische Hochschule MittelhessenGiessen 35390Germany Department of Biochemistry and Molecular Medicine Keck-USC School of MedicineLos AngelesCA 90033United States Norris Comprehensive Cancer Center Keck-USC School of MedicineLos AngelesCA 90033United States Private Practice for Psychology Adelsdorf 91325Germany Department of General Surgery Southeast UniversityNanjing 210009Jiangsu ProvinceChina Department of Surgery The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009Zhejiang ProvinceChina Surgical Clinic MarienhospitalStuttgart 70177Germany

Rarely,scientific developments centered around the patient as a whole *** multidisciplinary group,headed by gastrointestinal surgeons,applied this research philosophy considering the most important aspects of thediseases“colon-and rectal cancer”in the long-term *** expertcooperation/knowledge at the Comprehensive Cancer Center Ulm(CCCU)wereapplied in several phase III trials for multimodal treatments of primary tumors(MMT)and metastatic diseases(involving nearly 2000 patients and 64 centers),fortreatment individualization of MMT and of metastatic disease,for psychooncology/quality of life involving the patients’wishes,and for disease *** of the targets initially were heavily rejected/discussed in thescientific communities,but now have become standards in treatments andnational guidelines or are topics in modern translational research protocolsinvolving molecular biology for e.g.,“patient centered individualized treatment”.In this context we also describe the paths we had to tread in order to realize ournew goals,which at the end were highly beneficial for the patients from manypoints of *** description is also important for students and youngresearchers who,with an actual view on our recent developments,might want toknow how medical progress was achieved.

关键词： Colon-and rectal cancer Translational research Interdisciplinary treatment Personalized treatment National guidelines

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