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Anti-atherosclerotic effects and molecular targets of ginkgolide B from Ginkgo biloba

Acta Pharmaceutica Sinica B 2024年第1期14卷 1-19页

作者： Weile Ye Jiaojiao Wang peter JLittle Jiami Zou Zhihua Zheng Jing Lu Yanjun Yin Hao Liu Dongmei Zhang Peiqing Liu Suowen Xu Wencai Ye Zhiping Liu International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of China Jinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs research College of PharmacyJinan UniversityGuangzhou 510632China State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China Pharmacy Australia Centre of Excellence School of PharmacyUniversity of QueenslandWoolloongabba QLD 4102Australia Sunshine Coast Health Institute and School of Health and Behavioural Sciences University of the Sunshine CoastBirtinya QLD 4575Australia National-Local Joint Engineering Lab of Druggability and New Drugs Evaluation Guangdong Provincial Key Laboratory of New Drug Design and EvaluationSun Yat-sen UniversityGuangzhou 510006China School of Pharmacy Bengbu Medical CollegeBengbu 233030China Institute of Endocrine and Metabolic Diseases the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China

Bioactive compounds derived from herbal medicinal plants modulate various therapeutic targets and signaling pathways associated with cardiovascular diseases(CVDs),the world’s primary cause of *** biloba,a well-known traditional Chinese medicine with notable cardiovascular actions,has been used as a cardio-and cerebrovascular therapeutic drug and nutraceutical in Asian countries for *** studies have shown that ginkgolide B,a bioactive component in Ginkgo biloba,can ameliorate atherosclerosis in cultured vascular cells and disease *** clinical relevance,several clinical trials are ongoing or being completed to examine the efficacy and safety of ginkgolide B-related drug preparations in the prevention of cerebrovascular diseases,such as ischemia ***,we present a comprehensive review of the pharmacological activities,pharmacokinetic characteristics,and mechanisms of action of ginkgolide B in atherosclerosis prevention and *** highlight new molecular targets of ginkgolide B,including nicotinamide adenine dinucleotide phosphate oxidases(NADPH oxidase),lectin-like oxidized LDL receptor-1(LOX-1),sirtuin 1(SIrT1),platelet-activating factor(PAF),proprotein convertase subtilisin/kexin type 9(PCSK9)and ***,we provide an overview and discussion of the therapeutic potential of ginkgolide B and highlight the future perspective of developing ginkgolide B as an effective therapeutic agent for treating atherosclerosis.

关键词： Cardiovascular disease Atherosclerosis Ginkgo biloba Ginkgolide B Endothelial dysfunction LOX-1 PCSK9 PAF-r antagonist

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Breakdown of a Commonly Practiced Technique in Quantum Mechanics

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Journal of Applied Mathematics and Physics 2024年第5期12卷 1919-1929页

作者： Pirooz Mohazzabi William D. Parker peter Kveton Department of Mathematics and Physics University of Wisconsin-Parkside Kenosha USA

The dynamically shifted oscillator is investigated quantum mechanically, both analytically and numerically. It is shown that the commonly used method of solving the Schrödinger equation using power series results in i... 详细信息

关键词： Dynamic Shift Oscillator Quantum Schrödinger Solution

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Antidiabetic Properties of Bidens pilosa and Its Polyacetylenic Compounds for Management of Diabetes: Systematic review

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Journal of Biosciences and Medicines 2024年第2期12卷 164-179页

作者： Kenneth Waititu Caroline Mugo Daisy Nyawira peter Mwethera Animal Sciences Department Kenya Institute of Primate Research Nairobi Kenya Center for Biodiversity National Museums of Kenya Nairobi Kenya Department of reproductive Health and Biology Kenya Institute of Primate Research Nairobi Kenya

Bidens pilosa is a member of the Asteraceae family that is widely distributed across the tropics. It has been utilized by different communities both as food and medicinal herb. This plant and its polyacetylenic compounds hold potential as a natural antidiabetic intervention that can be used to combat this global public health problem. Bioactive compounds found in this plant constitute promising interventions for combating obesity which is a major risk factor for the development of type 2 diabetes. These phytocompounds can work independently or synergistically to modulate appetite, lipase activity, adipogenesis and adipocyte apoptosis. However, the efficacy, mode of action and scope of management of diabetes by these compounds remains elusive. The current review aims to summarize data on efficacy in the management of diabetes, an antidiabetic candidate polyacetylenic compound and possible biological activities as an antidiabetic agent from the available literature. Much emphasis has been directed to cytopiloyne as a representative of polyacetylenic compounds extracted from Bidens pilosa and its activity on diabetic animal models. The majority of the studies conducted on animal models described antidiabetic mechanisms that range from hypoglycemic to secretagogue activity of cytopiloyne in a dose-dependent manner. A clinical trial pilot indicated improved glycemic control of Bidens pilosa formulation among diabetic patients in the study. Bidens pilosa and its compounds are highly potent antidiabetic agent(s) that should be graduated to an intervention for management of diabetes through pre-clinical and clinical trials to elucidate its efficacy and safety.

关键词： Antidiabetic Cytopiloyne Bidens pilosa Polyacetylenic Compounds

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Effect of Magnetic Field Configuration on Stray-Crystal Formation with Different Platform Sizes during Directional Solidification of Single-Crystal Superalloy

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Acta Metallurgica Sinica(English Letters) 2024年第5期37卷 904-914页

作者： Keke Lu Congjiang Zhang Xiaotan Yuan Hongbin Yu Weili ren Biao Ding Haibiao Lu Yunbo Zhong Zuosheng Lei Hui Wang Qiuliang Wang peter KLiaw Xuezhi Qin Lanzhang Zhou State Key Laboratory of Advanced Special Steel Shanghai Key Laboratory of Advanced FerrometallurgyShanghai UniversityShanghai 200444China Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN 37996USA Institute of Metal research Chinese Academy of SciencesShenyang 110016China

The magnetic field is an effective means to control the solidification structure and the defects of metal and semiconductor *** work investigates the effects of Cusp magnetic field(CMF)and longitudinal magnetic field(LMF)on the stray-crystal formation in the platform regions during the directional solidification of single-crystal superalloy with the different cross section *** application of CMF reduces the formation of platform stray-crystal,while LMF increases its *** the platform size increases,the stray-crystal ratio increases regardless of whether the magnetic fields are applied or not,the effectiveness of CMF increases,while that of LMF *** reason that the effects of CMF and LMF on the platform stray-crystal formation could be attributed to the change of flow structure from the distribution characteristics of the thermoelectric magnetic force and the magnetic damping force near the liquid-solid interface.

关键词： Stray-crystal Magnetic field Single-crystal superalloy Cross section change Directional solidification

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地球演化历史中氧逸度变化对壳幔循环启动、风化和超大陆循环的指示

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Science Bulletin 2024年第1期69卷 97-102页

作者：王瑞邬绍宸 roberto F.Weinberg William J.Collins peter A.Cawood State Key Laboratory of Geological Processes and Mineral resources Institute of Earth SciencesChina University of GeosciencesBeijing 100083China Frontiers Science Center for Deep-time Digital Earth China University of Geosciences(Beijing)Beijing 100083China School of Earth Atmosphere and EnvironmentMonash UniversityClayton VIC 3800Australia The Institute for Geoscience research Curtin UniversityPerth WA 6102Australia

We apply a zircon redox index to a global compilation of detrital zircons to track the variation of oxidation state,expressed asΔFMQ,through Earth's *** from I-type rocks,which comprise mantle and crustal igneous protoliths,including tonalite–trondhjemite–granodiorites(TTGs),generally have a high oxidation state(ΔFMQ>0).In contrast,zircons from igneous rocks derived from supracrustal source rocks(S-type)are commonly reduced(ΔFMQrobability density function derived from the Gaussian-Kernel-Density-Estimation,we use the maximum likelihood estimation(MLE)to distinguish Stype from I-type zircons through Earth's history using zircon *** S-type magma production shows a ca.600 Ma cyclicity that is closely related to the supercontinent *** link a cyclic drop in redox values after 2.6 Ga to periodic S-type magma generation associated with burial and melting of metasedimentary rocks during supercontinent assembly and ***ΔFMQ of the detrital zircons rise at~3.5 Ga followed by a consistent averageΔFMQ>0 over the last 3 *** that the redox state of magmas is independent of crustal thickness and silica variation,and elevated values are likely more closely related to tectonic setting,we suggest that the consistent averageΔFMQ>0 from ca.3.5 Ga onwards relates to recycling of oceanic lithosphere back into the mantle in what eventually became established as subduction *** more reduced magmas associated with sedimentary sources,became established at 2.6 Ga,presumably in response to continental rocks rising above sealevel,and follow peaks of productivity associated with the supercontinent cycle.

关键词： Oxidation state Supercontinent Weathering Subduction Zircon Granite

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A Bayesian hierarchical model for the inference between metal grade with reduced variance:Case studies in porphyry Cu deposits

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Geoscience Frontiers 2024年第2期15卷 304-314页

作者： Yufu Niu Mark Lindsay peter Coghill richard Scalzo Lequn Zhang CSIrO Mineral resources Lucas HeightsNew South Wales 2234Australia Mineral Exploration Cooperative research Centre Centre for Exploration TargetingSchool of Earth ScienceThe University of Western AustraliaPerthWA 6009Australia ArC centre for Data Analytics for resources and Environments(DArE) Perth and SydneyAustralia CSIrO Mineral resources Australian Resources Research CentreWA 6151Australia CSIrO Data61 ClaytonVIC 3168Australia

Ore sorting is a preconcentration technology and can dramatically reduce energy and water usage to improve the sustainability and profitability of a mining *** porphyry Cu deposits,Cu is the primary target,with ores usually containing secondary‘pay’metals such as Au,Mo and gangue elements such as Fe and *** to sensing technology limitations,secondary and deleterious materials vary in correlation type and strength with Cu but cannot be detected simultaneously via magnetic resonance(Mr)ore *** the relationships between Cu and other elemental abundances is particularly critical for mineral *** variations in metal grade relationships occur due to the transition into different geological *** raises two questions-how to define these geological domains and how the metal grade relationship is influenced by these geological *** this paper,linear relationship is assumed between Cu grade and other metal *** applies a Bayesian hierarchical(partial-pooling)model to quantify the linear relationships between Cu,Au,and Fe grades from geochemical bore core *** hierarchical model was compared with two other models-‘complete-pooling’model and‘nopooling’*** blocks were split based on spatial domain to construct hierarchical *** bore core data records metal grades measured from laboratory assay with spatial coordinates of sample *** case studies from different porphyry Cu deposits were used to evaluate the performance of the hierarchical *** chain Monte Carlo(MCMC)was used to sample the posterior *** results show that the Bayesian hierarchical model dramatically reduced the posterior predictive variance for metal grades regression compared to the no-pooling *** addition,the posterior inference in the hierarchical model is insensitive to the choice of *** data is wellrepresented in the posterior which indicates a robust *** results show that the spatial dom

关键词： Bayesian hierarchical model Porphyry Cu deposit Ore sorting Metal grade Linear regression

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Sepsis during short bowel syndrome hospitalizations:Identifying trends,disparities,and clinical outcomes in the United States

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World Journal of Gastrointestinal Pathophysiology 2024年第1期15卷 26-36页

作者： Dushyant Singh Dahiya Jennifer Wachala Shantanu Solanki Dhanshree Solanki Asim Kichloo Samantha Holcomb Uvesh Mansuri Khwaja Saad Haq Hassam Ali Manesh Kumar Gangwani Yash r Shah Teresa Varghese Hafiz Muzaffar Akbar Khan Simon peter Horslen Thomas D Schiano Syed-Mohammed Jafri Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States Department of Internal Medicine Samaritan Medical CenterWatertownNY 13601United States Division of Gastroenterology Hepatology&Nutrition The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Medicine Institute for Foreign Medical Graduate EducationHoustonTX 77030United States Department of Internal Medicine MedStar Harbor HospitalBaltimoreMD 21225United States Department of Internal Medicine WellStar Spalding Regional HospitalGriffinGA 30224United States Division of Gastroenterology Hepatology and NutritionEast Carolina University/Brody School of MedicineGreenvilleNC 27858United States Department of Gastroenterology and Hepatology University of Arkansas for Medical SciencesLittle RockAR 72205United States Department of Internal Medicine Trinity Health Oakland/Wayne State UniversityPontiacMI 48341United States Division of Gastroenterology and Hepatology SUNY Upstate Medical UniversitySyracuseNY 13210United States Department of Pediatrics School of Medicine and UPMC Children’s Hospital of PittsburghUniversity of PittsburghPittsburghPA 15219United States Division of Liver Diseases Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Division of Gastroenterology and Hepatology Henry Ford HospitalDetroitMI 48202United States

BACKGrOUND Short bowel syndrome(SBS)hospitalizations are often complicated with *** is a significant paucity of data on adult SBS hospitalizations in the United States and across the *** To assess trends and outcomes of SBS hospitalizations complicated by sepsis in the United *** The National Inpatient Sample was utilized to identify all adult SBS hospitalizations between *** study cohort was further divided based on the presence or absence of *** were identified,and hospitalization characteristics and clinical outcomes were *** of mortality for SBS hospitalizations complicated with sepsis were *** Of 247097 SBS hospitalizations,21.7%were complicated by *** SBS hospitalizations had a rising trend of hospitalizations from 20.8%in 2005 to 23.5%in 2014(P trendred to non-septic SBS hospitalizations,septic SBS hospitalizations had a higher proportion of males(32.8%vs 29.3%,Proups,and ethnic minorities,i.e.,Blacks(12.4%vs 11.3%,Prthermore,septic SBS hospitalizations had a higher proportion of patients with intestinal transplantation(0.33%vs 0.22%,Prtality(8.5%vs 1.4%,Pred to the non-sepsis cohort.A younger age,female gender,white race,and presence of comorbidities such as anemia and depression were identified to be independent predictors of inpatient mortality for septic SBS *** Septic SBS hospitalizations had a rising trend between 2005-2014 and were associated with higher inpatient mortality compared to non-septic SBS hospitalizations.

关键词： Short bowel syndrome Sepsis Outcomes Mortality Trends

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Interdigitated terahertz metamaterial sensors:design with the dielectric perturbation theory

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Photonics research 2024年第6期12卷 1115-1128页

作者： LEI CAO FANQI MENG ESrAÖZDEMIr YANNIK LOTH MErLE rICHTEr ANNA KATHArINA WIGGEr MAIrA BEATrIZ PÉrEZ SOSA ALAA JABBAr JUMAAH SHIHAB AL-DAFFAIE peter HArING BOLÍVAr HArTMUT G.rOSKOS State Key Laboratory of Advanced Electromagnetic Technology Huazhong University of Science and TechnologyWuhan 430074China Physikalisches Institut Johann Wolfgang Goethe-UniversitätFrankfurt am MainGermany University of Siegen Institute for High Frequency and Quantum ElectronicsSiegenGermany Department of Electrical Engineering Eindhoven University of Technology5612 AE EindhovenThe Netherlands

Designing terahertz sensors for highly sensitive detection of nanoscale thin films and a few biomolecules poses a substantial challenge but is crucial for unlocking their full potential in scientific research and advanced *** work presents a strategy for optimizing metamaterial sensors in detecting small quantities of dielectric *** amount of frequency shift depends on intrinsic properties(electric field distribution,Q-factor,and mode volume)of the bare cavity as well as the overlap volume of its high-electric-field zone(s)and the *** by the simplified dielectric perturbation theory,interdigitated electric split-ring resonators(ID-eSrrs)are devised to significantly enhance the detection sensitivity compared with eSrrs without interdigitated ***-eSrr’s fin-gers redistribute the electric field,creating strongly localized enhancements,which boost analyte *** periodic change of the inherent antiphase electric field reduces radiation loss,leading to a higher *** with ID-eSrr sensors operating at around 300 GHz demonstrate a remarkable 33.5 GHz frequency shift upon depositing a 150 nm SiO_(2)layer as an analyte simulant,with a figure of merit improvement of over 50 times compared with structures without interdigitated *** rational design offers a promising avenue for highly sensitive detection of thin films and trace biomolecules.

关键词： dielectric perturbation theory

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Characteristics of Extreme rainfall Events over Uganda during September to November rainfall Season

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Journal of Geoscience and Environment Protection 2024年第3期12卷 131-152页

作者： Donnata Alupot Guirong Tan Kokou romaric Posset peter Natiko Key Laboratory of Meteorological Disaster Ministry of Education (KLME)/Joint International Research Laboratory of Climate and Environment Change (ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters (CIC-FEMD) Nanjing University of Information Science and Technology Nanjing China Climate Change Department Pan African University Institute for Water and Energy Sciences (Including Climate Change) C/O Univer-sité Abou Bekr Belkaid Tlemcen Campus Chetouane Tlemcen Algeria Directorate of Weather Forecasting Uganda National Meteorological Authority Port Bell Road Kampala Uganda

Understanding the characteristics of extreme rainfall is crucial for effective flood management planning, as it enables the incorporation of insights from past extreme rainfall patterns and their spatiotemporal distribution. This work investigated the changes in the frequency and pattern of extreme rainfall over Uganda, using daily datasets sourced from Climate Hazard Group Infrared Precipitation with Station (CHIrPS-v2) for the period 1981 to 2022. The study utilized the extreme weather Indices provided by the Expert Team on Climate Change Detection and Indices (ETCCDI). Attention was directed towards September to November (SON) rainfall season with precise analysis of four indices (rx1day, rx5day, r95p, and r99p). The Sequential Mann-Kendall (SQMK) non-parametric test was applied to identify abrupt changes in SON extreme rainfall trends. results showed that October consistently recorded the highest count of extreme rainfall days across all four indices. The long-term analysis revealed fluctuations in extreme rainfall events across years, with certain periods exhibiting heightened intensity. The analysis portrayed a shift in the decadal variations and region-specific distribution of extreme rainfall, with Eastern Uganda and areas around Lake Victoria standing out compared to other regions. The findings further revealed an increase in extreme rainfall for all indices in the recent decade (2011-2022) with 2019/2020 standing out as the extreme years of SON for the study period. While trendlines suggested a slight increase in intense daily rainfall events, the SQMK tests revealed statistical significance in the trend of prolonged periods of intense daily rainfall. This study contributes to the understanding of the spatiotemporal variability and trends of extreme rainfall events over Uganda during the SON season, which is crucial for the assessment of climate change impacts and adaptation strategies. It provides valuable information for seasonal extreme rainfall forecas

关键词： CHIrPS Variability region-Specific Early Warning Climate Change

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Simultaneous Waveform Inverse Modelling for Litho-Fluid Prediction in an Old Marginal, “Agbbo”Field, Onshore Niger Delta, Nigeria

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Journal of Geoscience and Environment Protection 2024年第5期12卷 40-59页

作者： Charles Chibueze Ugbor peter Ogobi Odong Chukwuemeka Austine Okonkwo Department of Geology University of Nigeria Nsukka Nigeria Department of Geology and Mining Enugu State University of Science and Technology Enugu Nigeria

Simultaneous waveform inversion was used to predict lithofacies and fluid type across the field. Very often, characterizing reservoirs in terms of lithology and fluid type using conventional methods is replete with uncertainties, especially in marginal fields. An approach is employed in this study that integrated rock physics and waveform inverse modelling for lithology and fluid-type characterization to appropriately identify potential hydrocarbon saturated zones and their corresponding lithology. Seismic and well-log data were analyzed using Hampson russel software. The method adopted includes lithofacies and fluid content analysis using rock physics parameters and seismic simultaneous inverse modelling. rock physics analysis identified 2 broad reservoirs namely: HDZ1 and HDZ2 reservoirs. results from the inverse modelling showed that low values of acoustic impedance from 19,743 to 20,487 (ft/s)(g/cc) reflect hydrocarbon-bearing reservoirs while medium to high values shows brine and shale respectively, with brine zone ranging from 20,487 to 22,531 (ft/s)(g/cc) and shale above 22,531 (ft/s)(g/cc). Two lithofacies were identified from inversion analysis of Vp/Vs and Mu-rho, namely: sand and shale with VpVs 1.95 values respectively. Mu-rho > 12.29 (GPa)(g/cc) and represent sand and shale respectively. From 3D volume, it was observed that a high accumulation of hydrocarbon was observed to be saturated at the north to the eastern part of the field forming a meandering channel. Sands were mainly distributed around the northeastern to the southwestern part of the field, that tends to be away from Well 029. This was also validated by the volume of rigidity modulus (Mu-rho) showing high values indicating sands fall within the northeastern part of the field.

关键词： Simultaneous Waveform Inversion Lithofacies Fluid Type rock Physics Hydrocarbon Acoustic Impedance Mu-rho reservoir

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