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In vitro bench testing using patient-specific 3D models for percutaneous pulmonary valve implantation with Venus p-valve

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Chinese Medical Journal 2024年第8期137卷 990-996页

作者： Yu Han Zehua Shao Zirui Sun Yan Han Hongdang Xu Shubo Song Xiangbin pan peter p.T.de jaegere Taibing Fan Gejun Zhang department of Structure Heart Disease Central China Fuwai Hospital of Zhengzhou UniversityZhengzhouHenan 451460China Children’s Heart Center Central China Fuwai Hospital of Zhengzhou UniversityZhengzhouHenan 451460China department of Anesthesiology Central China Fuwai Hospital of Zhengzhou UniversityZhengzhouHenan 451460China department of Structure Heart Disease Fuwai Hospital Chinese Academy of Medical SciencesBeijing 100037China department of Cardiology Erasmus MCRotterdam 3015 GDNetherlands

Background:Due to the wide variety of morphology,size,and dynamics,selecting an optimal valve size and location poses great difficulty in percutaneous pulmonary valve implantation(ppVI).This study aimed to report our experience with in vitro bench testing using patient-specific three-dimensional(3D)-printed models for planning ppVI with the Venus ***:patient-specific 3D soft models were generated using polyJet printing with a compliant synthetic material in 15 patients scheduled to undergo ppVI between July 2018 and July 2020 in Central China Fuwai Hospital of Zhengzhou ***:3D model bench testing altered treatment strategy in all patients(100%).One patient was referred for surgery because testing revealed that even the largest Venus p-valve would not anchor *** the remaining 14 patients,valve size and/or implantation location was altered to avoid valve migration and/or compression coronary *** four patients,it was decided to change the point anchoring because of inverted cone-shaped right ventricular outflow tract(RVOT)(n=2)or risk of compression coronary artery(n=2).Concerning sizing,we found that an oversize of 2-5 mm *** of the valve was dictated by the flaring of the in-and outflow portion in the pulmonary *** was successful in all 14 patients(absence of valve migration,no coronary compression,and none-to-mild residual pulmonary regurgitation[pR]).The diameter of the Venus p-valve in the 3D simulation group was significantly smaller than that of the conventional planning group(36[2]vs.32[4],Z=-3.77,pp-valve to the degree recommended by the balloon-sizing technique,as 2-5 mm sufficed.

关键词： Heart valve prosthesis implantation percutaneous pulmonary valve intervention pulmonary regurgitation bench testing 3D printing Venus p-valve

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defective recovery of QT dispersion following transcatheter aortic valve implantation： frequency, predictors and prognosis

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Journal of Geriatric Cardiology 2015年第5期12卷 482-488页

作者： Rutger-Jan Nuis Gokhan Turgut Robert M van der Boon Nicolas M van Mieghem Sjoerd T Nauta patrick W Serruys Ron T van Domburg Giulio Zuchelli Luc Jordaens peter p de jaegere department of Cardiology Erasmus University Medical Center Rotterdam the Netherlands department of Electrophysiology Erasmus Thoraxcenter Rotterdam the Netherlands department of Biostatistics Erasmus Thoraxeenter Rotterdam the Netherlands Division of Cardiovascular Diseases Azienda Ospedaliero-Universitaria Pisana Pisa Italy

BackgroundCorrected QT 分散(cQTD ) 与不一致的室的 repolarisation 被相关并且增加了死亡。在有大动脉的狭窄的病人， cQTD 被显示出在大动脉的阀门培植(TAVI ) 是的 transcatheter 的外科的阀门代替，而是效果以后改善了未知。因此... 详细信息

BackgroundCorrected QT 分散(cQTD ) 与不一致的室的 repolarisation 被相关并且增加了死亡。在有大动脉的狭窄的病人， cQTD 被显示出在大动脉的阀门培植(TAVI ) 是的 transcatheter 的外科的阀门代替，而是效果以后改善了未知。因此，在 222 个病人全部的 *** 与在 2005 年 11 月和 2012 年 1 月之间的 Medtronic-CoreValve 系统经历了 TAVI 以后，我们寻求了在 6 个月探索频率，预言者和有缺点的 cQTD 恢复的预示的效果。或谁在一级或 III antiarrhythmics 上或在长期的血液透析上的病人发达 atrial 纤维性颤动，新捆分支块或在 TAVI 被排除以后，成为了依赖的心律调整器。作为结果， pre- ， up 以后和后续 ECG (中部：6 个月) 分析在 45 个合格病人是可得到的。有缺点的 cQTD 恢复在 6 *** 在基线 cQTD 以外被定义为任何前进 45 个病人，吝啬的 cQTD 是 47 ±；在基线的 23 ms， 45 ±；17 ms 立即在 TAVI 和 40 ± 以后；在 6 个月的 16 ms (15% 减小， p = 0.049 ) 。比作基线，而有缺点的 cQTD 恢复在 40% 是在场的，在 6 个月的 cQTD 在 60% 病人被改进。cQTD 增加立即在 TAVI 以后是在 6 个月的有缺点的 cQTD 恢复的一个独立预言者(每 10 ms 增加；或：1.89， 95% CI：1.15-3.12 ) 。由 univariable 分析，有缺点的 cQTD 恢复与迟了的死亡被联系(HR：1.52， 95% CI：1.05-2.17 ).Conclusionsdespite 在 TAVI 以后的 cQTD 的渐渐的减小， 40% 病人在与迟了的死亡被联系的 6 个月有有缺点的恢复。在 TAVI 以后的更多的详细 ECG 分析可以帮助避免迟了的死亡。

关键词：缺陷补救主动脉离散度频率 QT 植入导管预后

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A flexible,thin-film microchannel electrode array device for selective subdiaphragmatic vagus nerve recording

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Microsystems & Nanoengineering 2024年第1期10卷 115-128页

作者： Jongcheon Lim peter A.Zoss Terry L.powley Hyowon Lee Matthew p.Ward Weldon School of Biomedical Engineering Purdue UniversityWest LafayetteINUSA Birck Nanotechnology Center Purdue UniversityWest LafayetteINUSA Center for Implantable devices Purdue UniversityWest LafayetteINUSA department of psychological Sciences Purdue UniversityWest LafayetteINUSA purdue Institute of Integrative Neuroscience Purdue UniversityWest LafayetteINUSA Indiana University School of Medicine IndianapolisINUSA

The vagus nerve(VN)plays an important role in regulating physiological conditions in the gastrointestinal(GI)tract by communicating via the parasympathetic pathway to the enteric nervous system(ENS).However,the lack of knowledge in the neurophysiology of the VN and GI tract limits the development of advanced treatments for autonomic dysfunctions related to the *** better understand the complicated underlying mechanisms of the VN-GI tract neurophysiology,it is necessary to use an advanced device enabled by microfabrication *** several candidates including intraneural probe array and extraneural cuff electrodes,microchannel electrode array devices can be used to interface with smaller numbers of nerve fibers by securing them in the separate channel *** microchannel electrode array devices to interface teased nerve structures are relatively bulky with thickness around 200µ*** thick design can potentially harm the delicate tissue structures,including the nerve *** this paper,we present a flexible thin film based microchannel electrode array device(thickness:11.5µm)that can interface with one of the subdiaphragmatic nerve branches of the VN in a *** demonstrated recording evoked compound action potentials(ECAp)from a transected nerve ending that has multiple nerve ***,our analysis confirmed that the signals are from C-fibers that are critical in regulating autonomic neurophysiology in the GI tract.

关键词： electrode recording film

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Interdigitated terahertz metamaterial sensors:design with the dielectric perturbation theory

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photonics Research 2024年第6期12卷 1115-1128页

作者： LEI CAO FANQI MENG ESRAÖZdeMIR YANNIK LOTH MERLE RICHTER ANNA KATHARINA WIGGER MAIRA BEATRIZ pÉREZ SOSA ALAA JABBAR JUMAAH SHIHAB AL-DAFFAIE peter HARING BOLÍVAR HARTMUT G.ROSKOS State Key Laboratory of Advanced Electromagnetic Technology Huazhong University of Science and TechnologyWuhan 430074China physikalisches Institut Johann Wolfgang Goethe-UniversitätFrankfurt am MainGermany University of Siegen Institute for High Frequency and Quantum ElectronicsSiegenGermany department of Electrical Engineering Eindhoven University of Technology5612 AE EindhovenThe Netherlands

designing terahertz sensors for highly sensitive detection of nanoscale thin films and a few biomolecules poses a substantial challenge but is crucial for unlocking their full potential in scientific research and advanced *** work presents a strategy for optimizing metamaterial sensors in detecting small quantities of dielectric *** amount of frequency shift depends on intrinsic properties(electric field distribution,Q-factor,and mode volume)of the bare cavity as well as the overlap volume of its high-electric-field zone(s)and the *** by the simplified dielectric perturbation theory,interdigitated electric split-ring resonators(ID-eSRRs)are devised to significantly enhance the detection sensitivity compared with eSRRs without interdigitated ***-eSRR’s fin-gers redistribute the electric field,creating strongly localized enhancements,which boost analyte *** periodic change of the inherent antiphase electric field reduces radiation loss,leading to a higher *** with ID-eSRR sensors operating at around 300 GHz demonstrate a remarkable 33.5 GHz frequency shift upon depositing a 150 nm SiO_(2)layer as an analyte simulant,with a figure of merit improvement of over 50 times compared with structures without interdigitated *** rational design offers a promising avenue for highly sensitive detection of thin films and trace biomolecules.

关键词： dielectric perturbation theory

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Investigation of WZ Sge-type Dwarf Nova ASASSN-19oc: Optical Spectroscopy and Multicolor Light Curve Analysis

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Research in Astronomy and Astrophysics 2024年第8期24卷 22-33页

作者： Viktoriia Krushevska Sergey Shugarov paolo Ochner Yuliana Kuznyetsova Mykola petrov peter Kroll Astronomical Institute of the Slovak Academy of Sciences Main Astronomical Observatory of NAS of Ukraine INAF—Osservatorio Astronomico di padova department of physics and Astronomy University of Padova Max planck Computing and Data Facility (MpCDF) Sonneberg Observatory

In this study,we present an investigation of the newly discovered dwarf nova ASASSN-19oc during its superoutburst on 2019 June *** carried out detailed UBVRcIc-photometric observations and also obtained a spectrum on day 7 of the outburst,which shows the presence of hydrogen absorption lines commonly found in dwarf nova *** of photometric data reveals the occurrence of early superhumps in the initial days of observations,followed by ordinary and late *** have accurately calculated the period of the ordinary superhumps as pord=0.05681（10） days and determined the periods at different stages,as well as the rate of change of the superhump period (pdot=（5）p/p=8.1×10-5).Additionally,we have derived the mass ratio of the components （q=0.09）,and estimated the color temperature during the outburst as～11,000 K,the distance to the system （d=560 pc） and absolute magnitude of the system in outburst （MV=5.3）.We have shown that outbursts of this star are very rare:based on brightness measurements on 600 archival photographic plates,we found only one outburst that occurred in *** fact,as well as the properties listed above,convincingly shows that the variable ASASSN-19oc is a dwarf nova of WZ Sge type.

关键词： (stars:) binaries (including multiple): close (stars:) novae cataclysmic variables stars: dwarf novae

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On the analytic and geometric aspects of obstruction flatness

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Acta Mathematica Sinica,English Series 2024年

作者： peter EBENFELT Ming XIAO Hang XU department of Mathematics University of California at San Diego School of Mathematics (Zhuhai) Sun Yat-sen University

In this paper, we investigate analytic and geometric properties of obstruction flatness of strongly pseudoconvex CR hypersurfaces of dimension 2n-1. Our first two results concern local aspects. One asserts that any strongly pseudoconvex CR hypersurface M ? Cncan be osculated at a given point p ∈ M by an obstruction flat one up to order 2n + 4 generally and 2n + 5 if and only if p is an obstruction flat point. In the other result, we show that locally there are non-spherical but obstruction flat CR hypersurfaces with transverse symmetry for n = 2. The final main result in this paper concerns the existence of obstruction flat points on compact, strongly pseudoconvex, 3-dimensional CR hypersurfaces. It asserts that the unit sphere in a negative line bundle over a Riemann surface X always has at least one circle of obstruction flat points.

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Immunological Exploration of Helicobacter pylori Serotype O_(2) O-Antigen by Using a Synthetic Glycan Library

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Chinese Journal of Chemistry 2024年第3期42卷 243-251页

作者： Ming Zhao Guangzong Tian Chunjun Qin Xiaopeng Zou peter H. Seeberger Jing Hu Jian Yin Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of Biotechnology & School of Life Sciences and Health EngineeringJiangnan UniversityLihu Avenue 1800WuxiJiangsu214122 China Biomolecular Systems department Max Planck Institute of Colloids and InterfacesAm Mühlenberg 1Potsdam14476 Germany Wuxi School of Medicine Jiangnan UniversityLihu Avenue 1800WuxiJiangsu214122 China

Helicobacter pylori(***)infection is a threat to human *** lipopolysaccharide(LpS)O-antigen holds promise for developing *** is meaningful to explore the immunological activity of oligosaccharides with different lengths and frameshifts for antigen ***,a glycan library of *** O2 O-antigen containing eight fragments is *** screening with *** O2 LpS sera and patients’sera by glycan microarray,the disaccharide HpO2G-2b and trisaccharide HpO2G-3a show strong antigenicity and then are separately conjugated with carrier protein *** glycoconjugates elicit a robust immunoglobulin G(IgG)immune response in *** anti-HpO2G-3a IgG antibodies possess a much stronger binding affinity with the LpS and bacteria of *** O2 than the anti-HpO2G-2b IgG *** is no cross-reaction between both sera IgG antibodies with LpS and bacteria of *** O1,O6,and *** results demonstrate the trisaccharide HpO2G-3a is a promising candidate for *** vaccine development.

关键词： Glycoconjugates Helicobacter pylori Immunology Microarrays O-antigen Oligosaccharides

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Effect of age on the standardized ileal amino acid digestibility of soybean meal and canola meal in broilers

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Animal Nutrition 2024年第1期16卷 11-22页

作者： Mukti Barua M.Reza Abdollahi Faegheh Zaefarian Timothy J.Wester Channarayapatna K.Girish peter V.Chrystal Velmurugu Ravindran Monogastric Research Center School of Agriculture and EnvironmentMassey UniversityPalmerston North 4442New Zealand department of Animal Science and Nutrition Faculty of Veterinary MedicineChattogram Veterinary and Animal Sciences UniversityKhulshiChattogram 4225Bangladesh Nutrition and Care Animal NutritionEvonik(SEA)Pte.Ltd609927 Singapore Complete Feed Solutions Howick 2145AucklandNew Zealand

Standardized ileal digestibility coefficients(SIDC)of nitrogen(N)and amino acids(AA)in two protein sources(soybean meal[SBM]and canola meal[CM])were investigated at six broiler ages(d 7,14,21,28,35,and 42).Two assay diets were formulated to contain either SBM(413 g/kg)or CM(553 g/kg)as the sole dietary AA *** dioxide(5 g/kg)was added as an indigestible marker.A total of 696 male broilers at 1 d old were allotted to 12 replicate cages per age *** assay diet was offered to birds for 4 d prior to the ileal digesta collection on d 7(14 birds/cage),14(12 birds/cage),21(10 birds/cage),28(8 birds/cage),35(8 birds/cage)and 42(6 birds/cage),*** apparent digestibility coefficients were standardized using age-specific basal endogenous AA *** the SBM group,though the SIDC of N tended to be influenced(quadratic;p=0.075)by age,no linear or quadratic response of age effect was observed on the average SIDC of indispensable(IAA)and total AA(TAA).An age effect(quadratic;ppensable AA(DAA)in SBM with the highest value recorded at d 7,followed by a decrease from d 14 to 28,which increased beyond d *** SIDC of some individual AA(Arg,Thr,Trp,Cys,pro)were affected(ppppdeclined at d 21,and then increased beyond d *** average SIDC of IAA was low between d 7 and 28 and increased *** SIDC of individual AA were affected(linear or quadratic;ppdes by *** age influence on the SIDC AA was variable,depending on the protein source and *** results demonstrate that age-specific SIDC AA data might need consideration in broiler feed formulations.

关键词： Age Amino acid Broiler Digestibility protein source

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design and initial testing of a maize cob collection system

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 108-114页

作者： Bojan Dolšak Anita Breznik Klemen Kaučič Nataša Imenšek Marko Marčec peter Gselman Jani Humar Mitja Krajnc University of Maribor Faculty of Mechanical EngineeringSmetanova ulica 172000 MariborSlovenia ŽIpO Lenart Ltd. Šetarova 212230 LenartSlovenia KGS Krajnc Ltd Vinička vas 42230 LenartSlovenia Interkorn Ltd. Gančani 949231 BeltinciSlovenia

Maize cobs are valuable plant residues that can be used for many different purposes,including as a renewable energy *** their value,maize cobs are still underutilized,mainly because people are not aware of their potential and harvesting techniques for their collection are still being ***,this research focused on finding the most suitable energy-and time-efficient method for mechanical collection of maize *** the combine harvester with an additional hopper proved to be the most promising solution,as it allows harvesting and storage of maize grain and maize cobs in one pass,while the harvesting time remains almost the same and the maize cobs are of good quality,as they do not fall on the field.A prototype with enlarged openings in the straw walkers,an additional grab container for maize cobs,a transport auger,a transport cleaning fan with built-in knives,a transport tube and some other assemblies was fabricated and used in *** first test results are very encouraging(94.4%-96.0%purity of maize cobs)and the system has been patented as a promising solution,especially in times when the environmental sustainability of the planet and energy independence are becoming increasingly important.

关键词： maize cobs utilization mechanical harvesting combine harvester upgrade

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青藏高原及其周边前成冰纪综合地层、生物群与古地理演化

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中国科学：地球科学 2024年第4期54卷 915-935页

作者：胡培远翟庆国赵国春 peter A.CAWOOD 唐跃刘一鸣中国地质科学院地质研究所北京100037 香港大学地球科学系中国香港999077 大陆动力学国家重点实验室西北大学地质学系西安710069 School of Earth Atmosphere&EnvironmentMonash UniversityMelbourneVIC 3800Australia

青藏高原及邻区前成冰纪物质组成及其地质演化过程,在地球早期超大陆形成演化过程的研究中扮演了重要角色.本文系统梳理和总结了青藏高原及邻区前成冰纪沉积岩、古生物、岩浆和变质作用特征.根据现有资料,青藏高原及邻区前成冰纪沉积岩... 详细信息

青藏高原及邻区前成冰纪物质组成及其地质演化过程,在地球早期超大陆形成演化过程的研究中扮演了重要角色.本文系统梳理和总结了青藏高原及邻区前成冰纪沉积岩、古生物、岩浆和变质作用特征.根据现有资料,青藏高原及邻区前成冰纪沉积岩和古生物记录主要集中于中~新元古代,古元古代及更早的记录相对较少,最古老的地质记录为喜马拉雅和昌都地区前寒武纪变质沉积岩中的冥古宙碎屑锆石(约4.0Ga).青藏高原及邻区保存了凯诺兰超级克拉通以及哥伦比亚、罗迪尼亚和冈瓦纳超大陆形成演化过程的记录,其前成冰纪基底可划分为3种类型:塔里木型、扬子型和拉萨型.塔里木型基底与澳大利亚和印度大陆北缘具有古地理亲缘性,且不发育罗迪尼亚超大陆聚合相关的碎屑锆石年龄峰值和岩浆-变质记录(约1.3~0.9Ga);扬子型基底发育与前成冰纪最晚期全球变冷密切相关的火山活动记录,可见中~新元古代叠层石和微古植物化石,以及约1.1~1.0Ga与罗迪尼亚超大陆聚合相关的岩浆-变质作用记录;拉萨型基底发育新元古代早期大陆裂谷沉积记录(约900Ma)和晚期高压变质事件(约650Ma),具有明显的1.2~1.1Ga碎屑锆石年龄峰值,它很可能与非洲大陆具有古地理亲缘性.

关键词：青藏高原前成冰纪沉积地层古生物群古地理演化

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