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Open Science and Data Science

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Data Intelligence 2021年第1期3卷 95-105页

作者： peter Wittenburg Max Planck Computing and Data Facility Gießenbachstraße 285748 GarchingGermany

Data Science(DS)as defined by Jim Gray is an emerging paradigm in all research areas to help finding non-obvious patterns of relevance in large distributed data collections.“Open Science by Design”(OSD),i.e.,making artefacts such as data,metadata,models,and algorithms available and re-usable to peers and beyond as early as possible,is a pre-requisite for a flourishing DS ***,a few major aspects can be identified hampering a fast transition:(1)The classical“Open Science by Publication”(OSP)is not sufficient any longer since it serves different functions,leads to non-acceptable delays and is associated with high curation *** data lab practices towards OSD requires more fundamental changes than OSP.(2)The classical publication-oriented models for metrics,mainly informed by citations,will not work anymore since the roles of contributors are more difficult to assess and will often change,i.e.,other ways for assigning incentives and recognition need to be found.(3)The huge investments in developing DS skills and capacities by some global companies and strong countries is leading to imbalances and fears by different stakeholders hampering the acceptance of Open Science(OS).(4)Finally,OSD will depend on the availability of a global infrastructure fostering an integrated and interoperable data domain-“one data-domain”as George Strawn calls it-which is still not visible due to differences about the technological key *** therefore is a need for DS,but it will take much more time to implement it than we may have expected.

关键词： Open Science by Design Open Science by Publication Data Science Data infrastructure Digital Objects FAIR

Medical therapy for spermatogenic failure

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Asian Journal of Andrology 2012年第1期14卷 57-60,176页

作者： Ranjith Ramasamy peter J Stahl peter N Schlegel Department of Urology Weill Cornell Medical College New York NY 10065 USA

Medical treatment of men with primary spermatogenic failure remains largely ineffective in contrast to those with secondary testicular failure. Treatment has been attempted with a multitude of agents ranging from hormones to nutritional supplements （antioxidants）. While some studies have demonstrated benefit to some treatments, no treatments have consistently demonstrated efficacy nor has it been possible to reliably identify patients likely to benefit. Idiopathic spermatogenic failure likely results from multiple discrete defects in sperm production that are as yet unidentified. A better understanding of these defects will yield more effective treatment options and appropriate triage of patients to specific therapeutic regimens. This review focuses on the rationale and current evidence for hormonal and antioxidant therapy in medical treatment of male infertility, spermatogenic failure in particular. Although empiric medical therapy for spermatogenic failure has been largely replaced by assisted reproductive techniques, both treatment modalities could play a role, oerhaos as combination therapy.

关键词： antioxidant hormones male infertility sperm spermatogenesis spermatogenic failure testicular failure

Accurate, automatic annotation of peptidases with hotpep-protease

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Green Chemical Engineering 2020年第2期1卷 124-130页

作者： peter Kamp Busk Department of Science and Environment Roskilde UniversityUniversitetsvej 1DK-4000RoskildeDenmark

Peptidases are essential for intracellular protein processing,signaling and homeostasis,physiological processes and for digestion of ***,peptidases are important biotechnological enzymes used in processes such as industrial food processing,leather manufacturing and the washing *** of peptidases is a crucial step in their characterization but peptidase annotation is not a trivial task due to their large sequence *** the present study short,conserved sequence profiles were generated for all peptidase families with more than four members in the comprehensive Merops peptidase *** sequence profiles were combined with the Homology to Peptide Pattern(Hotpep)method for automatic annotation of *** method is a standalone software that annotates protease sequences to Merops family and subgroup and is suitable for large-scale sequence *** to the Mammalian Degradome Database Hotpep-protease had an accuracy of 92%and a sensitivity of 96%for annotation of the human *** by commonly used methods(Blast and conserved domains)had an accuracy of 69%and a sensitivity of 78%.For fungal genomes,there were large differences between annotation with Hotpep-protease,Blast-and Hidden Markov Model-based annotation and the Merops annotation,which confirms the difficulty of large-scale peptidase *** annotation indicated that Hotpep-protease had a positive prediction rate of 0.90 compared to a positive prediction rate of 0.67 for Blast ***,Hotpep-protease is highly accurate method for fast and accurate annotation of peptidases.

关键词： Gene annotation Proteinase Proteolytic enzyme Peptidase Merops

Prediction of disease course in inflammatory bowel diseases

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World Journal of Gastroenterology 2010年第21期16卷 2589-2590页

作者： peter Laszlo Lakatos 1st Department of Medicine Semmelweis UniversityH-1083 BudapestKoranyi S 2AHungary

Clinical presentation at diagnosis and disease course of both Crohn's disease(CD) and ulcerative colitis are heterogeneous and variable over *** most patients have a relapsing course and most CD patients develop complications(*** and/or perforation),much emphasis has been placed in the recent years on the determination of important predictive *** identification of these factors may eventually lead to a more personalized,tailored *** this TOPIC HIGHLIGHT series,we provide an update on the available literature regarding important clinical,endoscopic,fecal,serological/routine laboratory and genetic *** aim is to assist clinicians in the everyday practical decisionmaking when choosing the treatment strategy for their patients suffering from inflammatory bowel diseases.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Disease course Predictive markers Clinical Serology Genetics

Spin Polaron in a Diluted Parabolic Magnetic Quantum Well

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Communications in Theoretical Physics 2010年第4期53卷 782-786页

作者： A.John peter Department of Physics Zhejiang Institute of Modern Physics Zhejiang University

Theoretical investigations of spin polaron in a quantum well in the spin doping superlattice systems Cd1-xinMnxinTe/Cd1-xMnxout Te are presented in this paper. A variational procedure within the effective mass approximation is employed in the presence of magnetic field to calculate the donor ionization energy. Spin polaronic shifts are estimated using a mean field theory. The results show that the donor binding energy （i） Increases with the reduction in well sizes （ii） Decreases with the magnetic field is increased for a given well width （ill） Increases to a maximum value at 90 A and then decreases as the size of the well increases beyond 90 A and （iv） Spin polaronic shifts to the donor binding energy not only decrease in a magnetic field but also with the well width. The results are compared with the existing available literature.

关键词： spin polaron donor binding quantum dot semimagnetic system

A review of current understanding in tribochemical reactions involving lubricant additives

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Friction 2023年第4期11卷 489-512页

作者： Yan CHEN peter RENNER Hong LIANG Department of Materials Science and Engineering Texas A&M UniversityCollege Station 77843USA J.Mike Walker’66 Department of Mechanical Engineering Texas A&M UniversityCollege Station 77843USA

Lubricants have played important roles in friction and wear reduction and increasing efficiency of mechanical *** optimize tribological performance,chemical reactions between a lubricant and a substrate must be designed *** reactions are chemical reactions enabled or accelerated by mechanical *** activated lubricant additives play important roles in these *** this review,current understanding in mechanisms of chemical reactions under shear has been *** such as oil-soluble organics,ionic liquids(ILs),and nanoparticles(NPs)were analyzed in relation to the tribochemical reaction routes with elements in metallic *** results indicated that phosphorus,sulfur,fluorine,and nitrogen are key elements for tribochemical *** resulting tribofilms from zinc dithiophosphates(ZDDP)and molybdenum dithiocarbamate(MoDTC)have been widely reported,yet that from ILs and NPs need to investigate *** review serves as a reference for researchers to design and optimize new lubricants.

关键词： lubricant additives tribochemical reactions oil-soluble organics ionic liquids(ILs) nanoparticles(NPs)

Calibration of discrete element modeling: Scaling laws and dimensionless analysis

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Particuology 2022年第3期20卷 55-62页

作者： Yucang Wang peter Mora Yunpei Liang State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400044China College of Petroleum Engineering and Geosciences King Fahd University of Petroleum and MineralsSaudi Arabia

In this paper,dynamic similarity conditions are derived for discrete element simulations by non-dimensionalising the governing *** conditions must be satisfied so that the numerical model is a good representation of the physical *** a pure mechanical system,if three independent ratios of the corresponding quantities between the two models are set,then the ratios of other quantities must be chosen according to the similarity *** scalability of linear and non-linear contact laws is also *** tests of 3D uni-axial compression are carried out to verify the theoretical *** example is presented to show how to calibrate the model according to laboratory data and similarity ***,it is impossible to reduce computer time by scaling up or down certain parameters and continue to uphold the similarity *** results in this paper provide guidelines to assist discrete element modelers in setting up the model parameters in a physically meaningful way.

关键词： Discrete element method Dimensionless analysis Dynamic similarity Parameter calibration ESyS_Particle

The current perspective of the PA 1957 gas well pillar study and its implications for longwall gas well pillars

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International Journal of Mining Science and Technology 2021年第1期31卷 117-126页

作者： peter Zhang Daniel Su Chris Mark CDC NIOSH Pittsburgh Mining Research DivisionPittsburghPA 15236USA Mine Safety and Health Administration PittsburghPA 15217USA

Many states rely upon the Pennsylvania 1957 Gas Well Pillar Study to evaluate the coal barrier surrounding gas *** study included 77 gas well failure cases that occurred in the Pittsburgh and Freeport coal seams over a 25-year *** the time,coal was mined using the room-and-pillar mining method with full or partial pillar recovery,and square or rectangle pillars surrounding the gas wells were left to protect the *** study provided guidelines for pillar sizes under different overburden depths up to 213 m(700 ft).The 1957 study has also been used to determine gas well pillar sizes in longwall mines since longwall mining began in the 1970 *** original study was developed for room-and-pillar mining and could be applied to gas wells in longwall chain pillars under shallow ***,under deep cover,severe deformations in gas wells have occurred in longwall chain ***,with a better understanding of coal pillar mechanics,new insight into subsidence movements induced by retreat mining,and advances in numerical modeling,it has become both critically important and feasible to evaluate the adequacy of the 1957 study for longwall gas well *** this paper,the data from the 1957 study is analyzed from a new perspective by considering various factors,including overburden depth,failure location,failure time,pillar safety factor(SF),and floor *** pillar SF and floor pressure are calculated by considering abutment pressure induced by full pillar recovery.A statistical analysis is performed to find correlations between various factors and helps identify the most significant factors for the stability of gas wells influenced by retreat *** analyzing the data from the 1957 study,the guidelines for gas well pillars in the 1957 study are evaluated for their adequacy for roomand-pillar mining and their applicability to longwall *** modeling is used to model the stability of gas wells by quantifying the mining-induced s

关键词： Gas well pillar Pennsylvania 1957 gas well pillar study Room-and-pillar mining Longwall mining

Lactate-avid regulatory T cells:metabolic plasticity controls immunosuppression in tumour microenvironment

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1418-1419页

作者： Gabriele Multhoff peter Vaupel Radiation Immuno-Oncology Project Group TranslaTUM–Central Institute for Translational Cancer ResearchKlinikum rechts der IsarTU MünchenMunichGermany Department of Radiation Oncology Klinikum rechts der IsarTU MünchenMunichGermany Department of Radiooncology and Radiotherapy Tumour Pathophysiology GroupUniversity Medical Centre MainzMainzGermany

The excellent article by Watson et al.1 points the way ahead to the important role of lactic acid/lactate-anion and glucose on the immunosuppressive activity of lactate-and glucose-affine metabolically distinct subset... 详细信息

关键词： tumour al. microenvironment