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Asian Journal of Andrology 2024年第3期26卷 245-249页

作者： Xiaobo Wu Ivan Ching-Ho ko Cindy Yeuk-Lam Hong Samuel Chi-Hang Yee Jeremy Yuen-Chun Teoh Samson Yun-Sang Chan Ho-Man Tam Chi-Kwok Chan Chi-Fai Ng peter Ka-Fung Chiu SH Ho Urology Centre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong KongChina

This study aimed to report the outcomes of active surveillance(AS)in the management of low-risk prostate cancer(PCa).It recruited87 men who were prospectively followed up according to the Prostate Cancer Research International Active Surveillance(PRIAS)protocol with local adaptation at SH Ho Urology Centre,Prince of Wales Hospital,Hong kong,*** investigated the predictorsof disease progression and found that baseline prostate-specific antigen density(PSAD)and the presence of the highest ProstateImaging-Reporting and Data System(PI-RADS)score 5 lesion on magnetic resonance imaging(MRI)are significantly correlatedwith disease ***,men with PSAD>0.2 ng ml^(−2)or PI-RADS 4 or 5 lesions had significantly worse upgradingfree survival compared to those with PSAD≤0.2 ng ml−2 and PI-RADS 2 or 3 *** study concludes that AS is a safe andeffective management strategy for selected patients to defer radical treatment and that most disease progression can be detectedafter the first repeated *** combination of PSAD>0.2 ng ml^(−2)and PI-RADS 4 or 5 lesions may serve as a useful predictorof early disease progression and provide a guide to optimize follow-up protocols for men in different risk groups.

关键词： active surveillance cohort localized prostate cancer

Stress-controlled fatigue of HfNbTaTiZr high-entropy alloy and associated deformation and fracture mechanisms

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Journal of Materials Science & Technology 2022年第19期114卷 191-205页

作者： Shuying Chen Weidong Li Ling Wang Tao Yuan Yang Tong ko-Kai Tseng Jien-Wei Yeh Qingang Xiong Zhenggang Wu Fan Zhang Tingkun Liu Kun Li peter KLiaw Institute for Advanced Studies in Precision Materials Yantai UniversityYantai 264005China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN 37996USA Department of Industrial and Systems Engineering Ohio UniversityAthensOH 45701USA Department of Materials Science and Engineering High Entropy Materials CenterNational Tsing Hua UniversityHsinchu30013TaiwanChina State Key Laboratory of Pulp and Paper Engineering South China University of TechnologyGuangzhou 510640China School of Light Industry and Engineering South China University of TechnologyGuangzhou 510640China College of Materials Science and Engineering Hunan UniversityChangsha 410082China WPI Advanced Institute for Materials Research Tohoku UniversitySendai 980-8577Japan State Key Laboratory of Mechanical Transmission Chongqing UniversityChongqing 400044China

The stress-controlled fatigue tests are carried out at a stress ratio of 0.1 and a frequency of 10 Hz,and span both low-cycle and high-cycle regimes by varying the applied stress *** high-cycle fa-tigue regime gives a fatigue strength of 497 MPa and a fatigue ratio of *** equivalent conditions,the alloy’s fatigue strength is greater than all other high-entropy alloys(HEAs)with reported high-cycle fatigue data,dilute body-centered cubic alloys,and many structural alloys such as steels,titanium al-loys,and aluminum *** in-depth analyses of crack-propagation trajectories,fracture-surface morphologies and deformation plasticity by means of various microstructural analysis techniques and theoretical frameworks,the alloy’s remarkable fatigue resistance is attributed to delayed crack initiation in the high-cycle regime,which is achieved by retarding the formation of localized persistent slip bands,and its good resistance to crack propagation in the low-cycle regime,which is accomplished by intrin-sic toughening backed up by extrinsic ***,the stochastic nature of the fatigue data is neatly captured with a 2-parameter Weibull model.

关键词： Fatigue mechanisms Intrinsic toughening Extrinsic toughening Probabilistic modeling

Neurovascular ageing:transcriptomic readout and implications on therapeutic targeting in Alzheimer’s disease

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Neural Regeneration Research 2021年第12期16卷 2411-2412页

作者： Zhongqi Li Bonaventure Ip Vincent C.T.Mok Ho ko Division of Neurology Department of Medicine and TherapeuticsThe Chinese University of Hong KongHong Kong Special Administrative RegionChina Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongHong Kong Special Administrative RegionChina(Li ZKo H)Margaret K.L.Cheung Research Centre for Management of ParkinsonismThe Chinese University of Hong KongHong Kong Special Administrative RegionChina Chow Yuk Ho Technology Centre for Innovative Medicine The Chinese University of Hong KongHong Kong Special Administrative RegionChina Gerald Choa Neuroscience Centre School of Biomedical SciencesDepartment of PsychiatryPeter Hung Pain Research InstituteFaculty of MedicineThe Chinese University of Hong KongHong Kong Special Administrative RegionChina

Ageing is one of the greatest risk factors for neurodegenerative *** the complex biological changes in ageing increase the brain’s susceptibility to neurodegeneration remains incompletely *** into neurodegenerative disorders has shifted from a neuron-centric approach,to the contributing roles of age-related neurovascular and glial cell dysfunction.

关键词： incomplete susceptibility ageing

Effects of Ambient Conditions and Nozzle Design on the Velocity of Clustered Diesel Jets

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Journal of Physical Science and Application 2013年第5期3卷 279-286页

作者： Thorsten Brands peter Hottenbach Hans-Jargen ko Gerd Griinefeld Stefan Pischinger Philipp Adomeit Institute of Laser-Diagnostics in Thermofluiddynamics RWTH Aachen University Aachen 52062 Germany Institute of Technical Thermodynamics RWTH Aachen University Aachen 52062 Germany Institute for Combustion Engines RWTH Aachen University Aachen 52062 Germany FEV Motorentechnik GmbH Aachen 52078 Germany

The measurement of droplet velocities in Diesel sprays close to the nozzle is important because of the complexity of in-nozzle flow, spray break-up and evaporation. However, the measurement of droplet velocities in the dense region of Diesel sprays is very difficult or impossible by means of widely used laser diagnostic techniques, in particular under engine-like high-pressure and high-temperature conditions. The limitations of phase Doppler anemometry （PDA） and particle image velocimetry （PIV） prevent the application to the ultra-dense region of the spray. It was demonstrated that these problems can be greatly reduced by the laser flow tagging （LFT） technique. It was also demonstrated recently that LFT measurements can be conducted in clustered Diesel jets with improved spatial resolution and increased number of simultaneous measurements in the near-nozzle region. In the present work, the nozzle design, the temperature and pressure of the ambient air, and the fuel rail pressure are varied, in order to investigate the influence on the near-nozzle jet velocity and the underlying physical mechanisms.

关键词： Laser flow tagging velocimetry diesel fuel injection cluster nozzles engine-like conditions

Magnesite and talc origin in the sequence of geodynamic events in Veporicum, Inner Western Carpathians, Slovakia

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岩石学报 2004年第4期20卷 837-854页

作者： Zoltán NMETH Walter PROCHASKA Martin RADVANEC Martin koV■IK Ján MADARAS peter koD■RA L'ubomír HRA■ko Geological Survey of Slovak Republic Jesenskeho 8 SK-040 01 Kosice Slovak Republic Department of Geological Sciences University of Leoben A-8700 Leoben Austria Geological Survey of Slovak Republic Marku ovsk cesta 1 SK-052 01 Spisska Nova Ves Slovak Republic Geological Survey of Slovak Republic Mlynsk dolina 1 SK-817 04 Bratislava Slovak Republic

This paper summarizes recent data about magnesite and talc genesis in Carboniferous host rocks of Western Carpathians (Slovakia) , which occur in two distinct belts in tectonic superunit Veporicum and its contact zone with Gemericum. The northern Sinec magnesite and talc belt (with main deposits kokava, Sinec, Samo, Hnust'a-Mutnik) contains economic accummulation of magnesite and talc, while in the southern Ochtina belt ( main deposits in Dubrava massif-Dubrava, Mikova, Jedl'ovec; Lubenik, Ochtina, kosice-Bankov, Banisko, Medvedia) the magnesite is *** magnesite genesis by successive replacement of Carboniferous calcite to dolomite and magnesite during metamorphic process Ml (northern belt 280-400℃; , southern belt 370-420℃: ; Radvanec & Prochaska, 2001; kodera & Radvanec, 2002) , being supplied by Mg from Permoscythian evaporitic bittern brines, relates to Variscan post-collisional (post-VD) evolution. The extensional tectonics and the high heat flow facilitated the generation of a hydrothermal *** time-separated later metamorphic and sourcely different fluid flow event (M2; 1. c. ) produced talc. Tectonic, microtectonic, metamorphic and geochronological data relate the talc origin with the Alpine Upper Cretaceous (88-84 Ma; Maluski in kovacik et al. , 1996) tectonothermal event AD2. This event, being the consequence of Alpine collisional ( AD1 ) crustal thickening and metamorphic core complex origin, meant regional extension and pervasive fluid flow of open system in crustal discontinuities. This process was prominent in the northern belt ( Sinec shear zone) located more closely to Veporic thermal dome, while towards its peripheral parts (southern Ochtina belt) the M2 metamorphic process and steatitization gradually *** from Sinec shear zone (being the prominent AD2 -AD3 structure of northern Sinec belt) , where the dolomite/magnesite lenses (replacement in M1) and their accompanying lithology were in AD1 sandwitched between more com

关键词： Magnesite and talc genesis Geodynamic evolution Shear zones Microstructures Fluid inclusions WesternCarpathians

Some Properties of the Electromagnetic Radiation Emitted by the HV Transformers

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Energy and Power Engineering 2013年第4期5卷 1463-1467页

作者： Nikolay V. Kinsht Natalia N. Petrun’ko peter V. Katz Tech. Diagnosis Lab. Institute of Automation & Control Processes FEB RAS Vladivostok Russia

One important way to control the technical condition of the high-voltage power equipment element is the monitoring and interpretation of electromagnetic radiation. Analysis of the spectra of emitted high-voltage equipment EMR provides information on which determines the intensity discharge processes occurring in insulation and other structural elements of high voltage equipment under the operating voltage without interfering with the process.

关键词： Partial Discharge Power Transformer Emitted Electromagnetic Radiation Technical Condition

Association between smoking,pancreatic insulin secretion and insulin resistance in Chinese subjects with or without glucose intolerance

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Chinese Medical Journal 2007年第24期120卷 2233-2237页

作者： ko Gary Tin-Choi TONG peter Chun-Yip SO Wing-Yee COCKRAM Clive S. CHAN Juliana Chung-Ngor Hong kong Institute of Diabetes and Obesity Hong Kong China Department of Medicine and Therapeutics Chinese University of Hong Kong Prince of Wales Hospital Shatin N.T. Hong KongChina

Background There are studies suggesting smoking may increase the risk of type 2 diabetes. Effects of smoking on insulin secretion and insulin resistance （IR） are, however, controversial. Methods This is a cross-sectional study. Since there were very few smokers among Hong kong Chinese women, only men （n=-1068） were analyzed in this report. Fasting and 2-hour plasma glucose and insulin were measured. Insulinogenic index as well as beta-cell function and IR based on homeostatic model assessment （HOMA） by computer model （HOMA Calculator v2.2） were calculated. Results Of the 1068 men, 147 had newly diagnosed diabetes, 131 newly diagnosed impaired glucose tolerance （IGT） and 790 were non-diabetic normal controls. Smokers had similar fasting and 2-hour insulin levels, insulinogenic index and HOMA derived beta-cell function as compared to non-smokers in the groups with diabetes, IGT or normal oral glucose tolerance test （OGTT）. IR was also similar between smokers, ex-smokers and non-smokers in those with normal OGTT. In men with IGT or diabetes, after adjustment for age and body mass index, smokers were more insulin resistant as compared to non-smokers （IR, IGT： 1.59±1.07 vs 1.03±0.54, P〈0.05; diabetes： 1.96±1.36 vs 1.06±0.45, P〈0.01）. With Logistic regression analysis, comparing smokers and non-smokers, IR was independently associated with smoking （odds ratio （95% C/）, IGT： 2.23 （1.05, 4.71）; diabetes： 3.92 （1.22, 12.58））. None of the other insulin parameters enter into the model among those with normal OGTT or comparing ex-smokers and non-smoker or smokers and ex-smokers. Conclusions In Chinese men, smoking did not show any direct association with insulin levels and pancreatic insulin secretion. Smoking men with IGT or diabetes appeared more insulin resistant than their non-smoking counterparts.

关键词： smoking diabetes mellitus insulin Chinese

医用TC4钛合金激光-化学复合抛光及表面形貌演化

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中国表面工程 2024年第2期37卷 227-237页

作者：邵勇孙树峰王萍萍蒙卡·彼得·帕沃尔陈博文张丰云王茜孙维丽青岛理工大学机械与汽车工程学院青岛266520 青岛理工大学信息与控制工程学院青岛266520 斯洛伐克科希策技术大学制造技术学院普雷绍夫08001 青岛黄海学院智能制造学院青岛266427

表面粗糙度是医疗器械构件最重要的质量特征之一,然而现有的激光抛光、化学抛光等单一表面抛光技术存在一定局限性。针对医用TC4钛合金表面的精密抛光需求,设计并搭建一套激光-化学复合抛光系统,通过激光-化学复合加工材料去除机理分析... 详细信息

表面粗糙度是医疗器械构件最重要的质量特征之一,然而现有的激光抛光、化学抛光等单一表面抛光技术存在一定局限性。针对医用TC4钛合金表面的精密抛光需求,设计并搭建一套激光-化学复合抛光系统,通过激光-化学复合加工材料去除机理分析和开展TC4钛合金的激光-化学复合抛光试验,深入探究复合抛光过程中不同抛光阶段材料表面形貌的演变过程及粗糙度变化并进行分析,进而明确激光-化学复合抛光机理。研究结果表明,激光-化学复合抛光材料去除是基于激光热-力效应与激光诱导化学腐蚀溶解共同作用的结果,而且两者具有一定协同效应,在适当的工艺窗口内,化学腐蚀溶解可以完全去除激光烧蚀产生的残渣和重熔物。激光辐照会在工件表面“峰-谷”区域产生温度差,进而导致化学溶解速率差异,即“山峰”区域溶解速率快,“山谷”区域溶解速率慢,从而实现表面粗糙度的降低。最后采用合适的工艺参数,优化了抛光效果,实现了医用TC4钛合金的选择性精密抛光,激光辐照区域表面粗糙度Ra由初始的5.230μm下降至0.225μm,Sa由初始的8.630μm下降至0.571μm,分别下降95.7%和93.4%。研究结果可为钛合金或其他自钝化金属的精密抛光提供参考。

关键词：激光钛合金抛光表面形貌化学腐蚀

斯洛伐克西喀尔巴阡山koice-Medvedia菱镁矿床的矿物学、流体包裹体和碳-氧-锶同位素研究(英文)

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岩石学报 2004年第4期20卷 855-876页

作者： Martin RADVANEC peter koDERA Walter PROCHASKA Geological Survey of Slovak Republic Markusovska cesta 1 052 01 Spisska Nova Ves SlovakiaGeological Survey of Slovak Republic Mlynskd dolina 1 817 04 Bratislava SlovakiaDepartment of Geological Sciences University of Leoben. A-8700 Leoben Austria

kosice矿床是斯洛伐克第二大的菱镁矿床(150Mt),位于Gemeric的东部.其镁质碳酸盐矿体赋存于石炭纪石灰石和含白云石的石灰石中,同时下盘黑色片岩中也含有被铁质碳酸盐交代的薄层碳酸盐透镜体.在华力西期造山运动(M1)中,古生代岩石受到... 详细信息

kosice矿床是斯洛伐克第二大的菱镁矿床(150Mt),位于Gemeric的东部.其镁质碳酸盐矿体赋存于石炭纪石灰石和含白云石的石灰石中,同时下盘黑色片岩中也含有被铁质碳酸盐交代的薄层碳酸盐透镜体.在华力西期造山运动(M1)中,古生代岩石受到了低级变质作用(绿泥石带).镁交代作用始于白云岩1的结晶作用,其后形成菱镁矿,最终沿裂隙形成铁菱镁矿.铁质碳酸盐包括早期铁白云石-白云石,铁白云石和后期含方解石和石英的菱铁矿.根据碳酸盐矿物对地质温度计,白云石l结晶作用发生在300～340℃.这一结果与M1的变质矿物组合(绿泥石,白云母-伊利石)吻合.铁白云石的结晶作用发生在320～370℃.少量细脉中可见白云石2,绿泥石和伊利石-多硅白云母,它们是由于阿尔卑斯期造山运动M2变质作用形成的更晚的矿物组合.菱镁矿的流体包裹体(FI)研究,显示存在不同成分的热卤水,卤水成分变化相当于NaCl含量21～42 wt%,但其它成分的盐含量高于NaCl,溶解的CO2含量也有变化.两相包裹体均一温度(Th)的范围为164～217℃,含石盐子晶包裹体均一温度的范围为217～344℃.富CO2包裹体(盐度相当于NaCl含量1～22wt%,CO2的密度为0.28～0.77 g·cm-3,均一温度为289～344℃)在菱镁矿中是次要的,但这种包裹体在与矿石伴生的石英中是主要的,并且与含石盐子晶流体包裹体共生.在后期镁交代过程中流体中的CO2逐渐增加.和铁质碳酸盐伴生的石英中只有两相包裹体,包裹体中CO2含量有所变化,盐度范围为17～24 wt%的NaCl(或者34～36 wt%的MgCl2),均一温度为152～195℃.包裹体的数据结合碳酸盐地质温度计显示镁交代作用的压力范围是180～320MPa(7～12km),铁交代作用的压力范围是280～420MPa(10～16km),说明地热梯度约为25～35℃/km.包裹体浸出液的分析表明Cl/Br和Na/Br的比值存在变化,但仍旧说明富镁的卤水来源是上二叠纪和下三叠纪的分馏蒸发岩来源.铁质碳酸盐流体的高溴和高碘含量,说明在铁交代过程中周围黑色片岩的明显影响.菱镁矿和铁交代作用,表明交代流体中的碳和二氧化碳,主要是海洋沉积的来源.菱铁矿的'Sr/86Sr比值((0.71124～0.71140),说明锶的多来源,最初应是石炭纪和二叠纪的海水,但它被当地其它陆壳中的锶混染.

关键词：菱铁矿包裹体包裹体流体化学蒸发趋势地质温度计 P—T条件 C-O-Sr同位素 Gemericum区西喀尔巴阡山

CHIP regulates bone mass by targeting multiple TRAF family members in bone marrow stromal cells

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Bone Research 2018年第2期6卷 145-154页

作者： Tingyu Wang Shan Li Dan Yi Guang-Qian Zhou Zhijie Chang peter X.Ma Guozhi Xiao Di Chen Department of Pharmacy Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Department of Orthopedic Surgery Rush University Medical Center Department of Medical Cell Biology and Genetics Shenzhen Key Laboratory and the Center for Anti-Ageing and Regenerative Medicine Shenzhen University Medical School State Key Laboratory of Biomembrane and Membrane Biotechnology Tsinghua University School of Medicine Department of Biologic and Materials Science University of Michigan

Carboxyl terminus of Hsp70-interacting protein（CHIP or STUB1） is an E3 ligase and regulates the stability of several proteins which are involved in different cellular functions. Our previous studies demonstrated that Chip deficient mice display bone loss phenotype due to increased osteoclast formation through enhancing TRAF6 activity in osteoclasts. In this study we provide novel evidence about the function of CHIP. We found that osteoblast differentiation and bone formation were also decreased in Chip ko mice. In bone marrow stromal（BMS） cells derived from Chip^-/- mice, expression of a panel of osteoblast marker genes was significantly decreased. ALP activity and mineralized bone matrix formation were also reduced in Chip-deficient BMS cells. We also found that in addition to the regulation of TRAF6, CHIP also inhibits TNFα-induced NF-κB signaling through promoting TRAF2 and TRAF5 degradation. Specific deletion of Chip in BMS cells downregulated expression of osteoblast marker genes which could be reversed by the addition of NF-κB inhibitor. These results demonstrate that the osteopenic phenotype observed in Chip^-/- mice was due to the combination of increased osteoclast formation and decreased osteoblast differentiation. Taken together, our findings indicate a significant role of CHIP in bone remodeling.

关键词： CHIP regulates bone mass targeting multiple TRAF family members marrow stromal cells