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Intraprocedural gastric juice analysis as compared to rapid urease test for real-time detection of Helicobacter pylori

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World journal of Gastroenterology 2023年第10期29卷 1638-1647页

作者： Riccardo Vasapolli Florent Ailloud Sebastian Suerbaum jens Neumann Nadine Koch Lukas Macke jörg Schirra julia Mayerle peter Malfertheiner Christian Schulz Medical DepartmentⅡ University Hospital LMU MunichMunich 81377Germany Deutsches Zentrum für Infektionsforschung Partner Site MunichMunich 81377Germany Max von Pettenkofer Institute Faculty of MedicineLudwig-Maximilians University of MunichMunich 80336Germany National Reference Center for Helicobacter pylori Munich 81377Germany Institute of Pathology Faculty of MedicineLudwig-Maximilians-University of MunichMunich 81377Germany

BACKGROUND Endofaster is an innovative technology that can be combined with upper gastrointestinal endoscopy(UGE)to perform gastric juice analysis and real-time detection of Helicobacter pylori(***).AIM To assess the diagnostic performance of this technology and its impact on the management of *** in the real-life clinical *** Patients undergoing routine UGE were prospectively *** were taken to assess gastric histology according to the updated Sydney system and for rapid urease test(RUT).Gastric juice sampling and analysis was performed using the Endofaster,and the diagnosis of *** was based on real-time ammonium *** detection of *** served as the diagnostic gold standard for comparing Endofaster-based *** diagnosis with RUT-based *** *** A total of 198 patients were prospectively enrolled in an *** diagnostic study by Endofasterbased gastric juice analysis(EGjA)during the *** for RUT and histological assessment were performed on 161 patients(82 men and 79 women,mean age 54.8±19.2 years).*** infection was detected by histology in 47(29.2%)***,the sensitivity,specificity,accuracy,positive predictive value,and negative predictive value(NPV)for *** diagnosis by EGjA were 91.5%,93.0%,92.6%,84.3%,and 96.4%,*** patients on treatment with proton pump inhibitors,diagnostic sensitivity was reduced by 27.3%,while specificity and NPV were *** and RUT were comparable in diagnostic performance and highly concordant in *** detection(κ-value=0.85).CONCLUSION Endofaster allows for rapid and highly accurate detection of *** during *** may guide taking additional biopsies for antibiotic susceptibility testing during the same procedure and then selecting an individually tailored eradication regimen.

关键词： Helicobacter pylori diagnostic Chronic gastritis Gastric juice Endofaster Rapid urease test Antimicrobial susceptibility testing

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Are Off-Field Activities an Underestimated Risk for Hamstring Injuries in Dutch Male Amateur Soccer Players?An Exploratory Analysis of a Prospective Cohort Study

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journal of Science in Sport and Exercise 2022年第1期4卷 28-36页

作者： jur j.Brauers peter Alexander van de Hoef Maarten van Smeden Frank j.G.Backx Michel S.Brink Department of Rehabilitation Physical Therapy Science and SportsUtrecht UniversityUniversity Medical Center UtrechtBrain CenterUtrechtThe Netherlands julius Center for Health Sciences and Primary Care University Medical Center UtrechtUtrecht UniversityUtrechtThe Netherlands Center for Human Movement Sciences University of GroningenUniversity Medical Center GroningenGroningenThe Netherlands

Purpose The purpose of this study was to explore what extent male amateur soccer players participate in off-field activities and whether these off-field activities are associated with the development of hamstring *** Amateur soccer players(n=399)from first-class selection teams(n=32)filled out a baseline screening question-naire concerning off-field activities(i.e.,work and study type and hours,traveling time,sleep,energy costs,and time spent on other activities)and their history of hamstring injury as a part of a cluster-randomized controlled *** one competition,the players reported weekly their hamstring injuries,which were verified by medical/technical ***-able Firth corrected logistic regression models were used to explore associations between off-field activities and hamstring *** Sixty-five hamstring injuries were *** injury was significantly associated with hamstring injuries(OR ranging from 1.94[95%CI 1.45-2.61]to 2.02[95%CI 1.49-2.73]),but off-field activities were *** Although amateur soccer players spent a relatively large amount of time on off-field activities,we did not find off-field activities measured at baseline to be associated with hamstring injuries in the subsequent competitive soccer *** contrast,previous hamstring injury was found to be strongly associated with(recurrent)hamstring injuries.

关键词： Risk factors Activities of daily living Psychosocial factors Football Athletic injuries

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Polyelectrolyte multilayer electrostatic gating of graphene field-effect transistors

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Nano Research 2014年第11期7卷 1650-1658页

作者： Yung Yu Wang peter j. Burke Department of Chemical Engineering and Materials Science University of California Irvine Irvine California 92697 USA Department of Electrical Engineering and Computer Science University of California Irvine Irvine California 92697 USA

我们使用由到 graphene 的表面的断然控告的 polyallylamine hydrochloride 和否定地控告的钠聚苯乙烯 sulfonate 的连续交替的吸附的多层的电影回答的聚合电解质效果晶体管。在迪拉克电压的摆动与轮流出现变积极、否定的层清楚地在这... 详细信息

我们使用由到 graphene 的表面的断然控告的 polyallylamine hydrochloride 和否定地控告的钠聚苯乙烯 sulfonate 的连续交替的吸附的多层的电影回答的聚合电解质效果晶体管。在迪拉克电压的摆动与轮流出现变积极、否定的层清楚地在这个简单模型系统表明静电的 gating 效果。一个简单静电的模型说明很好迪拉克电压移动的符号和大小。用这个系统，我们能随意创造 p 类型或 n 类型 graphene。这个模型用作理解控告的聚合物用 graphene 设备察觉到的机制的基础，一潜在地在象定序的 DNA 那样的区域的 graphene 的技术上重要的申请，为癌症察觉的 biomarker 试金，和察觉到应用的另外的蛋白质。

关键词：聚电解质多层膜场效应晶体管静电模型石墨门控模型系统电压转换癌症检测

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1,10-邻菲啉衍生物钌配合物的合成、表征及与DNA和BSA的相互作用

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高等学校化学学报 2019年第1期40卷 30-40页

作者：赵雅晨李季张培培刘姝娴魏代娜苏志钱勇王飞利 peter john sadler 刘红科南京师范大学化学与材料科学学院南京210023 西北大学化工学院西安710069 Department of Chemistry University of Warwick

通过2-(4-吡啶)-咪唑[4,5-f]-1,10-邻菲啉(L_1)与[Ru(η~6-cymene)(μ-Cl) Cl]_2反应合成了3种新型芳基钌配合物,并利用新配体2-(4-咪唑基苯基)咪唑[4,5-f]-1,10-邻菲啉(L_2)与RuCl_3反应合成了配合物4.利用核磁共振波谱、质谱等对... 详细信息

通过2-(4-吡啶)-咪唑[4,5-f]-1,10-邻菲啉(L_1)与[Ru(η~6-cymene)(μ-Cl) Cl]_2反应合成了3种新型芳基钌配合物,并利用新配体2-(4-咪唑基苯基)咪唑[4,5-f]-1,10-邻菲啉(L_2)与RuCl_3反应合成了配合物4.利用核磁共振波谱、质谱等对配合物进行了表征.通过紫外光谱和圆二色谱研究了配合物在缓冲溶液中的稳定性及与CT-DNA的相互作用,利用荧光光谱研究了配合物与牛血清蛋白的作用,用乌氏黏度计测试了配合物对DNA黏度的影响,并通过荧光光谱、凝胶电泳研究了配合物4在不同pH条件下的荧光响应及与pBR322 DNA的作用.结果表明,配合物通过嵌入的方式与DNA作用,并对DNA的二级结构产生影响;配合物1～4均可与牛血清蛋白的一个位点发生相互作用并使其发生静态荧光猝灭.配合物4在光照条件下有活性氧生成,可以使pBR322 DNA断裂并在酸性溶液中荧光增强.

关键词：芳基钌配合物 1,10-邻菲啰啉 DNA作用 BSA作用光断裂

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Characterization of multi-GNSS between-receiver differential code biases using zero and short baselines

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Science Bulletin 2015年第21期60卷 1840-1849页

作者： Baocheng Zhang peter j.G.Teunissen Global Navigation Satellite System (GNSS) Research Centre Curtin University Geoscience and Remote Sensing Delft University of Technology

Care should be taken to minimize adverse impact of receiver differential code biases(DCBs) on global navigation satellite system(GNSS)-derived ionospheric parameters. It is therefore of importance to ascertain the intrinsic characteristics of receiver DCBs,preferably in the context of new-generation GNSS. In this contribution, we present a method that enables time-wise retrieval of between-receiver DCBs(BR-DCBs) from dualfrequency, code-only measurements collected by a pair of co-located receivers. This method is applicable to the US GPS as well as to a new set of GNSS constellations including the Chinese Bei Dou, the European Galileo and the japanese QZSS. With the use of this method, we determine the multi-GNSS BR-DCB time-wise estimates covering a time period of up to 2 years(january 2013–March 2015) with a 30-s time resolution for five receiverpairs(four zero and one short baselines). For the BR-DCB time-wise estimates pertaining to an arbitrary receiver-pair and constellation, we demonstrate their promising intraday stability by means of statistical hypothesis testing. We also find that the Bei Dou BR-DCB daily weighted average(DWA) estimates show a dependence on satellite type, in particular for receiver-pairs of mixed types. Finally, we demonstrate that long-term variability in BR-DCB DWA estimates can be closely associated with hardware temperature variations inside the receivers.

关键词： GNSS接收机短基线差分码偏差全球导航卫星系统时间分辨率 DCBS 表征

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British Soccer Academy Personnel Perceive Psychological and Technical/Tactical Attributes as the Most Important Contributors to Development

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journal of Science in Sport and Exercise 2022年第1期4卷 37-48页

作者： Rich j.Kite Mark R.Noon Rhys Morris peter Mundy Neil D.Clarke Faculty of Health Academy Sports Science and Medical Department Coventry City Football ClubCoventryUK

Purpose Understanding the desired attributes for talented soccer players may give insight into the process of(de)selection and player *** study aimed to explore soccer academy personnel’s perceptions of attributes associated with talent and *** Thirty English and Scottish academy personnel(managers,coaches,recruitment,sports scientists)provided per-ceptions into what attributes contribute to‘talent’,via an online *** an E-Delphi method,seven experts refined these inputs over several rounds until a consensus was reached,resulting in 82 agreed *** terminology was resubmitted via a second online survey,where 45 academy personnel rated each using a Likert *** A ranking of attributes by importance was produced,finding Psychological and Technical/Tactical attributes con-sidered of greatest *** were observed,whereby recruitment personnel consistently over-emphasised the importance of several attributes compared to other personnel(P=0.02-0.04).When analyzed within each age phase,11 variations in the perceived importance of attributes were demonstrated in the youth phase(11-16 years,P=0.01)compared with 5 in the professional phases(17-23 years,P=0.01-0.05)Conclusion The present study demonstrates that‘talent’requires multifaceted developments,with academy personnel per-ceiving psychological attributes the most important contributor to development.

关键词： Talent development Characteristics Elite player performance plan Youth

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A-posteriori error estimation for second order mechanical systems

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Acta Mechanica Sinica 2012年第3期28卷 854-862页

作者： Thomas Ruiner jrg Fehr Bernard Haasdonk peter Eberhard Institute of Engineering and Computational Mechanics University of StuttgartPfaffenwaldring 970569 StuttgartGermany Institute of Applied Analysis and Numerical Simulation University of StuttgartPfaffenwaldring 5770569 StuttgartGermany

One important issue for the simulation of flexible multibody systems is the reduction of the flexible bodies de- grees of freedom. As far as safety questions are concerned knowledge about the error introduced by the reduction of the flexible degrees of freedom is helpful and very important. In this work, an a-posteriori error estimator for linear first order systems is extended for error estimation of me- chanical second order systems. Due to the special second order structure of mechanical systems, an improvement of the a-posteriori error estimator is achieved. A major advan- tage of the a-posteriori error estimator is that the estimator is independent of the used reduction technique. Therefore, it can be used for moment-matching based, Gramian matrices based or modal based model reduction techniques. The capability of the proposed technique is demon- strated by the a-posteriori error estimation of a mechanical system, and a sensitivity analysis of the parameters involved in the error estimation process is conducted.

关键词： A-posteriori error estimator. Flexible multibodysystems Model reduction

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Three-dimensional simulation of liquid injection,film formation and transport,in fluidized beds

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Particuology 2009年第5期7卷 337-346页

作者： Paul Zhao peter j. O'Rourke Dale Snider CPFD Software LLCAlbuquerqueNM 87111USA CFD d'OR Software and Consulting LLCLos AlamosNM 87544USA

Liquid injection, and film formation and transport in dense-phase gas-solids fluidized beds are numerically simulated in three dimensions using a collisional exchange model that is based on the mechanism that collisions cause transfer of liquid mass, momentum, and energy between particles. In the model, each of the particles is represented by a solid core and a liquid film surrounding the core. The model is incorporated in the framework of the commercial code Barracuda developed by CPFD Software. The commercial software is an advanced CFD-based computational tool where the particles are treated as discrete entities, calculated by the MP-PIC method, and tracked using the Lagrangian method. Details of the collisional liquid transfer model have been previously presented in O＇Rourke, Zhao, and Snider （2009）; this paper presents new capabilities and proof-testing of the collision model and a new method to better quantify the penetration length. Example calculations of a fluidized bed without liquid injection show the expected effect of collisions on the reduction of granular temperature （fluctuational kinetic energy） of the bed. When applied to liquid injection into a dense-phase fluidized bed under different conditions, the model predicts liquid penetration lengths comparable to the experiments. In addition, the simulation reveals for the first time the dynamic mixing of the liquid droplets with the bed particles and the transient distribution of the droplets inside the bed.

关键词： MP-PIC Liquid injection Fluidized bed Particle collisions CPFD jet penetration

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Emotions,Perceptions and Health Behaviors of Adult Congenital Heart Disease Patients during COVID-19 in New York City

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Congenital Heart Disease 2022年第5期17卷 519-531页

作者： jodi L.Feinberg peter Sheng Stephanie Pena Adam j.Small Susanna Wendelboe Katlyn Nemani Vikram Agrawal Dan G.Halpern Leon H.Charney Division of Cardiology NYU Grossman School of MedicineNew YorkUSA Department of Medicine NYU Grossman School of MedicineNew YorkUSA Department of Psychiatry NYU Grossman School of MedicineNew YorkUSA Department of Cardiology Mount Sinai MorningsideNew YorkUSA

Background:Adults with congenital heart disease(ACHD)have increased prevalence of mood and anxiety *** are limited data regarding the influence of the COVID-19 pandemic on the mental health and health behaviors of these ***:The purpose is to evaluate the perceptions,emotions,and health behaviors of ACHD patients during the COVID-19 ***:In this cross-sectional study of ACHD patients,we administered surveys evaluating self-reported emotions,perceptions and health *** regressions were performed to determine the adjusted odds of displaying each perception,emotion and health behavior based on predictor ***:Ninety-seven patients(mean age 38.3 years,46.4%female,85.6%moderate or complex lesion)completed the *** majority of patients reported feeling moderately or very sad(63.1%),and 48.4%of patients identified themselves as feeling moderately or very *** majority of patients perceived their risk of COVID-19 as moderate or *** were more likely to report feeling sad and anxious(95%CI 1.06–10.96,p-value 0.039,and 95%CI 1.44–15.30,p-value=0.012,respectively),and were associated with higher odds of having a perceived increased risk of COVID-19(95%CI 1.33–10.59,p-value 0.012).There was no association between ACHD anatomic or physiologic classification and perceptions,emotions and health ***:Females were more likely to report feeling sad,anxious and an increased risk of COVID-19 in comparison to *** findings indicate the need for mental health support and promotion of health behaviors during the pandemic amongst all ACHD patients,regardless of underlying condition.

关键词： Adult congenital heart disease COVID-19 health behaviors anxiety depression

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Longitudinal Heating Gradient: Another Possible Factor Influencing the Intensity of the Asian Summer Monsoon Circulation

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Advances in Atmospheric Sciences 1992年第4期9卷 397-410页

作者： peter j.Webster The Pennsylvania State University University Park Pennsylvania 16802 USAhe largest longitudinal heating gradients in the tropics exist between the African desert and Asian convective regions during summer once the South Asian monsoon is established. The heating gradients are anchored by the latent heat release and net radiative flux convergence over the monsoon region and by the dominant net radiative flux divergence over the desert.An apparent relationship is found between the intensity of the Asian summer monsoon circulation and the longitudinal heating gradients mentioned in addition to the latitudinal heating gradients cross the monsoon region. The monsoon circulation measured in terms of the zonal wind component is stronger when the longitudinal heating gradients are large and vice versa. Thus we claim that the longitudinal heating gradient may be another important factor which influences the intensity of the Asian summer monsoon circulation. There is little evidence that the interannual variability of the longitudinal heating gradients between Africa and Asia and thus the intensity of the Asian summer monsoon circulation is a strong function of the El Nino / Southern Oscillation cycle.

The largest longitudinal heating gradients in the tropics exist between the African desert and Asian convective regions during summer once the South Asian monsoon is established. The heating gradients are anchored by the latent heat release and net radiative flux convergence over the monsoon region, and by the dominant net radiative flux divergence over the *** apparent relationship is found between the intensity of the Asian summer monsoon circulation and the longitudinal heating gradients mentioned, in addition to the latitudinal heating gradients cross the monsoon region. The monsoon circulation measured in terms of the zonal wind component is stronger when the longitudinal heating gradients are large, and vice versa. Thus, we claim that the longitudinal heating gradient may be another important factor which influences the intensity of the Asian summer monsoon circulation. There is little evidence that the interannual variability of the longitudinal heating gradients between Africa and Asia and, thus, the intensity of the Asian summer monsoon circulation, is a strong function of the El Nino / Southern Oscillation cycle.

关键词： Asia over OLR Longitudinal Heating Gradient

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