检索结果-南通市图书馆

Cell membrane coating for reducing nanoparticle-induced inflammatory responses to scaffold constructs

Nano Research 2018年第10期11卷 5573-5583页

作者： Zhiyuan Fan peter Y. li Junjie Deng Stephen C. Bady Hao Cheng Department of materials Science and Engineering Drexel University Philadelphia Pennsylvania 19104 USA Engineering Research Center of Clinical Functional materials and Diagnosis & Treatment Devices of Zhejiang Province Wenzhou Institute of Biomaterials and Engineering Chinese Academy of Sciences Wenzhou 325011 China

The controlled release of therapeutics from microparticles or nanoparticles （NPs） has been well-studied. Incorporation of these particles inside biomaterial scaffolds is promising for tissue regeneration and immune modulation. However, these particles may induce inflammatory and foreign body responses to scaffold constructs, limiting their applications. Here we show that widely used poly（lactic-co-glycolic acid） nanoparticles （PLgA NPs） formed by double emulsion dramatically increased neutrophil infiltration and pro-inflammatory cytokines in alginate scaffolds 1 day after the subcutaneous injection of the scaffolds into mice. The coating of red blood cell （RBC） membranes on PLgA NPs completely eliminated these short-term inflammatory responses. For a longer term of 10 days, neither PLgA NPs nor RBC membrane-coated NPs exerted a significant effect on the infiltration of neutrophils or macrophages in alginate scaffolds, possibly due to the degradation and/or clearance of NPs by infiltrating cells. Despite the extensive exploration of cell membrane-coated NPs, our study is the first to investigate the effects of cell membrane coating on foreign body reaction to NPs. By harnessing the natural biocompatibility of cell membranes, our strategy of anti-inflammatory protection for scaffolds may be pivotal for many applications such as those relying on the recruitment of stem cells and/or progenitor ceils to scaffolds.

关键词： regenerative medicine wound healing drug delivery endothelial cell immune tolerance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Real-time Object Subspace Searching Based on Discrete Searching Paths and Local Energy

引用

International Journal of Automation and computing 2016年第2期13卷 99-107页

作者： Wen-Ju Zhou Zi-Xiang Fei Huo-Sheng Hu li liu Jing-Na li peter James Smith School of Computer Science and Electronic Engineering University of Essex Colchester CO4 3SQ UK School of Information and Electronic Engineering Ludong University Yantai 264025 China Vitec Videocom Ltd Bury St Edmunds Suffolk IP33 3TB UK

In automatic visual inspection, the object image subspace should be segmented and matched quickly so that the affine relationship can be built between the template image and the sample image. When the interference is strong and the illumination is uneven, for example in an industrial application, this can make it difficult to obtain an objects subspace quickly and accurately in real-time. In this paper, a novel strategy is proposed to adopt discrete radial search paths instead of searching all points in an image. Therefore, the searching time can be substantially reduced. In order to reduce the influence coming from the industrial environment, the paper proposes another method that is local energy level set segmentation, which can locate the object subspace more efficiently and accurately. The detection of ＂crown caps＂ is presented as an example in this paper. Detection effects and computing time are compared between several detection methods, and the mechanisms of inspection have also been analyzed.

关键词： Real-time object subspace discrete paths fast match level set local energy function

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Coalescence of Al_(0.3)CoCrFeNi polycrystalline high-entropy alloy in hot-pressed sintering: a molecular dynamics and phase- field study

引用

npj Computational materials 2023年第1期9卷 424-436页

作者： Qingwei guo Hua Hou Kaile Wang muxi li peter K.liaw Yuhong Zhao School of materials Science and Engineering Collaborative Innovation Center of Ministry of Education and Shanxi Province for High-performance Al/Mg Alloy MaterialsNorth University of ChinaTaiyuan 030051P R China School of materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024P R China Department of materials Science and Engineering The University of TennesseeKnoxvilleTNUSA Beijing Advanced Innovation Center for materials genome Engineering University of Science and Technology BeijingBeijing 100083P R China Institute of materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004P R China

Existing hot sintering models based on molecular dynamics focus on single-crystal *** work proposes a new multiparticle model based on molecular dynamics to investigate coalescence kinetics during the hot-pressed sintering of a polycrystalline Al_(0.3)CoCrFeNi high-entropy *** accuracy and effectiveness of the multiparticle model are verified by a phase-field *** this model,it is found that when the particle contact zones undergo pressure-induced evolution into exponential power creep zones,the occurrences of phenomena,such as necking,pore formation/filling,dislocation accumulation/decomposition,and particle rotation/rearrangement are *** on tensile test results,young’s modulus of the as-sintered Al_(0.3)CoCrFeNi high-entropy alloy is calculated to be 214.11±1.03 gPa,which deviates only 0.82%from the experimental value,thus further validating the feasibility and accuracy of the multiparticle model.

关键词： alloy creep entropy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regulation of 1, 4, 5-triphosphate receptor channel gating dynamics by mutant presenilin in Alzheimer＇s disease cells

引用

Frontiers of physics 2017年第3期12卷 139-148页

作者： Fang Wei Xiang li meichun Cai Yanping liu peter Jung Jianwei Shuai Department of Physics Xiamen University Xiamen 361005 China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling Network School of Life Sciences Xiamen University Xiamen 361005 China Department of Physics and Astronomy and Quantitative Biology Institute Ohio University Athens OH 45701 USA Research institute for Biomimetics and Soft matter Fujian Provincial Key Laboratory for Soft Functional Materials Research Xiamen University Xiamen 361005 China

In neurons of patients with Alzheimer＇s disease, the intracellular Ca^2＋ concentration is increased by its release from the endoplasmic reticulum via the inositol 1, 4, 5-triphosphate receptor （IP3R）. In this paper, we discuss the IP3R gating dynamics in familial Alzheimer＇s disease （FAD） cells induced with presenilin mutation PS1. By fitting the parameters of an IP3R channel model to experimental data of the open probability, the mean open time and the mean closed time of IP3R channels, in control cells and FAD mutant cells, we suggest that the interaction of presenilin mutation PS1 with IP3R channels leads the decrease in the unbinding rates of IP3 and the activating Ca^2＋ from IP3Rs. As a result, the increased affinities of IP3 and activating Ca^2＋ for IP3R channels induce the increase in the Ca^2＋ signal in FAD mutant cells. Specifically, the PS1 mutation decreases the IP3 dissociation rate of IP3R channels significantly in FAD mutant cells. Our results suggest possible novel targets for FAD therapeutic intervention.

关键词： Ca^2+ signal channel neuron Alzheimer's disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biological transfer of silver under silver nanoparticle exposure and nitrogen transfer via a collembolan- predatory mite food-chain and ecotoxicity of silver sulfide

引用

Soil Ecology Letters 2022年第4期4卷 435-443页

作者： Simin li Zhu li Xin Ke Longhua Wu peter Christie CAS Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Institute of Plant Physiology and Ecology Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200032China

The development of nanotechnology has accelerated the use of silver nanoparticles(AgNPs)in household chemicals and the accumulation of Ag in sewage treatment *** application of sewage sludge products to soils raises concerns over the safety of Ag in the function and biogeochemical cycles of the soil belowground ***,we assess the potential risk of the accumulation and transfer of Ag under AgNPs exposure and its effects on the trophic transfer of nitrogen(N)through a soil animal food chain(Folsomia candida–Hypoaspis aculeifer).The formation of stable silver sulfide(Ag_(2)S)was also studied via a single species test using *** of Ag in *** increased with increasing AgNPs concentration,as did those in the predator ***,but the Ag bioaccumulation factors of both animals werelined markedly compared with that of *** sulfide did have adverse effects on the survival and reproduction of *** Ag concentrations of *** increased with increasing Ag_(2)S concentration in sludge-treated *** sulfide showed ecotoxicity to the collembolan,therefore ecotoxicity resulting from the transformation and fate of AgNPs in soils needs to be considered before biosolid products are applied to agricultural soils.

关键词： AgNPs Ag_(2)S 15N Soil animals Food chain

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Revisiting the formation mechanism for coronal rain from previous studies

引用

Research in Astronomy and Astrophysics 2021年第10期21卷 135-150页

作者： Le-Ping li Hardi peter Lakshmi Pradeep Chitta Hong-Qiang Song CAS Key Laboratory of Solar Activity National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China max Planck Institute for Solar System Research D-37077 GottingenGermany Shandong Provincial Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment and Institute of Space SciencesShandong UniversityWeihai 264209China

Solar coronal rain is classified generally into two categories:flare-driven and quiescent coronal *** latter is observed to form along both closed and open magnetic field ***,we proposed that some of the quiescent coronal rain events,detected in the transition region and chromospheric diagnostics,along loop-like paths could be explained by the formation mechanism for quiescent coronal rain facilitated by interchange magnetic reconnection between open and closed field *** this study,we revisited 38 coronal rain reports from the *** these earlier works,we picked 15 quiescent coronal rain events out of the solar limb,mostly suggested to occur in active region closed loops due to thermal nonequilibrium,to scrutinize their formation *** the extreme ultraviolet images and line-of-sight magnetograms,the evolution of the quiescent coronal rain events and their magnetic fields and context coronal structures is *** find that six,comprising 40%,of the 15 quiescent coronal rain events could be totally or partially interpreted by the formation mechanism for quiescent coronal rain along open structures facilitated by interchange *** results suggest that the quiescent coronal rain facilitated by interchange reconnection between open and closed field lines deserves more attention.

关键词： plasmas instabilities Sun:corona Sun:UV radiation magnetic reconnection Sun:magnetic fields

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Preliminary Survey of Arbuscular mycorrhizal Fungi Associated with marsh Plants in Lhalu Wetland,Suburban Lhasa,South Tibet

引用

湿地科学 2010年第1期8卷 28-36页

作者： YANg Fuyu peter Christie li Xiaolin DAI Yan li guizhen gAI Jingping Department of grassland Science China Agricultural University Bering 100193 P. R. China Agricultural and Environmental Science Department Queen＇s University Belfast Newforge Lane Belfast BT 95 PX UK Department of Environmental Science and Engineering China Agricultural University Beijing 100193 P. R. China

A survey was made of the spore community of arbuscular mycorrhizal fungi (AmF) and root colonization by AmF in 16 plant species in Lhalu wetland on the outskirts of Lhasa city in Tibet. It was found that 13 of the 16 plant species investigated (81. 5% ) formed arbuscular mycorrhizal structures and dark septate endophytic fungi colonized the roots of most species. Total AmF colonization ranged from 0 to 82. 6% in dicots and 0 to 54. 5% in monocots. Both total AmF and arbuscular colonization were greater in dicots than that in monocots. A total of 48 taxa representing 7 genera of AmF were isolated and identified. Of these,9 species belonged to Acaulospora,2 to Appendicispora,34 to glomus,and 1 each to Pacispora,Paraglomus and Scutellospora. Spores of glomus aggregatum,g. deserticola and g. etunicatum were most common and abundant in the spore survey. Spores of 8 to 26 AmF species were isolated from the rhizosphere soil of individual plant species. Spore densities in soil associated with the 16 plant species ranged from 20 to 475 per 20 g soil,with an average of (92. 3 ± 14. 6). Species richness of AmF ranged from 6 to 12. 7. There were no significant differences between dicots and monocots in AmF spore density or species richness. Future work directed towards under- standing the response of the wetland plants to AmF may provide some insight into the role that these fungal symbionts may play in influencing plant diversity in this important urban wetland.

关键词： Lhalu wetland arbuscular mycorrhiza root colonization spore density

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Plasticity performance of Al_(0.5)CoCrCuFeNi high-entropy alloys under nanoindentation

引用

Journal of Iron and Steel Research International 2017年第4期24卷 390-396页

作者： li-ping Yu Shu-ying Chen Jing-li Ren Yang Ren Fu-qian Yang Karin A.Dahmen peter K.liaw School of mathematics and Statistics Zhengzhou University Department of materials Science and Engineering The University of Tennessee State Key Laboratory of Nonlinear mechanics Institute of MechanicsCAS X-ray Science Division Argonne National Laboratory Department of Chemical and materials Engineering University of Kentucky Department of Physics University of Illinois at Urbana-Champaign

The statistical and dynamic behaviors of the displacement-load curves of a high-entropy alloy,Al_（0.5）CoCrCuFeNi,were analyzed for the nanoindentation performed at two *** behavior of serrations at room temperature and chaotic flows at 200°C were *** results are attributed to the interaction among a large number of slip *** the nanoindentation at room temperature,recurrent partial events between slip bands introduce a hierarchy of length scales,leading to a critical *** the nanoindentation at 200°C,there is no spatial interference between two slip bands,which is corresponding to the evolution of separated trajectory of chaotic behavior.

关键词： High-entropy alloys Nanoindentation Critical behavior Chaotic behavior

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An electrospun scaffold loaded with anti-androgen receptor compound for accelerating wound healing

引用

Burns & Trauma 2013年第2期1卷 95-101页

作者： Cassandra Chong Yiwei Wang peter K. m. maitz Ulla Simanainen Zhe li Burns & Reconstructive Surgery Research group Concord Repatriation General Hospital Concord New South Wales 2139 Australia Burns & Reconstructive Surgery Research group Concord Repatriation General Hospital Concord New South Wales 2139 Australia Burns Unit Concord Repatriation General Hospital Concord New South Wales 2139 Australia Andrology group of ANZAC Research Institute Concord Repatriation General Hospital Concord New South Wales 2139 Australia

Current dermal regenerative scaffolds provide wound coverage, and structural support and guidance for tissue repair, but usually lack enough bio-signals needed for speeding up skin cell growth, migration, wound closure, and skin regeneration. In this study, an androgen receptor (AR) inhibitor called ASC-J9 is used to demonstrate the concept and feasibility of fabricating drug-loaded scaffolds via electrospinning. Inhibition of androgen is known to promote skin wound healing. The novel ASC-J9 - loaded porous scaffold was fabricated for skin wound repair using electrospun fibers of collagen and polycaprolactone (PCL) blend. Our preliminary results indicated that ASC-J9 - loaded scaffolds facilitated more efficient attachment and ingrowth of dermal fibroblasts, compared to the control collagen-PCL scaffold. A significant increase of cell proliferation was observed with the drug-loaded scaffold over a 28-day period. The drug-loaded scaffold also accelerated keratinocyte migration and wound closure in a contraction-inhibited mouse wound model over 21 days. The data indicated a sustained release of ASC-J9 from the scaffold and its potential to accelerate wound healing by promoting cell proliferation and migration over an extended period of time. more importantly, our results proved the concept and feasibility of fabricating drug-releasing or bioactive dermal scaffolds for more effective wound healing.

关键词： Wound healing electrospun scaffold adrogen receptor inhibition ASC-J9

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Enhanced 1.54-μm photo-and electroluminescence based on a perfluorinated Er(Ⅲ) complex utilizing an iridium(Ⅲ) complex as a sensitizer

引用

light(Science & Applications) 2020年第1期9卷 1706-1715页

作者： Hong-Fei li Xiao-Qi liu Chen Lyu Jelena gorbaciova li-li Wen guo-gang Shan peter B.Wyatt Huan-Qing Ye William P.gillin materials Research Institute and School of Physics and Astronomy Queen Mary University of LondonMile End RoadE14NS LondonUK Institute of Functional material Chemistry Faculty of ChemistryNortheast Normal UniversityChangchun 130024China materials Research Institute and School of Biological and Chemical Sciences Queen Mary University of LondonMile End RoadE14NS LondonUK Chromosol Ltd The Walbrook Building25 WalbrookLondon EC4N 8AUK

Advanced 1.5-μm emitting materials that can be used to fabricate electrically driven light-emitting devices have the potential for developing cost-effective light sources for integrated silicon *** erbium(Er^(3+))in organic materials can give bright 1.5-μm luminescence and provide a route for realizing 1.5-μm organic light emitting diodes(OLEDs).However,the Er3+electroluminescence(EL)intensity needs to be further improved for device ***,an efficient 1.5-μm OLED made from a sensitized organic Er3+co-doped system is realized,where a“traditional”organic phosphorescent molecule with minimal triplet–triplet annihilation is used as a chromophore *** chromophore provides efficient sensitization to a co-doped organic Er^(3+) complex with a perfluorinatedligand *** large volume can protect the Er^(3+) 1.5-μm luminescence from vibrational *** average lifetime of the sensitized Er^(3+) 1.5-μm luminescence reaches ~0.86 ms,with a lifetime component of 2.65 ms,which is by far the longest Er^(3+) lifetime in a hydrogen-abundant organic environment and can even compete with that obtained in the fully fluorinated organic Er^(3+) *** optimal sensitization enhances the Er^(3+) luminescence by a factor of 1600 even with a high concentration of the phosphorescent molecule,and bright 1.5-μm OLEDs are obtained.

关键词： electroluminescence lifetime luminescence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：