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Skeletal muscle as a molecular and cellular biomarker of disease progression in amyotrophic lateral sclerosis:a narrative review

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Neural Regeneration Research 2024年第4期19卷 747-753页

作者： peter h.king Department of Neurology and Center for Neurodegeneration and Experimental Therapeutics The University of Alabama at BirminghamBirminghamALUSA Birmingham Veterans Affairs Medical Center BirminghamALUSA

Amyotrophic lateral sclerosis is a fatal multisystemic neurodegenerative disease with motor neurons being a primary *** progressive weakness is a hallmark feature of amyotrophic lateral sclerosis,there is considerable heterogeneity,including clinical presentation,progression,and the underlying triggers for disease *** on longitudinal studies with families harboring amyotrophic lateral sclerosis-associated gene mutations,it has become apparent that overt disease is preceded by a prodromal phase,possibly in years,where compensatory mechanisms delay symptom *** 85-90%of amyotrophic lateral sclerosis is sporadic,there is a strong need for identifying biomarkers that can detect this prodromal phase as motor neurons have limited capacity for *** Food and Drug Administration-approved therapies work by slowing the degenerative process and are most effective early in the *** muscle,including the neuromuscular junction,manifests abnormalities at the earliest stages of the disease,before motor neuron loss,making it a promising source for identifying biomarkers of the prodromal *** accessibility of muscle through biopsy provides a lens into the distal motor system at earlier stages and in real *** advent of“omics”technology has led to the identification of numerous dysregulated molecules in amyotrophic lateral sclerosis muscle,ranging from coding and non-coding RNAs to proteins and *** technology has opened the door for identifying biomarkers of disease activity and providing insight into disease mechanisms.A major challenge is correlating the myriad of dysregulated molecules with clinical or histological progression and understanding their relevance to presymptomatic phases of *** are two major goals of this *** first is to summarize some of the biomarkers identified in human amyotrophic lateral sclerosis muscle that have a clinicopathological correlation with disease activi

关键词： amyotrophic lateral sclerosis biomarkers clinicopathological correlation disease progression muscle biomarkers neurogenic atrophy neuromuscular junction non-coding RNAs presymptomatic stages skeletal muscle SOD1G93A mouse model

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Kh型剪切调控蛋白:星形胶质细胞炎性细胞因子生成检测点

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神经损伤与功能重建 2012年第6期7卷 436-442,446页

作者： XUELIN LI WEI-JYE LIN ChING-YI ChEN YING SI XIAOWEN ZhANG LIANG LU ESThER SUSWAM LEI ZhENG peter h. king Department of Neurology University of Alabama Birmingham Alabama Departmentof Biochemistry University of Alabama Birmingham Alabama Department of Genetics Uni-versity of Alabama Birmingham Alabama Department of Cell Developmental and IntegrativeBiology University of Alabama Birmingham Alabama Department of Veterans Affairs Med-ical Center Birmingham Alabama Department of Neuroscience Mount Sinai School of Medi-cine New York New York

中枢神经系统(CNS)慢性炎性反应是许多神经退行性疾病和自身免疫性疾病的主要病理特点之一。作为免疫活性细胞,星形胶质细胞(Ast)在CNS炎性反应过程中发挥了重要作用。它可表达许多细胞因子,如肿瘤坏死因子-α(TNF-α)和白介素-1β(IL-1... 详细信息

中枢神经系统(CNS)慢性炎性反应是许多神经退行性疾病和自身免疫性疾病的主要病理特点之一。作为免疫活性细胞,星形胶质细胞(Ast)在CNS炎性反应过程中发挥了重要作用。它可表达许多细胞因子,如肿瘤坏死因子-α(TNF-α)和白介素-1β(IL-1β)等,这些细胞因子可直接或通过募集免疫细胞等途径间接促进炎性反应。检测点的存在可保证这些细胞因子的生成受到严密控制。细胞因子mRNA3’-非翻译区的腺苷酸/尿苷酸富含元件(ARE)由于可调节mRNA稳定性和翻译效率而扮演着主要检测点的角色。Kh型剪切调控蛋白(KSRP)是一种RNA结合蛋白,可通过与ARE结合降低mRNA的稳定性。本研究检测了KSRP对Ast细胞因子表达和旁分泌表型的影响。笔者发现了一个包括TNF-α和L-1β在内的炎性介质网络。与同窝出生的对照小鼠相比,KSRP-/-小鼠Ast上述炎性介质的表达在RNA水平增高了2～4倍。而这种KSRP-/-小鼠Ast激活后产生的TNF-α和IL-1β甚至能达到对照组的15倍以上。离体情况下,KSRP-/-Ast条件性培养液有趋化作用且能诱导神经元死亡。令人惊讶的是,笔者发现仅通过特定途径激活Ast后才能观察到部分mRNA半衰期延长。荧光素酶报告系统研究显示KSRP可在转录水平和转录后水平调节细胞因子基因的表达。本研究提示KSRP在促炎介质的调控方面发挥重要作用,因此在CNS炎性和自身免疫性疾病中有广泛意义。

关键词： RNA稳定性 AU富含元件肿瘤坏死因子-α 白介素-1β

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FUNCTIONAL POLYhYDROXYALKANOATES SYNThESIZED BY MICROORGANISMS

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Chinese Journal of Polymer Science 2000年第5期18卷 389-396页

作者： peter h.Yu Open Laboratory of Chiral Technology Hong Kong Polytechnic University Hong Kong China

Many bacteria have been found to synthesize a family of polyesters termed polyhydroxyalkanoate, abbreviated as PhA. Some interesting physical properties of PhAs such as piezoelectricity, non-linear optical activity, biocompatibility and biodegradability offer promising applications in areas such as degradable packaging, tissue engineering and drug delivery. Over 90 PhAs with various structure variations have been reported and the number is still increasing. The mechanical property of PhAs changes from brittle to flexible to elastic, depending on the side-chainlength of PhA. Many attempts have been made to produce PhAs as biodegradable plastics using various microorganisms obtained from screening natural environments, genetic engineering and mutation. Due to the high production cost, PhAs still can not compete with the nondegradable plastics, such as polyethylene and polypropylene. Various processes have been developed using low cost raw materials for fermentation and an inorganic extraction process for PhA purification. however, a super PhA production strain may play the most critical role for any large-scale PhA production. Our recent study showed that PhA synthesis is a common phenomenon among bacteria inhabiting various locations, especially oil-contaminated soils. This is very important for finding a suitable bacterial strain for PhA production. In fact, PhA production strains capable of rapid growth and rapid PhA synthesis on cheap molasses substrate have been found on molasses contaminated soils. A combination of novel properties and lower cost will allow easier commercialization of PhA for many applications.

关键词： polyhydroxybutyrate polyhydroxyalkanoate biopolymer polyester

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初产母猪营养性乏情

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国外畜牧科技 1987年第4期 21-23页

作者：郑友民 h.king

母猪断奶后超过10天不发情,通常称为乏情。乏情是经产和初产母猪最常见的繁殖机能异常现象之一,初产母猪尤为严重。大约有50%的初产母猪在断奶后一周内不发情,而经产母猪约为20%。本文综述初产母猪断奶后乏情与营养因素间的关系.一、泌... 详细信息

母猪断奶后超过10天不发情,通常称为乏情。乏情是经产和初产母猪最常见的繁殖机能异常现象之一,初产母猪尤为严重。大约有50%的初产母猪在断奶后一周内不发情,而经产母猪约为20%。本文综述初产母猪断奶后乏情与营养因素间的关系.一、泌乳期采食量泌乳母猪,特别是初产母猪通常采食不

关键词：初产母猪乏情泌乳期

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Fabrication and Tissue Anchoring Performance of Nylon and Polypropylene Barbed Surgical Sutures

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Journal of Donghua University(English Edition) 2013年第5期30卷 391-393页

作者：丛慧 ROE Simon MENTE peter RUFF Gregory king W Martin College of Textiles North Carolina State University College of Veterinary Medicine North Carolina State University Department of Biomedical Engineering North Carolina State University Vilcom Circle Chapel Hill College of Textiles Donghua University

Barbed surgical sutures have attracted worldwide attention in recent years. The plurality of barbs projecting out and penetrating into surrounding tissue eliminates the need for tying a knot. In the current study,nylon and polypropylene( PP) barbed sutures with two different barb geometries designed to anchor in porcine skin and tendon tissues were fabricated by a specially designed mechanical cutting machine. The tensile properties were compared between the barbed and unbarbed control sutures. The in vitro tissue anchoring ability was measured by two tissue /suture pullout tests,one for skin and the other for tendon tissue. Regardless of the type of tissue,the PP barbed suture with its higher modulus had a superior anchoring ability. Given the same suture material,improved anchoring performance was shown in tendon tissue.

关键词： barbed surgical sutures nylon polypropylene(PP) barb configuration skin and tendon

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Phytochrome-regulated Gene Expression

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Journal of Integrative Plant Biology 2007年第1期49卷 11-20页

作者： peter h. Quail Department of Plant and Microbial Biology University of Cafifomia Berkeley CA 94720 USA U.S. Department of Agriculture/Agriculture Research Service-Plant Gene Expression Center 800 Buchanan Street Albany CA 94710 LISA

Identification of all genes involved in the phytochrome （phy）-medieted responses of plants to their light environment is an important goal in providing an overall understanding of light-regulated growth end development. This article highlights end integrates the central findings of two recent comprehensive studies in Arabidopsis that have identified the genome-wide set of phy-reguleted genes that respond rapidly to red-light signals upon first exposure of dark-grown seedlings, and have tested the functional relevance to normal seedling photomorphogenesis of an Initial subset of these genes. The data：（a） reveal considerable complexity in the channeling of the light signals through the different phy-femily members （phyA to phyE） to responsive genes; （b） identify a diversity of transcription-factor-encoding genes as major early, if not primary, targets of phy signaling, end, therefore, as potentially important regulators in the transcriptional-network hierarchy; and （c） identify auxin-related genes as the dominant class among rapidly-regulated, hormone-related genes. however, reverse-genetic functional profiling of a selected subset of these genes reveals that only a limited fraction are necessary for optimal phy-induced seedling deetioletion.

关键词： expression profiling phytochrome signaling transcriptional networks microarrays reverse genetics functional profiling transcription factors auxin-related genes

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The Cauchy problem for non-autonomous nonlinear Schr(o)dinger equations

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Science China Mathematics 2005年第4期48卷 522-538页

作者： peter Y. h. Pang Department of Mathematics

In this paper we study the Cauchy problem for cubic nonlinear Schr(o)dinger equation with space-and time-dependent coefficients on Rm and Tm. By an approximation argument we prove that for suitable initial values, the... 详细信息

关键词： non-autonomous Schr(o)dinger equations, local existence, global existence.

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Appreciation of a Great Man:Wu Zhengyi(1916-2013)

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Plant Diversity 2016年第6期38卷 262-263页

作者： peter h.Raven Missouri Botanical Garden

Wu Zhengyi was the leading systematic botanist of China during the second half of the 20th *** encyclopedic knowledge of Chinese plants,their medicinal uses,and their distributions was shared through a wide variety of... 详细信息

关键词： Appreciation of a Great Man FRPS

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Overcoming Contradictions Between Growth and Sustainability:Institutional Innovation in the BRICS

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Chinese Journal of Population,Resources and Environment 2008年第3期6卷 3-13页

作者： peter h. May Graduate Program in Development Agriculture and Society-CPDA/UFRRJAv. Presidente Vargas

The recent accelerated growth rates or efforts to emulate countries that have achieved a rapid pace of economic growth are widely acclaimed as means to uplift millions from poverty. In so doing, however, this rapid economic growth is most likely to coincide with unsustainable levels of consumption, place excessive pressure on life support systems and terrestrial sinks and foreshorten options for the future. Rather than pursuing the "Environmental Kuznets Curve"(EKC) hypothesis that higher income will bring with it the means to reduce the impacts of greater consumption, ecological economists assert that buying our way out of future scarcity with fast growth is indeed contradictory with sustainabil- ity. To better understand these contradictions and explore potential institutional innovations that may enable developing nations to better confront them (in effect,"tunneling under"the EKC), this article refers to recent experience in the BRICS countries (Brazil, Russia, India, China and South Africa). Beginning with a brief comparative summary of major development and environmental indicators, pressures on resources and society in each of the BRICS are discussed, followed by identification of institutional and policy frameworks each country has evolved to confront the challenges of growth and sustainability. The article closes with general conclusions for further research and information sharing among developing nations.

关键词： growth sustainability BRICS institutions innovation development policy

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Plant Conservation in the Future:New Challenges,New Opportunities

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植物分类与资源学报 2011年第1期33卷 1-9页

作者： peter h.RAVEN Missouri Botanical Garden

Throughout the world,plant diversity is being reduced rapidly by the extinction of species and of local differentiated *** presenting possible solutions to this very serious problem I will first briefly describe the factors that have led to the development of China's wealth of biodiversity;then examine the causes of extinction,with an emphasis on the situation in China;and conclude with recommendations on how to most effectively conserve plants in this huge and botanically diverse country.

关键词： Plant diversity Biological richness human impacts Plant conservation in China Strategies for plant conservation

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