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主动脉弓上动脉成像:3.0T高空间分辨率MR血管成像对比剂用量减少的可行性研究

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国际医学放射学杂志 2009年第1期32卷 78-79页

作者： A. Tomasian n. Salamon D.G. Lohan M. Jalili J.P. Villablanca J.P. Finn 陈仁彪 Department of Radiological Sciences David Geffen School of Medicine University of California at Los Angeles Suite 3371 Peter V. Ueberroth Building 10945 Le Conte Ave Los Angeles CA 90095-7206 USA

目的评估和比较3种不同剂量的对比剂给药方案对主动脉上动脉的3．0T高空间分辨率三维MR血管成像的诊断影像质量。材料和方法本研究经机构委员会批准，免除知情同意，遵从HIPAA。120例接受主动脉上动脉3．0T三维高空间分辨率对比增... 详细信息

目的评估和比较3种不同剂量的对比剂给药方案对主动脉上动脉的3．0T高空间分辨率三维MR血管成像的诊断影像质量。材料和方法本研究经机构委员会批准，免除知情同意，遵从HIPAA。120例接受主动脉上动脉3．0T三维高空间分辨率对比增强MR血管成像的连贯的病人按同样的检查序列检查，

关键词： MR血管成像空间分辨率主动脉弓对比剂用量 HIPAA 影像质量给药方案

Enhanced ion acceleration from transparency-driven foils demonstrated at two ultraintense laser facilities

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Light(Science & Applications) 2023年第4期12卷 593-604页

作者： nicholas P.Dover Tim Ziegler Stefan Assenbaum Constantin Bernert Stefan Bock Florian-Emanuel Brack Thomas E.Cowan Emma J.Ditter Marco Garten Lennart Gaus Ilja Goethel George S.Hicks Hiromitsu Kiriyama Thomas Kluge James K.Koga Akira Kon Kotaro Kondo Stephan Kraft Florian Kroll Hazel F.Lowe Josefine Metzkes-ng Tatsuhiko Miyatake Zulfikar najmudin Thomas Püschel Martin Rehwald Marvin Reimold Hironao Sakaki Hans-peter Schlenvoigt Keiichiro Shiokawa Marvin E.P.Umlandt Ulrich Schramm Karl Zeil Mamiko nishiuchi Kansai Photon Science Institute National Institutes for Quantum Science and Technology8-1-7 UmemidaiKizugawaKyoto 619-0215Japan The John Adams Institute for Accelerator Science Blackett LaboratoryImperial College LondonLondon SW72AZUnited Kingdom Helmholtz-Zentrum Dresden-Rossendorf 01328 DresdenGermany Technische Universitat Dresden 01069 DresdenGermany Interdiscipllinary Graduate School of Engineering Sciences Kyushu University6-1Kasuga-KoenKasugaFukuoka 816-8580Japan

Laser-driven ion sources are a rapidly developing technology producing high energy,high peak current *** suitability for applications,such as compact medical accelerators,motivates development of robust acceleration schemes using widely available repetitive ultraintense femtosecond *** applications not only require high beam energy,but also place demanding requirements on the source stability and *** can be seriously affected by the laser temporal contrast,precluding the replication of ion acceleration performance on independent laser systems with otherwise similar ***,we present the experimental generation of>60 MeV protons and>30 MeV u-1 carbon ions from sub-micrometre thickness Formvar foils irradiated with laser intensities>1021 *** are accelerated by an extreme localised space charge field≥30TVm-1,over a million times higher than used in conventional *** field is formed by a rapid expulsion of electrons from the target bulk due to relativistically induced transparency,in which relativistic corrections to the refractive index enables laser transmission through normally opaque *** replicate the mechanism on two different laser facilities and show that the optimum target thickness decreases with improved laser contrast due to reduced *** demonstration that energetic ions can be accelerated by this mechanism at different contrast levels relaxes laser requirements and indicates interaction parameters for realising application-specific beam delivery.

关键词： acceleration intense transparency

Fungal diversity notes 253-366:taxonomic and phylogenetic contributions to fungal taxa

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Fungal Diversity 2016年第3期78卷 1-237页

作者： Guo Jie Li Kevin D.Hyde Rui Lin Zhao Sinang Hongsanan Faten Awad Abdel-Aziz Mohamed A.Abdel-Wahab Pablo Alvarado Genivaldo Alves-Silva Joseph F.Ammirati Hiran A.Ariyawansa Abhishek Baghela Ali Hassan Bahkali Michael Beug D.Jayarama Bhat Dimitar Bojantchev Thitiya Boonpratuang Timur S.Bulgakov Erio Camporesi Marcela CBoro Oldriska Ceska Dyutiparna Chakraborty Jia Jia Chen K.W.Thilini Chethana Putarak Chomnunti Giovanni Consiglio Bao Kai Cui Dong Qin Dai Yu Cheng Dai Dinushani A.Daranagama Kanad Das Monika C.Dayarathne Eske De Crop Rafael J.V.De Oliveira Carlos Alberto Fragoso de Souza JoséIde Souza Bryn T.M.Dentinger Asha J.Dissanayake Mingkwan Doilom E.Ricardo Drechsler-Santos Masoomeh Ghobad-nejhad Sean P.Gilmore Aristóteles Góes-neto MichałGorczak Charles H.Haitjema Kalani Kanchana Hapuarachchi Akira Hashimoto Mao Qiang He John K.Henske Kazuyuki Hirayama Maria J.Iribarren Subashini C.Jayasiri Ruvishika S.Jayawardena Sun Jeong Jeon Gustavo H.Jerônimo Ana L.Jesus E.B.Gareth Jones Ji Chuan Kang Samantha C.Karunarathna Paul M.Kirk Sirinapa Konta Eric Kuhnert Ewald Langer Haeng Sub Lee Hyang Burm Lee Wen Jing Li Xing Hong Li Kare Liimatainen Diogo Xavier Lima Chuan Gen Lin Jian Kui Liu Xings Zhong Liu Zuo Yi Liu J.Jennifer Luangsa-ard Robert Lücking H.Thorsten Lumbsch Saisamorn Lumyong Eduardo M.Leaño Agostina V.Marano Misato Matsumura Eric H.C.McKenzie Suchada Mongkolsamrit peter E.Mortimer Thi Thuong Thuong nguyen Tuula niskanen Chada norphanphoun Michelle A.O’Malley Sittiporn Parnmen Julia Pawłowska Rekhani H.Perera Rungtiwa Phookamsak Chayanard Phukhamsakda Carmen L.A.Pires-Zottarelli Olivier Raspé Mateus A.Reck Sarah C.O.Rocha AndréL.C.M.Ade Santiago Indunil C.Senanayake Ledo Setti Qiu Ju Shang Sanjay K.Singh Esteban B.Sir Kevin V.Solomon Jie Song Prasert Srikitikulchai Marc Stadler Satinee Suetrong Hayato Takahashi Takumasa Takahashi Kazuaki Tanaka Li Ping Tang Kasun M.Thambugala Donnaya Thanakitpipattana Michael K.Theodorou Benjarong Thongbai Tuksaporn Thummarukcharoen Qing Tian Saowaluck Tibpromma Annemieke State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesNo 31st West Beichen RoadChaoyang DistrictBeijing 100101People’s Republic of China Centre of Excellence in Fungal Research and School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Department of Botany and Microbiology Faculty of ScienceSohag UniversitySohag 82524Egypt ALVALAB C/La Rochela nº47E-39012 SantanderSpain Micolab Programa de Pós-Graduação em Biologia de FungosAlgas e PlantasDepartamento de BotânicaUniversidade Federal de Santa CatarinaCampus Universitário TrindadeCEP:88040-900 FlorianópolisSanta CatarinaBrazil Department of Biology University of WashingtonBox 351800SeattleWA 98195-1800USA Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouPeople’s Republic of China national Fungal Culture Collection of India(nFCCI) Biodiversity and Palaeobiology GroupMACS’Agharkar Research InstituteG.G.Agarkar RoadPune 411004India PO Box 116 HusumWA 98623-0116USA Formerly Department of BotanyGoa UniversityGoaIndia no.128/1-J Azad Housing SocietyCurcaP.O.Goa Velha 403108India *** 345 Shipwatch LaneHerculesCA 94547USA Microbe Interaction Laboratory(BMIT) BIOTECNational Science and Technology Development Agency(NSTDA)113 Thailand Science ParkThanon PhahonyothinTombon Khlong NuengAmphoeKhlong LuangPathum Thani 12120Thailand Academy of Biology and Biotechnology Southern Federal UniversityRostov-on-Don 344090Rostov regionRussia A.M.B.Gruppo Micologico Forlivese BAntonio“Cicognani” Via Roma Forlì Italy 18 A.M.B.Circolo Micologico“Giovanni Carini”C.P.314BresciaItaly Societàper gli Studi naturalistici della Romagna C.P.144Bagnacavallo

notes on 113 fungal taxa are compiled in this paper,including 11 new genera,89 new species,one new subspecies,three new combinations and seven reference *** geographic and taxonomic range of fungal taxa are *** the Ascomycota the new genera Angustospora(Testudinaceae),Camporesia(Xylariaceae),Clematidis,Crassiparies(Pleosporales genera incertae sedis),Farasanispora,Longiostiolum(Pleosporales genera incertae sedis),Multilocularia(Parabambusicolaceae),neophaeocryptopus(Dothideaceae),Parameliola(Pleosporales genera incertae sedis),and Towyspora(Lentitheciaceae)are *** introduced species are Angustospora nilensis,Aniptodera aquibella,Annulohypoxylon albidiscum,Astrocystis thailandica,Camporesia sambuci,Clematidis italica,Colletotrichum menispermi,***,Comoclathris pimpinellae,Crassiparies quadrisporus,Cytospora salicicola,Diatrype thailandica,Dothiorella rhamni,Durotheca macrostroma,Farasanispora avicenniae,Halorosellinia rhizophorae,Humicola koreana,Hypoxylon lilloi,Kirschsteiniothelia tectonae,Lindgomyces okinawaensis,Longiostiolum tectonae,Lophiostoma pseudoarmatisporum,Moelleriella phukhiaoensis,***,Mucoharknessia anthoxanthi,Multilocularia bambusae,Multiseptospora thysanolaenae,neophaeocryptopus cytisi,Ocellularia arachchigei,***,Ochronectria thailandica,Ophiocordyceps karstii,Parameliola acaciae,***,Parastagonospora cumpignensis,Pseudodidymosphaeria phlei,Polyplosphaeria thailandica,Pseudolachnella brevifusiformis,Psiloglonium macrosporum,Rhabdodiscus albodenticulatus,Rosellinia chiangmaiensis,Saccothecium rubi,Seimatosporium pseudocornii,***,Sigarispora ononidis and Towyspora *** combinations are provided for Eutiarosporella dactylidis(sexual morph described and illus trated)and Pseudocamarosporium ***,illustrations and/or reference specimens are designated for Aposphaeria corallinolutea,Cryptovalsa ampelina,Dothiorella vidmadera,Ophiocordyceps formosana,P

关键词： Ascomycota Basidiomycota neocallimastigomycota Oomycota.Zygomycota Phylogeny Taxonomy new genus new species

Fungal diversity notes 1036-1150:taxonomic and phylogenetic contributions on genera and species of fungal taxa

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Fungal Diversity 2019年第3期96卷 1-242页

作者： Kevin D.Hyde Danushka S.Tennakoon Rajesh Jeewon DJayarama Bhat Sajeewa S.n.Maharachchikumbura Walter Rossi Marco Leonardi Hyang Burm Lee Hye Yeon Mun Jos Houbraken Thuong T.T.nguyen Sun Jeong Jeon Jens Christian Frisvad Dhanushka n.Wanasinghe Robert Lucking Andre Aptroot Marcela E.S.Caceres Samantha C.Karunarathna Sinang Hongsanan Rungtiwa Phookamsak nimali Ide Silva Kasun M.Thambugala Ruvishika S.Jayawardena Indunil C.Senanayake Saranyaphat Boonmee Jie Chen Zong-Long Luo Chayanard Phukhamsakda Olinto L.Pereira Vanessa P.Abreu Andre Wilson Campos Rosado Buyck Bart Emile Randrianjohany Vale rie Hofstetter Tatiana B.Gibertoni Adriene Mayrada Silva Soares Helio Longoni Plautz Jr Helen Maria Pontes Sotao William Kalhy Silva Xavier Jadson Diogo Pereira Bezerra Thays Gabrielle Linsde Oliveira Cristina Mariade Souza-Motta Oliane Maria Correia Magalhaes Digvijayini Bundhun Dulanjalee Harishchandra Ishara S.Manawasinghe Wei Dong Sheng-nan Zhang Dan-Feng Bao Milan C.Samarakoon Dhandevi Pem Anuruddha Karunarathna Chuan-Gen Lin Jing Yang Rekhani H.Perera Vinit Kumar Shi-Ke Huang Monika C.Dayarathne Anusha H.Ekanayaka Subashini C.Jayasiri Yuanpin Xiao Sirinapa Konta Tuula niskanen Kare Liimatainen Yu-Cheng Dai Xiao-Hong Ji Xue-Mei Tian Armin Mesic Sanjay K.Singh Kunthida Phutthacharoen Lei Cai Touny Sorvongxay Vinodhini Thiyagaraja Chada norphanphoun napalai Chaiwan Yong-Zhong Lu Hong-Bo Jiang Jin-Feng Zhang Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahmanage Ming Zeng Thilini Chethana Deping Wei Martina Reblova Jacques Fournier Jana nekvindova Renan do nascimento Barbosa Jose Ewerton Felintodos Santos neiva Tintide Oliveira Guo-Jie Li Damien Ertz Qiu-Ju Shang Alan J.L.Phillips Chang-Hsin Kuo Erio Camporesi Timur S.Bulgakov Saisamorn Lumyong E.B.Gareth Jones Putarak Chomnunti Eleni Gentekaki Frank Bungartz Xiang-Yu Zeng Sally Fryar Zdenko Tkalcec Junmin Liang Guangshuo Li Ting-Chi Wen Paras nath Singh Yusufjon Gafforov Itthayakorn Promputtha Erandi Yasanthika Ishani D.Goonasekara Rui-Lin Zhao Qi Zhao Paul M Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand East and Central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanPeople’s Republic of China Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Department of Plant Medicine National Chiayi University300 Syuefu RoadChiayi City 60004TaiwanPeople’s Republic of China Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius Formerly Department of Botany Goa UniversityGoaIndia no.128/1-J Azad Housing SocietyCurcaGoa Velha 403108India Department of Crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityPO Box 8123 Al KhoudOman Sect.Environmental Sciences Dept.MeSVAUniversity of L’Aquila67100 CoppitoAQItaly Division of Food Technology Biotechnology&AgrochemistryCollege of Agriculture&Life SciencesChonnam National UniversityGwangju 61186Korea Fungal Resources Research Division NNIBRSangju-si 37242Korea Westerdijk Fungal Biodiversity Institute Uppsalalaan 83584 CT UtrechtThe Netherlands Department of Biotechnology and Biomedicine DTUBioengineeringTechnical University of Denmark2800 Kongens LyngbyDenmark Botanischer Garten und Botanisches Museum Berlin Freie Universitat BerlinKonigin-Luise-StraßBe 6-814195 BerlinGermany Laboratorio de Botanica/Liquenologia Instituto de BiocienciasUniversidade Federal de Mato Grosso do SulAvenida Costa e Silva s/nBairro UniversitarioCampo GrandeMatto Grosso do Sul CEP 79070-900Brazil Departamento de Biociencias Universidade Federal de SergipeItabaianaSergipe CEP:49500-000Brazil Shenzhen Key Laboratory of Microbial

This article is the tenth series of the Fungal Diversity notes,where 114 taxa distributed in three phyla,ten classes,30 orders and 53 families are described and *** described in the present study include one new family(*** in Dothideomycetes),five new genera(Caatingomyces,Cryptoschizotrema,neoacladium,Paramassaria and Trochilispora)and 71 new species,(*** thailandica,Amniculicola aquatica,***,Angustimassarina sylvatica,Blackwellomyces lateris,Boubovia gelatinosa,Buellia viridula,Caatingomyces brasiliensis,Calophoma humuli,Camarosporidiella mori,Canalisporium dehongense,Cantharellus brunneopallidus,***,Castanediella meliponae,Coprinopsis psammophila,Cordyceps succavus,Cortinarius minusculus,***,Diaporthe italiana,***,Diatrypella delonicis,Dictyocheirospora aquadulcis,***,Digitodesmium chiangmaiense,Distoseptispora dehongensis,***,Dothiorella styphnolobii,Ellisembia aurea,Falciformispora aquatic,Fomitiporia carpinea,***,Grammothele aurantiaca,***,Hermatomyces bauhiniae,Jahnula queenslandica,Kamalomyces mangrovei,Lecidella yunnanensis,Micarea squamulosa,Muriphaeosphaeria angustifoliae,neoacladium indicum,neodidymelliopsis sambuci,neosetophoma miscanthi,***,nodulosphaeria aquilegiae,***,Paramassaria samaneae,Penicillium circulare,***,***-pumilae,***,***,Phaeoisaria siamensis,Phaeopoacea asparagicola,Phaeosphaeria penniseti,Plectocarpon galapagoense,Porina sorediata,Pseudoberkleasmium chiangmaiense,Pyrenochaetopsis sinensis,Rhizophydium koreanum,Russula prasina,Sporoschisma chiangraiense,Stigmatomyces chamaemyiae,***,***,***,***,Thysanorea uniseptata,Torula breviconidiophora,***,Trochilispora schefflerae and Vaginatispora palmae).Further,twelve new combinations(*** cryptotrema,Prolixandromyces australi,***,***,***,P.

关键词： 71 new taxa Ascomycota Basidiomycota Dothideomycetes Eurotiomycetes Lecanoromycetes Leotiomycetes Pezizomycetes Phylogeny Taxonomy

一个基于共享内存的GPU资源调度器的设计与实现

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科研信息化技术与应用 2012年第5期3卷 29-33页

作者：李长华崔辰州 peter Berczik 薛随建 Rainer Spurzem 中国科学院国家天文台北京100012

集群作业管理系统目前对GPU资源的管理还不是很完善,尤其在单节点多GPU的情况下,经常由于GPU设备的使用冲突、负载不均等原因而导致GPU设备利用率低。为此,本文设计并实现了一种基于共享内存方式的GPU资源调度器,结合集群作业管理系统,... 详细信息

集群作业管理系统目前对GPU资源的管理还不是很完善,尤其在单节点多GPU的情况下,经常由于GPU设备的使用冲突、负载不均等原因而导致GPU设备利用率低。为此,本文设计并实现了一种基于共享内存方式的GPU资源调度器,结合集群作业管理系统,可以自动为用户作业分配需要的GPU设备资源,避免多个GPU设备的使用冲突,从而使得GPU设备的使用率达到最高。基于SAPPORO的GPU多体模拟程序在本系统环境下得到了很好的应用。

关键词： GPU设备调度作业管理系统共享内存

Pregnancy Rate of Bunaji Cows in a Fixed Time AI Synchronization Protocol Using Ovatide

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Journal of Agricultural Science and Technology(A) 2019年第1期9卷 46-55页

作者： Ubah Simon Azubuike Rekwot peter Ibrahim Adewuyi Abdulmujeeb Bode Omontese Bobwealth Oakina Adeyeye Adewale Ayodeji Columbus Philemon Kwinjoh Abah Owoicho Kenneth Agbonu Oluwa Adikpe Ejiofor Charles Ejike Department of Theriogenology University of AbujaNigeria Artificial Insemination Unit National Animal Production Research InstituteShikaZariaKaduna StateNigeria Department of Theriogenology and Animal Production Usmanu Danfodiyo UniversitySokotoNigeria Department of Veterinary Physiology and Biochemistry University of AbujaNigeria Department of Veterinary Parasitology University of AbujaNigeria

This study accessed the reproductive performance of Bunaji cows in an Ovsynch protocol involving *** cows(n=16)aged 4-6 years and weighing between 250-350 kg with body condition scores(BCS)of 2.5-3.5 were *** were two treatment groups for synchronization of *** group 1 comprising Bunaji(n=8)received 50μg of gonadotropin releasing hormone(GnRH)(Cystorelin)and 25 mg of PGF2α.While,treatment group 2 comprising Bunaji(n=8)received 50μg of ovatide and 25 mg of PGF2α.All cows from both treatment groups were inseminated at 16 h after each second GnRH or ovatide *** that showed mucus discharge from the vagina on the day of artificial insemination(AI)were recorded as well as those that had patent *** dilation was measured by taking note of the cows that had mid cervix insemination due to non-passage of the AI gun through the *** palpation was conducted twice at a month interval to select cycling cows within 5-12 d of the estrous cycle before initiating Ovsynch *** was repeated on day 45 post AI to confirm pregnancies in *** showed that the rate of mucus discharge from the vagina was 37.5%and 87.5%for ovatide and Cystorelin,respectively;while the rate of cervical dilation were 75%and 87.5%for ovatide and Cystorelin,respectively(p>0.05),and pregnancy rates were 0%and 12.5%for ovatide and Cystorelin,*** were no significant differences between the two *** was concluded that treatment of Bunaji cows with 50μg ovatide in Ovsynh protocol has heat and ovulation synchronization potentials and zero pregnancy *** was recommended that further studies be carried out using graded doses of 50,100 and 150μg of ovatide in a fixed time AI synchronization protocol in Bunaji cows,to tap the potentials of the hormone in manipulation of bovine reproduction.

关键词： Pregnancy ovatide fixed time AI synchronization cows

动脉粥样硬化血栓形成门诊患者1年内心血管事件的发生率

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美国医学会杂志（中文版） 2007年第4期26卷 195-203页

作者： Gabriel Steg Deepak L. Bhatt peter W. F. Wilson Ralph D＇ Agostino E. Magnus Ohman Joachim Roether Chiau-Suong Liau Alan T. Hirsch Jean-Louis Mas Yasuo Ikeda Michael J. Pencina Shinya Goto 徐成斌（译）李呈亿（校） Departement de Cardiologie Hopital Bichat-Claude Bernard Paris France Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio Cardiology Division Emory University School of Medicine Atlanta Ga Statistics and Consulting Unit Department of Mathematics and Statistics Boston University Boston Mass Division of Cardiology Duke University Durham NC Department of neurology Klinikum Minden Minden Germany Department of internal Medicine National Taiwan University Hospital and School of Medicine Taipei Taiwan Minneapolis Heart Institute Foundation and Division of Epidemiology and Community Health University of Minnesota School of Public Health Minneapolis Service de neurologie Centre Raymond Garcin Hopital Sainte-Anne Paris France Department of Internal Medicine Keio University School of Medicine Tokyo Japan Department of Medicine Tokai University School of Medicine Kanagawa Japan 不详

背景：目前，有关社区中动脉粥样硬化血栓形成稳定患者心血管（cardiovascular，CV）事件发生率的资料比较少，既往也无国际性队列研究对冠状动脉病（coronary artery disease，CAD）、脑血管病（cerebrovascular disease，CVD）、外周... 详细信息

背景：目前，有关社区中动脉粥样硬化血栓形成稳定患者心血管（cardiovascular，CV）事件发生率的资料比较少，既往也无国际性队列研究对冠状动脉病（coronary artery disease，CAD）、脑血管病（cerebrovascular disease，CVD）、外周动脉病（peripheral arterial disease，PAD）确诊患者以及此类疾病高危患者不同事件的发生率进行评估。目的：在患有动脉疾病的门诊患者或存在多个动脉粥样硬化血栓形成危险因素的门诊患者中确定当今世界1年内CV事件的发生率。设计、地点及参试者：“减少动脉粥样硬化血栓形成维系健康（Reduction of Artherotllrombosis for Continued Health，REACH）”注册研究是一项国际前瞻性队列研究。研究人员于2003—2004年从44个国家、5587名医生入选68236例已确诊的动脉粥样硬化性血管病患者（CAD、PAD、CVD；n=55814）以及至少存在3个动脉粥样硬化血栓形成危险因素的患者（n=12422）。主要观测指标：CV死亡、心肌梗死（myocardial infarction，MI）及卒中的发生率。结果：截至2006年7月，共有95．22％的患者（n=64977）提供了1年内的结局。心血管死亡、MI及卒中的总体发生率为4．24％；动脉粥样硬化性血管病患者为4．69％，仅存在多个危险因素的患者为2．15％。CAD、CVD及PAD患者CV死亡、MI及卒中的总体发生率分别为4．52％、6．47％和5．35％。CAD、CVD及PAD患者发生终点事件（即CV死亡、MI、卒中）以及因动脉粥样硬化血栓形成事件入院的几率分别为15．20％、14．53％和21．14％。上述事件发生率随症状性动脉疾病病变部位数量的增加而增加，仅存在危险因素的患者为5．31％，有1处症状性动脉疾病的患者为12．58％，有2处症状性动脉疾病的患者为21．14％，有3处症状性动脉疾病的患者为26．27％（趋势P〈0．001）。结论：在这项当代大型国际研究中，患有动脉粥样硬化性血管病的门诊患者以及有动脉粥样硬化血栓形成危险的门诊患者CV事件的年发生率相对较高。存在多部位病变者CV事件的1年发生率升高。

关键词：动脉粥样硬化血栓形成心血管事件年发生率门诊患者动脉粥样硬化性血管病前瞻性队列研究 arterial 动脉疾病

Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity

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Molecular Plant 2022年第3期15卷 520-536页

作者： Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer nolan Bornowski peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers Department of Plant Biology Michigan State UniversityEast LansingMI 48824USA Department of Horticultural Science University of MinnesotaSt.PaulMN 55108USA Department of Plant Science McGill UniversitySainte-Anne-de-BellevueQC H9X 3V9Canada Plant Breeding Wageningen University&ResearchPlant Breeding6708 PB Wageningenthe Netherlands IBG-4 Bioinformatics Forschungszentrum JülichWilhelm Johnen Str52428 JülichGermany Department of Plant Soiland Microbial SciencesMichigan State UniversityEast LansingMI 48824USA Bayer Crop Science WoodlandCA 95695USA Averis Seeds B.V. 9640 AA Veendamthe Netherlands International Potato Center 1895 Avenida La MolinaLimaPeru USDA-ARS ProsserWA 99350USA Agriculture and Agri-Food Canada Fredericton Research and Development Centre FrederictonNB E3B 4Z7Canada School of Integrative Plant Science Cornell UniversityIthacaNY 14853-1901USA Department of Plant Sciences University of IdahoMoscowID 83844USA USDA-ARS Small Grains and Potato Germplasm ResearchAberdeenID 83210USA HZPC Research B.V. Edisonweg 58501 XG Jourethe Netherlands Department of Crop and Soil Science Oregon State UniversityHermistonOR 97838USA School of Biology and Ecology University of Maine5735 Hitchner Hall OronoME 04469USA Department of Horticultural Sciences Texas A&M UniversityCollege StationTX 77843-2133USA Department of Horticulture Oregon State UniversityCorvallisOR 97331USA Department of Horticultural Science North Carolina State UniversityRaleighNC 27695-7609USA Department of Horticulture University of Wisconsin-MadisonMadisonWI 53706USA Department of Horticulture Michigan State UniversityEast LansingMI 48824USA Institute for Biological Data Science Heinrich Heine UniversityDusseldorf40225 DusseldorfGermany Plant Resilience Institute Michigan State UniversityEast LansingMI 48824USA Present address:Gennovation B.V. Wageningenthe Netherlands

Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous *** assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous *** species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding *** a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid *** a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic *** StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent *** of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids.

关键词： potato allele diversity phased assembly polyploid pan-genome wild introgressions

ACUPUnCTURE FOR DYSPHAGIA AFTER CHEMORADIATIOn THERAPY In HEAD AnD nECK CAnCER:A PILOT RAnDOMIZED SHAMCOnTROLLED TRIAL

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Journal of Integrative Medicine 2014年第3期 294-294页

作者： Wei-dong Lu peter M.Wayne Hai-lun Li Eric A.Macklin Julie E.Buring David S.Rosenthal Roy B.Tishler Robert I.Haddad The Leonard P.Zakim Center for Integrative Therapies DanaFarber Cancer Institute/Harvard Medical School Osher Center for Integrative Medicine Brigham and Women's Hospital/Harvard Medical School Department of Biostatistics and Computational Biology Dana-Farber Cancer Institute Biostatistics Center Massachusetts General Hospital/ Harvard Medical School Boston Department of Radiation Oncology Dana-Farber Cancer Institute/Harvard Medical School Department of Medical Oncology Dana-Farber Cancer Institute/Harvard Medical School

Background: Dysphagia is a common side effect following chemoradiation(CRT) in patients with head and neck cancer(HnC).The purpose of this pilot trial was to assess the feasibility of recruiting HnC patients and to collect preliminary data on the efficacy and safety of acupuncture on dysphagia-related quality of life(QOL).Methods: Patients were eligible if diagnosed with stage IIIIV HnC, without evidence of distance metastasis, receiving curative-intent *** were randomized to 12 sessions of either active or sham acupuncture, once every two weeks, over 24 weeks from during CRT to 20-week *** study personnel and the patients were blinded, while the treating acupuncturists were *** and other questionnaires were measured at baseline(end of CRT), end of acupuncture, and at six months follow-up(12-month post-CRT).Data were analyzed by repeated-measures AnOVA adjusting for ***: Accrual was completed in December *** 42 patients enrolled, 35(83%) received at least 8 sessions of acupuncture, and 28(67%) received all *** patients withdrew due to time *** serious side effects were *** mean MDADI total scores improved from baseline in both treatment arms(64.5(SE±2.4) vs.71.4(SE±3.1), P=0.048; 64.5(SE±2.4) vs.77.8(SE±3.0), Pnce in improvement was not significant(P=0.12).The median feeding tube duration did not differ between active and sham treatments(n=39, median 125 d vs.147 d, P=0.93).Conclusion: Acupuncture is a safe and feasible treatment for HnC *** the pilot trial, improvements in QOL parameters from end of CRT to the time points examined were observed but they did not differ between the two *** of acupuncture to improve swallowing-related QOL in HnC patients may require more frequent or longer duration of treatment.

关键词： HnC CRT ACUPUnCTURE FOR DYSPHAGIA AFTER CHEMORADIATIOn THERAPY In HEAD AnD nECK CAnCER QOL