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Effect of humic substances on the precipitation of calcium phosphate

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Journal of Environmental Sciences 2006年第5期18卷 852-857页

作者： SONg Yong-hui Hermann H. HAHN Erhard HOFFMANN peter g. WEIDLER Chinese Research Academy of Environmental Sciences Beijing 100012 China Institute for Aquatic Environmental Engineering University of Karlsruhe Karlsruhe D-76128 Germaay Institute for Technical Chemistry Research Centre of Karlsruhe Eggenstein-Leopoldshafen D-76344 Germany

For phosphorus （P） recovery from wastewater, the effect of humic substances （HS） on the precipitation of calcium phosphate was studied. batch experiments of calcium phosphate precipitation were undertaken with synthetic water that contained 20 mg/L phosphate （as P） and 20 mg/L HS （as dissolved organic carbon, DOC） at a constant pH value in the range of 8.0-10.0. The concentration variations of phosphate, calcium （Ca） and HS were measured in the precipitation process; the crystalline state and compositions of the precipitates were analysed by powder X-ray diffraction （XRD） and chemical methods, respectively. It showed that at solution pH 8.0, the precipitation rate and removal efficiency of phosphate were greatly reduced by HS, but at solution pH ≥9.0, the effect of HS was very small. The Ca consumption for the precipitation of phosphate increased when HS was added; HS was also removed from solution with the precipitation of calcium phosphate. At solution pH 8.0 and HS concentrations ≤3.5 mg/L, and at pH ≥ 9.0 and HS concentrations ≤ 10 mg/L, the final precipitates were proved to be hydroxyapatite （HAP） by XRD. The increases of solution pH value and initial Ca/P ratio helped reduce the influence of HS on the precipitation of phosphate.

关键词： calcium phosphate phosphorus recovery precipitation humic substances initial CaJP ratio solution pH value

ELECTROACTIVE AND NANOSTRUCTURED POLYMERS AS SCAFFOLD MATERIALS FOR NEURONAL AND CARDIAC TISSUE ENgINEERINg

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Chinese Journal of Polymer Science 2007年第4期25卷 331-339页

作者： Paul bidez Elizabeth guterman-Tretter Alan g. MacDiarmid peter I. Lelkes 危岩 School of biomedical Engineering Science & Health SystemsDrexel UniversityPhiladelphiaPA 19104USA School of biomedical Engineering Science & Health SystemsDrexel UniversityPhiladelphiaPA 19104USA Department of ChemistryDrexel UniversityPhiladelphiaPA 19104USA Department of Chemistry University of PennsylvaniaPhiladelphiaPA 19104USA

Conducting polymer, polyaniline （PANI）, has been studied as a novel electroactive and electrically conductive material for tissue engineering applications. The biocompatibility of the conductive polymer can be improved by （i） covalently grafting various adhesive peptides onto the surface of prefabricated conducting polymer films or into the polymer structures during the synthesis, （ii） co-electrospinning or blending with natural proteins to form conducting nanofibers or films, and （iii） preparing conducting polymers using biopolymers, such as collagen, as templates. In this paper, we mainly describe and review the approaches of covalently attaching oligopeptides to PANI and electrospinning PANI-gelatin blend nanofibers. The employment of such modified conducting polymers as substrates for enhanced cell attachment, proliferation and differentiation has been investigated with neuronal PC-12 cells and H9c2 cardiac myoblasts. For the electrospun PANI- gelatin fibers, depending on the concentrations of PANI, H9c2 cells initially displayed different morphologies on the fibrous substrates, but after one week all cultures reached confluence of similar densities and morphologies. Furthermore, we observed, that conductive PANI, when maintained in an aqueous physiologic environment, retained a significant level of electrical conductivity for at least 100 h, even though this conductivity was decreasing over time. Preliminary data show that the application of micro-current stimulates the differentiation of PC-12 cells. All the results demonstrate the potential for using PANI as an electroactive polymer in the culture of excitable cells and open the possibility of using this material as an electroactive scaffold for cardiac and/or neuronal tissue engineering applications that require biocompatibility of conductive polymers.

关键词： Polyaniline Conductive polymer biocompatibility Tissue engineering.

A genetically Encoded Toolkit for Probing the Post Translational Modifications of Lysine in Mammalian Cells

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生物物理学报 2009年第S1期25卷 166-167页

作者： Dan groff peter g.Schultz The Scripps Research Institute 10550 N.Torrey Pines RdLa JollaCA92037USA

Post translational modifications (PTMs) of lysine play a crucial role on modulating the activity and stability of essential proteins in eukaryotic cells including the tumor

关键词： Post translational modifications photocaged Lysine Unnatural amino acid Mammalian cells.

Seed selections for crystallization of calcium phosphate for phosphorus recovery

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Journal of Environmental Sciences 2007年第5期19卷 591-595页

作者： SONg Yong-hui Dietfried DONNERT Ute bERg peter g. WEIDLER Rolf NUEESCH Chinese Research Academy of Environmental Sciences Beijing 100012 China Institute for Technical Chemistry-Section of Water- and geo-technology （ITC-WgT） Research Centre of Karlsruhe Karlsruhe D-76021 Germany

Seed induces and promotes the crystallization of calcium phosphate, and acts as carrier of the recovered phosphorus （P）. In order to select suitable seed for P recovery from wastewater, three seeds including Apatite （AP）, Juraperle （JP） and phosphate-modified Juraperle （M-JP） were tested and compared. batch and fixed-bed column experiments of seeded crystallization of calcium phosphate were undertaken by using synthetic wastewater with 10 mg/L P phosphate. It shows that AP has bad enduring property in the crystallization process, while JP has better performance for multiple uses, and M-JP is a hopeful seed for P recovery by crystallization of calcium phosphate.

关键词： crystallization seed phosphorus recovery Juraperle Apatite

geodynamics of oceanic plateau and plume head accretion and their role in Phanerozoic orogenic systems of China

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geoscience Frontiers 2015年第1期6卷 49-59页

作者： peter g.betts Louis Moresi Meghan S.Miller David Willis School of Earth Atmosphere and EnvironmentMonash UniversityClayton Campus School of Mathematical Sciences Monash UniversityClayton Campus Department of Earth Sciences University of Melbourne Department of Earth Sciences University of Southern California

We present three 3D numerical models of deep subduction where buoyant material from an oceanic plateau and a plume interact with the overriding plate to assess the influence on subduction dynamics, trench geometry, and mechanisms for plateau accretion and continental growth. Transient instabilities of the convergent margin are produced, resulting in： contorted trench geometry; trench migration parallel with the plate margin; folding of the subducting slab and orocline development at the convergent margin; and transfer of the plateau to the overriding plate. The presence of plume material beneath the oceanic plateau causes fiat subduction above the plume, resulting in a ＂bowed＂ shaped subducting slab. In plateau-only models, plateau accretion at the edge of the overriding plate results in trench migration around the edge of the plateau before subduction is re-established directly behind the trailing edge of the plateau. The plateau shortens and some plateau material subducts. The presence of buoyant plume material beneath the oceanic plateau has a profound influence on the behaviour of the convergent margin. In the plateau ~ plume model, plateau accretion causes rapid trench advance. Plate convergence is accommodated by shearing at the base of the plateau and shortening in the overriding plate. The trench migrates around the edge of the plateau and subduction is re-established well behind the trailing edge of the plateau, effectively embedding the plateau into the overriding plate. A slab window forms beneath the accreted plateau and plume material is transferred from the subducting plate to the over- riding plate through the window. In all of the models, the subduction zone maintains a relatively stable configuration away from the buoyancy anomalies within the downgoing plate. The models provide a dynamic context for plateau and plume accretion in Phanerozoic accretionary orogenic systems such as the East China Orogen and the Central Asian Orogen （Altiads）, which ar

关键词： Subduction Accretion Plateau Plume Central Asian Orogen geodynamics

A method to evaluate the bioactive function of fruit extracts of Chinese wild Citrus with microtubular activity

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Journal of Integrative Agriculture 2017年第4期16卷 867-873页

作者： gUAN Xin TAN Si günther buchholz peter Nick ZHOU Zhi-qin College of Horticulture and Landscape Architecture Southwest University Chongqing 400716 P.R. China Molecular Cell biology Botanical Institute Karlsruhe Institute of Technology Karlsruhe D-76128 Germany RLP AgroScience/AIPlanta-institute for Plant Research Neustadt an der Weinstrasse D-67435 Germany Laboratoire Vigne biotechnologies et Environnement EA-3991 Universit6 de Haute-Alsace Colmar 68000 France Key Laboratory of Horticulture Science for Southern Mountainous Regions Ministry of Education Chongqing 400716 P.R. China

China is one of the most important centers of origin for Citrus genetic resources. Due to the high content of secondary metabolites, mining wild Chinese Citrus for novel medical applications is promising. In this study, extracts of Chinese wild species from different taxonomical groups were screened for potential effects on microtubules （MTs） in vitro. MT density as a readout for nucleation, and frequency distribution over MT lengths as a readout for elongation and decay were determined by quantitative image analysis via a standardized coverslJp assay using fluorescently labelled neurotubulin. Extract from peels of Citrus ichangensis Swing. strongly increased the density of MTs; whereas, extract from peels of Cfurs limon （L.） burm.f. exerted the opposite effect. Extract from pulp of Citrus limonia Osbeck promoted MT elongation, and in addition induced a small population of very long MTs. These data suggest that wild Chinese Citrus harbour compounds that act specifically on different aspects of MT nucleation, elongation, and decay.

关键词： fruit extract natural product-based pharmaceuticals Chinese wild Citrus microtubules secondary plant metabolites

The Ogaden Dyke Swarm: Red Sea Rifting Continued in the Somalia Plate?

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Acta geologica Sinica(English Edition) 2016年第S1期90卷 56-58页

作者： Daniel MègE peter g.PURCELL Antoine béZOS Fred JOURDAN Space Research Centre Polish Academy of Sciences Planetology and geodynamics Laboratory UMR CNRS 6112 University of Nantes P & R geological Consultants Western Australia Argon Isotope Facility Curtin University

Opening of the Red Sea started while the core of the lavas of the Ethiopian Large Igneous Province（LIP）was being erupted at;0 Ma（Hughes et al.,1991）and has continued to the *** the southern Red Sea,oceanic

关键词： Red Sea Rifting Continued in the Somalia Plate The Ogaden Dyke Swarm

Should China Join the New Trans-Pacific Partnership?

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China & World Economy 2020年第2期28卷 18-36页

作者： peter A.Petri Michael g.Plummer brandeis University Johns Hopkins University

After President Donald Trump s ill-advised pullout from the Trans-Pacific Partnership(TPP)and despite the absence of the US,the remaining 11 Asian and Pacific countries agreed on a deal,renamed the Comprehensive and Progressive Agreement for Transpacific Partnership(CPTPP).The accord took effect on 30 December 2018 and provides rigorous,up-to-date rules for Asia-Pacific trade,but excludes the region s two biggest economies:the US and *** this paper,we calculate that Chinese membership in the CPTPP would yield large economic and political benefits to China and other *** CPTPP,in its current form,would generate global income gains estimated at US$147bn *** China were to join,these gains would quadruple to US$632bn,or a quarter more than in the original TPP with the *** to join the CPTPP,China would have to undertake unprecedented reforms and manage complex political challenges.

关键词： Asia-Pacific Comprehensive and Progressive Agreement for Trans-Pacific Partnership trade agreement Trans-Pacific Partnership

The N-formyl peptide receptors: contemporary roles in neuronal function and dysfunction

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Neural Regeneration Research 2020年第7期15卷 1191-1198页

作者： peter J.g. Cussell Margarita gomez Escalada Nathaniel g.N. Milton Andrew W.J. Paterson Centre for biomedical Science Research School of Clinical and Applied Sciences Leeds Beckett University

N-formyl peptide receptors(FPRs)were first identified upon phagocytic leukocytes,but more than four decades of research has unearthed a plethora of non-myeloid roles for this receptor *** are expressed within neuronal tissues and markedly in the central nervous system,where FPR interactions with endogenous ligands have been implicated in the pathophysiology of several neurodegenerative diseases including Alzheimer's disease and Parkinson's disease,as well as neurological cancers such as *** the homeostatic function of FPRs in the nervous system is currently undefined,a variety of novel physiological roles for this receptor family in the neuronal context have been posited in both human and animal *** developments in recent years have implicated FPRs in the process of neurogenesis and neuronal differentiation which,upon greater characterisation,could represent a novel pharmacological target for neuronal regeneration therapies that may be used in the treatment of brain/spinal cord injury,stroke and *** review aims to summarize the recent progress made to determine the physiological role of FPRs in a neuronal setting,and to put forward a case for FPRs as a novel pharmacological target for conditions of the nervous system,and for their potential to open the door to novel neuronal regeneration therapies.

关键词： Alzheimer's disease formyl peptide receptor neural regeneration neuroblastoma neurodegeneration neuroinflammation neuronal differentiation stroke