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An overview of the latest developments in facial imaging

Forensic Sciences Research 2019年第1期4卷 10-28页

作者： Carl N.Stephan Jodi M.Caple Pierre Guyomarc'h peter claes Laboratory for Human Craniofacial and Skeletal Identification(HuCS-ID Lab) School of Biomedical SciencesThe University of QueenslandSt LuciaAustralia Unite Mixte de Recherche(UMR)5199 De la Préhistoireàl'Actuel:Culture Environnement et Anthropologie(PACEA)Ministère de la Culture et de la Communication(MCC)Centre National de la Recherche Scientifique(CNRS)Universitéde BordeauxPessacFrance Department of Electrical Engineering Department of Electrical Engineering(ESAT)/Processing of Speech and Images(PSI)KU LeuvenLeuvenBelgium Medical Imaging Research Center(MIRC) Universitair ZiekenhuisLeuvenBelgium

Facial imaging is a term used to describe methods that use facial images to assist or facili-tate human identification. This pertains to two craniofacial identification procedures that use skulls and faces—facial approximation and photographic superimposition—as well as face-only methods for age progression/regression, the construction of facial graphics from eye-witness memory (including composites and artistic sketches), facial depiction, face mapping and newly emerging methods of molecular photofitting. Given the breadth of these facial imaging techniques, it is not surprising that a broad array of subject-matter experts partici-pate in and/or contribute to the formulation and implementation of these methods (includ-ing forensic odontologists, forensic artists, police officers, electrical engineers, anatomists, geneticists, medical image specialists, psychologists, computer graphic programmers and software developers). As they are concerned with the physical characteristics of humans, each of these facial imaging areas also falls in the domain of physical anthropology, although not all of them have been traditionally regarded as such. This too offers useful opportunities to adapt established methods in one domain to others more traditionally held to be disciplines within physical anthropology (e.g. facial approximation, craniofacial super-imposition and face photo-comparison). It is important to note that most facial imaging methods are not currently used for identification but serve to assist authorities in narrowing or directing investigations such that other, more potent, methods of identification can be used (e.g. DNA). Few, if any, facial imaging approaches can be considered honed end-stage scientific methods, with major opportunities for physical anthropologists to make meaningful contributions. Some facial imaging methods have considerably stronger scientific underpin-nings than others (e.g. facial approximation versus face mapping), some currently lie ent

关键词： Forensic anthropology craniofacial identification facial approximation photographic superimpos-ition facial depiction age progression facial composites molecular photofitting

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醛糖还原酶抑制剂对小鼠胰岛山梨醇代谢的影响

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中华内分泌代谢杂志 1993年第3期9卷 161-162页

作者：李佐强 Naeser peter claes Hellerstr 重庆医科大学附属第一医院内科 630042 瑞典Uppsala大学医学细胞物系

观察了一种醛糖还原酶抑制剂(ICI 128436)对小鼠胰岛体外培养时山梨醇代谢的影响情况。小鼠胰岛培养72小时后,酶抑制剂处理过的胰岛山梨醇水平较对照组显著降低。结果表明小鼠胰岛可以合成山梨醇,其生成水平与醛糖还原酶的活性密切有关。

关键词：胰岛醛糖还原酶抑制剂山梨醇

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Application of Artificial Intelligence for Efficient Development,Manufacturing and Implementation of Steel

Application of Artificial Intelligence for Efficient Develop...

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第十三届中国钢铁年会

作者： Hedstr?m peter Mu Wangzhong Serrano Ismael García Kolli Satish Chowdary Kailash Holmstr?m claes KTH Royal Institute of Technology Department of Materials Science and Engineering

Data-driven methods,based on artificial intelligence(AI) or machine learning,contribute to a paradigmatic shift in materials science and engineering at present The conventional approach of materials development manufacturing and implementation,requires extensive experimental testing,and by replacing certain parts,or ultimately most parts,to AI-based methods this process can be made significantly more *** will present the underlying methodology which has been developed over the past years in collaboration between Materials Science at KTH Royal Institute of Technology and the company Ferritico *** will give application examples and an outlook on AI for *** work aims at supporting the implementation of the concept Steel Industry 4.0.

关键词： artificial intelligence machine learning manufacturing material design steels industry 4.0

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NOTUM inhibition increases endocortical bone formation and bone strength

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Bone Research 2019年第1期7卷 54-65页

作者： Robert Brommage Jeff Liu peter Voge Faika Mseeh Andrea Y.Thompson David G.Potter Melanie K.Shadoan Gwenn M.Hansen Sabrina Jeter-Jones Jie Cui Dawn Bright Jennifer P.Bardenhagen Deon D.Doree Sofia Moverare-Skrtic Karin H.Nilsson Petra Henning Ulf H.Lerner claes Ohlsson Arthur T.Sands James E.Tarver David R.Powell Brian Zambrowicz Qingyun Liu Lexicon Pharmaceuticals The WoodlandsTXUSA Wntrix HoustonTXUSA PRA Health Sciences RaleighNCUSA University of Pennsylvania PhiladelphiaPAUSA Regeneron Pharmaceuticals TarrytownNYUSA University of Texas HoustonTXUSA Centre for Bone and Arthritis Research Institute of MedicineThe Sahlgrenska Academy at University of GothenburgGothenburgSweden Centre for Bone and Arthritis Research University of GothenburgGothenburgSweden Biogen CambridgeMAUSA St.Jude Children’s Research Hospital MemphisTNUSA MD Anderson Cancer Center HoustonTXUSA Bethyl Laboratories MontgomeryTXUSA Merck RahwayNJUSA Nurix San FranciscoCAUSA

The disability,mortality and costs caused by non-vertebral osteoporotic fractures are *** osteoporosis therapies are highly effective at reducing vertebral but not non-vertebral *** bone is a major determinant of non-vertebral bone *** identify novel osteoporosis drug targets,we phenotyped cortical bone of 3 366 viable mouse strains with global knockouts of druggable *** bone thickness was substantially elevated in Notum?/?*** is a secreted WNT lipase and we observed high NOTUM expression in cortical bone and osteoblasts but not *** orally active small molecules and a neutralizing antibody inhibiting NOTUM lipase activity were *** increased cortical bone thickness and strength at multiple skeletal sites in both gonadal intact and ovariectomized rodents by stimulating endocortical bone ***,inhibition of NOTUM activity is a potential novel anabolic therapy for strengthening cortical bone and preventing non-vertebral fractures.

关键词： disability osteoporosis fractures

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