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Bleeding outcomes after non-emergency percutaneous coronary intervention in the very elderly

Journal of Geriatric Cardiology 2017年第10期14卷 624-631页

作者： Vimalraj Bogana Shanmugam Dennis T Wong Hashrul Rashid James D cameron Yuvaraj Malaiapan peter J Psaltis Monash Cardiovascular Research Centre Clayton Campus of Monash University Victoria Australia South Australian Health and Medical Research Institute Adelaide Australia

Background Octogenarians constitute an increasing proportion of patients presenting for non-emergency percutaneous coronary intervention （PCI）. Methods This study evaluated the in-hospital procedural characteristics and outcomes, including the bleeding events of 293 octogenarians presenting between January 2010 and December 2012 for non-emergency PCI to a single large volume tertiary care Aus- tralian center. Comparisons were made with 293 consecutive patients aged less than or equal to 60 years, whose lesions were matched with the octogenarians. Results Non-ST elevation myocardial infarction was the most frequent indication for non-emergency PCI in octoge- narians. Compared to the younger cohort, they had a higher prevalence of co-morbidities and more complex coronary disease, comprising more type C and calcified lesions. Peri-procedural use of low molecular weight heparin （LMWH; 1.0% vs. 5.8%; P 〈 0.001） and glycopro- tein IIb/IIIa inhibitors （2.1% vs. 9.6%; P 〈 0.001） was lower, while femoral arterial access was used more commonly than in younger patients （80.9% vs. 67.6%; P 〈 0.001）. Overall, there was a non-significant trend towards higher incidence of all bleeding events in the elderly （9.2% vs. 5.8%; P = 0.12）. There was no significant difference in access site or non-access site bleeding and major or minor bleeding between the two cohorts. Sub-analysis did not reveal any significant influence on bleeding rates by the use of LMWH, glycoprotein IIb/IIIa inhibitors or femoral arterial access. In addition, there were no significant differences in the rates of in-hospital mortality, stroke or acute stent thrombosis between the two groups. Conclusions In this single center study, we did not observe significant increases in adverse in-hospital outcomes including the incidence of bleeding in octogenarians undergoing non-emergency PCI.

关键词： Bleeding Coronary artery disease Octogenarians Percutaneous coronary intervention

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Effects of soil warming history on the performances of congeneric temperate and boreal herbaceous plant species and their associations with soil biota

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Journal of Plant Ecology 2017年第4期10卷 670-680页

作者： Madhav P.Thakur peter B.Reich cameron Wagg Nicholas A.Fisichelli Marcel Ciobanu Sarah E.Hobbie Roy L.Rich Artur Stefanski Nico Eisenhauer German Centre for Integrative Biodiversity Research(iDiv)Halle-Jena-Leipzig MitteDeutscher Platz 5E04103 LeipzigGermany Institute of Biology Leipzig UniversityJohannisallee 2104103 LeipzigGermany Department of Forest Resources University of Minnesota1530 North Cleveland AvenueSt.PaulMN 55108USA Hawkesbury Institute for the Environment University of Western SydneyPenrithNew South Wales 2751Australia Institute of Evolutionary Biology and Environmental Studies University of ZurichWinterthurerstrasse 190CH-8057 ZurichSwitzerland Forest Ecology Program Schoodic Institute at Acadia National ParkWinter HarborME 04693USA Institute of Biological Research Branch of the National Institute of Research and Development for Biological Sciences48 Republicii Street400015 Cluj-NapocaRomania Department of Ecology Evolutionand BehaviorUniversity of MinnesotaSt.PaulMN 55108USA

Aims Climate warming raises the probability of range expansions of warm-adapted temperate species into areas currently dominated by cold-adapted boreal ***-induced plant range expansions could partly depend on how warming modifies relationships with soil biota that promote plant growth,such as by mineralizing ***,we grew two pairs of congeneric herbaceous plants spe-cies together in soil with a 5-year warming history(ambient,+1.7℃,+3.4℃)and related their performances to plant-beneficial soil *** Each plant pair belonged to either the mid-latitude temperate climate or the higher latitude southern boreal *** soils were extracted from a chamberless heating experiment at two field sites in the temperate-boreal ecotone of North *** isolate poten-tial effects of different soil warming histories,air temperature for the greenhouse experiment was identical across *** hypothesized that soil with a 5-year warming history in the field would enhance the performance of temperate plant species more than boreal plant species and expected improved plant performances to have positive associations with plant growth-promoting soil biota(microbial-feeding nematodes and arbuscular mycorrhizal fungi).Important Findings Our main hypothesis was partly confirmed as only one temperate spe-cies performed better in soil with warming history than in soil with his-tory of ambient ***,this effect was restricted to the site with higher soil water content in the growing season of the sampling year(prior to soil collection).One of the boreal species performed con-sistently worse in previously warmed soil,whereas the other species showed neutral responses to soil warming *** found a positive correlation between the density of microbial-feeding nematodes and the performance of one of the temperate species in previously wetter soils,but this correlation was negative at the site with previously drier *** found no signific

关键词： seedling emergence soil biota range shift ecotone Aster cordifolius

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老年人与交通事故的调查分析(英文)

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中华急诊医学杂志 2006年第1期15卷 6-12页

作者： HENG Kenneth PAN Shuming LAYDE M peter ZHU Shankuan Injury Research Center Medical College of Wisconsin Milwaukee WIUSA Emergency Department of Xinhua Hospital Shanghai Jiao TongUniversity School of Medicine

目的中国目前正在经历老年人口与交通车辆的同时快速增长。随着人口的老龄化加剧以及社会的发展,老年驾驶者人数将预期明显增加。国际上对老年人交通安全的经验可能对中国即将增加的老年驾驶者有借鉴作用。方法检索并分析了中国以及一... 详细信息

目的中国目前正在经历老年人口与交通车辆的同时快速增长。随着人口的老龄化加剧以及社会的发展,老年驾驶者人数将预期明显增加。国际上对老年人交通安全的经验可能对中国即将增加的老年驾驶者有借鉴作用。方法检索并分析了中国以及一些发达国家,如美国等有关老年驾驶者以及交通事故安全的论文及论著。结果尽管老年人较少开车且普遍地使用安全带,但他们交通事故发生数以及死亡率较其他年龄组高。老年人视觉以及感知功能的损害也增加了发生交通事故的危险性,同时也产生了其独特的事故形式。与年轻人相比,在相同的受伤程度下,老年人体格上的衰退和疾病因素可能对会产生更坏的结果。虽然老年驾驶者在中国还是少数,与其他年龄组相比,老年人有较高的交通事故伤害率、步行者死亡率和较高的农村老年人受害率。结论国际上对老年人交通安全的经验,比如更好的道路安全设计,高可视安全标识和安全带法律的实施,安全带使用的公共教育,以及老年驾驶证的更新等对中国的交通安全设计者以及法律的制定者可能会有帮助。这些经验对损伤预防研究者在老年人交通事故危险因素的识别方面,以及对工程师在驾驶环境和车辆设计等方面也有着重要的意义。

关键词：交通事故伤害老年人口交通安全安全设计农村老年人安全带发达国家感知功能疾病因素公共教育

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Silicon microcavity arrays with open access and a finesse of half a million

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Light(Science & Applications) 2019年第1期8卷 862-868页

作者： Georg Wachter Stefan Kuhn Stefan Minniberger cameron Salter peter Asenbaum James Millen Michael Schneider Johannes Schalko Ulrich Schmid Andre Felgner Dorothee Huser Markus Arndt Michael Trupke Faculty of Physics University of ViennaVCQBoltzmanngasse 51090 ViennaAustria Institute for Atomic and Subatomic Physics TU WienVCQStadionallee 21020 ViennaAustria Institute for Sensor and Actuator Systems TU Wien1040 ViennaAustria Physikalisch-Technische Bundesanstalt Bundesallee 100D-38116 BraunschweigGermany Department of Physics King’s College LondonStrandLondon WC2R 2LSUK

Optical resonators are essential for fundamental science,applications in sensing and metrology,particle cooling,and quantum information *** can significantly enhance interactions between light and *** many applications they perform this task best if the mode confinement is tight and the photon lifetime is *** access to the mode center is important in the design to admit atoms,molecules,nanoparticles,or solids into the light ***,we demonstrate how to machine microcavity arrays of extremely high quality in pristine *** to an almost perfect parabolic shape with a surface roughness on the level of 2A and coated to a finesse exceeding F=500,000,these new devices can have lengths below 17μm,confining the photons to 5μm waists in a mode volume of 88λ^(3).Extending the cavity length to 150μm,on the order of the radius of curvature,in a symmetric mirror configuration yields a waist smaller than 7μm,with photon lifetimes exceeding 64 *** cleanroom fabrication delivers an entire microcavity array in a single *** precision furthermore yields alignment structures that result in mechanically robust,pre-aligned,symmetric microcavity arrays,representing a lightmatter interface with unprecedented performance.

关键词： process field. exceeding

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热风炉内氧—燃料燃烧——减少30%CO2排放的基础

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世界钢铁 2014年第5期14卷 7-14页

作者： Andy cameron Andy Richardson Reed Heine peter Martin 仇晓磊英国燃气公司 2. 林德气体公司 3. 西门子工业有限公司

"无焰"氧—燃料燃烧是一项成形技术,已在钢包预热和加热炉上应用。在应用过程中发现,该项技术可以节省约50%的燃料,同时也可以减少CO2排放。将部分无焰氧—燃料燃烧原理应用到高炉热风炉是一种新的尝试。与传统燃烧方式相比,该技术可使... 详细信息

"无焰"氧—燃料燃烧是一项成形技术,已在钢包预热和加热炉上应用。在应用过程中发现,该项技术可以节省约50%的燃料,同时也可以减少CO2排放。将部分无焰氧—燃料燃烧原理应用到高炉热风炉是一种新的尝试。与传统燃烧方式相比,该技术可使操作成本大幅降低,这是源于其有效的废热回收,以及采用"热"的富氧烟气循环来替代"冷"空气。由于用二氧化碳替代了不辐射的氮分子,增强了炉内的热量传递。氧—燃料燃烧概念的一个重要推论就是烟道烟气中CO2的体积分数大约可提升40%~50%,且质量流量变为原来的两倍。该项技术容易实现低成本碳捕获,而且如果实现碳封存,那么就有可能减少整个炼钢流程中大约30%的碳足迹。

关键词：燃料热风炉 CO2排放

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Impact of Marijuana on Response Inhibition: an fMRI Study in Young Adults

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Journal of Behavioral and Brain Science 2011年第3期1卷 124-133页

作者： Andra M. Smith Rocío A. López Zunini Christopher D. Anderson Carmelinda A. Longo Ian cameron Matthew J. Hogan peter A. Fried 不详

Rationale: Marijuana use in adolescence is prevalent and increasing. Understanding the neural correlates of the impact of this use is critical for policy making and for youth awareness. Objectives The effects of marijuana use on response inhibition were investigated in 19–21-year-olds using functional magnetic resonance imaging (fMRI). Methods: Participants were members of the Ottawa Prenatal Prospective Study, a longitudinal study that collected a unique body of information on participants from infancy to young adulthood including: prenatal drug history, detailed cognitive/behavioral performance, and current and past drug use. This information allowed for the control of an unparalleled number of potentially confounding variables including: prenatal marijuana, nicotine, alcohol, and caffeine exposure and offspring alcohol, marijuana, and nicotine use. Ten marijuana users and 14 nonusers that served as controls performed a Go/No-Go task while fMRI blood oxygen level-dependent response was examined. Results: Despite similar task performance, there was a positive relationship between amount of marijuana smoked and activation in right thalamus, premotor cortex and middle frontal gyrus. These regions form part of the neural network responsible for inhibition control. There was also a positive dose dependent relationship with marijuana and activation in inferior parietal lobe and precuneus, also parts of response inhibition pathways. Conclusions: These results suggest a dose dependent alteration in neural functioning during response inhibition after controlling for other prenatal and current drug use. These alterations may be necessary in order to compensate for neural changes in response inhibition circuits caused by long term marijuana use that began during adolescence/young adulthood.

关键词： Prefrontal Cortex fMRI Marijuana Young Adulthood Response Inhibition

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预防医学再访Rose:减少冠心病的策略

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英国医学杂志中文版 2007年第1期10卷 44-47页

作者： Douglas G Manuel Jenny Lim peter Tanuseputro Geoffrey M Anderson David A Alter Andreas Laupacis cameron A Mustard 王增武（译）高润霖（校） Institute for Clinical Evaluative Sciences G106-2075Bayview AvenueToronto ON Canada M4N 3M5 Department of PublicHealth Sciences University ofToronto Toronto Institute for Work and Health Toronto

近些年来，我们评价冠心病风险的方法已经变得更精确了。这一结果是如何影响一级预防和二级预防的功效呢？

关键词：冠心病预防医学二级预防一级预防

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脑动静脉畸形血管造影评估和血管内治疗的报道标准

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国际脑血管病杂志 2013年第1期21卷 1-7页

作者： Mahesh V Jayaraman Philip M Meyers Colin P Derdeyn Justin F Fraser Joshua A Hirsch M Shazam Hussain Kristine A Blackham Clifford J Eskey Mary E Jensen Christopher J Moran Charles Joseph Prestigiacoma peter A Rasmussen cameron G McDoumll 冀雅彬(译) 姬仲(译) From the Departments of Diagnostic Imaging and Neurosury Alp ert Medical School Brown University Providence Rhode Island USA Department of Radiology and Neurological Surgery Columbia University New York New York USA Neuroradiology Department Washington University in St Louis St Louis Missouri USA Department of Neurological Surgery University of Kentucky Louisville Kentucky USA Departt of Interventional and Diagnostic Neuromdiology Massachusetts General Hospital Boston Massachusetts USA Cerebrovascular Center Cleveland Clinic Cleveland Ohio USA University Hospitals Department of Radiology Case Westem Reserve University Cleveland Ohio USA Department of Radiology Neurology and Neurosur Dartrnouth-Hitchcock Medical Center Lebanon New Hampshire USA Department of Radiology and Neurological Surgery University of irginia Charlottesville V-trginia USA Department of Neurological Surgery New Jersey Medical School University of Medicine and Dentistry of New Jersey Newark New Jersey USA Neurosurgery Department Cleveland Clinic Cleveland Ohio USA Neurosurgery Department Barrow Neurological Institute Phoenix Arizona USA 南方医科大学南方医院神经内科广州510515

本指南根据一个致力于中枢神经系统动静脉畸形（arteriovenousmalformation，AVM）患者评估和治疗的多学科专家组共识制定。该报道标准为临床试验设计以及那些希望报道脑AVM血管内治疗的临床研究人员提供了一个样板。不同治疗方案的直... 详细信息

本指南根据一个致力于中枢神经系统动静脉畸形（arteriovenousmalformation，AVM）患者评估和治疗的多学科专家组共识制定。该报道标准为临床试验设计以及那些希望报道脑AVM血管内治疗的临床研究人员提供了一个样板。不同治疗方案的直接比较对于医疗诊治的标准化、良好治疗转归的最大化以及新方法和新技术的评估至关重要。

关键词：脑动静脉畸形血管内治疗标准化血管造影临床研究人员中枢神经系统脑AVM 试验设计

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Altered energy metabolism and metabolic gene expression associated with increased metastatic capacity identified in MDA -MB-231 cell line variants

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Journal of Cancer Metastasis and Treatment 2018年第1期4卷 678-693页

作者： Yan Tu cameron N.Johnstone James G.Ryall Guillermo H.Lopez-Campos Christine R.Keenan Alastair G.Stewart Department of Pharmacology and Therapeutics the University of MelbourneParkvilleVictoria 3010Australia Cancer Research Division Peter MacCallum Cancer CentreEast MelbourneVictoria 3000Australia Olivia Newton-John Cancer Research Institute HeidelbergVictoria 3084Australia School of Cancer Medicine La Trobe UniversityBundooraVictoria 3086Australia Department of Biochemistry&Molecular Biology Monash UniversityClaytonVictoria 3800Australia Department of Pathology the University of MelbourneParkvilleVictoria 3010Australia Department of Physiology the University of MelbourneParkvilleVictoria 3010Australia Health and Biomedical Informatics Centre Melbourne Medical Schoolthe University of MelbourneVictoria 3010Australia The Wellcome-Wolfson Institute for Experimental Medicine Queen's UniversityBelfast BT97BLUK The Walter and Eliza Hall Institute of Medical Research ParkvilleVictoria 3010Australia Department of Medical Biology The University of MelbourneParkvilleVictoria 3010Australia

Aim:Despite current advances in therapies and the gradual decline in breast cancer-related mortality,metastasis remains a major therapeutic challenge for *** reprogramming is now recognized to be an important part of tumorigenic processes,but its relevance in metastatic dissemination has yet to be ***:Using the ***5 cell line,a novel,highly metastatic variant line derived from TN hu-man breast adenocarcinoma MDA-MB-231 line,alteration in growth and energy metabolisms associated with en-hanced metastatic potential were *** and oxidative phosphorylation(OXPHOS)was character-ized using the seahorse XF *** transcriptome sequencing(RNA-seq)and quantitative real-time PCR was used to ascertain expression differences in metabolic ***:We observed reduced proliferation,and an elevation of both glycolytic and OXPHOS metabolism in the highly metastatic daughter *** elevated metabolic rate is only partially reflected by transcript levels of rel-evant metabolic *** mitochondrial respiration is potentially underpinned by increased expres-sion mitochondrial electron transport chain ***,increased glycolysis was not underpinned by up-regulation of metabolic genes encoding enzymes participating in ***:Our results indicate breast tumour cells with elevated metastatic propensity are more metabolic *** also identified differentially expressed metabolic genes,such as IDH2,that may play a part in the meta-static process beyond energy reprogramming.

关键词： Breast cancer energy reprogramming cancer metabolism metastasis RNA-seq

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吞噬作用能促进线虫的程序性细胞死亡

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四川解剖学杂志 2002年第2期10卷 94-94页

作者： peter W.Reddien Scott cameron H.Robert Horvit 魏星第三军医大学学员旅5队

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