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Surgical treatment of metastatic germ cell cancer

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Asian Journal of Urology 2021年第2期8卷 155-160页

作者： Andreas Hiester peter albers Department of Urology University of DuesseldorfMedical FacultyHeinrich-Heine-UniversityDuesseldorfGermany

Among young men between the ages of 15 and 40 years,germ cell cancer is the most common solid tumor[1].The worldwide incidence of germ cell cancer is 70000 *** to all solid tumors of men,germ cell cancer accounts for 1%of all male ***,the mortality of this rare tumor entity is about 13%since 9507 patients died worldwide of germ cell *** improvement in survival of germ cell cancer patients is due to a multimodal treatment of germ cell cancer including cisplatin-based chemotherapy and surgery leading to higher cure-rates even in advanced stages[1],whereas the increasing incidence of germ cell cancers cannot be thoroughly *** this article we review the current indications for surgery in metastatic germ cell cancers,highlight the strength and weaknesses of techniques and indications and raise the question how to improve surgical treatment in metastatic germ cell cancer.

关键词： Germ cell cancer Metastatic germ cell cancer Retroperitoneal lymphnode dissection Retroperitoneal surgery

Molecular and epigenetic pathogenesis of germ cell tumors

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Asian Journal of Urology 2021年第2期8卷 144-154页

作者： Melanie R.Müller Margaretha A.Skowron peter albers Daniel Nettersheim Department of Urology Urological Research LabTranslational UroOncologyUniversity Hospital DüsseldorfDüsseldorfGermany Department of Urology University Hospital DüsseldorfDüsseldorfGermany

The development of germ cell tumors(GCTs)is a unique pathogenesis occurring at an early developmental stage during specification,migration or colonization of primordial germ cells(PGCs)in the genital *** driver mutations could not be identified so far,the involvement of the epigenetic machinery during the pathogenesis seems to play a crucial ***,it is investigated whether epigenetic modifications occurring between the omnipotent two-cell stage and the pluripotent implanting PGCs might result in disturbances eventually leading to *** progress in understanding epigenetic mechanisms during PGC development is ongoing,little is known about the complete picture of its involvement during GCT development and eventual classification into clinical *** review will shed light into the current knowledge of the complex epigenetic and molecular contribution during pathogenesis of GCTs by emphasizing on early developmental stages until arrival of late PGCs in the *** questioned how misguided migrating and/or colonizing PGCs develop to either type Ⅰ or type Ⅱ ***,we asked how pluripotency can be regulated during PGC development and which epigenetic changes contribute to GCT *** propose that SOX2 and SOX17 determine either embryonic stem cell-like(embryonal carcinoma)or PGC-like cell fate(seminoma).Finally,we suggest that factors secreted by the microenvironment,*** and BMP inhibiting molecules,dictate the fate decision of germ cell neoplasia in situ(into seminoma and embryonal carcinoma)and seminomas(into embryonal carcinoma or extraembryonic lineage),indicating an important role of the microenvironment on GCT plasticity.

关键词： Germ cell tumor Primordial germ cell Epigenetic reprogramming Plasticity Microenvironment BMP signaling SOX2 SOX17

Testicular germ cell tumors

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Asian Journal of Urology 2021年第2期8卷 143-143页

作者： peter albers Düsseldorf University Hospital Medical FacultyHeinrich-Heine University DüsseldorfGermany

Optimal quality of cancer care is crucial for best *** is especially true for patients suffering from testicular germ cell *** patients are very young,sometimes adolescent,usually healthy and cure rates independent of stage of the disease in industrialized countries approach 97%.With these figures,testicular germ cell tumors present a role model for a curable *** life expectancy of patients in early stages with local treatment followed by active surveillance is not limited compared to the general *** patients with metastatic disease tumor recurrences do not impact on the life expectancy either since most of the recurrences are curable as ***,in metastatic patients,the long-term sequelae of the initial systemic treatment like secondary malignancies and life-threatening long-term toxicities due to cisplatin meanwhile represent the most frequent causes of death 30 and more years after end of treatment.

关键词： tumors patients metastatic

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HTML5未来展望

程序员 2011年第4期 61-64页

作者： peter Lubbers Ric Smith Frank Salim Brian albers

我们将讨论一些还不够成熟但却极具潜力的HTML5特性。

关键词： HTML5 网络浏览器计算机网络网络协议

隐源性卒中的心电监测策略：2015年卒中诊断和监测专题组的报告

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国际脑血管病杂志 2017年第7期25卷 592-600页

作者： Gregory W. albers Richard A. Bernstein Johannes Brachmann John Camm J. Donald Easton peter Fromm Shinya Goto Christopher B. Granger Stefan H. Hohnloser Elaine Hylek Amir K. Jaffer Derk W. Krieger Rod Passman Jesse M. Pines Shelby D. Reed peter M. Rothwell peter R. Kowey 地力木拉提·阿米提朱沂李红燕牛晓珊 Department of Neurology and Neurological Sciences Stanford University Stanford CA Davee Department of Neurology Feinberg School of Medicine of Northwestern University Chicago IL Hospital Klinikum Coburg Teaching Hospital of the University of Wurzburg Coburg Germany Cardiovascular and Cell Sciences Research Institute St. George's University of London and Imperial College London LK Department of Neurology University of California San Francisco Sandier Neurosciences Center San Francisco CA Center for Cardiovascular Health South Nassau Communities Hospital Oeeanside NY Department of Medicine Tokai University School of Medicine Isehara Japan Cardiac Care Unit Duke University Medical Center Durham NC Division of Clinical Electrophysiology Department of Cardiology J.W. Goethe University Frankfurt Germany Boston University School of Medicine Boston MA Department of Medicine Rush Lhiversity Medical Center Chicago IL Faculty of Health and Medical Science University of Copenhagen Denmark German Neuroscience Center Dubal Healthcare City Dubai UAE Bluhm Cardiovascular Institute Northwestern University Feinberg School of Medicine Chicago IL Office for Clinical Practice Innovation George Washington Lhiversity Washington DC Duke Clinical Research Institute Duke University Durham NC Stroke Prevention Research Unit Nuffield Department of Clinical Neurosciences University of Oxford UK Division of Cardiovascular Diseases Lankenau Heart Institute Wyrmewood PA Department of Medicine Jefferson Medical College Philadelphia PA 新疆维吾尔自治区人民医院神经内科乌鲁木齐830001

卒中是一个重要的全球性公共卫生问题。2010年全世界总共发生3300万例卒中，其中1690万为首发卒中。卒中是仅次于心脏病的第二大全球人口死亡原因，占全部死亡的10％以上。卒中是一类异质性疾病，其病因可以是血管破裂（出血性）或血管... 详细信息

卒中是一个重要的全球性公共卫生问题。2010年全世界总共发生3300万例卒中，其中1690万为首发卒中。卒中是仅次于心脏病的第二大全球人口死亡原因，占全部死亡的10％以上。卒中是一类异质性疾病，其病因可以是血管破裂（出血性）或血管闭塞（缺血性）。缺血性卒中约占全部卒中的85％，可根据发病机制进行分类。

关键词：缺血性卒中心电监测隐源性专题诊断公共卫生问题死亡原因异质性疾病

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美国国家卒中协会短暂性脑缺血发作处理指南

国际脑血管病杂志 2007年第3期15卷 161-171页

作者： S. Claiborne Johnston Mai N. Nguyen-Huynh Miriam E. Schwarz Kate Fuller Christina Williams S. Andrew Josephsort Graeme J. Hankey Robert G. Hart Steven R. Levine Jose Biller Robert D. Brown Ralph L. Sacco L. Jaap Kappelle peter J. Koudstaal Julien Bogousslavsky Louis R. Caplan Jan van Gijn Ale Algra peter M. Rothwell Harold P. Adams Gregory W. albers 李海峰（译）不详青岛大学医学院附属医院神经内科 266003

目的：短暂性脑缺血发作（TIA）是常见和重要的卒中先兆。其处理方法多样，大多数发表的指南在近年来均未被更新。我们试图制定一个全面的、无偏倚的、循证的TIA处理指南。方法：根据一种客观标准（可以预测在该研究领域中执业医师对专... 详细信息

目的：短暂性脑缺血发作（TIA）是常见和重要的卒中先兆。其处理方法多样，大多数发表的指南在近年来均未被更新。我们试图制定一个全面的、无偏倚的、循证的TIA处理指南。方法：根据一种客观标准（可以预测在该研究领域中执业医师对专家提名的文献测量学方法）挑选出15名专家组成员。通过系统回顾检索到过去发表的指南，由专家对其中的推荐意见的质量进行独立评价。选择出质量最高的推荐意见，然后让专家组采用改良Delphi法通过多次问卷调查的方式进行修订，从而对新的修改达成共识。给专家们提供近期临床研究的系统评价，要求专家根据新的证据判断措辞修改的合理性并且根据证据等级和质量对最终的推荐意见进行评定。不允许专家在预期有可能存在任何利益冲突的专题方面提出推荐意见。结果：通过系统回顾检索到257个指南，其中有13篇文献包括的137条推荐意见符合所有纳入标准。需要6次重复的问卷调查对53条最终推荐意见的措辞达成共识。最终的推荐意见涉及TIA的初步处理、评价、内科治疗、外科治疗和危险因素控制。结论：对TIA患者医疗诊治的最终推荐意见强调了紧急评价和治疗的重要性。这种用于制定本指南的新方法是可行的，考虑到了快速更新并能减少偏倚。

关键词：短暂性脑缺血发作指南国家卒中协会

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美国国家卒中协会短暂性脑缺血发作处理指南

中华脑血管病杂志（电子版） 2007年第1期1卷 46-59页

作者： S. Claibome Johnston Mai N. Nguyen-Huynh Miriam E. Schwarz Kate Fuller Christina Williams S. Andrew Josephson Graeme J. Hankey Robert G. Hart Steven R. Levine Jose Biller Robert D. Brown Ralph L. Sacco L. Jaap Kappelle peter J. Koudstaal Julien Bogousslavsky Louis R. Caplan Jan van Gijn Ale Algra peter M. Rothwell Harold P. Adams Gregory W. albers 李海峰（译）不详青岛大学医学院附属医院神经内科 266003

关键词：短暂性脑缺血发作指南国家卒中协会

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急性卒中影像学研究路径图Ⅱ

国际脑血管病杂志 2014年第2期22卷 81-92页

作者： Max Wintermark Gregory W. albers Joseph P. Broderick Andrew M. Demchuk Jochen B. Fiebach Jens Fiehler James C. Grotta Gary Houser Tudor G. Jovin Kennedy R. Lees Michael H. Lev David S. Liebeskind Marie Luby Keith W. Muir Mark W. Parsons Rudiger von Kummer Joanna M. Wardlaw Ona Wu Albert J. Yoo Andrei V. Alexandrov Jeffry R. Alger Richard I. Aviv Roland Bammer Jean-Claude Baron Fernando Calamante Bruce C.V. Campbell Trevor C. Carpenter Sφren Christensen William A. Copen Colin P. Derdeyn E. Clarke Haley Jr Pooja Khatri Kohsuke Kudo Maarten G. Lansberg Lawrence L. Latour Ting-Yim Lee Richard Leigh Weili Lin Patrick Lyden Grant Mair Bijoy IC Menon Patrik Michel Robert Mikulik Raul G. Nogueira Left φstergaard Salvador Pedraza Christian H. Riedel Howard A. Rowley Pina C. Sanelli Makoto Sasaki Jeffrey L. Saver Pamela W. Schaefer peter D. Schellinger Georgios Tsivgoulis Lawrence R. Wechsler Philip M. White Greg Zaharchuk Osama O. Zaidat Stephen M. Davis Geoffrey A. Donnan Anthony J. Furlan Werner Hacke Dong-Wha Kang Chelsea Kidw ell Vincent N. Thijs Gotz Thomalla Steven J. Warach 严晓铭刘牧张晶晶柯开富不详南通大学附属医院神经内科 226001

卒中影像学研究组（StrokeImagingResearchGroup，STIR）、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议，最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议（Stro... 详细信息

卒中影像学研究组（StrokeImagingResearchGroup，STIR）、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议，最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议（Stroke Treatment Academy Industry Roundtable，STAIR）期间举行。

关键词：急性卒中影像学神经放射学路径会议基金会学会美国