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a.socia.ions of a.celerometer-determined physica. a.tivity a.d sedenta.y beha.ior with sa.copenia.a.d incident fa.ls over 12 months in community-dwelling Swedish older a.ults

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Journa. of Sport a.d Hea.th Science 2021年第5期10卷 577-584页

作者： Da.id Scott Jona. johansson a.oohya.Ga.dha. peter R.Ebeling peter Nordstrom a.na.Nordstrom Depa.tment of Medicine School of Clinical Sciences at Monash HealthMonash UniversityClaytonVIC 3168Australia Depa.tment of Medicine a.d a.stra.ia. Institute of Musculoskeleta. Science Melbourne Medical School Western Campusthe University of MelbourneSt AlbansVIC 3021Australia Depa.tment of Public Hea.th a.d Clinica. Medicine Section of Sustainable HealthUmea UniversityUmea SE-90187Sweden Depa.tment of Community Medicine UiT the Arctic University of NorwayTromsø9010Norway Depa.tment of Community Medicine a.d Reha.ilita.ion Geriatric MedicineUmea UniversityUmea SE-90187Sweden School of Sport Sciences UiT the Arctic University of NorwayTromsø9010Norway

Purpose:This study wa. a.med to determine a.socia.ions of a.celerometer-determined time a.d bouts of sedenta.y beha.ior,light physica. a.tivity(LPa.,a.d modera.e-to-vigorous Pa.MVPa.with sa.copenia.a.d incident fa.ls over 12 ***:a.tota. of 3334 Swedish 70-yea.-olds were a.sessed for sa.copenia.a. defined by the revised definition of the Europea. Working Group on Sa.copenia.in Older *** were ba.ed on low scores for a.pendicula. lea. ma.s(dua.-energy X-ra. a.sorptiometry),ha.d grip strength,a.d the Timed Up a.d Go *** 7 da.s a.ter ba.eline,tota. time a.d tota. number of bouts(≥10 min of continuous a.tivity a. a.given intensity)of a.tivity performed a. sedenta.y,LPa.a.d MVPa.intensities were a.sessed by *** fa.ls were self-reported 6 months a.d 12 months a.ter ***:Only 1.8%of pa.ticipa.ts ha. proba.le or confirmed *** multiva.ia.le a.justment for other levels of a.tivity,only grea.er MVPa.time wa. a.socia.ed with a.decrea.ed likelihood of ha.ing low a.pendicula. lea. ma.s,low ha.d grip strength,a.d slow Timed Up a.d Go time a. defined by the Europea. Working Group on Sa.copenia.in Older People criteria.a.l pa.d only MVPa.time wa. a.socia.ed with lower likelihood of proba.le or confirmed sa.copenia.odds ra.io=0.80,95%confidence interva.:0.71-0.91 h/week).Simila. a.socia.ions were identified for tota. number of bouts,with no evidence of threshold effects for longer dura.ion of bouts of MVPa.a.tota. of 14%of pa.ticipa.ts reported-1 fa.l,but neither tota. time nor bouts of a.tivity wa. a.socia.ed with incident fa.ls(a.l p>0.05).Conclusion:Higher a.ounts of a.celerometer-determined MVPa.a.e consistently a.socia.ed with a.decrea.ed likelihood of sa.copenia.a.d its components,rega.dless of the length of bouts or a.ounts of sedenta.y beha.ior.

关键词： a.celerometer Fa.ls Older a.ults Physica. a.tivity Sa.copenia

Insomnia.is a.socia.ed to depressive symptoms in pa.ients with chronic hea.t fa.lure

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Open Journa. of Nursing 2013年第1期3卷 33-41页

作者： peter johansson a.ders Brostrom Depa.tment of Ca.diology Linkoping University HospitalLinkopingSweden Depa.tment of Medicine a.d Ca.e Division of Cardiovascular MedicineFaculty of Health SciencesLinkoping UniversityLinkopingSweden Division of Clinica. Neurophysiology Linkoping University HospitalLinkopingSweden Depa.tment of Neuroscience a.d Locomotion Faculty of Health SciencesLinkoping UniversityLinkopingSweden

Introduction: Insomnia.a.d depressive symptoms a.e common a.ong pa.ients with chronic hea.t fa.lure (HF). a.m: The a.m wa. to describe the preva.ence of insomnia.a.d depressive symptoms, a. well a. to exa.ine the a.socia.ion between insomnia.a.d depressive symptoms in pa.ients with HF. Method: a.crosssectiona. descriptive study including 212 pa.ients with HF. a.l pa.ients responded to questionna.res rega.ding sleeping difficulties (Uppsa.a.Sleep Inventory-Chronic Hea.t Fa.lure), da.time sleepiness (Epworth Sleepiness Sca.e) a.d depressive symptoms (The Menta. Hea.th Sca.e). Results: Pa.ients with depressive symptoms (34%) ha., compa.ed to those without, significa.tly more ma.or compla.nts of insomnia.a. indica.ed by the sub-types;non-restora.ive sleep (66% vs. 32%, p a.nta.ning sleep (35% vs. 16%, p = 0.003), difficulty in initia.ing sleep (29% vs. 14%, p = 0.009) a.d ea.ly morning a.a.enings (25% vs. 10%, p = 0.004). The odds ra.io (OR) to suffer from depressive symptoms;were for;non-restora.ive sleep 5.2 (CI 95%, 2.2 - 12.3), difficulties ma.nta.ning sleep 2.5 (CI 95%, 1.2 - 4.9), difficulties in initia.ing sleep 2.2 (CI 95%, 1.1 - 4.4) a.d ea.ly morning a.a.enings 2.4 (CI 95%, 1.1 - 5.4). When ca.egorising insomnia.into three severity groups, 1) non insomnia. 2) mild insomnia. a.d 3) severe insomnia. the OR for depressive symptoms for the mild insomnia.a.d severe insomnia.group were 2.2 (CI 95%, 1.1 - 4.2) a.d 7.4 (CI 95%, 2.4 - 22.8) respectively, compa.ed to the non insomnia.group. Conclusion: Insomnia.is independently a.socia.ed to depressive symptoms. a.sessment of depressive symptoms a.d insomnia.in pa.ients with HF is importa.t since trea.ment could be ta.geted to depressive symptoms only a.d/or to the sleep disturba.ce.

关键词： Congestive Hea.t Fa.lure Insomnia.Disorders Depressive Symptoms

Ma.nesium impla.t degra.a.ion provides immunomodula.ory a.d proa.giogenic effects a.d a.tenua.es peri-impla.t fibrosis in soft tissues

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Bioa.tive Ma.eria.s 2023年第8期26卷 353-369页

作者： Heithem Ben a.a.a.Dia.a.C.Ma.tinez Furqa. a.Sha. a.na.johansson Loo Lena.Ema.uelsson Birgitta.Norlindh Regine Willumeit-Römer Toma.z Plocinski Wojciech Swieszkowski a.ders Pa.mquist Oma. Oma. peter Thomsen Depa.tment of Bioma.eria.s Institute of Clinical SciencesSahlgrenska AcademyUniversity of GothenburgGothenburgSweden Bioma.eria.s Group Materials Design DivisionFaculty of Materials Science and EngineeringWarsaw University of TechnologyWarsawPoland Institute of Meta.lic Bioma.eria.s Helmholtz-Zentrum HereonGeesthachtGermany

Impla.ts ma.e of ma.nesium(Mg)a.e increa.ingly employed in pa.ients to a.hieve osteosynthesis while degra.ing in *** Mg impla.ts a.d Mg^(2+)ha.e been suggested to possess a.ti-infla.ma.ory properties,the clinica.ly observed soft tissue infla.ma.ion a.ound Mg impla.ts is ***,using a.ra. soft tissue model a.d a.1-28 d observa.ion period,we determined the temporo-spa.ia. cell distribution a.d beha.ior in rela.ion to sequentia. cha.ges of pure Mg impla.t surfa.e properties a.d Mg^(2+)*** to nondegra.a.le tita.ium(Ti)impla.ts,Mg degra.a.ion exa.erba.ed initia. *** of Mg degra.a.ion products a. the tissue-impla.t interfa.e,culmina.ing a. 3 d,a.tively initia.ed chemota.is a.d upregula.ed mRNa.a.d protein immunomodula.ory ma.kers,pa.ticula.ly inducible nitric oxide syntha.e a.d toll-like receptor-4 up to 6 d,yet without a.cytotoxic *** va.cula.iza.ion wa. demonstra.ed morphologica.ly,preceded by high expression of va.cula. endothelia. growth *** tra.sition to a.propria.e tissue repa.r coincided with impla.t surfa.e enrichment of Ca.a.d P a.d reduced peri-impla.t Mg^(2+)*** impla.ts revea.ed a.thinner fibrous enca.sula.ion compa.ed with *** deta.led understa.ding of the rela.ionship between Mg ma.eria. properties a.d the spa.ia. a.d time-resolved cellula. processes provides a.ba.is for the interpreta.ion of clinica. observa.ions a.d future ta.loring of Mg impla.ts.

关键词： Ma.nesium Biodegra.a.le impla.ts Infla.ma.ion Foreign-body rea.tion Gene expression Neova.cula.iza.ion

Undia.nosed obstructive sleep a.nea.in hypertensive outpa.ients in prima.y ca.e—a.socia.ions with sleep compla.nts, depressive symptoms a.d globa. perceived hea.th

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Open Journa. of Nursing 2013年第6期3卷 445-452页

作者： a.ders Brostrom Ola.Sunnergren Kristofer a.estedt peter johansson Per Nilsen Bengt Fridlund Eva.Sva.borg Depa.tment of Nursing Science School of Health SciencesJonkoping UniversityJonkopingSweden Depa.tment of Clinica. Neurophysiology Linkoping University HospitalLinkopingSweden Depa.tment of Clinica. a.d Experimenta. Medicine Division of Clinical NeurophysiologyFaculty of Health SciencesLinkoping UniversityLinkopingSweden Depa.tment of ENT Ryhov HospitalJonkopingSweden School of Hea.th a.d Ca.ing Sciences Faculty of HealthSocial Work and Behavioural SciencesLinnaeus UniversityKalmarSweden Depa.tment of Medicine a.d Hea.th Sciences Division of Nursing SciencesFaculty of Health SciencesLinkoping UniversityLinkopingSweden Depa.tment of Ca.diology Linkoping University HospitalLinkopingSweden. Depa.tment of Medicine a.d Hea.th Sciences Division of Cardiovascular MedicineFaculty of Health SciencesLinköping UniversityLinkopingSweden Division of Hea.th Ca.e a.a.ysis Faculty of Health SciencesDepartment of Health and SocietyLinkoping UniversityLinkopingSweden

Objective: 1) To describe the preva.ence of undia.nosed obstructive sleep a.nea.(OSa. a.d depressive symptoms in hypertensive men a.d women below 65 yea.s of a.e, a.d 2) to describe the a.socia.ion of OSa.to subjective sleep compla.nts, depressive symptoms a.d globa. perceived hea.th. Design: Cross-sectiona. design focusing on nursing ca.e outcomes of obstructive sleep a.nea. Setting: Four prima.y ca.e hea.th centres in Sweden. Pa.IENTS: 411 consecutive pa.ients (52% women), mea. a.e 57.9 yea.s (SD 5.9 yea.s), with dia.nosed hypertension (BP > 140/90). Ma.n Outcome Mea.ures: Preva.ence of OSa.a.d depressive symptoms, a.d a.socia.ion of OSa.to sleep compla.nts, depressive symptoms a.d globa. perceived hea.th. RESULTS: Mild, modera.e a.d severe OSa.wa. seen a.ong 29%, 16% a.d 14% of pa.ients, respectively. Depressive symptoms were seen in 16% of the tota. group, with a.higher preva.ence a.ong men, compa.ed to women, 21% vs. 12%. No differences were found rega.ding blood pressure, estima.ed sleep need, sleep sufficiency index, insomnia.symptoms, da.time sleepiness or depressive symptoms with respect to different degrees of OSa. a.nea.hypopnea.index wa. significa.tly a.socia.ed to perceived hea.th a.ter a.justment for gender a.d comorbidities, but when depressive symptoms a.d non-restora.ive sleep were a.ded to the model, 33% of the va.ia.ce in globa. perceived hea.th wa. expla.ned. Conclusion: OSa.is highly preva.ent a.ong pa.ients with hypertension in prima.y ca.e a.d does together with sleep compla.nts a.d depressive symptoms ha.e a.nega.ive impa.t on globa. perceived hea.th. Hypertensive pa.ients without subjective sleep compla.nts or depressive symptoms ma. still ha.e OSa.

关键词： Depression Globa. Perceived Hea.th Hypertension Nursing Ca.e Obstructive Sleep a.nea Sleep Disordered Brea.hing Sleep

Recta. nitric oxide a. bioma.ker in the trea.ment of infla.ma.ory bowel disea.e: Responders versus nonresponders

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World Journa. of Ga.troenterology 2006年第21期12卷 3386-3392页

作者： Tryggve Ljung Sofie Lundberg Ma.k Va.sa.yi Ca.ha.ina.johansson peter T Schmidt Ma. Herulf Jon O Lundberg Per M Hellstr(o|¨)m Depa.tment of Ga.troenterology a.d Hepa.ology Ka.olinska.University Hospita. Site SolnaStockholmSweden Depa.tment of Physiology a.d Pha.ma.ology Ka.olinska.Institutet StockholmSweden

a.M： To explore recta. nitric oxide （NO） a. bioma.ker of trea.ment response in ulcera.ive colitis （UC） a.d Crohn＇s disea.e （CD）, a.d exa.ine rela.ionships between recta. NO, mucosa. expression of NO syntha.es （NOS）, a.d pro-infla.ma.ory cytokines. METHODS： Twenty-two pa.ients with UC a.d 24 with CD were monitored during steroid trea.ment. Recta. NO levels were mea.ured a.d clinica. a.tivities were a.sessed on da.s 1, 3, 7 a.d 28. Mucosa. presence of NOS a.d pro-infla.ma.ory cytokines were a.a.yzed by immunohistochemistry a.d RT-PCR. RESULTS： a.tive UC a.d CD displa.ed ma.kedly increa.ed recta. NO levels （10950 ± 7610 a.d 5 040 ± 1 280 pa.ts per billion （ppb）, respectively） a. compa.ed with the controls （154 ± 71 ppb, P 〈 0.001）. Recta. NO correla.ed wea.ly with disea.e a.tivity in both UC a.d CD （r = 0.34 for UC a.d r = 0.48 for CD, P 〈 0.01）. In 12 pa.ients, a.steroid-refra.tory course led to colectomy. These pa.ients ha. only slightly increa.ed NO levels （UC： 620 ± 270 ppb; CD： 1260 ± 550 ppb） compa.ed to those with a.thera.eutic response （UC： 18860 ± 530 ppb, P 〈 0.001, CD： 10060 ± 3200 ppb, P 〈 0.05）. CONCLUSION： Recta. NO level is a.useful bioma.ker of trea.ment response in IBD a. low NO levels predicts a.poor clinica. response to steroid trea.ment.

关键词： Crohn's disea.e CytokJnes Nitric oxide Steroids Ulcera.ive colitis

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透过TRa.E揭秘美国国债市场

金融市场研究 2018年第12期78卷 86-89页

作者：道格·布雷米歇尔·德·普特多布里斯拉夫·杜波夫迈克尔·弗莱明彼得·约翰逊柯林·琼斯弗兰克·基恩迈克尔·普利亚莉莎·莱德曼托尼·罗德里格斯欧·莎哈尔陈俊君(编译) 纽约联储市场组美联储理事会货币事务司货币与金融市场美联储理事会货币事务司纽约联储研究与统计组不详

美国国债市场被广泛认为是世界上最具深度、流动性最强的证券市场,在全球经济和美联储货币政策实施中扮演着关键角色。尽管如此,官方部门获取的现货市场交易信息一直有限。正如《联合工作报告》(JSR)所强调的,这一数据缺口在2014年10月1... 详细信息

美国国债市场被广泛认为是世界上最具深度、流动性最强的证券市场,在全球经济和美联储货币政策实施中扮演着关键角色。尽管如此,官方部门获取的现货市场交易信息一直有限。正如《联合工作报告》(JSR)所强调的,这一数据缺口在2014年10月15日国债市场闪崩事件的调查中表现得最为突出。

关键词：国债市场美国证券市场货币政策全球经济交易信息现货市场美联储