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Da.a.driving design of high-entropy a.loys for lightweight a.d dyna.ic a.plica.ions

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Science China.Physics,Mecha.ics & a.tronomy) 2024年第2期67卷 10-24页

作者： Ka.xua. Cui Junwei Qia. peter KLia. Yong Zha.g Sta.e Key La.ora.ory for a.va.ced Meta.s a.d Ma.eria.s University of Science and Technology BeijingBeijing 100083China College of Ma.eria.s Science a.d Engineering Taiyuan University of TechnologyTaiyuan 030024China Depa.tment of Ma.eria.s Science a.d Engineering University of TennesseeKnoxville TN 37996USA

The topic of high-entropy a.loys is one of the focus for both physics a.d ma.eria.s ***-entropy a.loys were usua.ly defined a. solid solution a.loys,while the solid solution is different from the tra.itiona. termina. solid solution,beca.se the solid solution without solvent element is the domina.t *** discovery of high-entropy a.loys grea.ly extended the composition spa.e a.d the possibility of crea.ing unique micro-a.d na.o-level structures,which ca. meet the dema.ds of lightweight a.d dyna.ic *** rela.ionship between the pha.es a.d the pa.a.eters for the high-entropy a.loys is ra.her *** da.a.driving design ca. screen the specific high-entropy *** correla.ion between the composition a.d properties of highentropy a.loys ca. be discovered by ma.eria. genetic engineering a.d da.a.science.

关键词： pha.e-forma.ion rules ma.eria.s genetic engineering lightweight high-entropy a.loys dyna.ic properties

Towa.ds implementa.ion of a.loy-specific thermo-fluid modelling for la.er powder-bed fusion of Mg a.loys

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Journa. of Ma.nesium a.d a.loys 2024年第6期12卷 2327-2344页

作者： Moha.ma. Hoseini-a.ha. Mika.l Ersson peter Hedström Depa.tment of Ma.eria. Science a.d Engineering KTH Royal Institute of TechnologyStockholmSE-10044 Sweden

Multi-physics thermo-fluid modeling ha. been extensively used a. a. a.proa.h to understa.d melt pool dyna.ics a.d defect forma.ion a. well a. optimizing the process-rela.ed pa.a.eters of la.er powder-bed fusion(L-PBF).However,its ca.a.ilities for being implemented a. a.relia.le tool for ma.eria. design,where minor cha.ges in ma.eria.-rela.ed pa.a.eters must be a.cura.ely ca.tured,is still in *** the present resea.ch,first,a.thermo-fluid computa.iona. fluid dyna.ics(CFD)model is developed a.d va.ida.ed a.a.nst experimenta. *** the predicted ma.eria. properties of the pure Mg a.d commercia. ZK60 a.d WE43 Mg a.loys,pa.a.etric studies a.e done a.tempting to elucida.e how the difference in some of the ma.eria. properties,i.e.,sa.ura.ed va.or pressure,viscosity,a.d solidifica.ion ra.ge,ca. influence the melt pool *** is found tha. a.higher sa.ura.ed va.or pressure,a.socia.ed with the ZK60 a.loy,lea.s to a.deeper unsta.le keyhole,increa.ing the keyhole-induced porosity a.d eva.ora.ion ma.s *** viscosity a.d wider solidifica.ion ra.ge ca. increa.e the non-uniformity of tempera.ure a.d velocity distribution on the keyhole wa.ls,resulting in increa.ed keyhole insta.ility a.d forma.ion of ***,the WE43 a.loy showed the best beha.ior in terms of defect forma.ion a.d eva.ora.ion ma.s loss,providing theoretica. support to the extensive use of this a.loy in *** summa.y,this study suggests a. a.proa.h to investiga.e the effect of ma.eria.s-rela.ed pa.a.eters on L-PBF melting a.d solidifica.ion,which ca. be extremely helpful for future design of new a.loys suita.le for L-PBF.

关键词： Mg a.loys La.er powder-bed fusion(L-PBF) Melt pool dyna.ics Computa.iona. fluid dyna.ics Fluid flow

Prima.y la.era. sclerosis:more tha. just a. upper motor neuron disea.e

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Neura. Regenera.ion Resea.ch 2024年第9期19卷 1881-1882页

作者： Ee Ling Ta. Ja.min Lope peter Bede Computa.iona. Neuroima.ing Group(CNG) School of MedicineTrinity College DublinIreland Depa.tment of Neurology St James’s HospitalDublinIreland

a.va.ces in clinica. ca.e a.d recent resea.ch a.hievements:Prima.y la.era. sclerosis(PLS)ha. tra.itiona.ly been rega.ded a. a.pure upper motor neuron condition,a.view perpetua.ed by most medica. textbooks.

关键词： sclerosis clinica. tra.itiona.ly

Benchma.king visua. SLa. methods in mirror environments

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Computa.iona. Visua. Media 2024年第2期10卷 215-241页

作者： peter Herbert Jing Wu Ze Ji Yu-Kun La. School of Computer Science a.d Informa.ics Cardiff UniversityAbacws BuildingSenghennydd RdCardiff CF244AGUK School of Engineering Cardiff UniversityQueen’s BuildingsThe ParadeCardiff CF243AAUK

Visua. simulta.eous loca.isa.ion a.d ma.ping(vSLa.)finds a.plica.ions for indoor a.d outdoor na.iga.ion tha. routinely subjects it to visua. complexities,pa.ticula.ly mirror *** effect of mirror presence(time visible a.d its a.era.e size in the fra.e)wa. hypothesised to impa.t loca.isa.ion a.d ma.ping performa.ce,with systems using direct techniques expected to perform ***,a.da.a.et,MirrEnv,of ima.e sequences recorded in mirror environments,wa. collected,a.d used to eva.ua.e the performa.ce of existing representa.ive *** ORB-SLa.3 a.d BundleFusion a.pea. to show modera.e degra.a.ion of a.solute tra.ectory error with increa.ing mirror dura.ion,whilst the rema.ning results did not show significa.tly degra.ed loca.isa.ion *** mesh ma.s genera.ed proved to be very ina.cura.e,with rea. a.d virtua. reflections colliding in the reconstructions.a.discussion is given of the likely sources of error a.d robustness in mirror environments,outlining future directions for va.ida.ing a.d improving vSLa. performa.ce in the presence of pla.a. *** MirrEnv da.a.et is a.a.la.le a. https://***/10.17035/d.2023.0292477898.

关键词： visua. simulta.eous loca.isa.ion a.d ma.ping(vSLa.) mirror loca.isa.ion ma.ping reflection da.a.e

Boosting liver regenera.ion: kina.e inhibitor a. a.new tool to prevent liver fa.lure

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Signa. Tra.sduction a.d Ta.geted Thera.y 2024年第8期9卷 3145-3146页

作者： a.na.Sichler Norbert Huser Kla.s-peter Ja.ssen Depa.tment of Surgery School of Medicine and HealthTechnical University of MunichMunichGermany

In a.recent ma.uscript in Cell,a.first-in-cla.s sma.l molecule inhibitor of the kina.e MKK4(mitogen-a.tiva.ed protein kina.e kina.e 4)wa. described tha. grea.ly enha.ces liver regenera.ion a.ter pa.tia. hepa.ectomy in a.ima. models,with a. excellent sa.ety profile in huma.s.1 The findings of Zwirner et *** promise to a.ter the clinica. ma.a.ement of liver fa.lure in critica.ly ill pa.ients.

关键词： liver a.. clinica.

Prefrontocortica. a.trocytes Regula.e Domina.ce Hiera.chy in Ma.e Mice

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Neuroscience Bulletin 2024年第3期40卷 415-417页

作者： Yong Ta.g Ha.-Ya. Yin peter Illes School of a.upuncture a.d Tuina Chengdu University of Traditional Chinese MedicineChengdu 610075China Interna.iona. Joint Resea.ch Center on Purinergic Signa.ing Chengdu University of Traditional Chinese MedicineChengdu 610075China Rudolf Boehm Institute for Pha.ma.ology a.d Toxicology University of Leipzig04107 LeipzigGermany

Socia. hiera.chy is a.genera. self-orga.iza.iona. scheme in a.ima. societies in which ea.h member a.hieves a.certa.n sta.us of domina.ion or subordina.ion when getting a.cess to resources,with profound consequences for surviva.,hea.th,reproductive success,a.d multiple beha.iors[1,2].The prefronta. cortex(PFC)wa. recognized a. a.centra. regula.or of neurona. circuits determining the forma.ion of socia. hiera.chy;bra.n a.ea. upstrea. of the PFC convey informa.ion a.out socia. sta.us,a.d downstrea. bra.n regions execute domina.ce beha.ior[3].Socia. deficits ha.e been suggested to be due to a. eleva.ion of excita.ory/inhibitory(E/l)ba.a.ce within the mouse dorsomedia.(dm)PFC[4].a.compensa.ory increa.e of inhibitory cell excita.ility pa.tia.ly rescued socia. deficits ca.sed by such a.disturba.ce of E/l ba.a.ce.

关键词： consequences hiera.chy determining

Multiple sclerosis drug repurposing for neuroregenera.ion

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Neura. Regenera.ion Resea.ch 2024年第3期19卷 507-508页

作者： peter Göttle Micha.l Dietrich Pa.rick Küry Depa.tment of Neurology Medical FacultyHeinrich-Heine UniversityDüsseldorfGermany

Multiple sclerosis(MS)is a. a.toimmune disorder of the centra. nervous system(CNS)a.d is prima.ily cha.a.terized by immune cell infiltra.ion lea.ing to rela.ses followed by remission pha.es a.d a.disea.e course turning progressive over time with neurodegenera.ive processes ta.ing over(a.in a.d Hersh,2023).Of note,beyond rela.se-a.socia.ed worsening ea.ly in disea.e progression independent of rela.se a.tivity ma. a.ise independently of rela.se a.tivity a.d ca. occur in a.l ***-media.ed da.a.e of myelin shea.hs a.d the subsequent loss of ma.ure oligodendrocytes a.e resulting in impa.red a.ona. integrity,neurodegenera.ion a.d a.counts for irreversible neurona. da.a.e(Kuhlma.n et a..,2023).The current la.dsca.e of a.a.la.le disea.e-modifying thera.ies comprises ma.nly immunomodula.ory drugs tha. effectively diminish rela.ses a.d slow down progression a. the onset form of the disea.e,na.ely rela.sing MS(RMS).In this rega.d,a.number of drugs ha.e been a.proved a. disea.e-modifying thera.ies for MS by US Food a.d Drug a.ministra.ion a.d Europea. Medicines a.encies(Box 1).

关键词： drugs impa.red irreversible

Chemica. short-ra.ge-order induced multisca.e strengthening in refra.tory medium entropy a.loys

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a.ta.Mecha.ica.Sinica 2024年第6期40卷 41-49页

作者： Weizheng Lu Ya.g Chen Jia.Li peter K.Lia. Qihong Fa.g Sta.e Key La.ora.ory of a.va.ced Design a.d Ma.ufa.turing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha410082China Depa.tment of Ma.eria.s Science a.d Engineering The University of TennesseeKnoxvilleTN37996USA

High/medium entropy a.loys(H/MEa.)a.e genera.ly possible to exhibit chemica. short-ra.ge order(SRO).However,the complex role of SRO on mecha.ica. properties from na.o-sca.e to meso-sca.e is still cha.lenging so ***,we study the strengthening mecha.ism a.d deforma.ion beha.ior in a.model body-centered-cubic HfNbTa.MEa.by using a.omic-sca.e molecula. dyna.ics,micro-sca.e disloca.ion dyna.ics,a.d meso-sca.e crysta. pla.ticity finite *** SRO inhibits disloca.ion nuclea.ion a. the a.omic sca.e,improving the flow *** SRO-induced ultra.trong loca. stress fluctua.ion grea.ly improves the micro-sca.e disloca.ion-ba.ed strength by the significa.t disloca.ion forest ***,the Ta.rich loca.ly ordered structure lea.s to a. obvious heterogeneous stra.n a.d stress pa.titioning,which forms a.strong stra.n gra.ient in the a.ja.ent gra.n interiors a.d contributes to the strong ba.k-stress-induced stra.n ha.dening.

关键词： High/medium entropy a.loys Multisca.e strengthening Chemica. short-ra.ge order

Fluidiza.ion a.d Tra.sport of Vibra.ed Gra.ula. Ma.ter:a.Review of La.dma.k a.d Recent Contributions

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Fluid Dyna.ics & Ma.eria.s Processing 2024年第1期20卷 1-29页

作者： peter Wa.son Seba.tien Vincent Bonnieu Ma.cello La.pa Depa.tment of Mecha.ica. a.d a.rospa.e Engineering University of StrathclydeGlasgowUK Europea. Spa.e a.ency European Space Research and Technology CentreNoordwijkNetherland

We present a.short retrospective review of the existing litera.ure a.out the dyna.ics of(dry)gra.ula. ma.ter under the effect of *** ma.n objective is the development of a. integra.ed resource where vita. informa.ion a.out pa.t findings a.d recent discoveries is provided in a.single *** a.tention is pa.d to those works where successful synthetic routes to a.-yet unknown phenomena.were *** la.dma.k results a.e a.a.yzed,while smoothly blending them with a.history of the field a.d introducing possible ca.egoriza.ions of the preva.ent *** no cla.sifica.ion is perfect,a.d it is ha.d to distilla.e genera. properties out of specific observa.ions or rea.iza.ions,two possible wa.s to interpret the existing results a.e defined a.cording to the type of forcing or the emerging(ensuing)regime of *** pa.ticula.,first results concerning the ca.e where vibra.ions a.d gra.ity a.e concurrent(vertica. sha.ing)a.e exa.ined,then the compa.ion situa.ion with vibra.ions perpendicula. to gra.ity(horizonta. sha.ing)is *** cla.ses a.e introduced a. follows:(1)Regimes where sa.d self-orga.izes lea.ing to highly regula. geometrica.“pulsa.ing”pa.terns(thin la.er ca.e);(2)Regimes where the ma.eria. undergoes“fluidiza.ion”a.d develops a. interna. multicellula. convective sta.e(tick la.ers ca.e);(3)Regimes where the free interfa.e sepa.a.ing the sa.d from the overlying ga. cha.ges inclina.ion or develops a.kind a.pa.terned configura.ion consisting of sta.le va.leys a.d mounta.ns or tra.elling wa.es;(4)Regimes where segrega.ion is produced,i.e.,pa.ticles of a.given size tend to be sepa.a.ed from the other gra.ns(deep conta.ners).Where possible,a. a.a.ogy or pa.a.lelism is dra.n with respect to the compa.ion field of fluid-dyna.ics for which the a.sumption of“continuum”ca. be a.plied.

关键词： Gra.ula. ma.eria.s vibra.ions fluidiza.ion flowa.ility symmetry brea.ing