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Multi-scale characterizations of colon polyps via computed tomographic colonography

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Visual Computing for Industry,Biomedicine,and Art 2019年第1期2卷 245-256页

作者： Weiguo Cao Marc j.Pomeroy Yongfeng Gao Matthew A.Barish Almas F.Abbasi perry j.pickhardt Zhengrong Liang The Department of Radiology Stony Brook UniversityStony BrookNY 11794USA The Departments of Radiology and Biomedical Engineering Stony Brook UniversityStony BrookNY 11794USA The Department of Radiology School of MedicineUniversity of WisconsinMadisonWI 53792USA

Texture features have played an essential role in the field of medical imaging for computer-aided *** gray-level co-occurrence matrix(GLCM)-based texture descriptor has emerged to become one of the most successful feature sets for these *** study aims to increase the potential of these features by introducing multi-scale analysis into the construction of GLCM texture *** this study,we first introduce a new parameter-stride,to explore the definition of *** we propose three multi-scaling GLCM models according to its three parameters,(1)learning model by multiple displacements,(2)learning model by multiple strides(LMS),and(3)learning model by multiple *** models increase the texture information by introducing more texture patterns and mitigate direction sparsity and dense sampling problems presented in the traditional Haralick *** further analyze the three parameters,we test the three models by performing classification on a dataset of 63 large polyp masses obtained from computed tomography colonoscopy consisting of 32 adenocarcinomas and 31 benign ***,the proposed methods are compared to several typical GLCM-texture descriptors and one deep learning *** obtains the highest performance and enhances the prediction power to 0.9450 with standard deviation 0.0285 by area under the curve of receiver operating characteristics score which is a significant improvement.

关键词： Colon cancer Computed tomographic colonography Polyp characterization Texture feature

CT肝脏偶发病灶管理--美国放射学院(ACR)偶发病变委员会白皮书

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放射学实践 2018年第2期33卷 115-122页

作者： Richard M.Gore perry j.pickhardt Koenraad j.Mortele Elliot K.Fishman jeanne M.Horowitz Claus j.Fimmel Mark S.Talamonti Lincoln L.Berland Pari V.Pandharipande 宋彬严福华杨正汉叶惠义姜慧杰不详四川大学华西医院放射科成都上海交通大学医学院附属瑞金医院放射科上海首都医科大学附属北京友谊医院放射科北京中国人民解放军总医院放射科北京哈尔滨医科大学附属第二医院放射科哈尔滨

美国放射学院(American College of Radiology,ACR)偶发病变委员会(Incidental Findings Committee,IFC)发布了关于肝脏CT偶发病灶的管理建议。这些建议是对ACR 2010年胰腺、肾上腺、肾脏及肝脏偶发病变管理白皮书中肝脏部分的更新。该... 详细信息

美国放射学院(American College of Radiology,ACR)偶发病变委员会(Incidental Findings Committee,IFC)发布了关于肝脏CT偶发病灶的管理建议。这些建议是对ACR 2010年胰腺、肾上腺、肾脏及肝脏偶发病变管理白皮书中肝脏部分的更新。该方案由肝脏亚组委员会(包括5位腹部影像学专家,1位肝病学专家和1位肝胆外科医生)制定。这些建议结合已发表的文献及专家意见,并最终达成专家共识。该方案主要基于患者特征及影像学特征对肝脏病灶进行分类,评估终点为某种良性诊断或具体的随访建议。该方案适用于大多数病理或临床情况,但并非所有情况均适用。该方案旨在通过提供肝脏偶发病灶管理意见以提升医疗质量。

关键词：偶发病变肝囊肿血管瘤局灶性结节增生肝转移肝细胞癌

Managing Student Protest in Republican China： Yenching and St. john＇s Compared

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Frontiers of History in China 2013年第1期8卷 3-31页

作者： Elizabeth j. perry Department of Government Harvard University Cambridge MA 02138 USA

Although similar in many respects, the two major Christian universities in Republican China adopted markedly different approaches to the common challenge of student nationalism. Case studies of the May Thirtieth Movement at St. john＇s University and the December Ninth Movement at Yenching University illustrate the consequences of these sharply contrasting experiences. Whereas St. john＇s was crippled by May Thirtieth, Yenching escaped December Ninth relatively unscathed. The explanation for the contrast, this paper suggests, lies not in any fundamental disagreement in the mission of the two universities or the philosophies of their famous and forceful presidents. It must be sought instead in the different campus cultures in which the student protests originated, and in the urban micro-environments in which the two universities were located： treaty-port Shanghai and post-imperial Peking.

关键词： student protest nationalism Christian universities higher education

The role of the N-methyl-D-aspartate receptor in the proliferation of adult hippocampal neural stem and precursor cells

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Science China(Life Sciences) 2014年第4期57卷 403-411页

作者： TAYLOR Chanel j HE RongQiao BARTLETT perry F Queensland Brain Institute The University of QueenslandBrisbane Institute of Biophysics Chinese Academy of Sciences

New neurons are continuously generated from resident pools of neural stem and precursor cells(NSPCs)in the adult *** are multiple pathways through which adult neurogenesis is regulated,and here we review the role of the N-methyl-D-aspartate receptor(NMDAR)in regulating the proliferation of NSPCs in the adult ***-dependent learning tasks,enriched environments,running,and activity-dependent synaptic plasticity,all potently up-regulate hippocampal NSPC *** first consider the requirement of the NMDAR in activity-dependent synaptic plasticity,and the role the induction of synaptic plasticity has in regulating NSPCs and newborn *** address how specific NMDAR agonists and antagonists modulate proliferation,both in vivo and in vitro,and then review the evidence supporting the hypothesis that NMDARs are present on *** believe it is important to understand the mechanisms underlying the activation of adult neurogenesis,given the potential that endogenous stem cell populations have for repopulating the hippocampus with functional new *** conditions such as age-related memory decline,neurodegeneration and psychiatric disease,mature neurons are lost or become defective;as such,stimulating adult neurogenesis may provide a therapeutic strategy to overcome these conditions.

关键词： adult neurogenesis stem cell precursor cell NMDA receptor hippocampus synaptic plasticity long-term potentiation(LTP)

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人权的道德性

人权法学 2024年第2期3卷 1-43,151,152页

作者： [美]迈克尔·j佩里张伟(译) 刘思源(译) 美国埃默里大学中国政法大学人权研究院

《世界人权宣言》体现了一种特殊的道德属性:人权的道德性。文章将探讨几个有关道德的问题,其中最首要的基本问题是:在人权的道德性存在的前提下,其应当以何种理由被接受而非拒绝。文章将对道德平等权和道德自由权两类人权进行详细解释... 详细信息

《世界人权宣言》体现了一种特殊的道德属性:人权的道德性。文章将探讨几个有关道德的问题,其中最首要的基本问题是:在人权的道德性存在的前提下,其应当以何种理由被接受而非拒绝。文章将对道德平等权和道德自由权两类人权进行详细解释,进而探究其对堕胎和同性婚姻这两项人权争议产生的影响。

关键词：人权道德堕胎同性婚姻

A review of geometry-confined perovskite morphologies:From synthesis to efficient optoelectronic applications

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Nano Research 2022年第8期15卷 7402-7431页

作者： jinshuai Zhang perry Ping Shum Lei Su School of Engineering and Materials Science Queen Mary University of LondonLondon E14NSUK College of Engineering Department of Electrical and Electronic EngineeringSouthern University of Science and TechnologyShenzhen 518055China

With the continuous study of metal halide perovskite,geometry-confined technologies have been widely applied to reduce the material dimensionality and to produce pre-designed structures,which can tune optical reflectance,scattering,and absorption,thereby optimizing the performance of perovskite-based optoelectronic devices and improving their commercial *** morphologies of perovskite active layer play a pivotal role in optoelectronic properties and the resulting device *** this review,we systematically summarized recent progress in the preparation and manufacture of various perovskite geometry-confined morphologies,as well as their promising advances in different optoelectronic applications,including photodetectors,solar cells(SCs),lasers,and light-emitting diodes(LEDs).In addition,the remaining challenges and further improvements of preparation unique geometry-confined perovskite morphologies for next-generation high quality optoelectronic devices are discussed.

关键词： geometry confinement metal halide perovskite controllable morphology optoelectronics

Ubiquitin-Specific Protease 14 （UBP14） Is Involved in Root Responses to Phosphate Deficiency in Arabidopsis

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Molecular Plant 2010年第1期3卷 212-223页

作者： Wen-Feng Li Paula j. perry Nulu N. Prafulla Wolfgang Schmidt Institute of Plant and Microbial Biology Academia Sinica 115 Taipei

A mutant isolated from a screen of EMS-mutagenized Arabidopsis lines, per1, showed normal root hair development under control conditions but displayed an inhibited root hair elongation phenotype upon Pi deficiency. Additionally, the per1 mutant exhibited a pleiotropic phenotype under control conditions, resembling Pi-deficient plants in several aspects. Inhibition of root hair elongation upon growth on low Pi media was reverted by treatment with the Pi analog phosphite, suggesting that the mutant phenotype is not caused by a lack of Pi. Reciprocal grafting experiments revealed that the mutant rootstock is sufficient to cause the phenotype. Complementation analyses showed that the PER1 gene encodes an ubiquitin-specific protease, UBP14. The mutation caused a synonymous substitution in the 12th exon of this gene, resulting in a lower abundance of the UBP14 protein, probably as a consequence of reduced translation efficiency. Transcriptional profiling of per1 and wild-type plants subjected to short-term Pi starvation revealed genes that may be important for the signaling of Pi deficiency. We conclude that UBP14 function is crucial for adapting root development to the prevailing local availability of phosphate.

关键词： Phosphate deficiency root hairs ubiquitin-specific protease root development.

Spatial targeting evaluation of energy and environmental performance of waste-to-energy processing

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Frontiers of Chemical Science and Engineering 2018年第4期12卷 731-744页

作者： Petar S.Varbanov Timothy G.Walmsley Yee V.Fan jiri j.Klemes Simon j.perry Sustainable Process Integration Laboratory NETME CentreFaculty of Mechanical EngineeringBmo University of Technology61669 Bmo Czech Republic Centre for Process Integration School of Chemical Engineering and Analytical ScienceThe University of ManchesterManchester M I 3ALUK

Waste-to-energy supply chains are important potential contributors to minimising the environmental impacts of municipal solid waste by reducing the amounts of waste sent to landfill, as well as the fossil fuel consumption and environmental footprints. Accounting for the spatial and transport properties of the waste-to-energy supply chains is crucial for understanding the problem and improving the supply chain designs. The most significant challenge is the distributed nature of the waste generation and the household energy demands. The current work proposes concepts and a procedure for targeting the size of the municipal solid waste collection zone as the first step in the waste-to-energy supply chains synthesis. The formulated concepts and the provided case study reveal trends of reducing the net greenhouse gas savings and energy recovery by increasing the collection zone size. Population density has a positive correlation with the greenhouse gas saving and energy recovery performance. For smaller zone size the energy recovery from waste approaches and in some cases may surpass the energy spent on waste transportation. The energy recovery and greenhouse gas savings remain significant even for collection zones as large as 200 km2. The obtained trends are discussed and key directions for future work are proposed.

关键词： waste-to-energy supply chain optimisation GHG savings energy recovery ratio

Visualizing the microtubule-associated protein tau in the nucleus

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Science China(Life Sciences) 2014年第4期57卷 422-431页

作者： LU jing LI Ting HE RongQiao BARTLETT perry F GTZ jürgen Clem jones Centre for Ageing Dementia Research Queensland Brain Institute The University of QueenslandBrisbane Institute of Biophysics Chinese Academy of Sciences

Although tau is mainly known as an axonal microtubule-associated protein,many studies indicate that it is not restricted to this subcellular *** tau’s subcellular distribution,however,is not trivial as is evident from transgenic mouse *** human tau is over-expressed,it can be immunohistochemically localized to axons and the somatodendritic domain,modeling what is found in neurodegenerative diseases such as Alzheimer’s ***,in wild-type mice,despite its abundance,tau is difficult to visualize even in the *** is even more challenging to detect this protein in the nucleus,where tau has been proposed to protect DNA from *** establish a framework for future studies into tau’s nuclear functions,we compared several methods to visualize endogenous nuclear tau in cell lines and mouse *** depending on the fixation and permeabilization protocol,we were able to detect nuclear tau in SH-SY5Y human neuroblastoma cells,we failed to do so in N2a murine neuroblastoma *** a second method we used subcellular fractionation of mouse tissue and found that in the nucleus tau is mainly present in a hypophosphorylated *** either full-length or truncated human tau was expressed,both accumulated in the cytoplasm,but were also found in the nuclear *** subcellular fractionation methods have their limitations,we finally isolated nuclei to probe for nuclear tau and found that the nuclei were free of cytoplasmic *** our analysis identifies several protocols for detecting tau in the nucleus where it is found in a less phosphorylated form.

关键词： Alzheimer's disease fractionation microtubule-associated protein neuroblastoma nucleus phosphorylation tau