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MIS 5e sea sur.ace temper.tur. estimation;a multi-pr.xy appr.ach using a mar.ne macr.fossil assemblage(Mar.Piccolo,Gulf of Tar.nto,Souther. Italy)

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Jour.al of Palaeogeogr.phy 2024年第2期13卷 327-350页

作者： Pier.uigi Santagati Edoar.o perri Mar.a Pia Ber.asconi Mar.o Bor.elli Salvator. Guer.ier. Salvator. Cr.telli Dipar.imento di Biologia Ecologia e Scienze della TerraUniversita della Calabriavia Pietro Bucci87036 Arcavacata di RendeCosenzaItaly Dipar.imento di Ingegner.a Ambientale Universita della Calabriavia Pietro Bucci87036 Arcavacata di RendeCosenzaItaly

It is r.por.ed a multi-pr.xy palaeoclimatic study conducted on a MIS 5e calcar.nite fr.m the Mar.Piccolo Basin(MP),Gulf of Tar.nto(GT)(Centr.l Mediter.anean).The calcar.nite r.tur.ed a r.ch malacofauna consisting of 120 extant species,including four.of the tr.pical Senegalese Fauna,today absent in the *** biogeogr.phic-climatic affinity of the assemblage shows,compar.d to today,a double per.entage of war. affinity species,while the cold affinity species ar. near.y equally r.pr.sented,indicating a war.er.but not str.ctly tr.pical *** is confir.ed by the most r.cur.ing pr.fer.ed SST r.nges of the assemblage,indicating an aver.ge of 20℃.The skeletal compositions of five well-pr.ser.ed molluscan and cor.l specimens wer. analyzed for.tr.ce elements and stable isotopes for.fur.her.mean SST *** the compar.son of the r.sults of sever.l equations available in liter.tur.,it appear. that only some SST estimations ar. r.alistic,conver.ing into similar.values of,on aver.ge,20.8±0.9℃.Consider.ng all the used pr.xies,the MIS 5e SST differ.nce compar.d to today falls in the r.nge 1.2—2.0℃for.the GT(being a mor. r.asonable scenar.o)and 2.0—2.8℃for.the *** is not a fir.ly tr.pical-like SST setting as suggested by the sole Senegalese fauna,indicating at least 2.7℃—3.5℃mor. than today’s GT and MP,*** appr.ximations and assumptions made for.obtaining SST values with any single pr.xy indicate the need of a multi-pr.xy appr.ach to define the best SST estimation.

关键词： MiS 5e Sea sur.ace temper.tur. Palaeoclimate pr.xy Fossil fauna Gulf of Tar.nto

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阿尔茨海默病与额叶型额颞痴呆:一组认知功能和行为特征的简短测验

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世界核心医学期刊文摘(神经病学分册) 2006年第2期 34-35页

作者： perri r. Koch G. Car.esimo G.A. 李一明 Fondazione Ir.CS Santa Lucia Via Ardeatina 306 00179 Roma Italy

The aim of this study was to investigate whether.a br.ef neur.psychological batter. consisting of a limited number.of cognitive tests and an evaluation of the behaviour.l domains intended to discr.minate between fr.ntotempor.l dementia (fv-FTD) and Alzheimer.s disease (AD), constitutes a useful instr.ment for.making a differ.ntial clinical diagnosis between these two pathologies. Nineteen fv-FTD and 39 AD patients wer. compar.d on cognitive tasks (assessing memor., executive functions, language and constr.ctional pr.xis) and on the NPI behaviour.l assessment. A stepwise discr.minant analysis was per.or.ed to identify the linear.combination of cognitive and behaviour.l measur.s able to best discr.minate between the two gr.ups. One test for.each of the investigated cognitive domains (Delayed Pr.se r.call, FAS ver.al fluency, Boston naming test, r.y's Figur. A Copy) and the four.subscales of the Neur.psychiatr. Inventor. (NPI) which best differ.ntiated between fv-FTD and AD patients (apathy, disinhi bition, euphor.a, aber.ant motor.behaviour. wer. used. The analysis selected r.y's Figur. A Copy, FAS ver.al fluency and NPI apathy subscale as the best discr. minants between fv-FTD and AD patients. The final equation assigned 73.7%of th e fv-FTD patients and 94.7%of the AD patients to the cor.ect diagnostic gr.up. A validation study conducted on a new independent sample of 11 fv-FTD and 22 A D patients confir.ed the high sensitivity (82.6 %) and specificity (81.8%) of the diagnostic equation in assigning fv-FTD and AD patients to the cor.ect deme ntia gr.up. Although both cognitive and behaviour.l differ.nces exist between FT D and AD, pr.vious studies have aimed at differ.ntiating the two pathologies by consider.ng the two aspects separ.tely and discr.minant analyses wer. focused on ly on neur.psychological or.neur.psychiatr.c evaluations. The pr.sent r.sults em phasise the impor.ance of r.ting both cognitive and behaviour.l clinical featur. s of the two syndr.mes as obj

关键词：额颞痴呆 FTD AD 患者认知功能阿尔茨海默病

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Chemical and miner.-petr.gr.phical changes on gr.nulite r.cks affected by weather.ng pr.cesses

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Fr.ntier. of Ear.h Science 2019年第2期13卷 247-261页

作者： Car.ine APOLLAr. Fr.ncesco perri Emilia LE PEr. Ilar.a FUOCO Ter.sa Cr.TELLI DiBEST University of Calabria1-87036 Arcavacata di Rende (CS)Italy

The pur.ose of this wor. is to study the weather.ng pr.cesses of the gr.nulite r.cks of the Ser.e Massif (souther. Calabr.a,Italy) using a multidisciplinar. appr.ach based on field studies,geochemical modeling,and miner.?petr.gr.phical *** gr.nulite r.cks ar. plagioclase-r.ch with minor.amphibole,clinopyr.xene,or.hopyr.xene,biotite,and gar.et and their.textur. ar. *** r.action path modeling was per.or.ed to simulate the evolution of gr.undwater. upon inter.ction with local gr.nulite by means of the softwar. package EQ3/6,ver.ion *** wer. per.or.ed in kinetic (time) mode under.a closed system at a constant temper.tur. of 11.5℃,(which r.pr.duces the aver.ge temper.tur. of local ar.a) and fixing the fugacity of CO2 at 10-2.34 bar.(mean value).Dur.ng the most advanced stage of weather.ng the main miner.logical changes ar.: par.ial destr.ction and tr.nsfor.ation of biotite and plagioclase associated with neofor.ation of fer.uginous pr.ducts and secondar. clay miner.ls pr.ducing a change in the or.gin r.ck *** secondar. solid phases obser.ed dur.ng the geochemical modeling (kaolinite,ver.iculite and fer.ihydr.te) ar. similar.to those found in this natur.l ***,the soil-like mater.al mainly char.cter.zed by mostly sand to gr.vel gr.in-size fr.ctions is the final r.sult of the weather.ng pr.cesses.

关键词： Ser.e Massif gr.nulitic r.cks miner.logy petr.gr.phy weather.ng pr.file r.action path-modeling

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Non invasive evaluation of liver.fibr.sis in paediatr.c patients with nonalcoholic steatohepatitis

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Wor.d Jour.al of Gastr.enter.logy 2006年第48期12卷 7821-7825页

作者： Angelo Iacobellis Matilde Mar.ellini Angelo Andr.ulli Fr.ncesco perri Gioacchino Leandr. r.ta Devito Valer.o Nobili Division of Gastr.enter.logy Hospital "Casa Sollievo della Sofferenza" IRCCS San Giovanni Rotondo Italy Liver.Unit Bambino Gesu' Children's Hospital Rome Italy Division of Gastr.enter.logy "De Bellis" Hospital IRCCS Castellana Grotte Italy Pathology Depar.ment Bambino Gesu' Childr.n's Hospital Rome Italy

AIM: To identify the independent pr.dictor. of hepatic fibr.sis in 69 childr.n with nonalcoholic steatohepatitis (NASH) due to nonalcoholic fatty liver.disease (NAFLD). METHODS: All patients with clinically suspected NASH under.ent liver.biopsy as a confir.ator. test. The following clinical and biochemical var.ables at baseline wer. examined as likely pr.dictor. of fibr.sis at histology: age, body mass index (BMI), systolic blood pr.ssur. (SBP), dyastolic blood pr.ssur. (DBP), fasting glucose, fasting insulin, homeostatic model assessment for.insulin r.sistence (HOMA-Ir., cholester.l, tr.glicer.des, alanine aminotr.nsfer.se (ALT), aspar.ate aminotr.nsfer.se (AST), AST/ALT r.tio, gamma glutamil tr.nsfer.se (GT), platelet count, pr.thr.mbin time (PT). r.SULTS: At histology 28 (40.6%) patients had no fibr.sis and 41 (59.4%) had mild to br.dging fibr.sis. At multivar.ate analysis, BMI > 26.3 was the only independent pr.dictor.of fibr.sis (Or.= 5.85, 95% CI = 1.6-21). CONCLUSION: BMI helps identify childr.n with NASH who might have fibr.tic deposition in the liver.

关键词： Nonalcoholic steatohepatitis Obesity Bodymass index Liver.fibr.sis Non invasive diagnosis

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Mitochondr.al dysfunction in Par.inson＇s disease： a possible tar.et for.neur.pr.tection

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Fr.ntier. in Biology 2014年第6期9卷 489-503页

作者： Jacqueline A. GLEAVE Peter.D. perri Joanne E. NASH Centr. for.Neur.biology of Str.ss Department of Biological Sciences University of Toronto Scarborough Toronto Ontario M1C1A4Canada

Mitochondr.a ar. dynamic or.anelles which ar. r.quir.d for.maintaining cellular.homeostasis. Thus, it is not sur.r.sing that ir.egular.ties in mitochondr.al function r.sult in cellular.damage and ar. linked with neur.degener.tive diseases, such as Par.inson＇s disease. Evidence that mitochondr.al dysfunction is key to the pathogenesis of Par.inson＇s disease is founded in studies in post-mor.em tissue fr.m patients with Par.inson＇s disease, and also fr.m genetic studies stemming fr.m patients with familial Par.inson＇s disease. Whether.tr.gger.d by envir.nmental or.genetic factor., mitochondr.al dysfunction occur. ear.y in the pathogenic pr.cess, and is centr.l to Par.inson＇s disease pathology. As such, tar.eting the mitochondr.a to slow or.halt disease pr.gr.ssion is an attr.ctive str.tegy for.disease-modifying agents in Par.inson＇s disease. Indeed, sever.l ther.pies which tar.et the mitochondr.a have been investigated as neur.pr.teetive tr.atments for.Par.inson＇s disease. This r.view will discuss the evidence suppor.ing mitochondr.al dysfunction in Par.inson＇s disease pathology as well as tr.atment str.tegies that tar.et the mitochondr.a.

关键词： Par.inson's disease mitochondr.a oxidative str.ss lysosome UPS

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Compar.son of a monoclonal antigen stool test (Hp StAr. with the ^(13)C-ur.a br.ath test in monitor.ng Helicobacter.pylor. er.dication ther.py

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Wor.d Jour.al of Gastr.enter.logy 2005年第37期11卷 5878-5881页

作者： Fr.ncesco perri Michele Quitadamo r.salba r.cciar.i Ada Piepoli r.sa Cotugno Annamar.a Gentile Alber.o Pilotto Angelo Andr.ulli Depar.ment of Inter.al Medicine Gastr.enter.logy Unit "Casa Sollievo della Sofferenza" Hospital IRCCS San Giovanni Rotondo Italy Depar.ment of Inter.al Medicine Ger.atr.cs Unit "Casa Sollievo della Sofferenza" Hospital IRCCS San Giovanni Rotondo Italy

AIM： To evaluate the agr.ement between a mAb-based stool test （HP STAr. and the ur.a br.ath test （UBT） in monitor.ng （H pylon） infection after.er.dication ther.py. METHODS： Patients with discor.ant r.sults on UBT and Hp STAr.under.ent endoscopy with biopsies for.r.pid ur.ase test, cultur., and histology to confir. H pylor. status. r.SULTS： Among 250 patients （50±14 year.）, 240 （96.0%） had concor.ant UBT and Hp STAr.tests with a significant cor.elation between DOB and A values （r.= 0.87; P〈0.0001）. The r.maining 10 （4.0%） patients had discor.ant tests （positive Hp STAr.and negative UBT） with the Hp STAr.inaccur.te in five cases （false positive） and UBT inaccur.te in the other.five cases （false negative）. The “maximal expected” sensitivity, specificity, ＋PV, -PV, ＋Lr. and -Lr.wer. 91%, 100%, 100%, 97.4%, ∞, and 8.2 r.spectively, for.the UBT, and 100%, 97.4%, 91%, 100%, 38.8, and 0, r.spectively, for.the Hp STAr. Over.ll accur.cy for.both tests was 98%. CONCLUSION： Both the UBT and the Hp StAr.ar. equally accur.te in monitor.ng H pylor. infection. Nowadays, the choice of the “best” non-invasive H pylor. test in the post-tr.atment setting should be done not only in ter.s of diagnostic accur.cy but also in view of cost and local facilities.

关键词： Diagnosis Helicobacter.pylor Stool antigen test Ur.a br.ath test

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Lack of association between UGT1A7,UGT1A9,Ar.,SPINK1 and CFTr.gene polymor.hisms and pancr.atic cancer.in Italian patients

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Wor.d Jour.al of Gastr.enter.logy 2006年第39期12卷 6343-6348页

作者： Ada Piepoli Annamar.a Gentile Mar.a r.sa Valvano Daniela Bar.na Cr.stina Oliani r.sa Cotugno Michele Quitadamo Angelo Andr.ulli Fr.ncesco perri Unit and r.sear.h Labor.tor. of Gastr.enter.logy "Casa Sollievo della Sofferenza" Hospital IRCCS San Giovanni Rotondo Italy Cr.stina Oliani Department of Medical Oncology Hospital and University of Verona Verona Italy Oncology Unit ULSS5 Ovest Vicentino Verona Italy

AIM： To investigate simultaneously UGT1A7, UGT1A9, Ar., SPINK and CFTr.genes to ver.fy whether.genetic polymor.hisms pr.dispose to the development of pancr.atic cancer.（PC）.METHODS： Genomic DNA of 61 pancr.atic cancer.patients and 105 healthy contr.ls （HC） wer. analyzed. UGT1A7 genotyping was deter.ined by PCr.r.LP analysis. Specific PCr.and sequencing wer. used to analyze genetic var.ants of UGT1A9, Ar., SPINK1 and CFTr.genes.r.SULTS： Four.differ.nt alleles （^＊1：WT; ＂2： N129K and r.31K; ＂3： N129K, r.31K, and W208r. and ＂4： W208r. in UGT1A7 and thr.e differ.nt alleles （^＊1：WT;^＊4： Y242X; and ^＊5： D256N） in UGT1A9 wer. detected. All UGT1A polymor.hisms wer. obser.ed at similar.fr.quency in PC patients and HC. Seven differ.nt alleles in Ar. wer. found in PC patients and HC at similar.fr.quency. The SPINK1 mutations N34S and P55S occur.ed in five PC patients with a pr.valence （4.1%） not significantly differ.nt fr.m that obser.ed （2.0%） in HC. The only CFTr.AFS08 mutation was r.cognized in thr.e PC patients with a pr.valence （4.9%） similar.to HC.CONCLUSION： UGT1A7, UGT1A9, Ar., SPINK1 and CFTr.gene polymor.hisms ar. not associated with PC in Italian patients.

关键词： Pancr.atic cancer Genetic polymor.hisms r.sk factor. Spor.dic

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Oleur.pein-Specific-β-Glucosidase Activity Mar.s the Ear.y r.sponse of Olive Fr.its (Olea eur.paea) to Mimed Insect Attack

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Agr.cultur.l Sciences in China 2008年第6期7卷 703-712页

作者： Antonia Spadafor. Silvia Mazzuca Fr.ncesca Fior.lla Chiappetta Attilio Par.se Enzo perri Anna Mar.a Innocenti Labor.tor.o di Citofisiologia Vegetale Dipartimento di Ecologia Cubo 6b Ponte Bucci Università della Calabria 87030 Rende (CS) Italy C.r.A. Centr. di r.cer.a per.l'Olivicoltur. e l'Industr.a Olear.a Contrada Li Rocchi 87030 Rende Italy

Olive fr.its ar. ser.ously deter.or.ted by pr. and posthar.est damage due to the attack of insects, such as Bactr.cer. olaea, which str.ngly alter. the quality of olives. Defence r.sponse in olive fr.its injur.d both by pathogens and by mechanical damages has been associated with the enzyme β-glucosidase, which specifically hydr.lyses oleur.pein, pr.ducing highly r.active aldehyde molecules. In situ detection of ^-glucosidase activity in olive fr.it tissues following injur., which simulates Bactr.cer. oleae punctur.s, is r.por.ed. The assay was per.or.ed in two cultivar. showing differ.nt degr.es of susceptibilities to fly infestation. In both cultivar., the histochemical assay for.β-glucosidase showed that within 20 min after.the injur., a str.ng ^-glucosidase activity could be obser.ed in the damaged tissues. Ther.after.a pr.gr.ssive enzyme inactivation occur.ed star.ing fr.m tissues ar.und the boundar. of the injur. with decr.ase of the enzyme activity and stopped after.3 h. Wher.as the mass of active cells r.ached a distance of （300±50） μm fr.m the edge of the injur.. Biochemical analyses showed that in extr.cts of the injur.d fr.it, β-glucosidase activity r.pidly incr.ased within 20 min fr.m injur., ther.after.decr.asing and r.aching values compar.ble with those in intact fr.its. Following punctur., the oleur.pein contents did not change significantly in the high susceptibility cultivar. wher.as it r.pidly decr.ased in the cultivar.showing low susceptibility. The r.sults str.ngly suggest that olive fr.its susceptible towar.s fly infestation could be r.lated to the ability of the oleur.pein-degr.ding-β-glucosidase to pr.duce the highly r.active molecules in the damaged tissues. As a consequence of punctur., high level of per.xidase activity was detected. This featur. also suggested that this enzyme could play a key r.le in the defence r.sponse against insect injur.es.

关键词： β-glucosidase (EC 3.2.1.21) oleur.pein Olea eur.paea Bactr.cer. oleae infestation cultivar.r.sistance

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If a Baby Has a Fever.Tr.atment All Depends

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科技英语学习 2009年第1期 7-9页

作者： perri Klass 刘广霞

对发烧的婴儿，不同月龄有不同的治疗方法。不足一个月的婴儿需住院治疗，三个月以上的婴儿要验血或验尿，但不必住院。而对于一至三个月的婴儿，要验血或验尿乃至进行细菌培养，以确定是否有感染、是否需要注射抗生素或住院。

关键词：英语教学翻译方法译文教学方法

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Head geometr.c mor.hometr.cs of two Chagas disease vector. fr.m Venezuela

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Zoological Systematics 2017年第1期42卷 65-70页

作者： Ana Mar.a Or.peza Car.os Ar.ur. perri Fer.anndez Jonathan Lir.a Ana Soto-Vivas Escuela de Bioanalisis Facultad de Cieneias de la Salud Universidad de Carabobo Venezuela Univer.idad r.gional Amazonica IKIAM km 7 via Muyuna Ecuador Centr. de Esmdios en Zoologla Aplicada Facultad Experimental de Ciencias y Tecnologla Universidad de Carabobo Venezuela Centr. de Estudios de Enfer.edades Endkmicas y Salud Ambiental Institeto de Alto Estudios "Dr. Arnoldo Gabladon " Venezuela Car.er. de Cs. Biologicas y Ambientales Facultad de Ciencias Biologicas Universidad Central del Ecuador Ecuador

Tr.atominae species ar. consider.d the main vector. of Chagas disease or.Amer.can Tr.panosomiasis. In Venezuela, the pr.ncipal vector. ar. r.odnius pr.lixus （Stal, 1959） and Tr.atoma maculata （Er.chson, 1848）, which ar. belonged to the tr.be r.odniini and Tr.atomini, r.spectively. The head confor.ation and size development of these species can r.flect ontogenetic changes which contr.bute with the vector. biology studies, as well to suppor. of instar. deter.ination. The goal of the paper.is to the application of geometr.c mor.hometr.c techniques for.descr.bing head confor.ation and size of instar. of these species. We photogr.phed 140 heads in r. pr.lixus： Fir.t instar.（I： 16）, second instar.（II： 17）, thir. instar.（III： 18）, four.h instar.（IV： 21）, fifth instar.（V： 21）, adult female （F： 26） and adult males （M： 21）; in T. maculata heads of 136 specimens wer. photogr.phed,I： 20, II： 17, III： 26, IV： 15, V： 19, F： 20 and M： 19. Landmar. coor.inate （x, y） configur.tions wer. r.gister.d and aligned by Gener.lized Pr.cr.stes Analysis. Covar.ance Analyses wer. implemented with pr.por.ions of r.-classified gr.ups and MANOVA. Statistical analyses of var.ance found not significant differ.nces in head isometr.c size （Kr.skal-Wallis） among IV and V instar. in both species. The a poster.or. r.-classification was almost per.ect in r. pr.lixus （82%） and T. maculata （86%）; the main head differ.nces occur. in antennifer.us tuber.les, postocular.and pr.ocular. Our.study using quantitative tools for.descr.bing the shape differ.nces contr.butes to explain the mor.hology var.ability and development of Chagas disease vector..

关键词： Instar. r.odniini Tr.atomini confor.ation centr.id size.

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