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董事会 2011年第8期 42-49页

作者： Ken Favaro per-ola karlsson Gary L.Neilson 博斯公司

在全世界范围内,CEO更替大幅减少,更替率仅有11.6%;因为国有化程度高,中国公司的更替率更是低至5.2%。然而,这丝毫不意味着CEO的职业生涯变得更轻松,恰恰相反。

关键词： CEO更替继任中国公司职业生涯战前

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全球CEO更替:趋同而紧凑的十年

董事会 2010年第7期 72-76页

作者： Ken Favaro per-ola karlsson Gary L.Neilson 博斯公司

首席执行官的角色正在转变,世界各地的CEO讨论成功带来的游戏规则。如今,CEO的工作有了新的趋势:CEO必须做得更多,做得更快;更多的CEO具有学徒身份;CEO绩效不佳不可原谅;

关键词： CEO更替首席执行官董事会主席游戏规则

Cancer-associated fibroblasts express CD1d and activate invariant natural killer T cells under cellular stress

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Cellular & Molecular Immunology 2024年第1期21卷 91-94页

作者： Shengduo Pei Jonas Sjölund Yueyun Pan Kristian Pietras Mikael C.I.karlsson Department of Microbiology Tumor and Cell BiologyKarolinska InstitutetStockholmSweden Division of Translational Cancer Research Department of Laboratory MedicineLund University Cancer CentreLund UniversityLundSweden

Invariant natural killer T(iNKT)cells are part of the family of unconventional T cells,and they recognize glycolipid antigens presented on the MHC class I like molecule CD1^([1]).In humans there are five CD1 molecules named CD1a to CD1e,whereas mice use only CD1d for lipid ***,iNKT cells can elicit both cytotoxicity similarly to conventional CD8 T cells and secrete cytokines that influence the adaptive immune response including providing direct T cell help to B cells^([2]).In the context of tumors,they can use both release of granzyme B and use Fas-mediated mechanisms for killing of tumor *** iNKT cells use a restricted TCR repertoire and CD1 molecules are non-heterogenous the risk of graft vs host disease is limited and thus these T cells have been an attractive option for off the shelf immunotherapy to treat cancer^([3]).

关键词： killer CD1d Cancer

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CEO 百年进化

“4R-4M”试验方法论在国家重大科技基础设施实验装置设计和建设中的应用与思考

创业家（中文版） 2014年第7期

作者： Ken Favaro per-ola karlsson Gary L.Neilson 史翔宇

CEO这一名词,大约出现在1917年,即现代商业管理理念初步成型时期。下面这篇文章回溯了过去一个世纪中这一角色的进化轨迹并且将其展望到了2040年。我们择要摘编了原文内容。1914年,君主型CEO1914年11月,一个寒冷的下午,第一次世界大战...

CEO这一名词,大约出现在1917年,即现代商业管理理念初步成型时期。下面这篇文章回溯了过去一个世纪中这一角色的进化轨迹并且将其展望到了2040年。我们择要摘编了原文内容。1914年,君主型CEO1914年11月,一个寒冷的下午,第一次世界大战刚刚爆发。位于芝加哥的新美术文艺复兴酒店15层的豪华客厅里,电灯泡刚刚被旋亮,四周物品的轮廓突然明晰起来:红色天鹅绒沙发,桃木长桌,深色波斯地毯,伴着火苗的剧烈跳动,大理石壁炉里不断传来低低的爆裂声。（共3页)

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科学通报 2024年第20期69卷 2838-2843页

作者：孙冬柏杨纯臻孟凡强周舟倪木一崔艺涛 Ulf karlsson 中山大学材料科学与工程学院广州510006 中山大学材料学院深圳518107 中山大学中法核工程技术学院珠海519082 中山大学物理学院广州510275 深圳综合粒子设施研究院深圳518107

当今世界科技强国之间的竞争,比拼的是国家战略科技力量.党的十八大以来,以习近平同志为核心的党中央坚持把科技创新摆在国家发展全局的核心位置,以前所未有的力度加强国家战略科技力量建设.国家重大科技基础设施是为促进科技创新、技... 详细信息

当今世界科技强国之间的竞争,比拼的是国家战略科技力量.党的十八大以来,以习近平同志为核心的党中央坚持把科技创新摆在国家发展全局的核心位置,以前所未有的力度加强国家战略科技力量建设.国家重大科技基础设施是为促进科技创新、技术变革提供极限研究手段的大型、复杂的科学研究系统,是提高我国高新技术研发和关键核心技术突破的重要平台[1].目前,我国在建和运行的重大科技基础设施项目总量达77个.完善和利用这些重大科技基础设施解决重点领域和战略产品“卡脖子”问题,对进一步推动解决关键核心技术、引领相关产业发展具有重要研究意义.

关键词：重大科技基础设施关键核心技术党的十八大以来实验装置设计应用与思考世界科技强国高新技术研发方法论

Direct generation of linearly polarized photon emission with designated orientations from site-controlled InGaN quantum dots

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Light(Science & Applications) 2014年第1期3卷 323-329页

作者： Anders Lundskog Chih-Wei Hsu K Fredrik karlsson Supaluck Amloy Daniel Nilsson Urban Forsberg per Olof Holtz Erik Janzen Department of Physics Chemistry and Biology(IFM) Linkoping UniversitySE-58183 LinkopingSweden Department of Physics Faculty of ScienceThaksin UniversityPhattalung 93110Thailand

Semiconductor quantum dots(QDs)have been demonstrated viable for efficient light emission applications,in particular for the emission of single photons on ***,the preparation of QDs emitting photons with predefined and deterministic polarization vectors has proven *** to linearly polarized photons is essential for various *** this report,a novel concept to directly generate linearly-polarized photons is *** concept is based on InGaN QDs grown on top of elongated GaN hexagonal pyramids,by which the predefined elongation determines the polarization vectors of the emitted photons from the *** growth scheme should allow fabrication of ultracompact arrays of photon emitters,with a controlled polarization direction for each individual emitter.

关键词： GaN InGaN photoluminescence polarized emission quantum dot

Volatile Organic Compound Emissions when Drying Wood Particles at High Dewpoints

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Chinese Journal of Chemical Engineering 2004年第6期12卷 767-772页

作者： Inge Johansson Tobias karlsson Roland Wimmerstedt S.E.P. Scandinavian Energy Project AB Bror Nilssons g. 16 SE-417 55 Goteborg SwedenThurne Teknik AB Heliosvagen 1 b SE-120 30 STOCKHOLM SwedenChemical Engineering Lund University P.O. Box 124 SE-221 00 LUND Sweden

Emission of volatile organic compounds (VOCs) during drying of wood particles for particleboard manufacture, or for production of refined biofuels, is a potential environmental problem. The aim of this work is to study the emissions of VOCs during drying, and the influence on the emissions by different drying *** experiments have mainly been done in a batch fluidized bed dryer, but measurements have also been done in a, pilot scale, continuous fluidized bed dryer. The parameters studied are air flow rate through the bed, air temperature, air dewpoint, and bed height. Since the present trend in biofuels and particle drying is towards very high dewpoints during drying, some measurements have been made at dewpoints up to 95℃, corresponding to a water content of 3.2 kg water per kilogram dry air. The emissions have been measured in two different ways,online during drying with a flame ionization detector and through wood analyses of the terpene content in the wood particles before and after drying. Substantial work has been made in developing the latter method as well as developing the drying equipment to be able to produce a wide range of conditions of the drying medium. It was shown that the VOCs emitted, during wood particle drying, mainly consist of terpenes. The behavior of the emissions was typical, at first contact with the drying gas a sharp peak in the release rate was detected. After that,the release rate stabilizes and declines slowly to a point where the material temperature increases and results in a second small peak in the release rate. Typically 80%-90% of the initial terpene content in the material was emitted during drying to low moisture content and it is not possible to significantly influence this release by changing the drying conditions. Up to 50% of the emitted terpenes are released during a very short period after contact with the drying medium. This fact could be utilized by employing a 2-step drying process. The fact that the VOC con

关键词： drying biofuels particleboard volatile organic compound high dewpoints

A novel feature extraction methodology using Siamese convolutional neural networks for intrusion detection

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Cybersecurity 2018年第1期1卷 847-859页

作者： Serafeim Moustakidis Patrik karlsson AIDEAS OU Narva mnt 5TallinnHarju maakondEstonia

Intrusion detection systems(IDS)can play a significant role in detecting security threats or malicious attacks that aim to steal information and/or corrupt network *** deal with the dynamic and complex nature of cyber-attacks,advanced intelligent tools have been applied resulting into powerful and automated IDS that rely on the latest advances of machine learning(ML)and deep learning(DL).Most of the reported effort has been devoted on building complex ML/DL architectures adopting a brute force approach towards the maximization of their detection ***,just a limited number of studies have focused on the identification or extraction of user-friendly risk indicators that could be easily used by security *** papers have explored various dimensionality reduction algorithms,however a large number of selected features is still required to detect the attacks successfully,which humans cannot intuitively or immediately *** enhance user’s trust and understanding on data without sacrificing on accuracy,this paper contributes to the transformation of the available data collected by IDS into a single actionable and easy-to-understand risk *** achieve this,a novel feature extraction pipeline was implemented consisting of the following components:(i)a fuzzy allocation scheme that transforms raw data to fuzzy class memberships,(ii)a novel modality transformation mechanism for converting feature vectors to images(Vec2im)and(iii)a dimensionality reduction module that makes use of Siamese convolutional neural networks that finally reduces the input data dimensionality into a 1-d feature *** performance of the proposed methodology was validated with respect to detection accuracy,dimensionality reduction performance and execution time on the NSL-KDD dataset via a thorough comparative analysis that demonstrated its effectiveness(86.64%testing accuracy using only one feature)over a number of well-known feature selection(FS)and extracti

关键词： Feature extraction Siamese convolutional neural networks Machine learning Intrusion detection

Surrogate potency assays:Comparison of binding profiles complements dose response curves for unambiguous assessment of relative potencies

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Journal of Pharmaceutical Analysis 2018年第2期8卷 138-146页

作者： Robert karlsson Veronica Fridh Asa Frostell Purification and Analysis GE Healthcare Life SciencesUppsalaSweden

Surface plasmon resonance(SPR) systems are widely used for detailed characterization of antibody activities including antigen and Fc-receptor binding. During the later stages of development, where the focus is to ensure that established critical quality attributes(CQAs) are maintained during cell culture,purification and formulation processes, analysis is simplified, and relative potencies are often determined. Here, simulation of binding data revealed that relative potency values, determined via parallel line analysis(PLA) and half maximal effective concentration(EC50) analysis accurately reflect changes in active concentration only if binding kinetics remain unchanged. Changes in the association rate constant shifted dose response curves, and therefore relative potencies, in the same way as changes in analyte concentration do. However, for interactions characterized by stable binding, changes in the dissociation rate constant did not result in any shift, suggesting that this type of change may go unnoticed in the dose response curve. Thus, EC50 and PLA analyses of dose response curves obtained with an anti-TNF-α antibody were complemented with the Biacore functionality for sensorgram comparison analysis, whereby changes in antigen and Fc-receptor binding profiles could be detected. Next, analysis of temperature stressed TNF-α antibody revealed that calibration free concentration analysis(CFCA) data correlated perfectly with relative potency values. Together, these results demonstrate that combinations of SPR based dose response curves, sensorgram comparison and CFCA can be used to strengthen the confidence in relative potency assessments, and suggest that SPR can potentially be used as a surrogate potency assay in the quality control of biotherapeutic medicines.

关键词： Surface plasmon resonance EC50 Sensorgram comparison Calibration free concentration analysis Surrogate potency assay TNF-a

Natural Regeneration on Planted Clearcuts—The Easy Way to Mixed Forest?

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Open Journal of Forestry 2016年第4期6卷 281-294页

作者： Emma Holmström per Magnus Ekö Karin Hjelm Matts karlsson Urban Nilsson Southern Swedish Forest Research Centre Swedish University of Agricultural Science Alnarp Sweden Skogforsk Sval&oumlv Sweden

Establishing mixed stands by stimulating natural in combination with planting could potentially ensure adequate stocking and meet shifting demands for forest products. Two long-term experiments were separately established in former Norway spruce (Picea abies L. Karst) stands in southern Sweden to be able to evaluate mixed forest establishment and management. The treatment plots were treated with different intensity of soil scarification (disc trenching, soil inversion and control) to test effects of soil disturbance on regeneration success. Five years later, both experiments were used for a first evaluation, where seedlings of all naturally regenerated tree species were counted together with estimates of the cover and height of other vegetation. This was made in sample plots in symmetric grids. Testing the effects of scarification and distance to seed source on natural regeneration of silver birch (Betula pendula Roth.) and downy birch (B. pubescens Ehrh.) showed that both scarification type and degree of soil disturbance significantly affected seedling counts but only if seed sources were close. In conclusion, conventional management practices for regenerating coniferous forest may be suitable for establishing mixed forest stands with combinations of planted and naturally regenerated seedlings.

关键词： Betula Birch Soil Scarification Seed Dispersal