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Colorectal cancer screening:The value of early detection and modern challenges

World Journal of Gastroenterology 2024年第20期30卷 2726-2730页

作者： Jian Li Zhi-Peng Li Wen-Jie Ruan Wei wang Department of Interventional Oncology Municipal Hospital Affiliated to Taizhou UniversityTaizhou 318000Zhejiang ProvinceChina School of Medicine Taizhou UniversityTaizhou 318000Zhejiang ProvinceChina

The screening of colorectal cancer(CRC)is pivotal for both the prevention and treatment of this disease,significantly improving early-stage tumor detection *** advancement not only boosts survival rates and quality of life for patients but also reduces the costs associated with ***,the adoption of CRC screening methods faces numerous challenges,including the technical limitations of both noninvasive and invasive methods in terms of sensitivity and ***,socioeconomic factors such as regional disparities,economic conditions,and varying levels of awareness affect screening *** coronavirus disease 2019 pandemic further intensified these challenges,leading to reduced screening participation and increased waiting ***,the growing prevalence of early-onset CRC necessitates innovative screening *** response,research into new methodologies,including artificial intelligence-based systems,aims to improve the precision and accessibility of *** measures by governments and health organizations to enhance CRC screening efforts are underway,including increased advocacy,improved service delivery,and international *** role of technological innovation and global health collaboration in advancing CRC screening is *** such as artificial intelligence and gene sequencing are set to revolutionize CRC screening,making a significant impact on the fight against this *** the rise in early-onset CRC,it is crucial for screening strategies to continually evolve,ensuring their effectiveness and applicability.

关键词： Colorectal cancer Early detection Economic implications Noninvasive tests Quality of life Survival rates Therapeutic modalities Technical challenges

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Structure,bioavailability and physicochemical properties of icariin-soymilk nanoparticle

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Food Science and Human Wellness 2024年第2期13卷 972-981页

作者： Jinping wang Lingrong Wen Yueming Jiang Hong Zhu Weizheng Sun Guangyi Dai Bao Yang Guangdong Provincial Key Laboratory of Applied Botany Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic ImprovementSouth China Botanical GardenChinese Academy of SciencesGuangzhou 510650China South China National Botanical Garden Guangzhou 510650China College of Food Science and Engineering Jilin Agricultural UniversityChangchun 130118China University of Chinese Academy of Sciences Beijing 100049China School of Food Sciences and Engineering South China University of TechnologyGuangzhou 510640China

Soymilk is a natural ***,the performance of flavonoid-soymilk nano-complex remains *** this work,icariin-soymilk nano-complexes(ISNCs)were successfully fabricated and *** effects of high-pressure homogenization(HPH)treatment on structure and physicochemical properties of soymilk and nano-complexes were *** treatment could significantly improve the surface hydrophobicity and interfacial activity of *** soymilk with HPH treatment could significantly improve the water solubility(20 folds),thermal stability and bioavailability of *** highest encapsulation efficiency(93.28%),loading capacity(39.09μg/mg),ζ-potentia(absolute value,31.20 mV)and bioavailability(72.14%)were observed in HSI-200(200 bar of homogenization pressure).While HSI-500(500 bar of homogenization pressure)showed the smallest particle size(183.73 nm).ISNCs showed a rougher surface and an irregular lamellar structure with large amount of fine particles by using Cryo-SEM,suggesting that icariin was encapsulated in *** data supplied a novel strategy to improve the performance of icariin in functional foods.

关键词： Encapsulation efficiency Flavonoid High pressure homogenization Loading capacity Nano-complex

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Construction of Naphthalenediimide Lanthanide(Ⅲ)-MOFs and Composites Incorporated Electron-Rich Pyrene Derivative as Multifunctional Fluorescence Sensing for Nitro Aromatic Compounds and Aldehydes

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Chinese Journal of Chemistry 2024年第3期42卷 283-293页

作者： Rong Huo Ting Zhang Guang Zeng Chen wang Yong Heng Xing Feng Ying Bai College of Chemistry and Chemical Engineering Liaoning Normal UniversityDalianLiaoning116029 China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianLiaoning116023 China

The development of host-guest MOF luminescent composites has attracted considerable attention. However,it is still a challenge to reasonably design large scale conjugated polycarboxylic acids metal-organic framework (MOF) and modulate donor-acceptor interaction. Herein,a series of isostructural 3D porous lanthanide MOF [Ln_(2)(BINDI)0.5(NO_(3))(DMA)(H_(2)O)]∙DMA∙2.5H_(2)O (Ln = La (1),Ce (2),Pr (3) and Nd (4);H_(4)BINDI (N,N’-bis(5-isophthalic acid)-1,4,5,8-naphthalenediimide) were synthesized. Considering the electron-deficient performances of Ln-BINDI MOFs,D-A type composites Ln-MOFs (1—4@H_(4)TBAPy) were prepared via the incorporation of electron-rich H_(4)TBAPy (1,3,6,8-tetrakis(p-benzoic acid) pyrene),which more improved the luminescence performance of complexes 1—4 and can be used as fluorescence sensors for the detection of nitro compounds and aldehydes. High sensitivity of 1@H_(4)TBAPy towards pNBA,pNA PNP,DNP,and TNP could be achieved through hydrogen bond interactions between MOF and analytes,as well as the π-π interaction between H_(4)TBAPy and the naphthalene ring of BINDI,thus the fluorescence quenching efficiency of 1@H_(4)TBAPy was better than that of the complex 1. In addition,it is found that 1@H_(4)TBAPy has high selectivity and sensitivity to aromatic aldehyde SA,5-Mesal and HMBA. Such strategy to enhance the emission of NDI based Ln-BINDI MOFs,will open up an avenue to obtain more fluorescent MOFs for sensing.

关键词： Ln-MOF Pyrene molecule NACs Aldehydes Fluorescence sensing Carboxylate ligands Charge transfer Donor-acceptor systems

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Intrinsically asymmetric atomic character regulates piezoelectricity in two-dimensional materials

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Frontiers of physics 2024年第3期19卷 153-162页

作者： Yun-Qin Li Qi-Wen He Dai-Song Tang Xiao Shang Xiao-Chun wang School of Physics Science and Information Technology Liaocheng UniversityLiaocheng 252000China Key Laboratory of Polar Materials and Devices Ministry of EducationDepartment of ElectronicsEast China Normal UniversityShanghai 200241China Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China

Decreasing of layer thickness causes the decrease of polarization until it disappears due to the existence of depolarization ***,the search for strong piezoelectric materials is highly desirable for multifunctional ultra-thin piezoelectric ***,we propose a common strategy for achieving strong piezoelectric materials through the electronic asymmetry induced by the intrinsically asymmetric atomic character of different chalcogen ***,in the tetrahedral lattice structures,for example,M4X3Y3(M=Pd/Ni,X/Y=S,Se or Te,X≠Y)monolayers are proved to display excellent out-of-plane ***4Se3Te3 possesses the largest piezoelectric coefficient d33 of 61.57 pm/V,which is much larger than that of most 2D *** the electronic asymmetry further increases the out-of-plane piezoelectricity of Janus M4X3Y3 ***,the out-of-plane piezoelectricity is positively correlated with the ratio of electronegativity difference(Red)and the electric dipole moment(P).This work provides alternative materials for energy harvesting nano-devices or self-energized wearable devices,and supplies a valuable guideline for predicting 2D materials with strong out-of-plane piezoelectricity.

关键词： piezoelectricity intrinsically asymmetric atomic character ratio of electronegativity difference electric dipole moment first-principles calculations

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Tbx 4 and Tbx 5 gene expression associated with appendage development and its relationship with the absence of the pelvic fin in Pampus argenteus

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Journal of Oceanology and Limnology 2024年第2期42卷 580-593页

作者： Shun ZHANG Xiaojing ZHU Lingzhu HU Kai LIAO Shanliang XU Danli wang Chunyang GUO School of Marine Science Ningbo UniversityNingbo 315211China Key Laboratory of Applied Marine Biotechnology Ningbo UniversityChinese Ministry of EducationNingbo 315211China

The Tbx family is first known through the study of their functions in the body and limbs,and its members Tbx4 and Tbx5 genes are important factors in determining the characteristics of the *** argenteus is one of the important economical marine fishes widely distributed in offshore ***,it is necessary to study the role of Tbx family genes in the deletion of pelvic fin in *** this study,we cloned Tbx4 and Tbx5 cDNA sequence of ***(GenBank:MH709128 and MH712458).The Western blot and real time PCR were used to detect the expressions of Tbx4 and Tbx5 in different developmental stages and tissues of *** addition,whole-mount in-situ hybridization was used to study the localization of Tbx4 and Tbx5 genes in different developmental stages of *** show that the translation of Tbx4 mRNA was inhibited during the critical period of pelvic fin *** different tissues,Tbx4 protein levels were the lowest in the abdominal epithelium,and even lower than that in the pectoral fin,suggesting that the protein expression was also inhibited in the abdominal epithelium of adult ***,the results indicated that upstream genes regulation led to the key stage-specific and low expression of Tbx4 during pelvic fin development and in the abdominal epithelium.

关键词： Stromateidae pelvic fin protein translation T-box aquaculture broodstock

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Elaidic acid leads to mitochondrial dysfunction via mitochondria-associated membranes triggers disruption of mitochondrial calcium fluxes

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Food Science and Human Wellness 2024年第1期13卷 287-298页

作者： Hui Liu Xuenan Li Ziyue wang Lu Li Yucai Li Haiyang Yan Yuan Yuan College of Food Science and Engineering Jilin UniversityChangchun 130062China

Elaidic acid(EA)stimulation can lead to endoplasmic reticulum stress(ERS),accompanied by a large release of Ca^(2+),and ultimately the activation of NLRP3 inflammasome in Kupffer cells(KCs).Mitochondrial instability or dysfunction may be the key stimulating factors to activate NLRP3 inflammasome,and sustained Ca^(2+)transfer can result in mitochondrial *** focused on KCs to explore the damage to mitochondria by *** EA stimulation,cells produced an oxidative stress(OS)response with a significant increase in ROS *** experiments and the addition of inhibitors revealed that the increase in the level of intracellular Ca^(2+)led to Ca^(2+)accumulation in the mitochondrial matrix via mitochondria-associated membranes(MAMs).This was accompanied by a significant release of m ROS,loss of MMP and ATP,and a significant increase in mitochondrial permeability transition pore opening,ultimately leading to mitochondrial *** findings confirmed the mechanism that EA induced mitochondrial Ca^(2+)imbalance in KCs via MAM,ultimately leading to mitochondrial ***,EA induced OS and the decrease of MMP and ATP in rat liver,and significant lesions were found in liver *** of the inner mitochondrial cristae and mitochondrial vacuolization occurred,with a marked increase in lipid droplets.

关键词： Elaidic acid(EA) Mitochondria-associated membranes(MAMs) Calcium Endoplasmic reticulum Mitochondria dysfunction

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Fatigue Crack Initiation and Propagation Dominated by Crystallographic Factors in TiB/near α-Ti Composite

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Acta Metallurgica Sinica(English Letters) 2024年第5期37卷 763-776页

作者： Fanchao Meng Rui Zhang Shuai wang Fengbo Sun Run Chen Lujun Huang Lin Geng School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China Waikato Centre for Advanced Materials and Manufacturing School of EngineeringUniversity of WaikatoHamilton 3240New Zealand State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China

Discontinuously reinforced titanium matrix composites(DRTMCs)with a network structure have been extensively researched due to their superior combination of strength and ***,their fatigue performance has remained *** order to elucidate the fatigue behavior of DRTMCs,a tension-tension fatigue test was performed on a TiB/nearα-Ti composite with network *** results showed that the variability of fatigue lifetime increased as the stress level *** analysis indicated that fatigue crack initiation was associated with facet formation,while the subsequent propagation was hindered by the network structure comprising TiB whiskers and *** characterization further revealed that facets formed due to a combination of shear and normal *** reduction in fatigue lifetime was attributed to an increase in the effective slip length,which was influenced by the orientation of grains near the crack-initiation sites toward basal slip in the life-limiting *** in situ observation suggested that the crack initiation was facilitated by both basal and prismatic slip ofα-Ti as well as fracture of *** propagation was found to be associated with basal and prismatic slip systems with high Schmid factors,regardless of whether the crack was intergranular or intragranular.

关键词： Titanium matrix composite TiBw Fatigue lifetime variability Crack initiation Crack propagation

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Interactions between myoblasts and macrophages under high glucose milieus result in inflammatory response and impaired insulin sensitivity

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World Journal of Diabetes 2024年第7期15卷 1589-1602页

作者： Wei Luo Yue Zhou Li-Ying wang Lei Ai Department of Sports and Health Sciences Nanjing Sport InstituteNanjing 210014Jiangsu ProvinceChina Department of Exercise Physiology Beijing Sport UniversityBeijing 100084China Department of Sports Physiology Research Jiangsu Research Institute of Sports ScienceNanjing 210033Jiangsu ProvinceChina

BACKGROUND Skeletal muscle handles about 80% of insulin-stimulated glucose uptake and become the major organ occurring insulin resistance(IR).Many studies have confirmed the interactions between macrophages and skeletal muscle regulated the inflammation and regeneration of skeletal ***,despite of the decades of research,whether macrophages infiltration and polarization in skeletal muscle under high glucose(HG)milieus results in the development of IR is yet to be elucidated.C2C12 myoblasts are well-established and excellent model to study myogenic regulation and its responses to *** exploration of macrophages'role in myoblasts IR and the dynamics of their infiltration and polarization is *** To evaluate interactions between myoblasts and macrophages under HG,and its effects on inflammation and IR in skeletal *** We detected the polarization status of macrophages infiltrated to skeletal muscles of IR mice by hematoxylin and eosin and immunohistochemical ***,we developed an in vitro co-culture system to study the interactions between myoblasts and macrophages under HG *** effects of myoblasts on macrophages were explored through morphological observation,CCK-8 assay,Flow Cytometry,and enzyme-linked immunosorbent *** mediation of macrophages to myogenesis and insulin sensitivity were detected by morphological observation,CCK-8 assay,Immunofluorescence,and 2-NBDG *** The F4/80 and co-localization of F4/80 and CD86 increased,and the myofiber size decreased in IR group(P0.8).In McM+HG group,F4/80+CD86+CD206-cells,monocyte chemoattractant protein 1,TNFα,IL-1βand IL-6 were increased,and F4/80+CD206+CD86-cells and IL-10 were decreased compared with Mc+HG group and McM group(P0.8).Compered to M group,myotube area,myotube n

关键词： Macrophages phenotype Myoblasts Cross-talk Glucose toxicity Chronic inflammation Insulin sensitivity

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Clarifying the relationship and analyzing the influential factors of bronchial asthma in children with attention-deficit hyperactivity disorder

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World Journal of Psychiatry 2024年第4期14卷 513-522页

作者： Gui-Xia wang Xiao-Ying Xu Xi-Qing Wu Department of Infectious Diseases Dongying People’s HospitalDongying 257000Shandong ProvinceChina Department of Children's Health Dongying People’s HospitalDongying 257000Shandong ProvinceChina Department of Children's Health Shengli Oilfield Central HospitalDongying 257000Shandong ProvinceChina

BACKGROUND Bronchial asthma is closely related to the occurrence of attention-deficit hyperactivity disorder(ADHD)in children,which can easily have adverse effects on children’s learning and social *** have shown that childhood asthma can increase the risk of ADHD and the core symptoms of *** with children with ADHD alone,children with asthma and ADHD are more likely to show high levels of hyperactivity,hyperactive-impulsive and other externalizing behaviors and anxiety in clinical practice and have more symptoms of somatization and emotional *** To explore the relationship between ADHD in children and bronchial asthma and to analyze its influencing *** This retrospective cohort study was conducted at Dongying People's Hospital from September 2018 to August *** diagnosed with ADHD at this hospital were selected as the ADHD group,while healthy children without ADHD who underwent physical examinations during the same period served as the control *** and parental data were collected for all participating children,and multivariate logistic regression analysis was employed to identify risk factors for comorbid asthma in children with *** differences were detected between the ADHD group and the control group in terms of family history ofasthma and allergic diseases, maternal complications during pregnancy, maternal use of asthma and allergymedications during pregnancy, maternal anxiety and depression during pregnancy, and parental relationshipstatus (P < 0.05). Out of the 183 children in the ADHD group, 25 had comorbid asthma, resulting in a comorbidityrate of 13.66% (25/183), compared to the comorbidity rate of 2.91% (16/549) among the 549 children in the controlgroup. The difference in the asthma comorbidity rate between the two groups was statistically significant (P <0.05). The results of the multivariate logistic regression analysis indicated that family history of asthma

关键词： Attention-deficit hyperactivity disorder Children Bronchial asthma Risk factors Anxiety Depression

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Aptasensing biosynthesized phosphatidylserine with a AuNPs nanozyme-based colorimetric aptasensor

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Food Science and Human Wellness 2024年第2期13卷 823-829页

作者： Sai wang Rui Ma Chengqiang Li Ling Zhang Haiyang Zhang Xuehan Li Xiangzhao Mao Qingdao Key Laboratory of Food Biotechnology College of Food Science and EngineeringOcean University of ChinaQingdao 266404China Key Laboratory of Biological Processing of Aquatic Products China National Light IndustryQingdao 266404China Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology Qingdao 266237China

Sensitive monitoring of the target products during the biosynthesis process is crucial,and facile analytical approaches are urgently ***,phosphatidylserine(PS)was chosen as the model target,a colorimetric aptasensor was developed for the rapid quantitation in biosynthesis samples.A chimeric aptamer was constructed with two homogeneous original PS *** recognition between the chimeric aptamer and PS results in the desorption of aptamer from the surface of the AuNPs nanozyme,and the peroxidase-like enzymatic activity of the AuNPs nanozyme was weakened in a relationship with the different *** developed aptasensor performed well when applied for analyzing PS in biosynthesis *** aptasensor offers good sensitivity and selectivity,under optimal conditions,achieving monitoring and quantitation of PS in the range of 2.5-80.0μmol/L,with a limit of detection at 536.2 nmol/***,the aptasensor provides good accuracy,with comparison rates of 98.17%-106.40%,when compared with the *** study provides a good reference for monitoring other biosynthesized products and promoting the development of aptamers and aptasensors in real-world applications.

关键词： Phosphatidylserine Chimeric aptamer AuNPs nanozyme Colorimetric aptasensor

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