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Correlation of tumor necrosis factor receptor superfamily 13B variation with sporadic intracranial aneurysm and clinical characteristics in Han Chinese populations

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Neural Regeneration Research 2010年第3期5卷 236-240页

作者： pengfei wu anhua wu yunjie wang Department of Neurosurgery First Affiliated Hospital of China Medical University Shenyang 110001 Liaoning Province China

BACKGROUND： Inflammatory reaction correlates with sporadic intracranial aneurysm （IA）. Variation of tumor necrosis factor receptor superfamily 13B （TNFRSF13B）, an inflammatory mediator receptor, may associate with IA. OBJECTIVE： To explore the relationship between TNFRSF13B gene and sporadic IA, as well as the clinical characteristics of sporadic IA. DESIGN, TIME AND SETTING： Case-control study of genetic association was performed at the Experimental Technology Center of China Medical University from November 2006 to January 2008. PARTICIPANTS： A total of 367 patients with IA, confirmed by three-dimensional computed tomography angiography, magnetic resonance angiography, digital subtraction angiography, and neuro surgery, were admitted to the Department of Neurosurgery, First Affiliated Hospital of China Medical University from 2006 to 2007, and were selected as the case group. All patients were Han, with no family history of IA. In addition, a total of 396 non-lA patients were selected as control subjects. METHODS： Peripheral vein blood was harvested to extract whole blood genomic DNA. Genotyping and TNFRSF13B single nucleotide polymorphism （SNP） rs11078355 G〉A allele polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism. The relationship of TNFRSF13B SNP rs11078355 G〉A polymorphisms to IA and IA clinical characteristics were analyzed using the chi-square and two-sided test. MAIN OUTCOME MEASURES： TNFRSF13B SNP rs11078355 G〉A genotype distribution. RESULTS： In the IA patients, TNFRSF13B SNP rs11078355 G〉A genotype frequency was significantly increased （X2 = 16.306, odds ratio = 1.881,95% confidence interval = 1.382 2.560, P 〈 0.001）. In IA patients aged 〉 65 years, the frequency of TNFRSF13B SNP rs11078355 GA ＋ AA genotype was significantly greater than the GG genotype （X2 = 26.604, odds ratio = 5.248, 95% confidence interval = 2.662 10.345, P 〈 0.001）. CONCLUSION： The TNFRSF13B gene may associate with sporadic IA in Ha

关键词： intracranial aneurysm single nucleotide polymorphism tumor necrosis factor receptor superfamily 13B gene

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Is type Ⅰ alpha 2 collagen gene responsible for intracranial aneurysm in Northeast China?

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Neural Regeneration Research 2013年第5期8卷 445-451页

作者： pengfei wu Bo Li anhua wu yunjie wang Department of Neurosurgery First Affiliated Hospital of China Medical University Department of Developmental Biology Key Laboratory of Cell Biology Ministry of Public Health of China China Medical University

In this study, we investigated whether a single nucleotide polymorphism （rs42524 G 〉 C） in the type I alpha 2 collagen gene was associated with sporadic ruptured intracranial aneurysm or its clinical characteristics in patients from Northeast China. Genotyping of the rs42524 G 〉 C polymorphism was carried out using a polymerase chain reaction-restriction fragment length polymorphism assay. The data showed that the frequency of the rs42524 GC ＋ CC genotype was significantly higher than the GG genotype among intracranial aneurysm patients whose Hunt and Hess grading scale was 〉 3. In addition, the rs42524 G 〉 C genotype was found to have a statistically significant association with intracranial aneurysm risk. These findings indicate that the type I alpha 2 collagen gene gene may be involved in a predisposition to intracranial aneurysm in the Northeast Chinese population. Crucially, the rs42524 C allele may be an important risk factor for increased severity of the condition in patients with ruptured intracranial aneurysms.

关键词： neural regeneration clinical practice intracranial aneurysm type I collagen gene single nucleotide polymorphism polymerase chain reaction-restriction fragment length polymorphism assay susceptibility risk factors neuroregeneration

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Pomegranate-type Si/C anode with SiC taped,well-dispersed tiny Si particles for lithium-ion batteries

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Journal of Advanced Ceramics 2021年第5期10卷 1129-1139页

作者： pengfei wu Benyang SHI Huibin TU Changqing GUO anhua LIU Guan YAN Zhaoju YU Key Laboratory of High-Performance Ceramic Fibers of Ministry of Education College of MaterialsXiamen UniversityXiamen 361005China Shenzhen Research Institute of Xiamen University Shenzhen 518000China College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China

Severe volume expansion and inherently poor lithium ion transmission are two major problems of silicon *** address these issues,we proposed a pomegranate-type Si/C composite anode with highly dispersed tiny silicon particles as the core assisted by small amount of *** exploiting the high heat from magnesiothermic reduction,SiC can assist the good dispersion of silicon and provide good interface compatibility and chemical *** silicon anchored to the carbon shell provides multipoint contact mode,that together with the carbon shell frame,significantly promoting the transfer of dual ***,the pomegranate-type microcluster structure also improves the tap density of the electrode,reduces the direct contact area between active material and electrolyte,and enhances the electrochemical performance.

关键词： Si/C anode anchored Si SiC tape magnesiothermic reduction pomegranate like

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Classification and microsurgical treatment of foramen magnum meningioma

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Chinese Neurosurgical Journal 2023年第2期9卷 114-126页

作者： pengfei wu Yanlei Guan Minghao wang Luyang Zhang Dan Zhao Xiao Cui Jiyuan Liu Bo Qiu Jun Tao yunjie wang Shaowu Ou Department of Neurosurgery the First Affiliated HospitalChina Medical University155 Nanjing StreetHeping DistrictShenyang 110001LiaoningChina

Background To investigate the classification and microsurgical treatment of foramen magnum meningioma(FMM).Methods We retrospectively analyzed 76 patients with FMM and classified them into two classifications,classification ABS according to the relationship between the FMM and the brainstem and classification SIM according to the relationship between the FMM and the vertebral artery(VA).All patients underwent either the far lateral approach(54 cases)or the suboccipital midline approach(22 cases).Results Of the 76 cases,47 cases were located ahead of the brainstem(A),16 cases at the back of the brainstem(B),and 13 cases were located laterally to the brainstem(S).There were 15 cases located superior to the VA(S),49 cases were inferior(I),and 12 cases were mixed type(M).Among 76 cases,71 cases were resected with Simpson grade 2(93.42%),3 with Simpson grade 3(3.95%),and 2 with Simpson grade 4(2.63%).We summarized four anatomical triangles:triangles SOT,VOT,JVV,and *** mean postoperative Karnofsky performance score was improved in all patients(p<0.05).However,several complications occurred,including hoarseness and CSF *** ABS and SIM classifications are objective indices for choosing the surgical approach and predicting the difficulty of FMMs,and it is of great importance to master the content,position relationship with the tumor,and variable anatomical structures in the four"triangles"for the success of the operation.

关键词： Classification Anatomical triangles Foramen magnum meningioma Microsurgical treatment Far lateral approach

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LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells

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Protein & Cell 2022年第7期13卷 490-512页

作者： Zhen Sun Hua Yu Jing Zhao Tianyu Tan Hongru Pan Yuqing Zhu Lang Chen Cheng Zhang Li Zhang anhua Lei Yuyan Xu Xianju Bi Xin Huang Bo Gao Longfei wang Cristina Correia Ming Chen Qiming Sun Yu Feng Li Shen Hao wu Jianlong wang Xiaohua Shen George Q.Daley Hu Li Jin Zhang Center for Stem Cell and Regenerative Medicine Department of Basic Medical Sciences and the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China Department of Molecular Pharmacology&Experimental Therapeutics Center for Individualized MedicineMayo ClinicRochesterMNUSA Tsinghua-Peking Center for Life Sciences School of MedicineTsinghua UniversityBeijing 100085China The Black Family Stem Cell Institute and Department of Cell Developmental and Regenerative BiologyIcahn School of Medicine at Mount SinaiNew YorkNY 10029USA Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou 31005&China Department of Biological Chemistry and Molecular Pharmacology Harvard Medical Schooland Program in Cellular and Molecular MedicineBoston Children's HospitalBostonMAUSA Stem Cell Transpla ntation Program Division of Pediatric Hematology On cologyBost on Children's HospitalDepartme nt of Biological Chemistry and Molecular PharmacologyHarvard Medical SchoolBostonMAUSA College of Life Sciences Zhejiang UniversityHangzhou 310058China Department of Biochemistry Zhejiang University School of MedicineHangzhou 310058China Institute of Life Science Zhejiang UniversityHangzhou 310058China Institute of Hematology Zhejiang UniversityHangzhou 310058China Zhejiang Laboratory for Systems and Precision Medicine Zhejiang University Medical CenterHangzhou 310058China

LIN28 is an RNA binding protein with important roles in early embryo development,stem cell differentiation/re-programming,tumorigenesis and *** studies have focused mainly on its role in the cytosol where it interacts with Let-7 microRNA precursors or mRNAs,and few have addressed LIN28's role within the ***,we show that LIN28 displays dynamic temporal and spatial expression during murine embryo *** LIN28 expression drops upon exit from the 2-cell stage,and zygotic LIN28 protein is induced at the forming nucleolus during 4-cell to blas-tocyst stage development,to become dominantly expressed in the cytosol after *** cultured pluripotent stem cells(PSCs),loss of LIN28 led to nucleolar stress and activation of a 2-cell/4-cell-like transcriptional program characterized by the expression of endogenous retrovirus ***,LIN28 binds to small nucleolar RNAs and rRNA to maintain nucleolar integrity,and its loss leads to nucleolar phase separation defects,ribosomal stress and activation of P53 which in turn binds to and activates 2C transcription factor ***28 also resides in a complex containing the nucleolar factor Nucleolin(NCL)and the transcrip-tional repressor TRIM28,and LIN28 loss leads to reduced occupancy of the NCL/TRIM28 complex on the Dux and rDNA loci,and thus de-repressed Dux and reduced rRNA ***28 knockout cells with nucleolar stress are more likely to assume a slowly cycling,translationally inert and anabolically inactive state,which is a part of previously unappreciated 2C-like transcriptional *** findings elucidate novel roles for nucleolar LIN28 in PSCs,and a new mechanism linking 2C program and nucleolar functions in PSCs and early embryo development.

关键词： LIN28 2-cell-like program nucleolar integrity NCL/TRIM28 complex

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热交换坩埚下降法制备大尺寸氟化铈晶体的热场设计与优化

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无机材料学报 2023年第3期38卷 288-295页

作者：穆宏赫王鹏飞施宇峰张中晗武安华苏良碧中国科学院上海硅酸盐研究所透明光功能无机材料重点实验室上海201899 中国科学院大学材料科学与光电工程中心北京100049

随着CeF_(3)晶体在激光和磁光领域应用的持续发展,大尺寸、高光学质量的CeF_(3)单晶的需求日益急迫,而CeF_(3)熔体的高黏度和低热导率的特性给晶体生长工艺带来了较大挑战。为研究CeF_(3)熔体低导热性引发的生长问题,探究其生长过程中... 详细信息

随着CeF_(3)晶体在激光和磁光领域应用的持续发展,大尺寸、高光学质量的CeF_(3)单晶的需求日益急迫,而CeF_(3)熔体的高黏度和低热导率的特性给晶体生长工艺带来了较大挑战。为研究CeF_(3)熔体低导热性引发的生长问题,探究其生长过程中炉体结构和工艺参数对温度分布和结晶界面的影响机制,本工作对热交换坩埚下降法(Heat Exchanger-Bridgman method,HEB)生长大尺寸(ϕ80 mm)CeF_(3)晶体中炉体结构与晶体/熔体温度分布关系、不同生长阶段界面的变化规律以及热场结构对生长界面的作用机制开展了数值模拟研究。研究结果表明:当发热体长度与坩埚长度相适应时,更有利于构建合理的温度梯度场,而放肩和等径生长阶段的凹界面问题则可以通过改变隔板形状和加反射屏调节坩埚壁温度分布得到有效解决。本研究成果不仅可以加深对CeF_(3)晶体结晶习性的理解,炉体结构和生长界面的优化思路对坩埚下降法制备其他晶体同样有实际指导意义。

关键词： CeF_(3)晶体热交换坩埚下降法数值模拟固液界面热场优化

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颅内软骨肉瘤的诊断与治疗（附17例报告）

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中华神经外科杂志 2018年第11期34卷 1102-1106页

作者：贺亮王军陶钧夏俊哲吴鹏飞王明昊王运杰中国医科大学附属第一医院神经外科沈阳110001

目的总结颅内软骨肉瘤的临床特点和诊疗经验，为其临床治疗提供参考依据。方法回顾性分析2007年6月至2016年12月中国医科大学附属第一医院神经外科收治的17例颅内软骨肉瘤患者的临床资料。所有患者均行手术治疗。9例术后行放射治疗。结... 详细信息

目的总结颅内软骨肉瘤的临床特点和诊疗经验，为其临床治疗提供参考依据。方法回顾性分析2007年6月至2016年12月中国医科大学附属第一医院神经外科收治的17例颅内软骨肉瘤患者的临床资料。所有患者均行手术治疗。9例术后行放射治疗。结果17例患者中，9例达到肿瘤全切除，8例为次全切除。术后病理学结果：普通型软骨肉瘤13例，黏液型软骨肉瘤3例，间叶型软骨肉瘤1例。术前误诊比例为14／17。术后新发脑神经功能障碍3例，脑脊液漏2例，颅内感染2例，出现精神症状1例。16例患者获得随访。术后随访时间为11～113个月，平均（55．9±23．1）个月。患者2年、5年的无进展生存率分别为81．3％和75．0％。随访期间，行次全切除的患者中，2例死亡，5例病情进展。结论颅内软骨肉瘤为颅内罕见的恶性肿瘤，临床表现和影像学表现缺乏特异性，术前易误诊。其治疗方法首选手术切除，肿瘤全切除的患者可获得较好的预后。

关键词：脑肿瘤软骨肉瘤显微外科手术预后

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鼻镜在显微手术治疗颅内动脉瘤术中应用的临床研究

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中国医疗器械杂志 2014年第4期38卷 312-314页

作者：温志锋仇波吴鹏飞佟志勇梁传声王运杰中国医科大学附属第一医院神经外科沈阳市110001

该文分析显微手术治疗颅内动脉瘤术中应用鼻镜的临床价值。术中应用鼻镜的87例患者中仅有2例术中出现动脉瘤破裂,而未应用鼻镜的94例患者中有9例术中出现动脉瘤破裂出血,P<0.05,有统计学差异;DSA随访复查见应用鼻镜的82例中瘤颈残留的2... 详细信息

该文分析显微手术治疗颅内动脉瘤术中应用鼻镜的临床价值。术中应用鼻镜的87例患者中仅有2例术中出现动脉瘤破裂,而未应用鼻镜的94例患者中有9例术中出现动脉瘤破裂出血,P<0.05,有统计学差异;DSA随访复查见应用鼻镜的82例中瘤颈残留的2例,而未用鼻镜的77例随访患者中瘤颈残留9例,P<0.05,存在统计学差异性。显微手术治疗颅内动脉瘤术中应用鼻镜辅助,能够降低术中动脉瘤破裂的风险,达到较好的临床应用效果。

关键词：显微手术颅内动脉瘤鼻镜临床研究

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听神经瘤切除程度和术后并发症的影响因素

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中国医科大学学报 2023年第1期52卷 24-29页

作者：黄金海吴鹏飞官彦雷王明昊王文宣王运杰欧绍武中国医科大学附属第一医院神经外科沈阳110001

目的分析听神经瘤切除程度和术后并发症的影响因素。方法收集197例听神经瘤患者的临床资料,分析年龄、性别、肿瘤直径、肿瘤包绕血管、肿瘤与面神经粘连、肿瘤压迫脑干导致脑干水肿等因素与肿瘤切除程度、术后并发症的关系。结果197... 详细信息

目的分析听神经瘤切除程度和术后并发症的影响因素。方法收集197例听神经瘤患者的临床资料,分析年龄、性别、肿瘤直径、肿瘤包绕血管、肿瘤与面神经粘连、肿瘤压迫脑干导致脑干水肿等因素与肿瘤切除程度、术后并发症的关系。结果197例患者均采用显微镜下乙状窦后入路进行手术治疗,肿瘤全切172例,次全切25例,全切率87.31%。术后出现新发并发症26例,无死亡病例。25例次全切患者中11例术后行伽马刀治疗,随访期间肿瘤无明显进展。术后KPS评分较术前明显升高(P=0.028)。全切组中肿瘤直径>3 cm的比例、肿瘤包绕血管的比例、肿瘤与面神经粘连的比例和肿瘤压迫脑干导致脑干水肿的比例均低于次全切组(均P 65岁的比例、肿瘤与面神经粘连的比例和肿瘤压迫脑干导致脑干水肿的比例均高于无术后并发症组(均P <0.05)。结论肿瘤直径、肿瘤包绕血管、肿瘤与面神经粘连及肿瘤压迫脑干导致脑干水肿是听神经瘤切除程度的主要影响因素;年龄、肿瘤与面神经粘连及肿瘤压迫脑干导致脑干水肿是听神经瘤切除术后并发症的主要影响因素。

关键词：听神经瘤显微手术切除程度并发症影响因素

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人脑胶质瘤干细胞中IL-10的mRNA表达

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中华神经外科疾病研究杂志 2011年第6期10卷 485-488页

作者：仇波张东勇陶钧吴安华王运杰中国医科大学第一医院神经外科辽宁沈阳110001

目的在转录水平上检测人脑胶质瘤干细胞(BGSCs)中白介素-10(IL-10)的mRNA表达,探讨其在胶质瘤免疫及免疫治疗中的作用。方法从8例临床标本中培养出BGSCs,并通过生物学特性和免疫细胞化学方法予以鉴定。然后提取BGSCs以及相对应的原代脑... 详细信息

目的在转录水平上检测人脑胶质瘤干细胞(BGSCs)中白介素-10(IL-10)的mRNA表达,探讨其在胶质瘤免疫及免疫治疗中的作用。方法从8例临床标本中培养出BGSCs,并通过生物学特性和免疫细胞化学方法予以鉴定。然后提取BGSCs以及相对应的原代脑胶质瘤细胞中的RNA进行实时逆转录-聚合酶链式反应(RT-PCR)检测,测定IL-10的mRNA表达水平,并予统计学分析。结果成功从8例临床标本中培养出BGSCs并通过鉴定。定量检测mRNA表达显示,在BGSCs中IL-10的mRNA表达显著高于相应的原代培养的脑胶质瘤细胞,配对t检验显示P<0.05,有统计学意义。结论首次检测了BGSCs中IL-10的mRNA表达水平,证实其高于相应的原代胶质瘤细胞。这可能是脑胶质瘤能逃避肿瘤免疫并且复发的原因,若要根治脑胶质瘤,应以BGSCs为靶点进行治疗。

关键词：脑胶质瘤脑胶质瘤干细胞白介素-10 免疫治疗

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