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PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong liu Xiaolin Li Xiaowei Zhou Wei Chen Aidong Wen Minna liu Yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

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High-precision magnetic field measurement system based on a coherent population trapping magnetometer onboard the SATech-01 satellite

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Science China Technological Sciences 2025年

作者： Hongbo XUE Wei SONG Haoran ZHAO Yiteng ZHANG Shanzhi YE Jindong WANG Ran TAO peng SANG Keli CHEN Xingzi BI Bingjun CHENG Bin ZHOU Yongliang XUE Yingying TANG liu liu Jinsong LI Xiaocheng ZHU Baoquan LI Jinguo liu Wen CHEN Xiaofeng ZHANG Yonghe ZHANG Lei LI State Key Laboratory of Space Weather National Space Science Center Chinese Academy of Sciences Key Laboratory of Solar Activity and Space Weather National Space Science Center Chinese Academy of Sciences Key Laboratory of Electronics and Information Technology for Space Systems National Space Science Center Chinese Academy of Sciences State Key Laboratory of Robotics Shenyang Institute of Automation Chinese Academy of Sciences Innovation Academy for Microsatellites Chinese Academy of Sciences

On July 27, 2022, a high-precision system for measuring the magnetic field based on a coherent population trapping magnetometer（referred to as the CPT system） was launched onboard the Space Advanced Technology demonstration satellite（SATech-01） by a ZK-1A rocket. The payload comprises a scalar coherent population trapping magnetometer（CPTM）, triaxial anisotropic magnetoresistance magnetometer（AMRM）, and nano star tracker mounted on a non-magnetic telescopic tubular mast. This configuration enables synchronized measurement of scalar and vector geomagnetic fields, as well as the attitude,making the payload with its compact sensors suitable for applications on miniature satellite platforms. On November 7, 2022,the novel telescopic tubular mast was deployed in orbit, extending to a length of 5.28 m. The CPTM, an absolute scalar magnetometer with an omnidirectional sensor, is the first China-developed quantum/atomic magnetometer successfully operating in space. In orbit, the CPTM has sensitivity of ～10 pT/Hz1/2and can automatically operate under complex magnetic field variations. The difference between the scalar fields obtained using the CPTM and CHAOS model has a mean deviation of–3.73 n T and a standard deviation of 26.11 nT（1σ）, without on-orbit calibration or correction. The miniaturized AMRM has a sensitivity of ～0.3 n T/Hz1/2and maintains stable and reliable operation in orbit. The low-power and miniaturized nano star tracker has a measurement uncertainty of 14.23″（1σ） in orbit. The mission has realized the on-orbit technical verification of the integrated and synchronized detection of the vector magnetic field and attitude and fully validated the system's performance,automation level, and reliability.

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Role of the Greenland Sea ice anomaly in the late-spring drought over Northwest China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 1-5页

作者： Yang liu Huopo Chen Nansen-Zhu International Research Centre Institute of Atmospheric Physics Chinese Academy of SciencesBeijingChina Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University for Information Science and TechnologyNanjingChina

Drought across Northwest China in late spring has exerted a vital effect on the local climate and agricultural production,and has been alleviated during the past *** study explored the influence of the preceding Arctic sea ice on the May drought in Northwest China caused by the precipitation *** analysis indicated that when the Greenland Sea ice concentration is abnormally high during February to April,the dry conditions in Northwest China tend to be *** increase of sea ice in the Greenland Sea can excite a meridional circulation,which causes sea surface temperature(SST)anomalies in the North Atlantic via the sea-air interaction,manifested as significant warm SST anomalies over the south of Greenland and the subtropical North Atlantic,but negative SST anomalies over the west of the *** abnormal SST pattern maintains to May and triggers a zonal wave train from the North Atlantic through Scandinavia and Central Asia to Northwest China,leading to abnormal cyclones in Northwest ***,Northwest China experiences a more humid climate than usual.

关键词： Arctic sea ice Greenland Sea North Atlantic SST Drought Northwest China

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MAPK/ERK信号通路在胃癌细胞来源的外来体诱导Jurkat T细胞凋亡中的作用

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世界华人消化杂志 2010年第19期18卷 1969-1973页

作者：曲晶磊赵明芳曲秀娟侯科佐姜又红杨向红刘云鹏中国医科大学附属第一医院肿瘤内科辽宁省沈阳市110001 中国医科大学附属第一医院肿瘤研究所辽宁省沈阳市110001 中国医科大学附属盛京医院病理科辽宁省沈阳市110004

目的:研究胃癌细胞来源的外来体对JurkatT细胞凋亡的影响,初步探讨MAPK/ERK通路在此过程中的作用.方法:采用离心超滤和蔗糖密度梯度超速离心的方法从胃癌SGC7901细胞的上清液中分离出胃癌细胞来源的外来体.透射电子显微镜下观察外来体形... 详细信息

目的:研究胃癌细胞来源的外来体对JurkatT细胞凋亡的影响,初步探讨MAPK/ERK通路在此过程中的作用.方法:采用离心超滤和蔗糖密度梯度超速离心的方法从胃癌SGC7901细胞的上清液中分离出胃癌细胞来源的外来体.透射电子显微镜下观察外来体形态,流式细胞仪PI染色检测细胞凋亡,Westernblot检测蛋白表达.结果:透射电子显微镜下观察胃癌SGC7901细胞来源的外来体具有特征性的盘状结构,由双层膜构成,他们的直径为30-100nm.外来体能以时间和剂量依赖性的方式诱导JurkatT细胞凋亡,在凋亡过程中伴有caspase-3,8的活化和p-ERK表达的下调.结论:胃癌细胞来源的外来体能诱导JurkatT细胞凋亡,其机制可能与抑制MAPK/ERK通路的活性有关.

关键词：外来体凋亡 MAPK/ERK通路胃癌

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Molecular Structure Tailoring of Organic Spacers for High‑Performance Ruddlesden–Popper Perovskite Solar Cells

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Nano-Micro Letters 2025年第2期17卷 314-357页

作者： pengyun liu Xuejin Li Tonghui Cai Wei Xing Naitao Yang Hamidreza Arandiyan Zongping Shao Shaobin Wang Shaomin liu School of Materials Science and Engineering State Key Laboratory of Heavy Oil ProcessingChina University of Petroleum(East China)Qingdao 266580People’s Republic of China School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo 255049People’s Republic of China Centre for Applied Materials and Industrial Chemistry(CAMIC) School of ScienceRMIT UniversityMelbourneVic 3000Australia WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia School of Chemical Engineering The University of AdelaideAdelaideSA 5005Australia School of Engineering Great Bay UniversityDongguan 523000People’s Republic of China

Layer-structured Ruddlesden–Popper(RP)perovskites(RPPs)with decent stability have captured the imagination of the photovoltaic research community and bring hope for boosting the development of perovskite solar cell(PSC)***,two-dimensional(2D)or quasi-2D RP PSCs are encountered with some challenges of the large exciton binding energy,blocked charge transport and poor film quality,which restrict their photovoltaic ***,these issues can be readily resolved by rationally designing spacer cations of *** review mainly focuses on how to design the molecular structures of organic spacers and aims to endow RPPs with outstanding photovoltaic *** firstly elucidated the important roles of organic spacers in impacting crystallization kinetics,charge transporting ability and stability of *** we brought three aspects to attention for designing organic ***,we presented the specific molecular structure design strategies for organic spacers of RPPs aiming to improve photovoltaic performance of RP *** proposed strategies in this review will provide new avenues to develop novel organic spacers for RPPs and advance the development of RPP photovoltaic technology for future applications.

关键词： Ruddlesden-Popper perovskites Low-dimensional perovskite solar cells Organic spacers Molecular structure Design strategies

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Research progress in the effects of terahertz waves on biomacromolecules

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Military Medical Research 2022年第1期9卷 63-70页

作者： liu Sun Li Zhao Rui-yun peng Beijing Institute of Radiation Medicine Haidian District27 Taiping RoadBeijing 100850China

With the rapid development of terahertz technologies,basic research and applications of terahertz waves in biomedicine have attracted increasing *** rotation and vibrational energy levels of biomacromolecules fall in the energy range of terahertz waves;thus,terahertz waves might interact with ***,terahertz waves have been widely applied to explore features of the terahertz spectrum of ***,the effects of terahertz waves on biomacromolecules are largely *** some progress has been reported,there are still numerous technical barriers to clarifying the relation between terahertz waves and biomacromolecules and to realizing the accurate regulation of biological macromolecules by terahertz ***,further investigations should be conducted in the *** this paper,we reviewed terahertz waves and their biomedical research advantages,applications of terahertz waves on biomacromolecules and the effects of terahertz waves on *** findings will provide novel ideas and methods for the research and application of terahertz waves in the biomedical field.

关键词： Terahertz waves Biomacromolecules Effect Review

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Overview and Prospect of Distributed Energy P2P Trading

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Energy Engineering 2025年第1期122卷 379-404页

作者： Jiajia liu Mingxing Tian Xusheng Mao School of Automation and Electrical Engineering Lanzhou Jiaotong UniversityLanzhou730070China

After a century of relative stability in the electricity sector,the widespread adoption of distributed energy resources,along with recent advancements in computing and communication technologies,has fundamentally altered how energy is consumed,traded,and *** change signifies a crucial shift as the power system evolves from its traditional hierarchical organization to a more decentralized *** the heart of this transformation are innovative energy distribution models,like peer-to-peer(P2P)sharing,which enable communities to collaboratively manage their energy *** effectiveness of P2P sharing not only improves the economic prospects for prosumers,who generate and consume energy,but also enhances energy resilience and *** allows communities to better leverage local resources while fostering a sense of collective responsibility and collaboration in energy ***,there is still no extensive implementation of such sharing models in today’s *** on distributed energy P2P trading is still in the exploratory stage,and it is particularly important to comprehensively understand and analyze the existing distributed energy P2P trading *** paper contributes with an overview of the P2P markets that starts with the network framework,market structure,technical approach for trading mechanism,and blockchain technology,moving to the outlook in this field.

关键词： Distributed energy P2P market mechanisms classification and comparison

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Endurable SSD-Based Read Cache for Improving the Performance of Selective Restore from Deduplication Systems

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Journal of Computer Science & Technology 2018年第1期33卷 58-78页

作者： Jian liu yun-peng Chai Xiao Qin Yao-Hong liu Division of Computer Science and Engineering Louisiana State University Baton Rouge LA 70803 U.S.A. Key Laboratory of Data Engineering and Knowledge Engineering Ministry of Education of China Beijing 100872 China School of Information Renmin University of China Beijing 100872 China Shelby Center for Engineering Technology Department of Computer Science and Software Engineering Samuel Ginn College of Engineering Auburn University Auburn AL 368~9-53~7 U.S.A.

Deduplication has been commonly used in both enterprise storage systems and cloud storage. To overcome the performance challenge for the selective restore operations of deduplication systems, solid-state-drive-based （i.e., SSD-based） re^d cache cm, be deployed for speeding up by caching popular restore contents dynamically. Unfortunately, frequent data updates induced by classical cache schemes （e.g., LRU and LFU） significantly shorten SSDs＇ lifetime while slowing down I/O processes in SSDs. To address this problem, we propose a new solution -- LOP-Cache to greatly improve tile write durability of SSDs as well as I/O performance by enlarging the proportion of long-term popular （LOP） data among data written into SSD-based cache. LOP-Cache keeps LOP data in the SSD cache for a long time period to decrease the number of cache replacements. Furthermore, it prevents unpopular or unnecessary data in deduplication containers from being written into the SSD cache. We implemented LOP-Cache in a prototype deduplication system to evaluate its pertbrmance. Our experimental results indicate that LOP-Cache shortens the latency of selective restore by an average of 37.3% at the cost of a small SSD-based cache with only 5.56% capacity of the deduplicated data. Importantly, LOP-Cache improves SSDs＇ lifetime by a factor of 9.77. The evidence shows that LOP-Cache offers a cost-efficient SSD-based read cache solution to boost performance of selective restore for deduplication systems.

关键词： data deduplication solid state drive (SSD) flash cache endurance

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Self-Compensating Displacement Sensor Based on Hydramatic Structured Transducer and Fiber Bragg Grating

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Photonic Sensors 2015年第4期5卷 351-356页

作者： Shimeng CHEN yun liu Xiuxin liu Yang ZHANG Wei peng College of Physics and Optoelectronics Engineering Dalian University of Technology Dalian 116024 China

An optical fiber displacement sensor with a large measuring range for simultaneous displacement and temperature measurement is presented in this paper. We developed a specific transducer based on the piston and hydraumatic structure to realize a large displacement measurement, which combined the large measuring range and high precision into a single sensor system. The spectrum showed two reflection peaks used to compensate for cross-sensitivity in the displacement detection. This displacement sensor can linearly work in a large measuring displacement range greater than 45 mm with a high sensitivity of 0.036nm/mm. The sensor we reported can be developed for real-time displacement monitoring in many industrial environments such as the mechanical shape or liquid level monitoring.

关键词： Hydraumatic structured transducer large measuring range temperature compensating optical fibersensor displacement

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Solution‑Processed Thin Film Transparent Photovoltaics:Present Challenges and Future Development

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Nano-Micro Letters 2025年第2期17卷 566-600页

作者： Tianle liu Munerah M.S.Almutairi Jie Ma Aisling Stewart Zhaohui Xing Mengxia liu Bo Hou Yuljae Cho UM-SJTU Joint Institute Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Physics and Astronomy Cardiff UniversityCardiff CF243AAWalesUK Department of Electrical and Computer Engineering Yale UniversityNew HavenCT 06511USA Energy Sciences Institute Yale UniversityWest HavenCT 06516USA Future Photovoltaics Research Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Electrical energy is essential for modern society to sustain economic *** soaring demand for the electrical energy,together with an awareness of the environmental impact of fossil fuels,has been driving a shift towards the utilization of solar ***,traditional solar energy solutions often require extensive spaces for a panel installation,limiting their practicality in a dense urban *** overcome the spatial constraint,researchers have developed transparent photovoltaics(TPV),enabling windows and facades in vehicles and buildings to generate electric *** TPV advancements are focused on improving both transparency and power output to rival commercially available silicon solar *** this review,we first briefly introduce wavelength-and non-wavelengthselective strategies to achieve *** of merit and theoretical limits of TPVs are discussed to comprehensively understand the status of current TPV *** we highlight recent progress in different types of TPVs,with a particular focus on solution-processed thin-film photovoltaics(PVs),including colloidal quantum dot PVs,metal halide perovskite PVs and organic *** applications of TPVs are also reviewed,with emphasis on agrivoltaics,smart windows and ***,current challenges and future opportunities in TPV research are pointed out.

关键词： Transparent semiconductors Solution-processable transparent solar cell Emerging solar cell materials Buildingintegrated photovoltaics

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