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Multi-Objective Optimization of Aluminum Alloy Electric Bus Frame Connectors for Enhanced Durability

Computer Modeling in Engineering & Sciences 2024年第7期140卷 735-755页

作者： Wenjun Zhou Mingzhi Yang Qian peng Yong peng Kui wang Qiang Xiao Key Laboratory of Traffic Safety on Track Ministry of EducationSchool of Traffic&Transportation EngineeringCentral South UniversityChangsha410018China School of Mechanical and Automotive Engineering Xiamen University of TechnologyXiamen361024China

The widespread adoption of aluminumalloy electric buses,known for their energy efficiency and eco-friendliness,faces a challenge due to the aluminum frame’s susceptibility to deformation compared to *** issue is further exacerbated by the stringent requirements imposed by the flammability and explosiveness of batteries,necessitating robust frame *** study aims to optimize the connectors of aluminum alloy bus frames,emphasizing durability,energy efficiency,and *** research delves into Multi-Objective Coordinated Optimization(MCO)techniques for lightweight design in aluminum alloy bus body *** goal is to enhance lightweighting,reinforce energy absorption,and improve deformation resistance in connector *** typical aluminum alloy connectors were selected and a design optimization platform was built for their MCO using a variety of software and ***,through three-point bending experiments and finite element analysis on three types of connector components,we identified optimized design parameters based on deformation ***,employing Optimal Latin hypercube design(OLHD),parametric modeling,and neural network approximation,we developed high-precision approximate models for the design parameters of each connector component,targeting energy absorption,mass,and logarithmic ***,utilizing the Archive-based Micro Genetic Algorithm(AMGA),Multi-Objective Particle Swarm Optimization(MOPSO),and Non-dominated SortingGenetic Algorithm(NSGA2),we explored optimized design solutions for these joint ***,we simulated joint assembly buckling during bus rollover crash scenarios to verify and analyze the optimized solutions in three-point bending *** joint component showcased a remarkable 30%–40%mass reduction while boosting energy *** design optimization method exhibits high efficiency and *** contemporary automation technology,the design optimiza

关键词： Aluminum connectors three-point bending simulation parametric design model multi-objective collaborative optimization

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Understanding the Relationship Between Shrinking Cities and Land Prices:Spatial Pattern,Effectiveness,and Policy Implications

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Chinese Geographical Science 2024年第1期34卷 1-18页

作者： wang Xiaohui peng Li HUANG Kexin DENG Wei College of Geography and Resources Sichuan Normal UniversityChengdu610101China Key Laboratory of Land Resources Evaluation and Monitoring in Southwest Ministry of EducationSichuan Normal UniversityChengdu610101China

Urban shrinkage has emerged as a widespread phenomenon globally and has a significant impact on land,particularly in terms of land use and *** study focuses on 2851 county-level cities in China in 2005–2018(excluding Hong Kong,Macao,Taiwan,and‘no data’areas in Qinhai-Tibet Plateau)as the fundamental units of *** employing nighttime light(NTL)data to identify shrinking cities,the propensity score matching(PSM)model was used to quantitatively examine the impact of shrinking cities on land prices,and evaluate the magnitude of this *** findings demonstrate the following:1)there were 613 shrinking cities in China,with moderate shrinkage being the most prevalent and severe shrinkage being the least.2)Regional disparities are evident in the spatial distribution of shrinking cities,especially in areas with diverse terrain.3)The spatial pattern of land price exhibits a significant correlated to the economic and administrative levels.4)Shrinking cities significantly negatively impact on the overall land price(ATT=–0.1241,P<0.05).However,the extent of the effect varies significantly among different spatial *** study contributes novel insights into the investigation of land prices and shrinking cities,ultimately serving as a foundation for government efforts to promote the sustainable development of urban areas.

关键词： shrinking cities land price propensity score matching(PSM) relative effectiveness China

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Heterogeneous data-driven aerodynamic modeling based on physical feature embedding

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Chinese Journal of Aeronautics 2024年第3期37卷 1-6页

作者： Weiwei ZHANG Xuhao peng Jiaqing KOU Xu wang School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Institute of Aerodynamics RWTH Aachen UniversityAachen 52062Germany

Aerodynamic surrogate modeling mostly relies only on integrated loads data obtained from simulation or experiment,while neglecting and wasting the valuable distributed physical information on the *** make full use of both integrated and distributed loads,a modeling paradigm,called the heterogeneous data-driven aerodynamic modeling,is *** essential concept is to incorporate the physical information of distributed loads as additional constraints within the end-to-end aerodynamic *** heterogenous data,a novel and easily applicable physical feature embedding modeling framework is *** framework extracts lowdimensional physical features from pressure distribution and then effectively enhances the modeling of the integrated loads via feature *** proposed framework can be coupled with multiple feature extraction methods,and the well-performed generalization capabilities over different airfoils are verified through a transonic *** with traditional direct modeling,the proposed framework can reduce testing errors by almost 50%.Given the same prediction accuracy,it can save more than half of the training ***,the visualization analysis has revealed a significant correlation between the discovered low-dimensional physical features and the heterogeneous aerodynamic loads,which shows the interpretability and credibility of the superior performance offered by the proposed deep learning framework.

关键词： Transonic flow Data-driven modeling Feature embedding Heterogenous data Feature visualization

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Chemical biology investigation of a triple-action,smart-decomposition antimicrobial booster based-combination therapy against“ESKAPE”pathogens

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Science China Chemistry 2024年第9期67卷 3071-3082页

作者： Min wang Huangsheng Pu Yangfan Xu Chenxuan Wu Yuanxin Gu Qingyun Cai Guoxing Yin peng Yin Chunhui Zhang Wing-Leung Wong Muyang wan Yugang Bai Xinxin Feng State Key Laboratory of Chem-/Bio-Sensing and Chemometrics Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biologyand School of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China College of Biology Hunan UniversityChangsha 410082China College of Advanced Interdisciplinary Studies&Hunan Provincial Key Laboratory of Novel Nano Optoelectronic Information Materials and Devices National University of Defense TechnologyChangsha 410073China Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research(Ministry of Education) College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China State Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityHong Kong SAR 999077China Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs The Third Hospital of Changsha(The Affiliated Changsha Hospital of Hunan University)Changsha 410015China

The global antibiotic resistance crisis necessitates urgent *** innovative approach involves potentiating antibiotics and non-antibiotic drugs with adjuvants or boosters.A major drawback of these membrane-active boosters is their limited biocompatibility,as they struggle to differentiate between prokaryotic and eukaryotic *** study reports the chemical biology investigation of a dual-action oligoamidine(OA1)booster with a glutathione-triggered decomposition ***1,when combined with other antimicrobial molecules,exhibits a triple-targeting mechanism including cell membrane disruption,DNA targeting,and intracellular enzyme *** multi-targeting mechanism not only enhances the in vitro and in vivo eradication of antibiotic-resistant“ESKAPE”pathogens,but also suppresses the development of bacterial ***,OA1 maintains its activity in bacterial cells by creating an oxidative environment,while it quickly decomposes in mammalian cells due to high glutathione *** mechanistic insights and design principles may provide a feasible approach to develop novel antimicrobial agents and effective anti-resistance combination therapies.

关键词： antimicrobial booster oligoamidine membrane disruption DNA targeting triggered degradation anti-resistance

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Pyramid-resolution person restoration for cross-resolution person re-identification

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Science China(Information Sciences) 2024年第6期67卷 451-452页

作者： Chunlei peng Bo wang Decheng LIU Nannan wang Xinbo GAO State Key Laboratory of Integrated Services Networks Xidian University School of Cyber Engineering Xidian University School of Telecommunications Engineering Xidian University Chongqing Key Laboratory of Image Cognition Chongqing University of Posts and Telecommunications

Person images captured by surveillance cameras are typically with various resolutions and are susceptible to pose changes,occlusion and background variations,thus affecting the performance of person Re *** approaches[1,2]either use an image restoration model to restore the lowresolution images to obtain a corresponding high-resolution image,

关键词： Restoration

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Prenatal amoxicillin exposure induces developmental toxicity in fetal mice and its characteristics

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Journal of Environmental Sciences 2024年第3期137卷 287-301页

作者： Yongguo Dai Yu peng Wen Hu Yi Liu Hui wang Department of Pharmacology Wuhan University School of Basic Medical SciencesWuhan 430071China Department of Pharmacy Zhongnan Hospital of Wuhan UniversityWuhan 430071China Hubei Provincial Key Laboratory of Developmentally Originated Disease Wuhan 430071China

Amoxicillin,a widely used antibiotic in human and veterinary pharmaceuticals,is now considered as an“emerging contaminant”because it exists widespreadly in the environment and brings a series of adverse ***,systematic studies about the developmental toxicity of amoxicillin are still *** explored the potential effects of amoxicillin exposure on pregnancy outcomes,maternal/fetal serum phenotypes,and fetal multiple organ development in mice,at different doses(75,150,300 mg/(kg·day))during late-pregnancy,or at a dose of 300 mg/(kg·day)during different stages(mid-/latepregnancy)and courses(single-/multi-course).Results showed that prenatal amoxicillin exposure(PAmE)had no significant infuence on the body weights of dams,but it could inhibit the physical development and reduce the survival rate of fetuses,especially during the ***,PAmE altered multiple maternal/fetal serum phenotypes,especially in *** multi-organ function results showed that PAmE inhibited testicular/adrenal steroid synthesis,long bone/cartilage and hippocampal development,and enhanced ovarian steroid synthesis and hepatic glycogenesis/lipogenesis,and the order of severity might be gonad(testis,ovary)>liver>*** analysis found that PAmE-induced multiorgan developmental and functional alterations had differences in stages,courses and fetal gender,and the most obvious changes might be in high-dose,late-pregnancy and multicourse,but there was no typical rule of a dose-response *** conclusion,this study confirmed that PAmE could cause abnormal development and multi-organ function alterations,which deepens our understanding of the risk of PAmE and provides an experimental basis for further exploration of the long-term harm.

关键词： Amoxicillin Prenatal exposure Fetal development Organ function Developmental toxicity

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Numerical Simulation on Unsteady Flow Mechanism of a 1.5-Stage Axial Transonic Compressor

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Journal of Thermal Science 2024年第5期33卷 1851-1866页

作者： peng Shuxuan ZHANG Xiaoyu wang Wentao ZHANG Hongwu LI Xinlong High Efficiency and Low Carbon Gas Turbine Digitalization Research Centre Nanjing Institute of Future Energy SystemNanjing 211135China Advanced Gas Turbine Laboratory Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China Key Laboratory of Advanced Energy and Power Chinese Academy of SciencesBeijing 100190China Innovation Academy for Light-Duty Gas Turbine Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China BYD Auto Industry Company Limited Shenzhen 518116China

In this paper,a numerical simulation method is used to calculate a 1.5-stage axial transonic compressor to explore its unsteady flow *** performance curve is compared with the experimental data to verify the calculation method with a high numerical accuracy,which shows that the unsteady calculation has good *** to the analysis of the data from the monitoring points under the near-stall condition,the unsteady disturbances originate from the tip region of blade and perform the strongest at the blade pressure surface with a broadband *** analysis is conducted by combining with the characteristics of the transient flow field at the tip of *** results show that the unsteady pressure fluctuations are caused by the migration of the new vortex *** new vortex cores are generated by the breakdown of leakage vortex in the downstream,which is induced by the leakage vortex and shock wave ***,the relationship between the unsteady flow characteristics and the working conditions is also *** leakage vortex intensity and the shock wave strength gradually increase with the decrease of flow *** the combination of the leakage vortex intensity and shock wave strength reaches the first threshold,a single frequency of unsteady disturbances appears at the blade *** the combination of the leakage vortex intensity and shock wave strength reaches the second threshold,the frequency of unsteady disturbances changes to a broadband.

关键词： numerical simulation axial transonic compressor unsteady flow vortex breakdown

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Recent progress in the development of dielectric elastomer materials and their multilayer actuators

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第3期25卷 183-205页

作者： Shengchao JIANG Junbo peng Lvting wang Hanzhi MA Ye SHI ZJU-UIUC Institute Zhejiang UniversityJiaxing 314400China College of Mechanical Engineering Zhejiang UniversityHangzhou 310058China Department of Polymer Science and Engineering Zhejiang UniversityHangzhou 310058China

Dielectric elastomers(DEs)have emerged as one of the most promising artificial muscle technologies,due to their exceptional properties such as large actuation strain,fast response,high energy density,and flexible processibility for various *** the past two decades,researchers have been working on developing DE materials with improved properties and exploring innovative applications of dielectric elastomer actuators(DEAs).This review article focuses on two main topics:recent material innovation of DEs and development of multilayer stacking processes for DEAs,which are important to promoting commercialization of *** begins by explaining the working principle of a ***,recently developed strategies for preparing new DE materials are introduced,including reducing mechanical stiffness,increasing dielectric permittivity,suppressing viscoelasticity loss,and mitigating electromechanical instability without *** the next section,different multilayer stacking methods for fabricating multilayer DEAs are discussed,including conventional dry stacking,wet stacking,a novel dry stacking method,and micro-fabrication-enabled stacking *** review provides a comprehensive and up-to-date overview of recent developments in high-performance DE materials and multilayer stacking *** highlights the progress made in the field and also discusses potential future directions for further advancements.

关键词： Dielectric elastomer actuator(DEA) Dielectric elastomer(DE) Material svnthesis Multilaver stacking method

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Long Duration Coverage Control of Multiple Robotic Surface Vehicles Under Battery Energy Constraints

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1695-1698页

作者： Shengnan Gao Zhouhua peng Haoliang wang Lu Liu Dan wang the School of Electrical and Control Engineering North China University of TechnologyBeijing 100144 the School of Marine Electrical Engineering Dalian Maritime UniversityDalian 116026China State Key Laboratory of Maritime Technology and Safety Dalian 116026 Dalian Key Laboratory of Swarm Control and Electrical Technology for Intelligent Ships Dalian 116026 the School of Marine Engineering Dalian Maritime UniversityDalian 116026

Dear Editor,This letter addresses long duration coverage problem of multiple robotic surface vehicles(RSVs) subject to battery energy constraints,in addition to uncertainties and disturbances. An anti-disturbance energy-aware control method is proposed for performing coverage task of RSVs. Firstly, a centroidal Voronoi tessellation(CVT) is used to optimize the partition of the given coverage area.

关键词： Robotic Battery partition

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Inducing mitochondriopathy-like damages by transformable nucleopeptide nanoparticles for targeted therapy of bladder cancer

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National Science Review 2024年第4期11卷 216-227页

作者： Da-Yong Hou Ni-Yuan Zhang Lu wang Mei-Yu Lv Xiang-peng Li peng Zhang Yue-Ze wang Lei Shen Xiu-Hai Wu Bo Fu peng-Yu Guo Zi-Qi wang Dong-Bing Cheng Hao wang wanhai Xu NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics Heilongjiang Key Laboratory of Scientific Research in Urology Harbin Medical University Department of Urology Harbin Medical University Cancer Hospital CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST) School of Chemistry Chemical Engineering & Life Science Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases Wuhan University of Technology

Mitochondriopathy inspired adenosine triphosphate(ATP) depletions have been recognized as a powerful way for controlling tumor growth. Nevertheless, selective sequestration or exhaustion of ATP under complex biological environments remains a prodigious challenge. Harnessing the advantages of in vivo self-assembled nanomaterials, we designed an Intracellular ATP Sequestration(IAS) system to specifically construct nanofibrous nanostructures on the surface of tumor nuclei with exposed ATP binding sites,leading to highly efficient suppression of bladder cancer by induction of mitochondriopathy-like ***, the reported transformable nucleopeptide(NLS-FF-T) self-assembled into nuclear-targeted nanoparticles with ATP binding sites encapsulated inside under aqueous conditions. By interaction with KPNA2, the NLS-FF-T transformed into a nanofibrous-based ATP trapper on the surface of tumor nuclei,which prevented the production of intracellular energy. As a result, multiple bladder tumor cell lines(T24,EJ and RT-112) revealed that the half-maximal inhibitory concentration(IC50) of NLS-FF-T was reduced by approximately 4-fold when compared to NLS-T. Following intravenous administration, NLS-FF-T was found to be dose-dependently accumulated at the tumor site of T24 xenograft mice. More significantly, this IAS system exhibited an extremely antitumor efficacy according to the deterioration of T24 tumors and simultaneously prolonged the overall survival of T24 orthotopic xenograft mice. Together, our findings clearly demonstrated the therapeutic advantages of intracellular ATP sequestration-induced mitochondriopathy-like damages, which provides a potential treatment strategy for malignancies.

关键词： self-assembly nucleopeptide nanomaterial bladder cancer mitochondriopathy

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