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High-Energy Tunable 6.5-12 μm Picosecond Mid-Infrared Radiation Generated from Optical Parametric Amplifier Based on LiInSe2 Crystal

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激光与光电子学进展 2024年第13期61卷 467-472页

作者： Zhang Jingjing Wang Shilei Yang Feng Wang Shanpeng Gao Hongwei Bo Yong Cui Dafu tao Xutang peng Qinjun Key Lab of Solid State Laser Technical Institute of Physics and Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Crystal Materials Shandong University

We report high-energy tunable 6.5-12 μm ps mid-infrared radiation generation based on OPA pumped using 1064 nm laser in LISe *** simulated the relationship between the idler energy and crystal *** optimum LISe length of 4 mm was used to enhance the idler energy *** a pump energy of ～9.4 mJ, energy levels of ～146 and of ～27 μJ are generated at 6.5 μm and 12 μm, *** highest energy of ～205 μJ is achieved at 8.1 μm at a pump energy of ～19 ***, the angular and spectral width acceptance are measured.

关键词： LiInSe2 crystal nonlinear optical crystal optical parametric amplifier tunable mid-infrared radiation

Electrodynamics with violations of Lorentz and U(1)gauge symmetries and their Hamiltonian structures

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Chinese Physics C 2024年第6期48卷 45-57页

作者：杨秀鹏李瀑飞朱涛 Institute for Theoretical Physics and Cosmology Zhejiang University of TechnologyHangzhou 310032China United Center for Gravitational Wave Physics(UCGWP) Zhejiang University of TechnologyHangzhou 310032China

This study aims to investigate Lorentz/U(1)gauge symmetry-breaking electrodynamics in the framework of the standard-model extension and analyze the Hamiltonian structure for the theory with a specific dimension of Lorentz breaking *** this purpose,we consider a general quadratic action of the modified electrodynamics with Lorentz/gauge-breaking operators and calculate the number of independent components of the operators at different dimensions in gauge invariance and *** this general action,we then analyze how Lorentz/gauge symmetry-breaking can change the Hamiltonian structure of the theories by considering Lorentz/gauge-breaking operators with dimension as *** show that the Lorentz-breaking operators with gauge invariance do not change the classes of the theory constrains and the number of physical degrees of freedom of the standard Maxwell *** U(1)gauge symmetry-breaking operators are present,the theories generally lack a first-class constraint and have one additional physical degree of freedom compared to the standard Maxwell electrodynamics.

关键词： standard model extension electrodynamics Lorentz violations

Natural variation of an autophagy-family gene among rice subspecies affects grain size and weight

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The Crop Journal 2024年第1期12卷 121-132页

作者： Shiying Huang peng Wang Caijing Li Qingwen Zhou tao Huang Yicong Cai Qin Cheng Hui Wang Qi Zhong Zhihao Chen Liping Chen Haohua He Jianmin Bian Key Laboratory of Crop Physiology Ecology and Genetic BreedingMinistry of Education.Jiangxi Agricultural UniversityNanchang 330045JiangxiChina Weill Cornell Medical Immunology and Microbiology1300 York AvenueBox 62New YorkNY 10065USA

Elucidating the genetic basis of natural variation in grain size and weight among rice varieties can help breeders develop high-yielding *** identified a novel gene,GW3a(Grain Weight 3a)(LOC_Os03g27350),that affects rice grain size and ***3a mutants showed higher total starch content and dry matter accumulation than the wild type(WT),Nipponbare,suggesting that GW3a negatively regulates grain size and ***,our study found that GW3a interacted with OsATG8 by cleaving it,suggesting that GW3a may be involved in the assembly of autophagosomes and starch degradation in *** haplotype analysis of GW3a showed functional differences between indica and japonica *** together,we conclude that GW3a is expressed in the autophagosome pathway regulating starch metabolism in rice,affecting yield-related traits,such as grain size,grain weight and thousand grain weight(TGW).Our findings also shed new light on autophagy-mediated yield trait regulation,proposing a possible strategy for the genetic improvement of high-yield germplasm in rice.

关键词： Grain size GW3a Autophagy Starch content

Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor

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National Science Review 2024年第4期11卷 206-215页

作者： Ziyan Liao Jie Jiang Wei Wu Jiaqi Shi Yanfang Wang Yuejun Yao tao Sheng Feng Liu Wei Liu peng Zhao Feifei Lv Jie Sun Hongjun Li Zhen Gu National Key Laboratory of Advanced Drug Delivery and Release Systems College of Pharmaceutical Sciences Zhejiang University Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang University Liangzhu Laboratory Zhejiang University Bone Marrow Transplantation Center of the First Affiliated Hospital and Department of Cell Biology Zhejiang University School of Medicine Department of Medical Oncology The First Affiliated Hospital School of Medicine Zhejiang University Department of Laboratory Medicine The First Affiliated Hospital Zhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang University Jinhua Institute of Zhejiang University MOE Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang University Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University

The limited infiltration and persistence of chimeric antigen receptor(CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process of T-cell proliferation in lymph nodes. This scaffold gathers the function of loading,delivery, activation and expansion for CAR-T cells to enhance their therapeutic effects on solid tumors. This porous device is made from poly(lactic-co-glycolic acid) by a microfluidic technique with the modification of T-cell stimulatory signals, including anti-CD3, anti-CD28 antibodies, as well as cytokines. This scaffold fosters a 50-fold CAR-T cell expansion in vitro and a 15-fold cell expansion in vivo. Particularly, it maintains long-lasting expansion of CAR-T cells for up to 30 days in a cervical tumor model and significantly inhibits the tumor growth. This biomimetic delivery strategy provides a versatile platform of cell delivery and activation for CAR-T cells in treating solid tumors.

关键词： drug delivery cell therapy bioinspired biomaterials cancer immunotherapy

Electrocatalytic CO_(2) reduction to C_(2)H_(4): From lab to fab

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Journal of Energy Chemistry 2024年第3期90卷 540-564,I0012页

作者： Zeyu Guo Fabao Yang Xiaotong Li Huiwen Zhu Hainam Do Kam Loon Fow Jonathan D.Hirst tao Wu Qiulin Ye Yaqi peng Hao Bin Wu Angjian Wu Mengxia Xu Department of Chemical and Environmental Engineering and New Materials InstituteUniversity of Nottingham Ningbo ChinaNingbo 315100ZhejiangChina Key Laboratory of Carbonaceous Waste Processing and Process Intensification of Zhejiang Province University of Nottingham Ningbo ChinaNingbo 315100ZhejiangChina Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute University of Nottingham Ningbo ChinaNingbo 315100ZhejiangChina State Key Laboratory of Clean Energy Utilization Department of Energy EngineeringZhejiang UniversityHangzhou 310027ZhejiangChina Institute for Composites Science Innovation(InCSI)and State Key Laboratory of Silicon and Advanced Semiconductor Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027ZhejiangChina School of Chemistry University of NottinghamUniversity ParkNottingham NG72RDUK Baima Lake Laboratory Hangzhou 310053ZhejiangChina

The global concerns of energy crisis and climate change,primarily caused by carbon dioxide(CO_(2)),are of utmost ***,the electrocatalytic CO_(2) reduction reaction(CO_(2)RR) to high value-added multi-carbon(C_(2+)) products driven by renewable electricity has emerged as a highly promising solution to alleviate energy shortages and achieve carbon *** these C_(2+) products,ethylene(C_(2)H_(4))holds particular importance in the petrochemical ***,this review aims to establish a connection between the fundamentals of electrocatalytic CO_(2) reduction reaction to ethylene(CO_(2)RRto-C_(2)H_(4)) in laboratory-scale research(lab) and its potential applications in industrial-level fabrication(fab).The review begins by summarizing the fundamental aspects,including the design strategies of high-performance Cu-based electrocatalysts and advanced electrolyzer ***,innovative and value-added techniques are presented to address the inherent challenges encountered during the implementations of CO_(2)RR-to-C_(2)H_(4) in industrial ***,case studies of the technoeconomic analysis of the CO_(2)RR-to-C_(2)H_(4) process are discussed,taking into factors such as costeffectiveness,scalability,and market *** review concludes by outlining the perspectives and challenges associated with scaling up the CO_(2)RR-to-C_(2)H_(4) *** insights presented in this review are expected to make a valuable contribution in advancing the CO_(2)RR-to-C_(2)H_(4) process from lab to fab.

关键词： CO_(2) electroreduction reaction Ethylene Gas diffusion electrode Machine learning Density functional theory Techno-economic analysis

指向人的教化的美学人类学——赫尔巴特美学视角下的教育理论

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华东师范大学学报（教育科学版） 2024年第1期42卷 85-98页

作者：彭韬教育部人文社会科学重点研究基地南京师范大学道德教育研究所南京210097

赫尔巴特的美学思想在美学和教育学领域未得到应有的重视和阐发,本文试图论证,赫尔巴特构建了一种美学人类学的视野,并将伦理学、教育学、文艺学等诸多领域的理论都纳入其中。这种美学人类学将以审美判断为核心的美学原理贯穿于有关人... 详细信息

赫尔巴特的美学思想在美学和教育学领域未得到应有的重视和阐发,本文试图论证,赫尔巴特构建了一种美学人类学的视野,并将伦理学、教育学、文艺学等诸多领域的理论都纳入其中。这种美学人类学将以审美判断为核心的美学原理贯穿于有关人类实践的各方面基本问题中,尤其显示出“伦理学的兴趣”,他将伦理学的基本原则建立在美学的原理之上,提出了一种美德融通的机制,并将其最终指向了人的教化(Bildung)。以人的教化为目的的教育行动必须沿着审美的道路才能促成道德性格的形成,这也是教学和训育具有教育性的前提条件。在这样的美学人类学视野中理解赫尔巴特的教育学,才能充分彰显其教育思想的当代意义。

关键词：赫尔巴特审美判断美学人类学教化教育

Yu Gan Long Ameliorates Hepatic Fibrosis by Inhibiting PI3K/AKT,Ras/ERK and JAK1/STAT3 Signaling Pathways in CCl4-induced Liver Fibrosis Rats

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Current Medical Science 2020年第3期40卷 539-547页

作者： Hou-gang LI peng-tao you Yu XI Yu CAI Yi-jun TU Meng-heng WANG Wan-ci SONG Tai-min QUAN Hui-ying REN Yan-wen LIU Han-xiong DAN Shi-qing XU Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine Hubei University of Chinese MedicineWuhan430065China College of Pharmacy Hubei University of Chinese MedicineWuhan430065China Wuhan Junan Pharmaceutical Co. Ltd.Wuhan430023China

Yu Gan Long(YGL)is a Chinese traditional herbal formula which has been reported to attenuate liver fibrosis for many years and we have explored its anti-fibrotic mechanism through blocking transforming growth factor(TGF-β)in the previous *** the mechanisms associated with platelet-derived growth factor(PDGF)-BB remain *** this study,we further investigated the mechanism of YGL reducing carbon tetrachloride(CCl4)-induced liver fibrosis in *** results showed that YGL suppressed CCl4-induced upregulation of collagen IV(Col IV),type HI precollagen(PCHI),hyaluronuc acid(HA)and laminin(LN),which are implicated in liver ***,YGL reduced theα-smooth muscle actin(α-SMA)expression,which acts as the indicator of liver ***,YGL decreased the serum levels of hepatic stellate cell(HSC)mitogen PDGF-BB and inflammation cytokines,including TNF-α,IL-1β,*** involved in liver fibrosis,such as Ras,p-Raf-1,p-ERK1/2,p-JNK,p-P38,p-PI3K,p-AKT,p-JAKl,p-STAT3 were downregulated significantly after treatment with *** results indicated that YGL ameliorated CCl4-induced liver fibrosis by reducing inflammation cytokines production,and suppressing Ras/ERK,PI3K/AKT,and JAK1/STAT3 signaling pathways,which provided further evidence towards elucidation of the anti-fibrotic mechanism of YGL.

关键词： Yu Gan Long traditional Chinese herbal therapy liver fibrosis Ras/ERK PI3K/AKT JAK1/STAT3

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“迈向成熟”:理解康德教育理论的一个视角

湖南师范大学教育科学学报 2024年第3期23卷 25-33,45页

作者：彭韬教育部人文社会科学重点研究基地/南京师范大学道德教育研究所江苏南京210097

在康德关于启蒙的观点中,人需要两次走出不成熟——第一次是走出自然的不成熟,第二次是走出自己造成的不成熟。走出自己造成的不成熟并不意味着达到成熟,而是意味着开始迈向成熟,迈向成熟需要三个条件。以迈向成熟为视角可以重新诠释康... 详细信息

在康德关于启蒙的观点中,人需要两次走出不成熟——第一次是走出自然的不成熟,第二次是走出自己造成的不成熟。走出自己造成的不成熟并不意味着达到成熟,而是意味着开始迈向成熟,迈向成熟需要三个条件。以迈向成熟为视角可以重新诠释康德教育思想。在康德的视域中,教育的使命在于使受教育者达到“教育上的成熟”,即支持受教育者走出自然的不成熟状态、达到自然的成熟,且避免陷入自己造成的不成熟,使其有能力自己迈向行动和政治的成熟。教育上的成熟既是教育的使命所在,也界定了教育的界限。教育无法制造成熟的人,也无法从高于现实社会的层次来改变社会。教育与政治只能在相互关系中推动人类的进步。

关键词：康德启蒙迈向成熟教育与政治

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数字政府中个人数据保护的法律规则转换

法学 2024年第4期 47-61页

作者：彭涛西北政法大学行政法学院

建设数字政府必定导致大量个人数据进入政府掌控的公共数据库,这些公共数据中的个人数据需要在数字政府内部共享,以及通过外部流通,从而促进社会公共利益的增加。这就必然导致之前以“告知—同意”为主的个人数据保护法律规则,无法适应... 详细信息

建设数字政府必定导致大量个人数据进入政府掌控的公共数据库,这些公共数据中的个人数据需要在数字政府内部共享,以及通过外部流通,从而促进社会公共利益的增加。这就必然导致之前以“告知—同意”为主的个人数据保护法律规则,无法适应数字政府中个人数据的应用状况。数字政府采用的数字技术对个人的意思表示会产生影响,同时这些技术也导致个人隐私在一定程度上透明化。个人数据及其权利的法律性质存在个人性及公共性的二元性,个人数据经过合法程序进入政府公共数据库之后,应当扩展个人数据的公共性。在数字政府中应当有与私法不同的个人数据保护规则,主要包括强调个人数据共享及流通,以增加社会价值的利用规则体系;强调国家监管以保护个人数据的保护规则体系;强调事前预防措施的救济体系。

关键词：数字政府个人数据保护规则数据共享公共利益