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Recurrent gastrointestinal bleeding and hepatic infarction after liver biopsy

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World Journal of Gastroenterology 2014年第7期20卷 1878-1881页

作者： Faraz Bishehsari peng-sheng ting Richard M Green Division of Gastroenterology and Hepatology Feinberg School of MedicineRobert H.Lurie Comprehensive Cancer CenterNorthwestern University Department of Medicine National Taiwan University College of Medicine

Hepatic artery pseudoaneurysms(HAP)are rare events,particularly after liver biopsy,but can be associated with serious *** a high suspicion is necessary for timely diagnosis and appropriate *** report on a case of HAP that potentially formed after a liver biopsy in a patient with *** HAP in our case was virtually undetectable initially by angiography but resulted in several complications including recurrent gastrointestinal bleeding,hemorrhagic cholecystitis and finally hepatic infarction with abscess formation until it became detectable at a size of *** patient remains asymptomatic over a year after endovascular embolization of the *** this report,we demonstrate that a small HAP can avoid detection by angiography at an early stage while being symptomatic for a prolonged course.A high clinical suspicion with a close clinical/radiological follow-up is needed in symptomatic patients with history of liver biopsy despite initial negative work *** diagnosed,HAP can be safely and effectively treated by endovascular embolization.

关键词： Gastrointestinal bleed Abnormal liver enzymes Hepatic artery pseudoaneurysms Liver biopsy Angiography

Hepatitis D virus and liver transplantation: Indications and outcomes

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World Journal of Hepatology 2021年第3期13卷 291-299页

作者： Haris Muhammad Aniqa Tehreem Muhammad Baraa Hammami peng-sheng ting Ramzan Idilman Ahmet Gurakar Department ofInternal Medicine Greater Baltimore Medical CenterTowsonMD 21204United States Department of Internal Medicine Sinai Hospital BaltimoreMD 21204United States Division of Gastroenterology and Hepatology Johns Hopkins University School of MedicineBaltimoreMA 21205United States Department of Gastroenterology Ankara University School of MedicineAnkara 06690Turkey

Hepatitis D virus(HDV)is a dependent virus that relies on hepatitis B virus for its replication and *** hepatitis D is a severe form of viral hepatitis that can result in end stage liver ***,pegylated interferon alpha is the only approved therapy for chronic HDV infection and is associated with significant side *** transplantation(LT)is the only treatment option for patients with end-stage liver disease,hepatocellular carcinoma,or fulminant hepatitis due to coinfection with *** LT for HDV and hepatitis B virus coinfection is uncommon in the United States,most data on the long-term impact of LT on HDV are from international *** this review,we discuss the indications and results of LT with treatment options in HDV patients.

关键词： Hepatitis delta virus Liver transplant Hepatitis B immunoglobins Hepatocellular carcinoma

IMP3 is a novel biomarker to predict metastasis and prognosis of gastric adenocarcinoma： a retrospective study

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Chinese Medical Journal 2010年第24期123卷 3554-3558页

作者： WANG Lin LI Hai-gang XIA Zhong-sheng Lv Jun peng ting-sheng Department of Pathology Sun Yat-sen Memorial Hospital Sun Yat-sen University Guangzhou Guangdong 510120 China Department of Gastroenterology Sun Yat-sen Memorial Hospital Sun Yat-sen University Guangzhou Guangdong 510120 China Department of Nephrology Sun Yat-sen Memorial Hospital Sun Yat-sen University Guangzhou Guangdong 510120 China Department of Pathology the First Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510080 China

Background Insulin-like growth factor-Ⅱ mRNA-binding protein 3 （IMP3） is a newly identified mRNA-binding protein that is involved in embryogenesis and carcinogenesis of some malignant tumors. The aim of this study was to detect the expression of IMP3 protein in gastric adenocarcinoma （GAC） and the correlation with clinicopathological *** IMP3 protein in 92 samples of GAC was evaluated by immunohistochemical method. The Mann-Whitney U test and Kruskal-Wallis H test were used to compare IMP3 expression and clinicopathological parameters. Kaplan-Meier survival curve, log-rank test and Cox-regression model were used to evaluate the correlation of IMP3 protein expression to the prognosis of *** Out of 92 cases of adjacent normal mucosa （ANM）, 10 with dysplasia demonstrated weak expression of IMP3 and 82 without dysplasia showed negative expression. Out of 92 cases of GAC, positive immunohistochemical stain for IMP3 was identified in 75 （82%） cases. A comparison of IMP3 expression in GAC and ANM showed stronger immunohistochemical reactivity in GAC （P ＜0.05）. High expression of IMP3 was found to be associated with lymphoid metastasis, high Ki-67 labelling index, and patient poor outcome （P ＜0.05）. There was a significant TNM stage difference between GAC with and without IMP3 expression （P＜0.05）. Tumors with higher stage showed higher level of IMP3 expression, In multivariate analysis, IMP3 emerged as an independent predictor of *** Increase of IMP3 expression suggests that IMP3 may play an importent role in the carcinogenesis and tumor metastasis in GAC. It could be regarded as a novel proliferation and prognostic indicator for patients with GAC.

关键词： stomach neoplasms IMP3 protein, human immunohistochemistry prognosis

Hepatocellular Carcinoma and the Role of Liver Transplantation:A Review

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Journal of Clinical and Translational Hepatology 2021年第5期9卷 738-748页

作者： Haris Muhammad Aniqa Tehreem peng-sheng ting Merve Gurakar Sean Young Li Cem Simsek Saleh A.Alqahtani Amy K.Kim Ruhail Kohli Ahmet Gurakar Department of Internal Medicine Greater Baltimore Medical CenterMDUSA Department of Internal Medicine Sinai HospitalBaltimoreMDUSA Division of Gastroenterology and Hepatology Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Medicine Osler Residency ProgramJohns Hopkins University School of MedicineBaltimoreMDUSA Duke University DurhamNCUSA

Hepatocellular carcinoma(HCC)is one of the leading causes of cancer deaths worldwide and liver transplantation(LT)is the only potentially curative *** the years,Milan criteria has been used for patient *** is ongoing research in this field with introduction of new biomarkers for HCC that can help guide future ***,newer therapies for downstaging of the tumor are being implemented to prevent dropout from the transplant *** addition,combination therapies for better outcome are under ***,the concept of living-donor LT and possible use of hepatitis C virus-positive donors has been implemented as an attempt to expand the organ ***,there is a conflict of opinion between different centers regarding its efficacy and data is *** aim of this review article is to outline the various selection criteria for LT,discuss the outcomes of LT in HCC patients,and explore future directions of LT for ***,a comprehensive PubMed/MEDLINE review was *** expand our search,references of the retrieved articles were also screened for additional *** selecting the studies,the authors independently reviewed them to identify the relevant *** careful evaluation 120 studies relevant to out topic are cited in the *** tables and two figures are also *** conclusion LT for HCC has evolved over the *** the introduction of several expanded criteria beyond Milan,the introduction of bridging therapies,such as transcatheter arterial chemoembolization and radiofrequency ablation,and the approval of newer systemic therapies,it is evident that there will be more LT recipients in the *** is promising to see ongoing trials and the continuous evolution of *** studies are needed to guide the development of a pre-LT criteria that can ensure low HCC recurrence risk and is not overly stringent,clarify the role of LDLT,and determine the optimal bridgin

关键词： Hepatocellular carcinoma Liver transplantation Model for endstage liver disease Trans-arterial radioembolization Locoregional therapies

Introduction of Foreign Genes into Silkworm Eggs by Electroporation and Its Application in Transgenic Vector Test

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Acta Biochimica et Biophysica Sinica 2004年第5期36卷 323-330页

作者： Xiu-Yang GUO#, Liang DONG#, sheng-peng WANG, ting-Qing GUO, Jian-Yang WANG, and Chang-De LU* Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, the Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences the Chinese Academy of Sciences

Electroporation as a methodology to introduce foreign genes into silkworm eggs was system- atically analyzed. The foreign gene in both the newly hatched and 3rd instar larva DNA can be detected by PCR. The amount of foreign gene in 3rd instar larva DNA was about 1/1000 of that in newly hatched larva DNA. The ratio of foreign gene entering into silkworm eggs was voltage dependent and showed significant difference between the tested silkworm strains. When the piggyBac transposon system was applied, the effect of nuclear localization signal (NLS) peptide and the in vitro transcribed transposase mRNA on the transposi- tion rate has been measured. Results showed that the in vitro transcribed transposase mRNA facilitated trans- position to take place earlier and NLS could result in higher transposition probability and earlier transposition as well. When linearized vectors containing varied length of flanking homologous sequences around a re- porter gene were introduced into silkworm eggs by electroporation, the one with 2.6 kb total arm length gave higher G1 positive ratio than that with total arm length of 1.5 kb and 800 bp.

关键词： silkworm eggs gene introduction electroporation transposon homologous sequences

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胎儿心室肌致密化不全一例

中华病理学杂志 2007年第10期36卷 713-714页

作者：唐芳彭挺生宋一璇中山大学附属第一医院病理科

患者女，25岁。因停经20周，B超发现胎儿心律异常1d于2006年6月20日入院。临床诊断为胎儿心动过速性心律失常；患者既往体健，无遗传性疾病家族史。体检：患者生命体征止常，心、肺检查未见异常。胎儿心率240～250次/min（正常胎心率为... 详细信息

患者女，25岁。因停经20周，B超发现胎儿心律异常1d于2006年6月20日入院。临床诊断为胎儿心动过速性心律失常；患者既往体健，无遗传性疾病家族史。体检：患者生命体征止常，心、肺检查未见异常。胎儿心率240～250次/min（正常胎心率为120～160次／min），心律尚齐；胎儿心脏B超：四腔切面可显示左、右心房、心窒比例基本对称，二尖瓣及三尖瓣可辨。

关键词：胎儿心率心室肌致密化不全心动过速性心律失常心律异常心脏B超遗传性疾病临床诊断生命体征

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睾丸大细胞钙化性支持细胞瘤一例

中华病理学杂志 2007年第4期36卷 281-282页

作者：张建伟苟新敏李智彭挺生中山大学附属第一医院病理科基础医学院病理学教研室广州浙江省台州医院病理科510080 中山大学附属第五医院病理科

患者男．25岁。双侧睾丸肿大半年余，伴咳嗽、咳痰和发热于2005年3月入院。体检：双侧睾丸上极均触及无痛性硬肿物，大小分别约1．5cm×1．5cm和0．5cm×0．2cm，可活动，与周围组织无粘连．既往无睾丸外伤史，无体态及毛发的改变。无... 详细信息

患者男．25岁。双侧睾丸肿大半年余，伴咳嗽、咳痰和发热于2005年3月入院。体检：双侧睾丸上极均触及无痛性硬肿物，大小分别约1．5cm×1．5cm和0．5cm×0．2cm，可活动，与周围组织无粘连．既往无睾丸外伤史，无体态及毛发的改变。无明显内分泌疾病症状和体征。手术切除双侧睾丸肿物，病理检查：两块肿物组织境界清楚，直径分别约1．5cm和0．5cm。切面为黄白色带有分散的钙化点，切开时有沙砾感.未见包膜的浸润．也无出血和坏死灶。镜下观察：肿瘤内钙化十分显著，瘤细胞排列呈小梁状、小管状和实体性区域，呈巢状分布（图1）。间质部分为疏松的黏液样基质，部分为纤维性间质，伴有形状不规则的钙化灶（图2）。瘤细胞胞体和细胞核均较大，可见明显的核仁和丰富的嗜酸性胞质。胞质内可见不规则的深红染小体样结构。核分裂象罕见。瘤细胞问可见少量淋巴细胞浸润。未见包膜和血管浸润．也未见Reinke结晶和脂褐素沉积。免疫组织化学染色示瘤细胞S-100蛋白和α-抑制素弥漫强阳性（图3，4），波形蛋白阳性。但平滑肌肌动蛋白（SMA）、细胞角蛋白（CK）、甲胎蛋白（AFP）、Ki-67阴性。

关键词：支持细胞瘤睾丸肿大钙化性大细胞 Reinke结晶免疫组织化学染色淋巴细胞浸润 S-100蛋白

CD44对骨肉瘤细胞增殖、黏附和侵袭性的影响

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中华病理学杂志 2005年第6期34卷 362-366页

作者：彭挺生丘钜世李智张萌梁惠珍中山大学中山医学院病理学教研室广州510080

目的研究细胞表面黏附分子CD44对骨肉瘤细胞增殖、黏附和侵袭特性的影响,探讨骨肉瘤细胞生长侵袭的机制。方法流式细胞术和Westernblot检测3株骨肉瘤细胞系MG63、HOS和U2-OS中CD44的阳性表达率和相对蛋白含量;逆转录聚合酶链反应(RTPCR... 详细信息

目的研究细胞表面黏附分子CD44对骨肉瘤细胞增殖、黏附和侵袭特性的影响,探讨骨肉瘤细胞生长侵袭的机制。方法流式细胞术和Westernblot检测3株骨肉瘤细胞系MG63、HOS和U2-OS中CD44的阳性表达率和相对蛋白含量;逆转录聚合酶链反应(RTPCR)法研究3株细胞系之间CD44mRNA的表达差异;同时应用MTT法、美蓝硼酸盐法和微孔迁移技术研究阻断CD44的作用前后3株细胞的增殖、黏附和侵袭能力的变化。结果HOS和U2-OS中CD44的阳性百分率均高于99%,但HOS中CD44的平均荧光强度显著高于U2-OS(P0.05)。结论CD44能促进骨肉瘤细胞系HOS的黏附和侵袭,并参与U2-OS的侵袭和MG-63的黏附过程,但是不影响骨肉瘤细胞的增殖速率。

关键词：细胞增殖逆转录-聚合酶链反应(RT-PCR) 侵袭性 Western 黏附分子CD44 骨肉瘤细胞系 blot检测平均荧光强度 CD44表达 HOS 蛋白含量 mRNA 瘤细胞生长流式细胞术阳性表达率细胞表面侵袭特性表达差异 MTT法侵袭能力

细胞因子HGF体外增强骨肉瘤细胞株的增殖和黏附性

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中山大学学报（医学科学版） 2006年第5期27卷 529-532页

作者：彭挺生李智丘钜世张萌王燕中山大学附属第一医院病理科//基础医学院病理学教研室广东广州510080 昆明医学院附属第二医院病理科云南昆明650224

【目的】研究肝细胞生长因子/离散因子(HGF/SF)及其受体蛋白c-Met在骨肉瘤细胞株MG-63和HOS中的表达及对瘤细胞生物学行为的影响,探讨HGF/c-Met系统在骨肉瘤细胞生长侵袭过程中的作用。【方法】用流式细胞术检测HGF-!、HGF-"、c-Met在2... 详细信息

【目的】研究肝细胞生长因子/离散因子(HGF/SF)及其受体蛋白c-Met在骨肉瘤细胞株MG-63和HOS中的表达及对瘤细胞生物学行为的影响,探讨HGF/c-Met系统在骨肉瘤细胞生长侵袭过程中的作用。【方法】用流式细胞术检测HGF-!、HGF-"、c-Met在2株骨肉瘤细胞株中的表达;外源性HGF刺激此2株细胞株后,用MTT法、黏附性检测方法研究细胞增殖速率和黏附性的变化。【结果】HGF-!、HGF-"、c-Met在2株骨肉瘤细胞株中的阳性表达率均低于3%。HGF浓度达50ng/mL以上时,MG-63和HOS的增殖速率显著增高,P0.05。【结论】HGF可以促进骨肉瘤细胞株MG-63和HOS的体外增殖和黏附能力。

关键词： HGF c-Met 骨肉瘤细胞株细胞增殖细胞黏附