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BARK-MIMETIC LAYER-BY-LAYER ASSEMBLED MONTMORILLONITE/POLY(p-AMINOSTYRENE) FLEXIBLE NANOCOMPOSITES SHIELDING ATOMIC OXYGEN EROSION

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Chinese Journal of Polymer Science 2013年第1期31卷 83-87页

作者： Min Gao Bing-jun Liu 高龙成 peng-gang yin Lei Jiang Key Laboratory of Bio-inspired Smart Interfacial Science and Technology of Ministry of Education School of Chemistry and EnvironmentBeiHang University Beijing National Laboratory for Molecular Sciences (BNLMS) Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of Sciences

Inspired by the birch bark, which has multilayered structures, we fabricated layer-by-layer （LbL） assembled montmorillonite （MMT） and poly（p-aminostyrene）（PPAS） nanocomposites on cotton fiber curved surfaces to provide protection from atomic oxygen （AO） erosion. The multilayer coated fibers had high flexibility, uniformity, defect free, ease of preparation and low cost. The AO erosion durability has been dramatically enhanced which was evidenced by testing in the ground-based AO effects simulation facility. And the dimension and surface morphologies of the fibers observed by SEM had few changes, indicating excellent AO erosion resistant ability of the coatings. These results provide us a new method to design fibrous materials exposed directly in low earth orbit environment.

关键词： Layer-by-layer assembly Atomic oxygen Biomimetics Adhesion Aerospace materials.

Improved Performance of a Wavelength-Tunable Arrayed Waveguide Grating in Silicon on Insulator

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Chinese Physics Letters 2019年第5期36卷 40-43页

作者： Pei Yuan Xiao-Guang Zhang Jun-Ming An peng-gang yin Yue Wang Yuan-Da Wu State Key Laboratory on Integrated Optoelectronics Institute of SemiconductorsChinese Academy of SciencesBeijing 100083 Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049 Key Laboratory of Bio-inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100083

The improved performance of a wavelength-tunable arrayed waveguide grating (AWG) is demonstrated, including the crosstalk, insertion loss and the wavelength tuning efficiency. A reduced impact of the fabrication process on the AWG is achieved by the design of bi-level tapers. The wavelength tuning of the AWG is achieved according to the thermo-optic effect of silicon, and uniform heating of the silicon waveguide layer is achieved by optimizing the heater design. The fabricated AWG shows a minimum crosstalk of 16 dB, a maximum insertion loss of 3.91 dB and a wavelength tuning efficiency of 8.92 nm/W, exhibiting a ～8 dB improvement of crosstalk, ～2.1 dB improvement of insertion loss and ～5 nm/W improvement of wavelength tuning efficiency, compared to our previous reported results.

关键词： Improved Performance of a Wavelength-Tunable Arrayed Waveguide Grating in Silicon on Insulator AWG

Theoretical Study of Surface-Enhanced Raman Spectra of 4,4’-thiobisbenzenethiol on metal surface

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Theoretical Study of Surface-Enhanced Raman Spectra of 4,4’...

Theoretical Study of Surface-Enhanced Raman Spectra of 2-Aminothiophenol

第十七届全国光散射学术会议

作者： Ting-Ting You peng-gang yin Beihang University

＜正＞4,4’-thiobisbenzenethiol（TBBT）TBBT molecule which is consist of two benzenethiols linked by a sulfur atom exhibit both good chemical activity and *** investigations have been performed on the adsorption behaviors and surface-enhanced Raman spectra of TBBT in various conditions.[1,2]In our work,a theoretical study was conducted to discuss the relationship between surface adsorption configuration and spectral enhancement.

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Theoretical Study of Surface-Enhanced Raman Spectra of 2-Ami...

Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

第十六届全国光散射学术会议

作者： Ting-Ting You,peng-gang yin (Beihang University,Beijing,100083)

＜正＞2-aminothiophenol（2-ATP） is a unique probe molecule for *** other popular probe molecule such as p-aminothiophenol（p-ATP） and 4-Mercapto benzoic acid,the spectral properties including vibrational assignment and enhancement on metal surface of this molecule still remain unclear and are less *** work is to investigate Raman and SERS spectra of 2-ATP utilizing quantum chemical simulations,as shown in figure 1.

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing peng yin Shihua Li Xiao-Jiang Li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma peng-peng Li Hai-Wei Pu Xin-Yian Guo Jian-gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

血清CYFRA21-1,HCY及CA15-3水平联合检测对乳腺癌辅助诊断的临床评价

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现代检验医学杂志 2020年第3期35卷 55-57,61页

作者：张维龙松权彭印钢桂林市中医医院检验科广西桂林541002

目的探讨血清细胞角蛋白19片段(cytokeratin 19 fragment,CYFR21-1)、同型半胱氨酸(homocysteine,HCY)和糖类抗原15-3(carbohydrate antigen 15-3,CA15-3)在乳腺癌患者体内的表达水平及其在乳腺癌诊断中的价值。方法选取2019年1~11月期间收治的乳腺癌患者73例为研究对象,良性乳腺瘤患者95例为疾病对照组,同期体检的健康志愿者80例为正常对照组,分别检测并比较三组研究对象CYFRA21-1,HCY和CA15-3水平,分析其对乳腺癌诊断的价值。结果乳腺癌组的CYFRA21-1,HCY和CA15-3检测水平分别为6.25±1.60ng/ml,19.42±3.67μmol/L和40.84±6.77U/ml;良性乳腺瘤组的CYFRA21-1,HCY和CA15-3检测水平分别为1.28±0.38 ng/ml,11.72±2.46μmol/L和16.44±3.71 U/ml;对照组的CYFRA21-1,HCY和CA15-3检测水平分别为0.86±0.21 ng/ml,9.57±2.22μmol/L和12.84±2.69 U/ml,结果显示乳腺癌组的三项指标表达水平明显高于乳腺瘤组和对照组,差异均有统计学意义(F=22.314~97.593,均P<0.05)。乳腺癌晚期患者(Ⅲ-Ⅳ期)血清CYFRA21-1,HCY和CA15-3水平显著高于早期患者(Ⅰ-Ⅱ期),差异均有统计学意义(t=6.311~11.720,均P<0.05)。血清CYFRA21-1,HCY和CA15-3联合检测灵敏度和准确度分别为89.04%和83.33%,与单项检测比较差异均有统计学意义(t=2.655~21.196,均P<0.05)。结论CYFRA21-1,HCY和CA15-3联合检测可明显提高乳腺癌诊断的灵敏度和准确度,为临床提供经济快捷有效的实验室依据。

关键词：乳腺癌细胞角蛋白19片段同型半胱氨酸糖类抗原15-3

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自卤仿产生二卤卡宾的单电子转移过程

化学学报 1987年第4期45卷 415-417页

作者：许临晓陶凤岗于同隐葛明陶陈士明复旦大学化学系复旦大学分析测试中心复旦大学分析测试中心上海

按照经典机理,由卤仿产生二卤卡宾是经过了一个简单的两步过程:虽然这一过程缺少可靠的全面验证,但该机理已被广泛接受,并推广到了许多类似反应,迄今尚未见有对其提出异议的报道。我们在研究溴仿和氯仿混合体系的反应中发现产物组成与... 详细信息

按照经典机理,由卤仿产生二卤卡宾是经过了一个简单的两步过程:虽然这一过程缺少可靠的全面验证,但该机理已被广泛接受,并推广到了许多类似反应,迄今尚未见有对其提出异议的报道。我们在研究溴仿和氯仿混合体系的反应中发现产物组成与预期结果不符。在烯烃存在下,反应同时给出三种偕二卤环丙烷。

关键词：卤素交换卡宾游离基庚烷自由基烷烃环丙烷环烷烃单电子转移过程

A novel prognostic gene signature,nomogram and immune landscape based on tanshinone IIA drug targets for hepatocellular carcinoma:Comprehensive bioinformatics analysis and in vitro experiments

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BIOCELL 2023年第7期47卷 1519-1535页

作者： BOWEN peng YUN GE gang yin School of Electronic Science and Engineering Nanjing UniversityNanjing210023China Department of Radiation Oncology Sichuan Cancer Hospital&InstituteChengdu610041China Radiation Oncology Key Laboratory of Sichuan Province Chengdu610041China

Tanshinone IIA,one of the main ingredients of Danshen,is used to treat hepatocellular carcinoma(HCC).However,potential targets of the molecule in the therapy of HCC are ***:In this study,we collected the tanshinone IIA targets from public databases for *** screened differentially expressed genes(DEGs)across HCC and normal tissues using mRNA expression profiles from The Cancer Genome Atlas(TCGA).Univariate Cox regression analysis and least absolute shrinkage and selection operator(LASSO)Cox regression models were used to identify and construct the prognostic gene ***:Finally,we discovered common genes across tanshinone IIA targets and HCC *** reported Fatty acid binding protein-6(FABP6),Polo-like Kinase 1(PLK1),deoxythymidylate kinase(DTYMK),Uridine Cytidine Kinase 2(UCK2),Enhancer of Zeste Homolog 2(EZH2),and Cytochrome P4502C9(CYP2C9)as components of a gene *** six-gene signature’s prognostic ability was evaluated using the Kaplan-Meier curve,time-dependent receiver operating characteristic(ROC),multivariate Cox regression analysis,and the *** mRNA level and protein expression of UCK2 were experimentally validated after treatment with different concentrations of tanshinone IIA in HEPG2 ***,TIMER2.0,and GEPIA2 tools were employed to explore the relationship between the prognostic signature and immune cell ***:We established a six-gene signature as a reliable model with significant therapeutic possibility for prognosis and overall survival estimation in HCC patients,which might also benefit medical decision-making for appropriate treatment.

关键词： Tanshinone IIA Hepatocellular carcinoma Immune cell infiltration Prognosis signatures