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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma peng-peng Li Hai-Wei Pu Xin-Yian Guo Jian-gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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血清CYFRA21-1,HCY及CA15-3水平联合检测对乳腺癌辅助诊断的临床评价

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现代检验医学杂志 2020年第3期35卷 55-57,61页

作者：张维龙松权彭印钢桂林市中医医院检验科广西桂林541002

目的探讨血清细胞角蛋白19片段(cytokeratin 19 fragment,CYFR21-1)、同型半胱氨酸(homocysteine,HCY)和糖类抗原15-3(carbohydrate antigen 15-3,CA15-3)在乳腺癌患者体内的表达水平及其在乳腺癌诊断中的价值。方法选取2019年1~11月期间收治的乳腺癌患者73例为研究对象,良性乳腺瘤患者95例为疾病对照组,同期体检的健康志愿者80例为正常对照组,分别检测并比较三组研究对象CYFRA21-1,HCY和CA15-3水平,分析其对乳腺癌诊断的价值。结果乳腺癌组的CYFRA21-1,HCY和CA15-3检测水平分别为6.25±1.60ng/ml,19.42±3.67μmol/L和40.84±6.77U/ml;良性乳腺瘤组的CYFRA21-1,HCY和CA15-3检测水平分别为1.28±0.38 ng/ml,11.72±2.46μmol/L和16.44±3.71 U/ml;对照组的CYFRA21-1,HCY和CA15-3检测水平分别为0.86±0.21 ng/ml,9.57±2.22μmol/L和12.84±2.69 U/ml,结果显示乳腺癌组的三项指标表达水平明显高于乳腺瘤组和对照组,差异均有统计学意义(F=22.314~97.593,均P<0.05)。乳腺癌晚期患者(Ⅲ-Ⅳ期)血清CYFRA21-1,HCY和CA15-3水平显著高于早期患者(Ⅰ-Ⅱ期),差异均有统计学意义(t=6.311~11.720,均P<0.05)。血清CYFRA21-1,HCY和CA15-3联合检测灵敏度和准确度分别为89.04%和83.33%,与单项检测比较差异均有统计学意义(t=2.655~21.196,均P<0.05)。结论CYFRA21-1,HCY和CA15-3联合检测可明显提高乳腺癌诊断的灵敏度和准确度,为临床提供经济快捷有效的实验室依据。

关键词：乳腺癌细胞角蛋白19片段同型半胱氨酸糖类抗原15-3

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自卤仿产生二卤卡宾的单电子转移过程

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化学学报 1987年第4期45卷 415-417页

作者：许临晓陶凤岗于同隐葛明陶陈士明复旦大学化学系复旦大学分析测试中心复旦大学分析测试中心上海

按照经典机理,由卤仿产生二卤卡宾是经过了一个简单的两步过程:虽然这一过程缺少可靠的全面验证,但该机理已被广泛接受,并推广到了许多类似反应,迄今尚未见有对其提出异议的报道。我们在研究溴仿和氯仿混合体系的反应中发现产物组成与... 详细信息

按照经典机理,由卤仿产生二卤卡宾是经过了一个简单的两步过程:虽然这一过程缺少可靠的全面验证,但该机理已被广泛接受,并推广到了许多类似反应,迄今尚未见有对其提出异议的报道。我们在研究溴仿和氯仿混合体系的反应中发现产物组成与预期结果不符。在烯烃存在下,反应同时给出三种偕二卤环丙烷。

关键词：卤素交换卡宾游离基庚烷自由基烷烃环丙烷环烷烃单电子转移过程

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Synthesis of chiral phosphine derivatives through a copper（I）-catalyzed desymmetric SNAr reaction

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Science China Chemistry 2025年

作者： Shuai Zhang Pei-Zhi Liu Yan-Bo Li Qi Zhang Jun-Zhao Xiao Yi-Fan Wang Tian-Yu Wei Jia-Wei Jiang Ye Wang Qian peng Liang yin Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Biosensing and Molecular Recognition College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Axially chiral phosphines are a class of extremely important ligands in asymmetric catalysis. Herein, an unprecedented copper（I）-catalyzed asymmetric SNAr reaction with HP（S）R2is uncovered, which delivers a series of axially chiral phosphine derivatives in high yields with excellent enantioselectivity. Furthermore, the diastereoselective reaction with the kinetic resolution of racemic HP（S）ArR proceeds smoothly, providing the products with moderate diastereoselectivity and excellent enantioselectivity. Control experiments indicate that HP（S）Ph2is much more active than HPPh2and HP（O）Ph2as the pronucleophile in the present reaction. It is found that the SNAr reaction （the first SNAr） proceeds in a desymmetric manner, providing the desired chiral products while a continued SNAr reaction （the second SNAr） slightly occurs in a kinetic resolution manner in the present catalytic system, which enhances the ee of the desired chiral products. DFTcalculations support a concerted reaction pathway rather than a step-wise mechanism. Finally, axially chiral olefin-phosphines produced by the present method work as suitable ligands in Pdcatalyzed asymmetric allylic substitution with C-, N-, and O-nucleophiles and Rh-catalyzed asymmetric addition of arylboronic acid to benzil.

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A novel prognostic gene signature,nomogram and immune landscape based on tanshinone IIA drug targets for hepatocellular carcinoma:Comprehensive bioinformatics analysis and in vitro experiments

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BIOCELL 2023年第7期47卷 1519-1535页

作者： BOWEN peng YUN GE gang yin School of Electronic Science and Engineering Nanjing UniversityNanjing210023China Department of Radiation Oncology Sichuan Cancer Hospital&InstituteChengdu610041China Radiation Oncology Key Laboratory of Sichuan Province Chengdu610041China

Tanshinone IIA,one of the main ingredients of Danshen,is used to treat hepatocellular carcinoma(HCC).However,potential targets of the molecule in the therapy of HCC are ***:In this study,we collected the tanshinone IIA targets from public databases for *** screened differentially expressed genes(DEGs)across HCC and normal tissues using mRNA expression profiles from The Cancer Genome Atlas(TCGA).Univariate Cox regression analysis and least absolute shrinkage and selection operator(LASSO)Cox regression models were used to identify and construct the prognostic gene ***:Finally,we discovered common genes across tanshinone IIA targets and HCC *** reported Fatty acid binding protein-6(FABP6),Polo-like Kinase 1(PLK1),deoxythymidylate kinase(DTYMK),Uridine Cytidine Kinase 2(UCK2),Enhancer of Zeste Homolog 2(EZH2),and Cytochrome P4502C9(CYP2C9)as components of a gene *** six-gene signature’s prognostic ability was evaluated using the Kaplan-Meier curve,time-dependent receiver operating characteristic(ROC),multivariate Cox regression analysis,and the *** mRNA level and protein expression of UCK2 were experimentally validated after treatment with different concentrations of tanshinone IIA in HEPG2 ***,TIMER2.0,and GEPIA2 tools were employed to explore the relationship between the prognostic signature and immune cell ***:We established a six-gene signature as a reliable model with significant therapeutic possibility for prognosis and overall survival estimation in HCC patients,which might also benefit medical decision-making for appropriate treatment.

关键词： Tanshinone IIA Hepatocellular carcinoma Immune cell infiltration Prognosis signatures

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基于BIM技术的公路征地拆迁中扬尘实时监测方法设计

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计算技术与自动化 2021年第2期40卷 184-188页

作者：何大为黄国华曾国平彭银刚中电建路桥集团有限公司北京100048 中电建(广东)中开高速公路有限公司广东江门529000

针对传统方法存在扬尘实时监测性能差的问题,提出了一种基于BIM技术的公路征地拆迁中扬尘实时监测方法。通过传感器实时采集公路征地拆迁中的扬尘信息,并展开融合处理。通过统计信息分析和BIM信息库融合的方法得到BIM信息调度函数,设计... 详细信息

针对传统方法存在扬尘实时监测性能差的问题,提出了一种基于BIM技术的公路征地拆迁中扬尘实时监测方法。通过传感器实时采集公路征地拆迁中的扬尘信息,并展开融合处理。通过统计信息分析和BIM信息库融合的方法得到BIM信息调度函数,设计公路征地拆迁中扬尘监测的BIM信息数据库,结合扬尘分布实现对公路征地拆迁中扬尘实时监测。仿真实验结果表明,所提方法相比传统方法进行公路征地拆迁中扬尘监测的开销时间曲线波动较小,时间开销更短,实时监测效率较高。可见所提方法为扬尘实时监测提供了一个有效方式。

关键词： BIM技术公路征地拆迁扬尘监测 BIM信息库谱特征量

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Stochastic Systems Arising from Markov Modulated Empirical Measures

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Journal of Systems Science & Complexity 2017年第5期30卷 999-1011页

作者： yin gang BUI Trang Department of Mathematics Wayne State UniversityDetroitMI 48202USA

This work is devoted to stochastic systems arising from empirical measures of random sequences(termed primary sequences) that are modulated by another Markov chain. The Markov chain is used to model random discrete events that are not represented in the primary sequences. One novel feature is that in lieu of the usual scaling in empirical measure sequences, the authors consider scaling in both space and time, which leads to new limit results. Under broad conditions, it is shown that a scaled sequence of the empirical measure converges weakly to a number of Brownian bridges modulated by a continuous-time Markov chain. Ramifications and special cases are also considered.

关键词： Brownian bridge limit empirical measure multi-scale modeling regime-switching model,weak convergence

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Tag recommendation for open source software

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Frontiers of Computer Science 2014年第1期8卷 69-82页

作者： Tao WANG Huaimin WANG gang yin Charles X. LING Xiao LI peng ZOU National Laboratory for Parallel and Distributed Processing College of Computer Department of Computer Science The University of Western Ontario London N6A5B7 Canada Academy of Equipment Beijing 101400 China

Nowadays open source software becomes highly popular and is of great importance for most software engi- neering activities. To facilitate software organization and re- trieval, tagging is extensively used in open source communi- ties. However, finding the desired software through tags in these communities such as Freecode and ohloh is still chal- lenging because of tag insufficiency. In this paper, we propose TRG （tag recommendation based on semantic graph）, a novel approach to discovering and enriching tags of open source software. Firstly, we propose a semantic graph to model the semantic correlations between tags and the words in software descriptions. Then based on the graph, we design an effec- tive algorithm to recommend tags for software. With com- prehensive experiments on large-scale open source software datasets by comparing with several typical related works, we demonstrate the effectiveness and efficiency of our method in recommending proper tags.

关键词： open source software semantic graph tag rec-ommendation

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Effects of intermittent negative pressure on osteogenesis in human bone marrow-derived stroma cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第3期10卷 188-192页

作者： Zhi YANG Miao LIU yin-gang ZHANG Xiong GUO peng XU Department of Orthopaedics the First Affiliated Hospital School of Medicine MOE Key Laboratory of Environment and Genes Related to Diseases Institute of Environmental and Endemic Diseases School of Materials Science and Engineering Xi 'an Jiaotong University Xi'an 710061 China

Objective： We investigated the effects of intermittent negative pressure on osteogenesis in human bone marrowderived stroma cells （BMSCs） in vitro. Methods： BMSCs were isolated from adult marrow donated by a hip osteoarthritis patient with prosthetic replacement and cultured in vitro. The third passage cells were divided into negative pressure treatment group and control group. The treatment group was induced by negative pressure intermittently （pressure： 50 kPa, 30 min/times, and twice daily）. The control was cultured in conventional condition. The osteogenesis of BMSCs was examined by phase-contrast mi- croscopy, the determination of alkaline phosphatase （ALP） activities, and the immunohistochemistry of collagen type 1. The mRNA expressions of osteoprotegerin （OPG） and osteoprotegerin ligand （OPGL） in BMSCs were analyzed by real-time polymerase chain reaction （PCR）. Results： BMSCs showed a typical appearance of osteoblast after 2 weeks of induction by intermittent negative pressure, the activity of ALP increased significantly, and the expression of collagen type I was positive. In the treatment group, the mRNA expression of OPG increased significantly （P〈0.05） and the mRNA expression of OPGL decreased significantly （P〈0.05） after 2 weeks, compared with the control. Conclusion： Intermittent negative pressure could promote osteogenesis in human BMSCs in vitro.

关键词： Negative pressure Bone marrow-derived stroma cells (BMSCs) Osteogenesis

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Sediment transport simulation and design optimization of a novel marsh shoreline protection technology using computational fluid dynamics (CFD) modeling

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International Journal of Sediment Research 2022年第1期37卷 14-25页

作者： Salman Saki Grant Besse peng yin Daniel gang Donald Hayes Department of Civil Engineering University of Louisiana at Lafayette University of Texas at San Antonio U.S.Army Engineer Research and Development Center (ERDC)

Coastal Louisiana has the nation’s most fragile and valuable wetlands,whose loss represents 80% of the total losses in the United *** severely restricted mobility of conventional shoreline protection structures makes them impossible to be *** Wave Suppression and Sediment Collection(WSSC) system is a novel technology of high mobility and compatible with existing shoreline protection *** laboratory studies on WSSC showed great potential for wave reduction and sediment *** current study aimed to optimize the design parameters of WSSC using a validated computational model.A computational fluid dynamics (CFD) model was developed and validated using experimental data from the previous laboratory ***,a parametric analysis was conducted with a focus on the performance optimization of wave reduction and sediment collection with respect to pipe diameter and face *** results showed that the wave reduction efficiency decreased with increasing pipe diameter and face *** contrast,the sediment transport efficiency was enhanced by increasing pipe diameter but was not affected significantly by varying face slopes.

关键词： Breakwaters Computational fluid dynamics Sediment transport Shoreline protection Coastal engineering ANSYS FLUENT

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