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蛴螬提取物对视网膜中央静脉阻塞模型兔小胶质细胞CD68表达的影响及机制研究

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中国现代医学杂志 2019年第12期29卷 7-11页

作者：蒋鹏飞董子奕彭俊马俊旭梁凯霞彭清华湖南中医药大学湖南长沙410208 天津市人民医院眼科天津300121 湖南中医药大学第一附属医院眼科湖南长沙410007

目的探讨蛴螬提取物对实验性兔视网膜静脉阻塞(RVO)的治疗作用及相关机制。方法选取40 只兔并随机分为空白组、模型组、复方血栓通组及蛴螬组。除空白组外,其余3 组采用光化学动力法复制RVO 动物模型,于给药后7、14 及28 d 行荧光素眼... 详细信息

目的探讨蛴螬提取物对实验性兔视网膜静脉阻塞(RVO)的治疗作用及相关机制。方法选取40 只兔并随机分为空白组、模型组、复方血栓通组及蛴螬组。除空白组外,其余3 组采用光化学动力法复制RVO 动物模型,于给药后7、14 及28 d 行荧光素眼底血管造影术(FFA),于给药后1、3、7、14及28 d 行免疫组织化学检测白细胞分化抗原68(CD68)的表达。结果 FFA 检查显示,模型组给药7 d后,中央静脉荧光渗漏、出血,出现无灌注区;复方血栓通组与蛴螬组出现无灌注区,但渗漏、出血较模型组少;给药28 d 后,模型组渗漏、出血的静脉周围无灌注区面积增大,并出现新生血管;复方血栓通组渗漏、出血明显减少;蛴螬组渗漏、出血基本吸收。复方血栓通组、蛴螬组与模型组给药后7、14 及28 d 的无灌注区与视盘面积比值比较,差异有统计学意义(P <0.05)。免疫组织化学结果显示,各模型组CD68 表达增加,复方血栓通和蛴螬提取物都使CD68 的阳性表达随时间的延长而减弱,但蛴螬组CD68 表达减弱得更快。复方血栓通组、蛴螬组与模型组3、7、14 及28 d CD68 表达比较,差异有统计学意义(P <0.05)。结论复方血栓通与蛴螬提取物均不同程度抑制视网膜小胶质细胞的活化,而蛴螬提取物的抑制作用更明显,说明其比单纯的活血化瘀药能更快地抑制小胶质细胞活化。

关键词：视网膜静脉阻塞视网膜新生血管蛴螬提取物小胶质细胞白细胞分化抗原68

Effect of continuous casting speed on mold surface flow and the related near-surface distribution of non-metallic inclusions

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International Journal of Minerals,Metallurgy and Materials 2019年第2期26卷 186-193页

作者： peng fei Yi Min Cheng-jun Liu Mao-fa jiang Key Laboratory for Ecological Metallurgy of Multimetallic Mineral ((Ministry of Education)) School of Metallurgy Northeastern University Key Laboratory for Ecological Metallurgy of Multimetallic Mineral (Ministry of Education)

For the control of surface defects in interstitial-free(IF) steel, quantitative metallographic analyses of near-surface inclusions and surface liquid flow detection via the nail-board tipping method were conducted. The results show that, at casting speeds of 0.8 and 1.0 m/min, a thin liquid mold flux layer forms and non-uniform floating of argon bubbles occurs, inducing the entrainment and subsequent entrapment of the liquid flux; fine inclusion particles of Al_2O_3 can also aggregate at the solidification front. At higher casting speeds of 1.4 and 1.6 m/min, the liquid mold flux can be entrained and carried deeper into the liquid steel pool because of strong level fluctuations of the liquid steel and the flux. The optimal casting speed is approximately 1.2 m/min, with the most favorable surface flow status and, correspondingly, the lowest number of inclusions near the slab surface.

关键词： non-metallic inclusions distribution casting speed surface flow

Dispersion characteristics of seabed Scholte waves with variable velocity seawater in deep water

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Applied Geophysics 2022年第4期19卷 537-552,604页

作者： jiang Jia-Meng Yu peng-fei College of Oceanography Hohai UniversityNanjing 210024China

Acoustic velocity varies in deep-water *** obtain accurate inversion interpretations,it is necessary to develop a horizontally layered seawater–seabed(HLSS)model with continuously varying *** this work,we used an HLSS model based on wave theory to deduce the Scholte wave dispersion equations and established an HLSS model based on the acoustic velocity profile and the submarine medium parameters of the South China *** studied the dispersion characteristics of Scholte waves and theoretically calculated the amplitude–depth *** also examined the influence of deep-water environments on the dispersion characteristics of Scholte *** the real geological parameters of the Dongsha Islands in the South China Sea,we exploited the spectral element method to simulate seismic wave propagation in the fluid–solid interface and extracted the Scholte wave dispersion curves using multichannel analysis of surface waves(MASW).The consistent theoretical and extracted dispersion curve results verified the accuracy of our *** experiments showed that the dispersion characteristics of Scholte waves in deep water are weaker than those in shallow *** addition to the seawater depth and the physical parameters of seabed sediments,the seawater’s variable velocity also influences Scholte wave dispersion characteristics.

关键词： Scholte waves variable-velocity seawater dispersion characteristics amplitudedepth distribution.

Exploring individuals’ effective preventive measures against epidemics through reinforcement learning

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Chinese Physics B 2021年第4期30卷 640-647页

作者： Ya-peng Cui Shun-jiang Ni Shi-fei Shen Institute of Public Safety Research Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Beijing Key Laboratory of City Integrated Emergency Response Science Beijing 100084China

Individuals’ preventive measures,as an effective way to suppress epidemic transmission and to protect themselves from infection,have attracted much academic concern,especially during the COVID-19 *** this paper,a reinforcement learning-based model is proposed to explore individuals’ effective preventive measures against *** extensive simulations,we find that the cost of preventive measures influences the epidemic transmission process *** infection scale increases as the cost of preventive measures grows,which means that the government needs to provide preventive measures with low cost to suppress the epidemic *** addition,the effective preventive measures vary from individual to individual according to the social *** who contact with others frequently in daily life are highly recommended to take strict preventive measures to protect themselves from infection,while those who have little social contacts do not need to take any measures considering the inevitable *** research contributes to exploring the effective measures for individuals,which can provide the government and individuals useful suggestions in response to epidemics.

关键词： epidemic simulation complex networks reinforcement learning preventive measures

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惰性气体被H_2分子散射的角分布研究

四川大学学报（工程科学版） 2002年第1期34卷 112-114页

作者：刘刚芦鹏飞蒋德琼何绍奎迟树良四川大学原子分子物理所四川成都610065

用T .T(K .T .***)势模型和公认精密度较高的密耦 (Close Coupling)近似方法计算了E =0 .0 5eV时 ,在 0 0 0 0弹性碰撞和 0 0 0 2非弹性碰撞时 ,得到了氢分子转动激发角分布 ,并研究了原子与分子弹性碰撞和非弹性激发角分布随角度增... 详细信息

用T .T(K .T .***)势模型和公认精密度较高的密耦 (Close Coupling)近似方法计算了E =0 .0 5eV时 ,在 0 0 0 0弹性碰撞和 0 0 0 2非弹性碰撞时 ,得到了氢分子转动激发角分布 ,并研究了原子与分子弹性碰撞和非弹性激发角分布随角度增加的变化规律。随散射角的增大 ,弹性碰撞角分布变小。且在角度为零点出现了散射极大 ,入射原子的约化质量增大 ,振荡幅度减小 ,当散射角大于 6 0°后 ,其变化规律趋于某一值附近。对于 0 0 0 2的非弹性碰撞入射原子约化质量增大 ,大角散射几率增大。

关键词：势函数转动激发角分布密耦方法惰性气体氢分子 H2 原子分子弹性碰撞

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-fei Song Zheng-Zhi Wu Qian-Qian jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

Design and Analysis of a Novel 2T2R Parallel Mechanism with the Closed-loop Limbs

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International Journal of Automation and computing 2021年第4期18卷 654-666页

作者： Hai-Rong Fang peng-fei Liu Hui Yang Bing-Shan jiang School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China

This paper presents a novel four degrees of freedom(DOF) parallel mechanism with the closed-loop limbs, which includes two translational(2 T) DOF and two rotational(2 R) DOF. By connecting the proposed parallel mechanism with the guide rail in series,the 5-DOF hybrid robot system is obtained, which can be applied for the composite material tape laying in aerospace industry. The analysis in this paper mainly focuses on the parallel module of the hybrid robot system. First, the freedom of the proposed parallel mechanism is calculated based on the screw theory. Then, according to the closed-loop vector equation, the inverse kinematics and Jacobian matrix of the parallel mechanism are carried out. Next, the workspace stiffness and dexterity analysis of the parallel mechanism are investigated based on the constraint equations, static stiffness matrix and Jacobian condition number. Finally, the correctness of the inverse kinematics and the high stiffness of the parallel mechanism are verified by the kinematics and stiffness simulation analysis, which lays a foundation for the automatic composite material tape laying.

关键词： 2T2R parallel mechanism close loop structure high stiffness kinematics analysis workspace

Orbitronics for energy-efficient magnetization switching

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Science China(Information Sciences) 2025年第1期 398-399页

作者： Yuxuan YAO Daoqian ZHU Qingtao XIA Jianing LIANG Yuhao jiang Zhiyang peng Jiaxu LI Chen XIAO Renyou XU Wenwen WANG Xiantao SHANG Shiyang LU Dapeng ZHU Hong-Xi LIU Kaihua CAO Weisheng ZHAO Fert Beijing Institute School of Integrated Circuit Science and Engineering Beihang University National Key Lab of Spintronics Institute of International Innovation Beihang University Qingdao Research Institute Beihang University Truth Memory Corporation

Spin-orbit torque （SOT）,as a promising writing method for magnetic random-access memory （MRAM）,has garnered widespread interest for over a decade [1].Heavy metals,such as β-W,have been broadly adopted as spin current sources,but suffer from phase change at a limited thickness,resulting in a dramatic reduction of the charge-tospin conversion efficiency θSH[2].The thickness limitation leads to stringent etching conditions and large distribution among devices,posing challenges for simultaneously satisfying SOT efficiency,etching-stop margins,and back-end-ofline （BEOL） compatibility.

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ReDB:A meiotic homologous recombination rate database

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Chinese Science Bulletin 2010年第27期55卷 3169-3173页

作者： SANG fei jiang peng WANG WenKai LU ZuHong Key Laboratory of Child Development and Learning Science Ministry of Education Research Center for Learning Science Southeast University Nanjing 210096 China State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University Nanjing 210096 China

Meiotic recombination occurs preferentially at certain regions in the genome referred to as hot spots which are important for generating genetic diversity and proper segregation of chromosomes during *** observations concerning individual hotspots have given clues as to the mechanism of recombination initiation,the nature and causes of recombination rate variation in the genome are still little known.A rational solution is to estimate and rank recombination rates along the ***,it is a high demand for a database that deposits and integrates those data to provide a systematical repository of genome-wide recombination *** recombination hotspots database is a web-based database of meiotic recombination rates,which comprises enormous data and information of human,mouse,rat,***,*** and *** can query the database in several alternative *** database stores various details for every sequence,such as chromosome number,hyperlinks to the respective reference,and the sequence in FASTA format.

关键词：数据库存储减数分裂同源重组重组率染色体数目全基因组遗传多样性分裂过程