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Germinal-center type B-cell classification and clinical characteristics of Chinese pediatric diffuse large B-cell lymphoma:a report of 76 cases

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Chinese Journal of Cancer 2013年第10期32卷 561-566页

作者： Yan Chen Xiao-fei Sun Zi-Jun Zhen Juan Wang Jia Zhu Su-Ying Lu fei-fei Sun fei Zhang peng-fei li Rui-Qing Cai State Key Laboratory of Oncology in South China Department of Pediatric Oncology Sun Yat-sen University Cancer Center

Pediatric diffuse large B-cell lymphoma(DLBCL)is a highly aggressive disease with unique clinical *** study analyzed the germinal-center type B-cell(GCB)classification and clinical characteristics of Chinese pediatric DLBCL.A total of 76 patients with DLBCL newly diagnosed in Sun Yatsen University Cancer Center between February 2000 and May 2011,with an age younger than 18 years,were included in the *** male/female ratio was 3.47:*** median age was 12 years(range,2 to 18 years),and 47(61.8%)patients were at least 10 years *** the 76 patients,48(63.2%)had stage III/IV disease,9(11.8%)had bone marrow involvement,1(1.3%)had central nervous system(CNS)involvement,and 5(6.6%)had bone *** GCB classification was assessed in 45 patients:26(57.8%)were classified as GCB subtype,and 19(42.2%)were classified as non-GCB *** modified B-NHL-BFM-90/95 regimen was administered to 50 patients,and the 4-year event-free survival(EFS)rate was 85.8%.Among these 50 patients,31 were assessed for the GCB classification:17(54.8%)were classified as GCB subtype,with a 4-year EFS rate of 88.2%;14(45.2%)were classified as non-GCB subtype,with a 4-year EFS rate of 92.9%.Our data indicate that bone marrow involvement and stage III/IV disease are common in Chinese pediatric DLBCL patients,whereas the percentage of patients with the GCB subtype is similar to that of patients with the non-GCB *** modified B-NHL-BFM-90/95protocol is an active and effective treatment protocol for Chinese pediatric patients with DLBCL.

关键词： B细胞淋巴瘤临床特征弥漫性中国分类小儿生发中枢神经系统

Analysis of Synonymous Codon Usage Bias in 09H1N1

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Virologica Sinica 2010年第5期25卷 329-340页

作者： Zhen-peng li De-quan YING peng li fei li Xiao-chen BO Sheng-qi WANG Beijing Institute of Radiation Medicine Beijing 100850 China

A novel subtype of influenza A virus 09H1N1 has rapidly spread across the world. Evolutionary analyses of this virus have revealed that 09H1N1 is a triple reassortant of segments from swine, avian and human influenza viruses. In this study, we investigated factors shaping the codon usage bias of 09H1N1 and carried out cluster analysis of 60 strains of influenza A virus from different subtypes based on their codon usage bias. We discovered that more preferentially used codons of 09H1N1 are A-ended or U-ended, and the intra-genomic codon usage bias of 09H1N1 is quite low. Base composition constraint, dinucleotide biases and translational selection are the main factors influencing the codon usage bias of 09H1N1. At the genome level, we find that the codon usage bias of 09H1N1 is similar to H1N1 (A/swine/Kansas/77778/2007H1N1), H9N2 from Asia, H1N2 from Asia and North America and H3N2 from North America. Our results provide insight for understanding the processes governing evolution, regulation of gene expression, and revealing the evolution of 09H1N1.

关键词： 09H1N1 Correspondence analysis Codon usage bias

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蛋白酶3及其与疾病的关系研究进展

生物化学与生物物理进展 2015年第3期42卷 244-253页

作者：刘广花邓莉彭礼飞广东省医学分子诊断重点实验室东莞523808 广东医学院寄生虫学和临床寄生虫检验学教研室湛江524000

蛋白酶3(proteinase 3,PR3)是中性粒细胞分泌的主要丝氨酸蛋白酶之一,其生物学功能广泛,不仅能降解多种组织蛋白,还可通过加工细胞因子、受体等调控炎症反应,与慢性炎症性疾病如血管炎性肉芽肿病、慢性阻塞性肺疾病、肺囊肿性纤维症的... 详细信息

蛋白酶3(proteinase 3,PR3)是中性粒细胞分泌的主要丝氨酸蛋白酶之一,其生物学功能广泛,不仅能降解多种组织蛋白,还可通过加工细胞因子、受体等调控炎症反应,与慢性炎症性疾病如血管炎性肉芽肿病、慢性阻塞性肺疾病、肺囊肿性纤维症的发生发展密切相关,可能作为疾病防治靶点.本文主要综述了PR3的生物学功能及其在疾病中的可能作用机制,期望为相关疾病的防治提供新的思路.

关键词：蛋白酶3 细胞因子抑制剂炎症性疾病血管炎性肉芽肿病慢性阻塞性肺疾病肺囊肿性纤维症

Brain metastasis in children with stage 4 neuroblastoma after multidisciplinary treatment

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Chinese Journal of Cancer 2015年第11期34卷 531-537页

作者： Jia Zhu Juan Wang Zi-Jun Zhen Su-Ying Lu fei Zhang fei-fei Sun peng-fei li Jun-Ting Huang Rui-Qing Cai Xiao-fei Sun State Key Laboratory of Oncology in South China Department of Pediatric Oncology Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center

Introduction: Brain metastasis is common in relapsed neuroblastoma patients, but the characteristics of brain metastasis remain largely unknown. This study aimed to investigate the status of brain metastasis with neuroblastoma in South ***: In this retrospective case?based study, 106 patients with stage 4 neuroblastoma from the Department of Pediatric Oncology in Sun Yat?sen University Cancer Center between January 2004 and May 2013 were included. The incidence, risk factors, and survival status of these patients were reviewed and ***: Of the 106 patients, 11(10.4%) developed brain metastasis, accounting for 20.0% of 55 patients with relapse or progression. The age at initial diagnosis of the 11 patients ranged from 2 to 10 years(median 4 years), which was younger than that of the patients without brain metastasis(median 5 years, range 1–10 years, P = 0.073). The male to female ratio of the 11 patients was 8:3, which was not signiicantly diferent from that of the patients with?out brain metastasis(P = 0.86). Patients with brain metastasis had higher lactate dehydrogenase levels than those without brain metastasis, but the diferences were not signiicant(P initial diagnosis to the develo= 0.076). Eight patients died, and 3 patients survived. The median interval from thepment of brain metastasis was 18 months(range 6–32 months). The median survival was 4 months(range 1 day to 29 months) after the diagnosis of brain metastasis. The median interval from the manifestation of brain metastasis to death was 3 months(range 1 day to 11 months).Conclusions: High?risk factors for brain metastasis in cases of neuroblastoma include bone marrow involvement and a younger age at initial diagnosis. Nevertheless, multiple treatment modalities can improve disease?free survival.

关键词： Neuroblastoma, Post treatment, Brain metastasis, Stage 4

Three-Center Experience on Patients with Influenza-Associated Acute Respiratory Distress Syndrome in Chongqing, China

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Chinese Medical Journal 2018年第10期131卷 1244-1245页

作者： Xue-fei Yang Tomer Talmy peng-fei li Yao-Rong Zhang Wei-Jun Song Yao-li Wang Jian Zhou Intensive Care Unit Trauma Center The Daping Hospital and Research Institute of Surgery of Army Medical University Chongqing 400042 China Hadassah Medical Center The Institute of Research in Military Medicine The Hebrew University of Jerusalem Jerusalem 91120 Israel Intensive Care Unit Changan Hospital Chongqing 400021 China Intensive Care Unit Wushan County People's Hospital of Chongqing Chongqing 404700 China

To the Editor：Influenza-associated acute respiratory distress syndrome （ARDS） remains a devastating clinical picture. From December 2017 to January 2018,ten patients with influenza-associated ARDS were admitted to three different hospital＇s Intensive Care Units （ICUs） in Chongqing,with all cases resulting in *** main documented reasons for their admission to the ICU were due to progressive dyspnea and worsening hypoxemia which lead to endotracheal intubation and mechanical ventilation in these *** of influenza viruses was achieved using nucleic-acid testing from venous *** study was approved by the Institutional Review Board of Daping Hospital,Army Medical University.

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Preparation and Structural Characterization of Polystyrene-Rectorite Nanocomposites

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Wuhan University Journal of Natural Sciences 2003年第03A期8卷 817-820页

作者： Fang peng\|fei, liu li\|ming, Zhang Ming, Zhang Shao\|ping, Wang Bo, Wang Shao\|jie School of Physics and Technology, Wuhan University, Wuhan 430072, Hubei,China Wuhan University

The polystyrene/rectorite nanocomposites were prepared by free radical polymerization of styrene containing dispersed organophilic rectorite. The structures and thermal properties of these hybrids have been investigated by X\|ray diffraction (XRD), fourier transform infrared (FT\|IR), positron annihilation spectroscopy (PAS) and thermal gravimetric analysis (TGA) techniques. It was found that exfoliation of rectorite in polystyrene (PS) matrix was achieved. The average free\|volume radius in the PS/clay nanocomposites is generally same as that in PS. Along with increment of rectorite contents, the interface between rectorite and polystyrene matrix increases, and the free\|volume concentration decreases obviously. And the polystyrene nanocomposites have higher thermal decomposition temperature than pure PS.

关键词： polystyrene rectorite nanocomposites positron annihilation spectroscopy

Complexation of Prop[3]iptycenes with Pyridinium Derivatives

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Complexation of Prop[3]iptycenes with Pyridinium Derivatives

Non-traumatic myositis ossificans circumscripta at elbow joint in a 9-year old child

全国第十六届大环化学暨第八届超分子化学学术讨论会

作者： peng-fei li Chuan-Feng Chen Institute of Chemistry Chinese Academy of Sciences

＜正＞In host-guest chemistry,the development of novel macrocyclic hosts with the capability of binding substrate species strongly and selectively is a permanent ***,chiral macrocycles have attracted increasing interest for their wide potential applications in the chiral recognition,assembly,and supramolecular ***,we have devoted ourselves to the synthesis of novel triptycene-derived hosts and their applications in supramolecular chemistry,and found that a new class of chiral macrocycle

关键词： propiptycenes pyridinium derivatives host-guest chemistry

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Chinese Journal of Traumatology 2016年第2期19卷 122-124页

作者： peng-fei li Zi-ling lin Zhi-Hui Pang First Clinic Medical College Guangzhou University of Chinese Medicine. Guangzhou 510405 China Department of Orthopedics The First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510405. China

Myositis ossificans circumscripta （MOC） is a kind of self-localized, benign and tumor-like lesions often seen in adults, with approximately 75% of cases caused by trauma. We reported a case of non-traumatic MOC occurred at the elbowjoint in a 9-year old child and it has been excised by surgery. After 18 months follow-up, a favorable outcome has been achieved with the Broberg-Morrey score of 100. We suggest that surgical resection should be done as soon as the diagnosis is confirmed.

关键词： Myositis ossificans circumscriptaChildren Elbow joint

Stenting of iliac vein obstruction following catheter-directed thrombolysis in lower extremity deep vein thrombosis

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Chinese Medical Journal 2013年第18期126卷 3519-3522页

作者： MENG Qing-YOU li Xiao-qiang JIANG Kun QIAN Ai-min SANG Hong-fei RONG Jian-jie DUAN peng-fei ZHU li-wei Department of Vascular Surgery Second Affiliated Hospital of Soochow University Suzhou Jiangsu 215004 China

Background Catheter-directed thrombolysis （CDT） for deep venous thrombosis （DV-F） of the lower extremity has good effect, but whether iliac vein stent placement after thrombolytic therapy is still controversial. The goal of this study was to evaluate the efficacy of stent placement in the iliac vein following CDT in lower extremity DVT. Methods This was a single-canter, prospective, randomized controlled clinical trial. After receiving CDT, the major branch of the distal iliac vein was completely patent in 155 patients with lower extremity DVT, and 74 of these patients with iliac vein residual stenosis of 〉50% were randomly divided into a control group （n=29） and a test group （n=45）. In the test group, stents were implanted in the iliac vein, whereas no stents were implanted in the control group. We evaluated the clinical indicators, including patency of the deep vein, C in CEAP classification, Venous Clinical Severity Score （VCSS）, and Chronic Venous Insufficiency Questionnaire （CIVIQ） Score. Results All patients had postoperative follow-up visits for a period of 6-24 months. Venography or color ultrasound was conducted in subjects. There was a significant difference between the patency rate at the last follow-up visit （87.5% vs. 29.6%） and the 1-year patency rate （86.0% vs. 54.8%） between the test and control groups. The change in the C in CEAP classification pre- and post-procedure was significantly different between the test and control groups （1.61±0.21 vs. 0.69±0.23）. In addition, at the last follow-up visit, VCSS and CIVIQ Score were both significantly different between the test and control groups （7.57±0.27 vs. 0.69±0.23; 22.67±3.01 vs. 39.34±6.66, respectively）. Conclusion The stenting of iliac vein obstruction following CDT in lower extremity DVT may increase the patency of the deep vein, and thus provides better efficacy and quality of life.

关键词： deep venous thrombosis catheter-directed thrombolysis stent