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Doxorubicin-loaded silicon nanoparticles impregnated into red blood cells featuring bright fluorescence, strong photostability, and lengthened blood residency

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Nano Research 2018年第4期11卷 2285-2294页

作者： Airui jiang Bin Song Xiaoyuan Ji fei peng Houyu Wang Yuanyuan Su Yao He Laboratory of Nanoscale Biochemical Analysis Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Institute of Functional Nano & Soft Materials (FUNSOM) and Collaborative Innovation Center of Suzhau Nano Science and Technology (NANO-CIC) Soochow University Suzhou 215123 China

Based on the unique advantages of fluorescent silicon nanoparticles （SiNPs）, long circulation red blood cells （RBCs）, and anti-cancer drug molecules （i.e., doxorubicin （DOX））, we developed multifunctional DOX-loaded SiNPs impregnated into RBCs. Importantly, the resulting drug delivery systems （DDSs） simultaneously exhibited bright fluorescence coupled with robust photostability （i.e., - 24% loss of fluorescent intensity after 25 min continuous laser irradiation） and significantly lengthened blood residency （i.e., t1/2 = 7.31 ± 0.96 h, 3.9-fold longer than pure DOX-loaded SiNPs）. Therefore, this novel DDS featuring multi-functionalities shows high potential for cancer diagnosis and therapy, particularly for tumor imaging and chemotherapy in a synchronous manner.

关键词： fluorescent silicon nanoparticles mulfi-function red blood cells drug delivery system

Synthesis,characterization and cytotoxicity of fluorescent organotin complexes of terpyridine derivatives

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Chinese Chemical Letters 2014年第4期25卷 586-588页

作者： peng-fei Shi Qin jiang Hai-Chao Duan Da-Qi Wang School of Chemistry Huaihai Institute of Technology School of Chemistry Liaocheng University

Five organotin complexes of terpyridine derivatives were synthesized and characterized. The mononuclear Sn（IV） complexes were six-coordinated adopting a distorted octahedral coordination geometry. A brief outline of... 详细信息

关键词： Organotin Terpyridine Antitumor

The Hot Spots Conjecture on a Class of Domains in R^n with n≥3

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Acta Mathematicae Applicatae Sinica 2011年第4期27卷 639-646页

作者： peng-fei YANG School of Science Beijing Institute of Technology Beijing 100081 China

In this paper, we define a class of domains in R^n. Using the synchronous coupling of reflecting Brownian motion, we obtain the monotonicity property of the solution of the heat equation with the Neumann boundary cond... 详细信息

关键词： synchronous coupling reflecting Brownian motion hot spots conjecture Neumann eigenfunctions

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惰性气体和H_2分子碰撞截面计算研究

西南民族学院学报（自然科学版） 2001年第4期27卷 426-428页

作者：刘刚芦鹏飞蒋德琼迟树良四川大学原子分子物理所成都610065

用T .T(K .T .*** .Toennies)势模型和公认精密度较高的密耦 (Close -Coupling)近似方法计算了E =0 .0 5ev时 0 0 - 0 0弹性碰撞 0 0 - 0 2非弹性碰撞 ,得出氢分子转动激发分波截面 ,并研究了原子与分子碰撞弹性分波截面和非弹性激发截... 详细信息

用T .T(K .T .*** .Toennies)势模型和公认精密度较高的密耦 (Close -Coupling)近似方法计算了E =0 .0 5ev时 0 0 - 0 0弹性碰撞 0 0 - 0 2非弹性碰撞 ,得出氢分子转动激发分波截面 ,并研究了原子与分子碰撞弹性分波截面和非弹性激发截面随量子数增加的变化规律 .

关键词：势函数转动激发分波截面密耦方法惰性气体氢气分子碰撞分子物理学

Multiplicity of Homoclinic Solutions for Second Order Hamiltonian Systems with Local Conditions at the Origin

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Acta Mathematica Sinica,English Series 2022年第4期38卷 735-744页

作者： peng LIU fei GUO School of Mathematics Tianjin UniversityTianjin 300354P.R.China Tianjin Key Laboratory of Brain-Inspired Intelligence Technology Tianjin 300354P.R.China

In this paper,the multiplicity of homoclinic solutions for second order non-autonomous Hamiltonian systemsü(t)-L(t)u(t)+▽uW(t,u(t))=0 is obtained via a new Symmetric Mountain Pass Lemma established by Kajikiya,where L∈C(R,RN×N)is symmetric but non-periodic,W∈C1(R×RN,R)is locally even in u and only satisfies some growth conditions near u=0,which improves some previous results.

关键词： Second order non-autonomous Hamiltonian systems Homoclinic solutions multiplicity new symmetric mountain pass lemma

Multiplicity of Periodic Solutions for Second Order Hamiltonian Systems with Asymptotically Quadratic Conditions

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Acta Mathematica Sinica,English Series 2020年第1期36卷 55-65页

作者： peng LIU fei GUO School of Mathematics Tianjin University

A class of second order non-autonomous Hamiltonian systems with asymptotically quadratic conditions is considered in this *** Fountain Theorem,one multiplicity result of periodic solutions is obtained,which improves s... 详细信息

关键词： Second order Hamiltonian systems asymptotically quadratic conditions Fountain Theorem periodic solution multiplicity

Multilocus phylogeny suggests a distinct species status for the Nepal population of Assam macaques(Macaca assamensis):implications for evolution and conservation

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Zoological Research 2021年第1期42卷 3-13页

作者： Laxman Khanal Mukesh Kumar Chalise peng-fei Fan Randall CKyes Xue-Long jiang Central Department of Zoology Institute of Science and TechnologyTribhuvan UniversityKathmandu 44613Nepal State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650203China Nepal Biodiversity Research Society(NEBORS) Lalitpur 23513Nepal School of Life Sciences Sun Yat-sen UniversityGuangzhouGuangdong 510275China Department of Psychology Global Healthand AnthropologyCenter for Global Field Studyand Washington National Primate Research CenterUniversity of WashingtonSeattle 98195USA

Phylogenetic relationships within the sinica-group of macaques based on morphological,behavioral,and molecular characteristics have remained *** Nepal population of Assam macaques(Macaca assamensis)(NPAM),the westernmost population of the species,is morphologically distinct but has never been used in phylogenetic ***,the phylogenetic relationship of NPAM with other congeners was tested using multiple mitochondrial and Ychromosomal *** divergence times and evolutionary genetic distances among macaques were also *** revealed two major mitochondrial DNA clades of macaques under the sinica-group:the first clade included ***,***,and eastern subspecies of Assam macaque(*** assamensis);the second clade included *** together with species from the eastern and central Himalaya,namely,***,***,and *** the second-clade species,NPAM was the first to diverge from the other members of the clade around 1.9 million years *** results revealed that NPAM is phylogenetically distinct from the eastern Assam macaques and closer to other species and hence may represent a separate *** of its phylogenetic distinctiveness,isolated distribution,and small population size,the Nepal population of sinica-group macaques warrants detailed taxonomic revision and high conservation priority.

关键词： Himalaya Macaques Paraphyletic sinica-group Taxonomy

ASSOCIATION BEHAVIOR OF PORPHYRIN PENDANTS IN pH-SENSITIVE WATER-SOLUBLE POLYMER

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Chinese Journal of Polymer Science 2012年第1期30卷 63-71页

作者： Ke—wei Ding fei Wang fei-peng Wu Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China Graduate University of Chinese Academy of Sciences Beijing 100049 China

A novel tripyridylporphyrin monomer,5-[4-[2-（acryloyloxy）ethoxy]phenyl]-10,15,20-tris（4-pyridyl）porphyrin （TrPyP）,was synthesized and polymerized with acrylamide（AM） to prepare the hydrophobically associating water-soluble polymer *** aggregation behavior of porphyrin pendants was investigated by UV-Visible and fluorescence *** polymer displays a strong tendency of hydrophobic association even in dilute *** increasing the concentration,the maximum absorption wavelength of Soret band changes from 416 nm to 407 nm,and the fluorescence corrected for the inner filter effect exhibits moderate concentration *** the results indicate thatπ-πinteraction of porphyrin pendants plays a key role in association of PAM-TrPyP,and H-aggregates of porphyrins are mainly formed in the concentrated *** the other hand,dynamic light scattering（DLS） and transmission electron microscopy（TEM） were used to follow the changes in size and structure of the macromolecular assemblies with the concentration *** polymer aggregation conformation changes from loose ＂vesicle-like＂ morphology to solid globule *** pH value of solution decreases to 4.3,pyridine moieties on porphyrin pendants could be protonated and the H-aggregates formed in macromolecular matrix are destroyed by electrostatic repulsion interactions.

关键词： Porphyrin Water-soluble polymer π-πInteractions H-aggregate pH-sensitivity

Abnormal Twinning Behavior and Constitutive Modeling of a Fine-Grained Extruded Mg-8.0Al-0.1Mn-2.0Ca Alloy under High-Speed Impact along Various Directions

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Acta Metallurgica Sinica(English Letters) 2023年第2期36卷 281-294页

作者： fei-Yang Chen peng-Cheng Guo Zi-Han jiang Xiao Liu Tie-Jun Song Chao Xie College of Mechanical and Electrical Engineering Central South University of Forestry and TechnologyChangsha410004China College of Mechanical Engineering and Mechanics Ningbo UniversityNingbo315211China College of Mechanical Engineering Xiangtan UniversityXiangtan411105China College of Material Science and Engineering Hunan University of Science and TechnologyXiangtan411201China

To understand the mechanical and twinning behaviors of a fine-grained extruded Mg-8.0Al-0.1Mn-2.0Ca alloy under high-speed impact,impact tests were carried out using a split Hopkinson pressure bar,and microstructures at strains of 0.05,0.10 and 0.20 were obtained using a series of stop rings manufactured by high-strength *** stress response and twinning behavior are closely related to loading direction and applied strain *** true stress-true strain curves are s-shaped in extrusion direction(ED)and c-shaped in transverse direction(TD),showing apparent anisotropy,while the yield strength is insensitive to loading *** identical strain-rate sensitivity is demonstrated by the stress in ED and ***,de-twinning is apparent as the applied strain increases to 0.20,and it is enhanced with increasing the applied strain *** contrast,the twin density in ED samples is clearly higher than that in TD *** modifying the terms of strain hardening and strain rate hardening in the classical JC model,an optimized model is built,which can accurately predict the stress response behavior of the studied alloy under high-speed impact along ED and *** correlation coefficient(R)and average absolute relative error(AARE)are 98.63%and 0.0199 for ED,and 96.88%and 0.0202 for TD,respectively.

关键词： High-speed impact Magnesium alloy Twinning behavior Constitutive model Anisotropy