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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan Li peng Hao Hongmei Duan fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

Crystallization Modulation and Holistic Passivation Enables Efficient Two‑Terminal Perovskite/CuIn(Ga)Se_(2)Tandem Solar Cells

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Nano-Micro Letters 2025年第1期17卷 205-215页

作者： Cong Geng Kuanxiang Zhang Changhua Wang Chung Hsien Wu Jiwen Jiang fei Long Liyuan Han Qifeng Han Yi‑Bing Cheng Yong peng State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Triumph Photovoltaic Materials Co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Two-terminal(2-T)perovskite(PVK)/CuIn(Ga)Se_(2)(CIGS)tandem solar cells(TSCs)have been considered as an ideal tandem cell because of their best bandgap matching regarding to Shockley–Queisser(S–Q)***,the nature of the irregular rough morphology of commercial CIGS prevents people from improving tandem device *** this paper,D-homoserine lactone hydrochloride is proven to improve coverage of PVK materials on irregular rough CIGS surfaces and also passivate bulk defects by modulating the growth of PVK *** addition,the minority carriers near the PVK/C60 interface and the incompletely passivated trap states caused interface recombination.A surface reconstruction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain ***,LiF is used to create this field effect,repelling hole carriers away from the PVK and C60 interface and thus reducing *** a result,a 2-T PVK/CIGS tandem yielded a power conversion efficiency of 24.6%(0.16 cm^(2)),one of the highest results for 2-T PVK/CIGS TSCs to our *** validation underscores the potential of our methodology in achieving superior performance in PVK/CIGS tandem solar cells.

关键词： PVK/CIGS TSCs Irregular rough surfaces Modulating the growth PVK/C60 interface recombination

Mesh‑free semi‑quantitative variance underestimation elimination method in Monte Caro algorithm

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Nuclear Science and Techniques 2023年第1期34卷 157-171页

作者： peng‑fei Shen Xiao‑Dong huo Ze‑Guang Li Zeng Shao Hai‑Feng Yang peng Zhang Kan Wang Department of Engineering Physics Tsinghua UniversityBeijing 100084China China Nuclear Power Engineering Corporation Beijing 100840China

The inter-cycle correlation of fission source distributions(FSDs)in the Monte Carlo power iteration process results in variance underestimation of tallied physical quantities,especially in large local *** study provides a mesh-free semiquantitative variance underestimation elimination method to obtain a credible confidence interval for the tallied *** method comprises two procedures:Estimation and *** FSD inter-cycle correlation length is estimated in the Estimation procedure using the Sliced Wasserstein distance *** batch method was then used in the elimination *** FSD inter-cycle correlation length was proved to be the optimum batch length to eliminate the variance underestimation *** exemplified this method using the OECD sphere array model and 3D PWR BEAVRS *** results showed that the average variance underestimation ratios of local tallies declined from 37 to 87%to within±5%in these models.

关键词： Monte Carlo algorithm Power iteration process Inter-cycle correlation Variance underestimation Sliced Wasserstein distance

Phase fraction evolution in hot working of a two-phase titanium alloy： experiment and modeling

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Rare Metals 2017年第10期36卷 769-779页

作者： Xiao-Guang Fan huo-Jun Zheng peng-fei Gao Mei Zhan Wen-Jia Mei School of Materials Science and Engineering Northwestern Polytechnical University Xi'an 710072 China State Key Laboratory of Solidification Processing Northwestern Polytechnical University Xi'an 710072 China

In the present work, the coupled effects of initial structure and processing parameters on microstructure of a two-phase titanium alloy were investigated to predict the microstructural evolution in multiple hot working. It is found that microstructure with different constituent phases can be obtained by regulating the initial structure and hot working conditions. The variation of deformation degree and cooling rate can change the morphology of the con- stituent phases, but do not alter the phase fraction. The phase transformation during heating and holding determi- nes the phase fraction for a certain initial structure. ^--at-~3 transformation occurs during heating and holding. [3 to ct transformation leads to a significant increase in content and size of lamellar ~. The ct to [3 transformation occurs simultaneously in equiaxed at and lamellar ct. The thickness of lamellar ~t increases with temperature, which is caused by the vanishing of fine a lamellae due to phase transformation and coarsening by termination migration. By assuming a quasi-equilibrium phase transformation in heating and holding, a modeling approach is proposed for predicting microstructural evolution. The three stages of phase transformation are modeled separately and combined to predict the variation of phase fraction with temperature. Model predictions agree well with the experimental results.

关键词： Titanium alloy Hot working Microstructure Modeling

Tailoring Morphology of PVDF-HFP Membrane via One-step Reactive Vapor Induced Phase Separation for Efficient Oil-Water Separation

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Chinese Journal of Polymer Science 2021年第5期39卷 610-619,I0007页

作者： peng huo Cheng-Tang Zhong Xiao-peng Xiong Department of Materials Science and Engineering College of MaterialsXiamen UniversityXiamen 361005China

Poly(vinylidene fluoride-co-hexafluoropropylene)(PVDF-HFP)receives increasing attention in membrane separation field based on its advantages such as high mechanical strength,thermal and chemical ***,controlling the microporous structure is still *** this work,we attempted to tailor the morphology of PVDF-HFP membrane via a one-step reactive vapor induced phase separation ***,PVDF-HFP was dissolved in a volatile solvent and then was cast in an ammonia water vapor *** complete evaporation of solvent,membranes with adjustable porous structure were prepared,and the microstructures of the membranes were analyzed by scanning electron microscopy,Fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy and X-ray diffraction *** on the results,a mechanism of dehydrofluorination induced cross-linking of PVDF-HFP has been suggested to understand the morphology *** our knowledge,this is the first report of one-step reactive vapor induced phase separation strategy to tailor morphology of PVDF-HFP *** addition,the membranes prepared in the ammonia water vapor exhibited enhanced mechanical strength and achieved satisfactory separation efficiency for water-in-oil emulsions,suggesting promising potential.

关键词： PVDF-HFP Membrane Tailoring Vapor induced phase separation Oil-water separation

Friction of graphene on a substrate with a cavity defect

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Science China(Technological Sciences) 2024年第9期67卷 2834-2841页

作者： ZHOU peng huo ZhanLei CHANG TienChong Shanghai Institute of Applied Mathematics and Mechanics Shanghai Key Laboratory of Mechanics in Energy EngineeringShanghai Frontier Science Center of MechanoinformaticsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200072China The Center for Computational Mechanics and Engineering Applications Provincial Mechanics Experimental Teaching Demonstration CenterSchool of Civil EngineeringHebei University of EngineeringHandan 056038China Shanghai Institute of Aircraft Mechanics and Control Tongji UniversityShanghai 200092China Joint-Research Center for Computational Materials Zhejiang LaboratoryHangzhou 311100China

The frictional behavior of supported graphene is known to be influenced by the physical properties and surface morphologies of the underlying substrate. However, it is unclear how a surface defect on the substrate affects the friction of supported graphene,and it is even unknown how to define the defect-induced friction force in this context. Here we conduct molecular dynamics(MD) simulations to investigate the friction between a square diamond slider and a graphene sheet supported by a copper substrate with a surface cavity defect. Our results demonstrate that the defect-induced friction exhibits a nonlinear increase with cavity size, while it decreases nonlinearly with slider size. We propose that the definition of defect-induced friction can be linked to the increase in friction work over the length of the slider, and is closely correlated to the defect-induced relative change in indentation depth and the ratio of the cavity area to the contact area. These findings provide a comprehensive evaluation of the impact of a substrate cavity defect on the friction of supported graphene and offer insights that may have broader implications for understanding defect-induced friction in other two-dimensional materials.

关键词： friction graphene underneath substrate cavity defect

法莫替丁预防急性重症脑血管病并发应激性溃疡的疗效观察

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临床医药实践 2004年第12期13卷 910-911页

作者：李卫军李复雄覃朋飞霍开秀深圳市龙岗中心医院广东深圳518116

目的 :了解法莫替丁在预防急性重症脑血管病后应激性溃疡的作用。方法 :选择急性重症脑血管病 82例 ,随机分为法莫替丁组与对照组各 4 1例 ,分别对照其应激性溃疡的发生及病死率。结果 :法莫替丁能有效地预防应激性溃疡的发生 (P<0 .0 1... 详细信息

目的 :了解法莫替丁在预防急性重症脑血管病后应激性溃疡的作用。方法 :选择急性重症脑血管病 82例 ,随机分为法莫替丁组与对照组各 4 1例 ,分别对照其应激性溃疡的发生及病死率。结果 :法莫替丁能有效地预防应激性溃疡的发生 (P<0 .0 1)及降低病死率 (P<0 .0 5 )。结论 :法莫替丁是急性重症脑血管病后预防应激性溃疡的发生并降低病死率的理想药物 ,值得推广使用。

关键词：法莫替丁急性脑血管病应激性溃疡

The role of lake heat flux in the growth and melting of ice

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Advances in Polar Science 2021年第4期32卷 364-373页

作者： Bin CHENG XIE fei LU peng huo Puzhen Matti LEPPÄRANTA Finnish Meteorological Institute Helsinki Fi-00101Finland State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116081China University of Helsinki Helsinki Fi-00014Finland

For shallow lakes,ice mass balance is largely dominated by thermodynamic *** heat flux from lake water plays a critical role for ice growth and *** this study,we applied a numerical thermodynamic lake model to investigate the sensitivity of the lake ice mass balance to the lake heat flux during the growth and melting *** groups of modelling experiments forced by simplified climatological weather data have been carried *** sites,Lake Wuliangsuhai inInner Mongolia,China’s arid region and Lake Orajärvi in snowy Finnish Lapland,were *** heat flux affects inversely proportional maximum ice thickness followed by ice break-up *** solar radiation and surface albedo complicate the effect of lake heat flux on lake ice mass balance during melting *** heavy snowfall,the increase of lake heat flux adds on the formation of granular ice but reduces the formation of columnar *** climatological weather conditions,theice cover winter seasonal mean lake heat flux were 14 W·m^(−2) and 4 W·m^(−2) in Lake Wuliangsuhai and Lake Orajärvi,respectively.

关键词： shallow lakes lake ice heat flux numerical modelling

Study of adaptive modulation and LDPC coding in multicarrier systems

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Journal of Systems Engineering and Electronics 2008年第1期19卷 39-45页

作者： huo Yongqing peng Qicong Shao Huaizong School of Communication and Information Engineering Univ. of Electronic Science and Technology of China Chengdu 610054 P. R. China

An adaptive modulation （AM） algorithm is proposed and the application of the adapting algorithm together with low-density parity-check （LDPC） codes in multicarrier systems is investigated. The AM algorithm is based on minimizing the average bit error rate （BER） of systems, the combination of AM algorithm and LDPC codes with different code rates （half and three-fourths） are studied. The proposed AM algorithm with that of Fischer et al is compared. Simulation results show that the performance of the proposed AM algorithm is better than that of the Fischer＇s algorithm. The results also show that application of the proposed AM algorithm together with LDPC codes can greatly improve the performance of multicarrier systems. Results also show that the performance of the proposed algorithm is degraded with an increase in code rate when code length is the same.

关键词： multicarrier adaptive modulation low-density parity-check coding bit error rate.