检索结果-南通市图书馆

Designing Electronic Structures of Multiscale Helical Converters for Tailored Ultrabroad Electromagnetic Absorption

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第1期17卷 439-455页

作者： Zhaobo Feng Chongbo liu Xin li Guangsheng Luo Naixin Zhai Ruizhe Hu Jing lin Jinbin peng Yuhui peng Renchao Che Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle School of Environmental and Chemical EngineeringNanchang Hangkong UniversityNanchang 330063People’s Republic of China School of Physics and Materials Nanchang UniversityNanchang 330031People’s Republic of China Key Laboratory of Nondestructive Testing Ministry of EducationNanchang Hangkong UniversityNanchang 330063People’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering and TechnologyFudan UniversityShanghai 200438People’s Republic of China

Atomic-scale doping strategies and structure design play pivotal roles in tailoring the electronic structure and physicochemical property of electromagnetic wave absorption(EMWA)***,the relationship between configuration and electromagnetic(EM)loss mechanism has remained ***,drawing inspiration from the DNA transcription process,we report the successful synthesis of novel in situ Mn/N co-doped helical carbon nanotubes with ultrabroad EMWA *** calculation and EM simulation confirm that the orbital coupling and spin polarization of the Mn–N4–C configuration,along with cross polarization generated by the helical structure,endow the helical converters with enhanced EM *** a result,HMC-8 demonstrates outstanding EMWA performance,achieving a minimum reflection loss of−63.13 dB at an ultralow thickness of 1.29 *** precise tuning of the graphite domain size,HMC-7 achieves an effective absorption bandwidth(EAB)of 6.08 GHz at 2.02 mm ***,constructing macroscale gradient metamaterials enables an ultrabroadband EAB of 12.16 GHz at a thickness of only 5.00 mm,with the maximum radar cross section reduction value reaching 36.4 dB *** innovative approach not only advances the understanding of metal–nonmetal co-doping but also realizes broadband EMWA,thus contributing to the development of EMWA mechanisms and applications.

关键词： Metal-nonmetal co-doping 3d-2p orbital coupling Spin polarization Helical structure Broadband EM wave absorption

在线全文

学校读者我要写书评

暂无评论

西部生态脆弱矿区地下水对高强度采煤的响应

煤炭学报 2016年第11期41卷 2672-2678页

作者：范立民向茂西彭捷李成李永红仵拨云卞惠瑛高帅乔晓英陕西省地质环境监测总站陕西西安710054 陕西省矿产资源勘查与综合利用重点实验室陕西西安710054

为研究榆神府矿区高强度煤层开采对地下水的影响,分析潜水位下降与煤层开采强度的关系,通过资料收集和实地调查两种方法,获取了矿区煤炭资源大规模开采前(1995年)地下水位和煤炭开采后(2014年)地下水位,2者叠加后求取了地下水位变化幅度... 详细信息

为研究榆神府矿区高强度煤层开采对地下水的影响,分析潜水位下降与煤层开采强度的关系,通过资料收集和实地调查两种方法,获取了矿区煤炭资源大规模开采前(1995年)地下水位和煤炭开采后(2014年)地下水位,2者叠加后求取了地下水位变化幅度,并与开采强度分区进行耦合,分析地下水位变化与开采强度的关系。研究区73.0%的区域地下水位未发生明显变化,但有7.3%区域地下水位下降幅度超过8 m,尽管比例小,但面积达758.9 km2,对区域地下水均衡产生了较大影响;高开采强度开采是矿区地下水位下降的主要驱动因素,71.5%的水位明显下降区(>8 m)是由高强煤层开采导致的。导水裂隙带和含水层特征是煤层开采过程中控制地下水位变化幅度和范围的关键所在。高强度煤层开采区必须推行保水采煤技术才能达到资源与环境和谐发展的目的。

关键词：保水采煤(保水开采) 水位下降萨拉乌苏组榆神府矿区

Sodium tanshinoneⅡ-A sulfonate modulates the kinetics and Ca2+ dependence of BKca in mouse cerebral arterial smooth muscle cells

在线全文

学校读者我要写书评

暂无评论

Sodium tanshinoneⅡ-A sulfonate modulates the kinetics and C...

Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Xiao-Qiu TAN,Yan YANG,Jun cheng,peng-Yun li,Xiao-Rong ZENG~* Department of Electrophysiology,Institute of Cardiovasology,Luzhou Medical College,Luzhou 646000,China

Aim:The large conductance Ca-sensitive K channels(BK) play a key role in buffering the vascular *** tanshinoneⅡ-A sulfonate(DS-201) is a water-soluble derivative of tanshinoneⅡA that is a main active constituent of Salvia miltiorrhiza(danshen).Here we aimed to investigate the effect of DS-201 on BK channel kinetics and Ca ***:Smooth muscle cells were freshly isolated from mouse cerebral ***-cell and single channel currents of BK were recorded by patch ***:DS-201 activated BK in a concentration-dependent *** action was modified by intracellular free Ca concentration([Ca]). DS-201 activated BK with the half maximal effective concentration(EC) of(68.5±5.66)μmol/L at 0.1μmol/L [Ca] and with an EC of(111.5±8.39)μmol/L at 0.01μmol/L[Ca].DS-201(120μmol/L) increased the total open probability(NPo)～38.7-fold at 0.1μmol/L[Ca](0.970±0.08 vs 0.025±0.01,n=5).DS-201 also changed the channel closing kinetics including the closed dwell time[(769.57±201.69) vs(48.17±31.71) ms]and the closed time constant[(1.01±0.14) vs(0.45±0.07) ms].There was no effect on the channel opening kinetics. DS-201 slowed the transition from open to closed state and did not alter that from closed to open ***-201 at 20 and 40μmol/L shifted the calcium dependence of BK with dissociation constant(K) from 2.21μmol/L to 1.17μmol/L and 0.19μmol/L.60μmol/L DS-201 also shifted the voltage ***:The data suggested that DS-201 is a BK channel activator via modulation of channel kinetics and calcium dependence mechanism.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing peng Yin Shihua li Xiao-Jiang li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan li peng Hao Hongmei Duan Fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

在线全文

学校读者我要写书评

暂无评论

硫磺回收装置冷凝冷却器泄漏原因分析及对策

石油化工设备 2023年第1期52卷 79-84页

作者：彭礼成林洪军程宏连善涛许博涛中化泉州石化有限公司福建泉州362103

针对中化泉州石化有限公司硫磺回收装置一/三级冷凝冷却器频繁泄漏情况,分别从制造、设计、腐蚀及生产操作等方面分析,认为设备泄漏主要系换热管与管板连接焊缝存在缺陷、设计不合理和恶劣的腐蚀环境引起,并提出了严控制造质量、优化工... 详细信息

针对中化泉州石化有限公司硫磺回收装置一/三级冷凝冷却器频繁泄漏情况,分别从制造、设计、腐蚀及生产操作等方面分析,认为设备泄漏主要系换热管与管板连接焊缝存在缺陷、设计不合理和恶劣的腐蚀环境引起,并提出了严控制造质量、优化工艺流程和设备结构、精细生产操作等改造和防护对策。

关键词：冷凝冷却器硫磺回收泄漏腐蚀分析

维普期刊数据库博看期刊

liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei Wu Yuqing liu Hongli li Lemei Zhu lingfeng Zeng Zhen Zhang Weijun peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli li Jianhua Huang Di Zhao Lemei Zhu Zheyu Zhang Min Yi Weijun peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le Wang Wenwu Zhang Gang li Xing cheng Peiqiang Su Yong Wan Xiang li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury