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Effectiveness of urban distributed runoff model for discharge and water depth calculation in urban drainage pipe networks

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Journal of Hydrodynamics 2024年第3期36卷 582-591页

作者： Yang Zhou Yi-ling Leng peng-yu wang Shang-hong Zhang yu-long Zhu yu-jun Yi School of Water Resources and Hydropower Engineering North China Electric Power UniversityBeijing102206China State Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal UniversityBeijing100875China

Effective urban land-use re-planning and the strategic arrangement of drainage pipe networks can significantly enhance urban flood defense *** at reducing the potential risks of urban flooding,this paper presents a straightforward and efficient approach to an urban distributed runoff model(UDRM).The model is developed to quantify the discharge and water depth within urban drainage pipe networks under varying rainfall intensities and land-use *** Nash efficiency coefficient of UDRM exceeds 0.9,which indicates its high computational efficiency and potential benefit in predicting urban *** prediction of drainage conditions under both current and re-planned land-use types is achieved by adopting different flood recurrence *** findings reveal that the re-planned land-use strategies could effectively diminish flood risk upstream of the drainage pipe network across 20-year and 50-year flood recurrence ***,in the case of extreme rainfall events(a 100-year flood recurrence),the re-planned land-use approach fell short of fulfilling the requirements necessary for flood disaster *** these instances,the adoption of larger-diameter drainage pipes becomes an essential requisite to satisfy drainage ***,the proposed UDRM effectively combines land-use information with pipeline data to give practical suggestions for pipeline modification and land-use optimization to combat urban ***,this methodology warrants further promotion in the field of urban re-planning.

关键词： Stormwater runoff water depth urban distributed runoff model urban drainage pipe networks urban land-use re-planning

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A systematic study of Erzhu Erchen decoction against damp-heat internalized type 2 diabetes based on data mining and experimental verification

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Traditional Medicine Research 2024年第2期9卷 27-41页

作者： peng-yu wang Jian-Fen Shen Shuo Zhang Qing Lan Guan-Di Ma Tong wang You-Zhi Zhang School of Pharmacy Hubei Engineering Research Center of Traditional Chinese Medicine of South Hubei ProvinceXianning Medical CollegeHubei University of Science and TechnologyXianning 437100China Department of Central Laboratory The First Affiliated Hospital of Jiaxing UniversityJiaxing 314000China

Background:Erzhu Erchen decoction(EZECD),which is based on Erchen decoction and enhanced with Atractylodes lancea and Atractylodes macrocephala,is widely used for the treatment of dampness and heat(The clinical manifestations of Western medicine include thirst,inability to drink more,diarrhea,yellow urine,red tongue,et al.)internalized ***,the mechanism of EZECD on damp-heat internalized Type 2 diabetes(T2D)remains *** employed data mining,pharmacology databases and experimental verification to study how EZECD treats damp-heat internalized ***:The main compounds or genes of EZECD and damp-heat internalized T2D were obtained from the pharmacology ***,the overlapped targets of EZECD and damp-heat internalized T2D were performed by the Gene Ontology,kyoto encyclopedia of genes and genomes *** the compound-disease targets-pathway network were constructed to obtain the hub ***,the hub genes and core related pathways were mined with weighted gene co-expression network analysis based on Gene Expression Omnibus database,the capability of hub compound and genes was valid in AutoDock ***,and violin plot and gene set enrichment analysis were performed to explore the role of hub genes in damp-heat internalized ***,the interactions of hub compound and genes were explored using Comparative Toxicogenomics Database and quantitative polymerase chain ***:First,herb-compounds-genes-disease network illustrated that the hub compound of EZECD for damp-heat internalized T2D could be ***,the hub genes were CASP8,CCL2,and AHR according to weighted gene co-expression network *** docking showed that quercetin could bind with the hub ***,gene set enrichment analysis and Gene Ontology represented that CASP8,or CCL2,is negatively involved in insulin secretion response to the TNF or lipopolysaccharide process,and AHR or CCL2 positively regulated li

关键词： data mining damp-heat internalized type 2 diabetes Erzhu Erchen decoction network pharmacology bioinformatics

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ARHGAP4 variants are associated with X-linked early-onset temporal lobe epilepsy

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World Journal of Pediatrics 2024年第8期20卷 859-867页

作者： yuan-yuan Hu wang Song Zhi-Gang Liu Xing-Guang Ye Hong-Wei Zhang Xin Li Jun-Xia Luo peng-yu wang Jie wang Xiao-Fei Lin Hong-Li Zhu Wei-Ping Liao Bin Li Xu-Qin Chen Department of Neurology Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of ChinaInstitute of Neuroscience and the Second Affiliated Hospital of Guangzhou Medical UniversityChang-gang-dong RoadGuangzhou510260China Epilepsy Center and Neurology Department of Children’s Hospital of Soochow University Suzhou215000JiangsuChina Department of pediatrics Foshan Women and Children HospitalFoshan528000China Children’s Hospital Affiliated to Shandong University Jinan250000ShandongChina Second Hospital of Shandong University Jinan250000China Huai’an Maternity&Child Healthcare Hospital Huai’an223001China Institute of Neuroscience of Guangzhou Medical University and Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Chang-gang-dong Road 250Guangzhou510260GuangdongChina

The ARHGAP4 gene(OMIM*300,023),also known as Rho GTPase activating protein 4,encodes a protein that has an essential role in the regulation of small ***4 message RNA(mRNA)is highly expressed during the developing and adult nervous *** the protein level,ARHGAP4 is exclusively present in certain brain regions,such as the mesial temporal lobe,specifically the stratum lucidum of the CA3 region[1].ARHGAP4 enhances the GTPase activity of Rho proteins,which modulate morphological alterations in neuron development and synaptic plasticity by interacting with the actin cytoskeleton[2].

关键词： epilepsy alterations stratum

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Enhancing Na^(+) diffusion dynamics and structural stability of O3-NaMn_(0.5)Ni_(0.5)O_(2)cathode by Sc and Zn dual-substitution

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Transactions of Nonferrous Metals Society of China 2024年第10期34卷 3344-3357页

作者： Bin-bin wang Yi-ming FENG Xin LUO Qun HUANG Zi-xing HOU Ya-qin WU peng-yu wang yu-yang QI Qing-fei MENG Wei-feng WEI Liang-jun ZHOU State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Vital Material Co. Ltd.Guangzhou 510623China The 48th Research Institute of China Electronics Technology Group Corporation Changsha 410111China Wuhan Zhongyuan Changjiang Technology Development Co. Ltd.Wuhan 430090China

Sc and Zn were introduced into O3-NaMn_(0.5)Ni_(0.5)O_(2)(NaMN)using the combination of solution combustion and solid-state *** effect of Sc and Zn dual-substitution on Na^(+) diffusion dynamics and structural stability of NaMN was *** physicochemical characterizations suggest that the introduction of Sc and Zn broaden Na^(+) diffusion channels and weaken the Na—O bonds,thereby facilitating the diffusion of sodium *** indicate that the Sc and Zn dual-substitution decreases the diffusion barrier of Na-ions and improves the conductivity of the *** dual-substituted NaMn_(0.5)Ni_(0.4)Sc_(0.04)Zn_(0.04)O_(2)(Na MNSZ44)cathode delivers impressive cycle stability with capacity retention of 71.2%after 200 cycles at 1C and 54.8%after 400 cycles at ***,the full cell paired with hard carbon anode exhibits a remarkable long-term cycling stability,showing capacity retention of 64.1%after 250 cycles at *** results demonstrate that Sc and Zn dual-substitution is an effective strategy to improve the Na^(+) diffusion dynamics and structural stability of NaMN.

关键词： layered oxide cathode Sc and Zn dual-substitution structural stability Na^(+)diffusion dynamics

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2,3,5,4’-Tetrahydroxystilbene-2-O-b-D-Glucoside modulates CHEK2 and CCND1 alternative splicing to inhibit MCF-7 cells proliferation

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Traditional Medicine Research 2024年第1期9卷 33-46页

作者： Hui Shen You-Zhi Zhang peng-yu wang Shuo Zhang Huan Pan Bei-Bei Liu Long-Sheng Xu Jian-Fen Shen Department of Central Laboratory The First Affiliated Hospital of Jiaxing UniversityJiaxing 314000China School of Pharmacy Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100China Hubei Engineering Research Center of Traditional Chinese Medicine of South Hubei Province Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100China

Background:In our previous study,we observed a synergistic effect of 2,3,5,4’-Tetrahydroxystilbene-2-O-b-D-glucoside combined with adriamycin to induce apoptosis in MCF-7 breast cancer ***,the underlying mechanisms of epigenetic modifications,such as alternative splicing,have not been *** this study,we aimed to investigate the mechanism by which THSG inhibits MCF-7 cell proliferation using full-length transcriptome ***:First,cell viability was examined using the methyl thiazolyl tetrazolium method and full-length transcriptome sequencing was performed to identify genes and *** Ontology and Kyoto Encyclopedia of Genes and Genomes were used to identify the principal pathways and targets of *** cytometry analysis of cell cycle distribution was ***,the analysis of alternative splicing and domains of the key proteins was *** polymerase chain reaction and western blotting were performed for ***:THSG showed significant cytotoxic activity in MCF-7 ***-length transcriptome sequencing revealed differential alternative splicing with 173 upregulated and 263 downregulated *** analysis identified distinct differential expression of genes(CHEK2-211 and CCND1-201)involved in the cell cycle in the THSG-treated ***,alternative splicing types of CHEK2(mutually exclusive exon)and CCND1(intron retention).We found that THSG downregulated mRNA expression,as confirmed by quantitative polymerase chain reaction ***,protein structural analysis revealed that THSG treatment led to the generation of CHK2-211,which was the result of a mutation in the amino acid residues(GLU-150,ASN-151)of the CHEK2 domain(VAL-150,GLY-151).and CyclinD1-201 were obtained when an amino acid(ASP-267)in the domain was lost in ***,molecular docking analysis demonstrated that the domains of key proteins could bind THSG more effectively,with no difference in

关键词： THSG breast cancer full-length transcriptome sequencing alternative splicing

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Recent advances in tribological and wear properties of biomedical metallic materials

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Rare Metals 2021年第11期40卷 3091-3106页

作者： Hua-Fang Li Jin-Yan Huang Gui-Cai Lin peng-yu wang School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

Biomedical metallic materials are commonly used in the repair and replacement of human *** the materials are implanted in the human body,the implants can rub against human tissue or other implants,resulting in wear and tear of the *** wear and tear of implants in the human body can lead to osteolysis and inflammation,which can affect the longevity of the implant and human *** the sake of human health and the longevity of implants,it is essential to study the frictional and wear properties of biomedical metallic *** present review summarizes the current research on the frictional and wear properties of biomedical metallic materials in recent years,as well as the methods and techniques to improve the frictional and wear properties of the *** significance of the present review lies in that it could provide momentus information for further investigation of the tribological properties of biomedical metallic materials.

关键词： Friction Wear Metallic materials Wear resistance Tribocorrosion

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A nonlocal dispersal and time delayed HIV infection model with general incidences

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Applied Mathematics(A Journal of Chinese Universities) 2024年第3期39卷 448-457页

作者： WU peng ZHANG yu-huai wang Ling School of Sciences Hangzhou Dianzi UniversityHangzhou 310018China School of Humanities and Management Zhejiang Chinese Medical UniversityHangzhou 311402China Public Foundational Courses Department Nanjing Vocational University of Industry TechnologyNanjing 210023China

Biologically,because of the impact of reproduction period and nonlocal dispersal of HIV-infected cells,time delay and spatial heterogeneity should be *** this paper,we establish an HIV infection model with nonlocal dispersal and infection ***,applying the theory of Fourier transformation and von Foerster rule,we transform the model to an integrodifferential equation with nonlocal time delay and *** well-posedness,positivity,and boundedness of the solution for the model are studied.

关键词： HIV model nonlocal dispersal time delay general incidences

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Stochastic Flexibility Evaluation for Virtual Power Plants by Aggregating Distributed Energy Resources

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 988-999页

作者： Siyuan wang Wenchuan Wu Qizhan Chen Junjie yu peng wang Department of Electrical Engineering Tsinghua UniversityBeijing 100084China Zhongshan Power Supply Bureau of the Guangdong Power Grid Corporation Zhongshan 528400China Beijing Qingda Gaoke System Control Company Beijing 102208China CSEE IEEE

To manage a large amount of flexible distributed energy resources(DERs)in the distribution networks,the virtual power plant(VPP)is introduced into the *** VPP can optimally dispatch these resources in a cluster manner and provide flexibility for the power system operation as a *** existing studies formulate the equivalent power flexibility of the aggregating DERs as deterministic optimization models without considering their *** this paper,we introduce the stochastic power flexibility range(PFR)and timecoupling flexibility(TCF)to describe the power flexibility of *** this model,both operational constraints and the randomness of the DERs’output are incorporated,and a combined model and data-driven solution is proposed to obtain the stochastic PFR,TCF,and cost function of *** aggregating model can be easily incorporated into the optimization model for the power system operator or market bidding,considering ***,a numerical test is *** results show that the proposed model not only has higher computational efficiency than the scenario-based methods but also achieves more economic benefits.

关键词： Chance constrained optimization combined model and data-driven stochastic power flexibility virtual power plant

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Porous Alumina Ceramics Fabricated by Spark Plasma Sintering

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Chinese Journal of Aeronautics 2006年第B12期19卷 257-260页

作者： wang Kun FU Zheng-yi peng Yong wang yu-cheng ZHANG Jin-yong ZHANG Qing-jie State Key Lab of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan 430070 China

Porous alumina of regular spherical particles was fabricated with the spark plasma sintering （SPS） and then compared to those obtained through conventional hot pressing （HP）. The effects of the parameters of the heating process on porosity were also investigated, Microstructural studies suggest that porous ingots including regular pores be made out of regular spherical alumina particles due to the close sphere packages. A comparative study on the relative necks of the specimens produced by SPS and HP indicates an enhancement of neck growth with SPS. Contrasting the theoretical values to the experimental results over the relative necks indicates that a proper relationship between the relative necks and the porosity can be established by a sintering model.

关键词： spark plasma sintering (SPS) porous alumina ceramics sintering neck

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Pd-catalyzed intermolecular Si–O formation via Si–C activation

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Science China Chemistry 2024年第8期67卷 2661-2669页

作者： Shuang Liu yu-Shu Chen Yichen Wu peng wang State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesShanghai 200032China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistryand Material Technology of Ministry of EducationHangzhou Normal UniversityHangzhou 311121China

The development of efficient Si–O bond formation reaction with 100% atom-economy, excellent functional group tolerance, and broad scope under mild conditions is highly desired due to the prevalence of silanol, silyl ether, and their derivatives in synthetic chemistry and materials science. Here, we have realized the Pd-catalyzed Si–O formation reaction via a Si–C activation approach with 100% atom-economy by employing silacyclobutanes(SCBs) and various hydroxy-containing substrates, including water,alcohols, phenols, and silanols. This protocol features a broad substrate scope, remarkable functional compatibility and mild conditions, providing a series of silanols, silyl ethers in high efficiency. Notably, this protocol could also be used for selective protection of hydroxy functionalities, and for the access of a class of novel polymers containing Si–O main chain. Preliminary mechanistic studies unveiled that this reaction underwent a Pd-catalyzed concerted ring-opening mechanism.

关键词： Si–O formation Si–C activation palladium silacyclobutane silanol silyl ether

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