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Crohn’s disease as the intestinal manifestation of pan-lymphatic dysfunction:An exploratory proposal based on basic and clinical data

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World Journal of Gastroenterology 2024年第1期30卷 34-49页

作者： Yu-Wei Zhou Yue Ren Miao-Miao Lu Ling-Ling xu Wei-Xin Cheng Meng-Meng Zhang Lin-Ping Ding Dong Chen Jian-Guo Gao Juan Du Ci-Liang Jin Chun-Xiao Chen Yun-Fei Li Tao Cheng peng-Lei Jiang Yi-Da Yang peng-xu qian peng-Fei xu Xi Jin Department of Gastroenterology The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology The Second Hospital of JiaxingJiaxing 314000Zhejiang ProvinceChina Endoscopy Center Children’s Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology The Second People’s Hospital of Yuhang DistrictHangzhou 310000Zhejiang ProvinceChina Department of Gastroenterology Hangzhou Shangcheng District People’s HospitalHangzhou 310003Zhejiang ProvinceChina Department of Colorectal Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Women’s Hospital and Institute of Genetics Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Center of Stem Cell and Regenerative Medicine and Bone Marrow Transplantation CenterThe First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Infectious Disease The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

Crohn’s disease(CD)is caused by immune,environmental,and genetic *** can involve the entire gastrointestinal tract,and although its prevalence is rapidly increasing its etiology remains *** biological and small-molecule drugs have advanced the treatment of CD;however,a considerable proportion of patients are non-responsive to all known *** achieve a breakthrough in this field,innovations that could guide the further development of effective therapies are of utmost *** this review,we first propose the innovative concept of pan-lymphatic dysfunction for the general distribution of lymphatic dysfunction in various diseases,and suggest that CD is the intestinal manifestation of pan-lymphatic dysfunction based on basic and clinical preliminary *** supporting evidence is fully summarized,including the existence of lymphatic system dysfunction,recognition of the inside-out model,disorders of immune cells,changes in cell plasticity,partial overlap of the underlying mechanisms,and common gut-derived fatty and bile acid *** benefit of this novel concept is that it proposes adopting the zebrafish model for studying intestinal diseases,especially CD,as this model is good at presenting and mimicking lymphatic *** importantly,the ensuing focus on improving lymphatic function may lead to novel and promising therapeutic strategies for CD.

关键词： Inflammatory bowel disease Crohn’s disease Lymphatic system Inside-out model Immune cells Zebrafish

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Guaranteed Cost Attitude Tracking Control for Uncertain Quadrotor Unmanned Aerial Vehicle Under Safety Constraints

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1447-1457页

作者： qian Ma peng Jin Frank L.Lewis School of Automation Nanjing University of Science and TechnologyNanjing 210094China UTA Research Institute University of Texas at ArlingtonFort WorthTexas 76118 USA IEEE

In this paper,guaranteed cost attitude tracking con-trol for uncertain quadrotor unmanned aerial vehicle(QUAV)under safety constraints is ***,an augmented system is constructed by the tracking error system and reference *** transformation aims to convert the tracking control prob-lem into a stabilization control ***,control barrier function and disturbance attenuation function are designed to characterize the violations of safety constraints and tolerance of uncertain disturbances,and they are incorporated into the reward function as penalty *** on the modified reward function,the problem is simplified as the optimal regulation problem of the nominal augmented system,and a new Hamilton-Jacobi-Bellman equation is ***,critic-only rein-forcement learning algorithm with a concurrent learning tech-nique is employed to solve the Hamilton-Jacobi-Bellman equa-tion and obtain the optimal *** proposed algorithm can not only ensure the reward function within an upper bound in the presence of uncertain disturbances,but also enforce safety *** performance of the algorithm is evaluated by the numerical simulation.

关键词： Attitude tracking control quadrotor unmanned aerial vehicle(QUAV) reinforcement learning safety constraints uncertain disturbances.

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Bio-inspired inorganic-protein coating on Mg-based biomaterials for bioengineering applications

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Science China Materials 2024年第5期67卷 1678-1680页

作者： xuwen peng Haolan xu Department of Chemistry Engineering Tsinghua UniversityBeijing100084China Department of Chemical and Materials Engineering University of AlbertaEdmontonAlbertaT6G 1H9Canada Future Industries Institute UniSA STEMUniversity of South AustraliaMawson Lakes CampusAdelaideSouth Australia5095Australia

Developing smart and advanced functional materials inspired by the unparalleled complexity and efficiency of biological tissues has received much attention across various *** alloys,particularly pure magnesium,have emerged as notable candidates in orthopedics and dentistry due to their exceptional biocompatibility,degradability,and ability to promote bone regeneration[1].However,the highly reactive chemical nature of magnesium and its rapid degradation upon exposure to water.

关键词： coating alloys magnesium

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Mobile genetic elements facilitate the transmission of antibiotic resistance genes in multidrug-resistant Enterobacteriaceae from duck farms

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Food Science and Human Wellness 2024年第2期13卷 729-735页

作者： Xin’er Zheng Dingting xu Jinchang Yan Min qian peng Wang Davood Zaeim Jianzhong Han Daofeng Qu School of Food Science and Biotechnology Zhejiang Gongshang UniversityHangzhou 310035China The Second Affiliated Hospital School of MedicineZhejiang UniversityHangzhou 311100China Agricultural and rural Bureau of Wangdian Town Xiuzhou DistrictJiaxing 314011China

Multidrug-resistant(MDR)Enterobacteriaceae critically threaten duck farming and public *** phenotypes,genotypes,and associated mobile genetic elements(MGEs)of MDR Enterobacteriaceae isolated from 6 duck farms in Zhejiang Province,China,were investigated.A total of 215 isolates were identified as Escherichia coli(64.65%),Klebsiella pneumoniae(12.09%),Proteus mirabilis(10.23%),Salmonella(8.84%),and Enterobacter cloacae(4.19%).Meanwhile,all isolates were resistant to at least two *** isolates carried tet(A)(85.12%),blaTEM(78.60%)and sul1(67.44%)resistance *** co-occurrence analysis showed that the resistance genes were associated with IS26 and integrons.A conjugative IncFII plasmid pSDM004 containing all the above MGEs was detected in Proteus mirabilis isolate *** isolate was resistant to 18 antibiotics and carried the blaNDM-5 ***,especially plasmids,are the primary antibiotic resistance gene transmission route in duck *** findings provide a theoretical basis for the rational use of antibiotics in farms which are substantial for evaluating public health and food safety.

关键词： Duck farm Mobile genetic element Antibiotic resistance gene Plasmid Food safety

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FeNi Prussian blue analogues on highly graphitized carbon nanosheets as efficient glucose sensors

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Rare Metals 2024年第6期43卷 2730-2738页

作者： Jin-Hang xue Qiu-Hong Sun Cheng Han Yuan-Dong Yang Shao-Jie xu Qi-peng Li Jin-Jie qian College of Life and Environmental Science Wenzhou UniversityWenzhou 325000China College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou 325000China College of Chemistry and Chemical Engineering Zhaotong UniversityZhaotong 657000China

Meeting the continuous glucose monitoring requirements of individuals necessitates the research and development of sensors with high sensitivity and *** this study,a straightforward strategy was proposed for synthesizing ultra-thin oxygen-rich graphitized carbon nanosheets(denoted as GCS-O).These nanosheets are obtained by calcining a topologically two-dimensional indium-based coordination ***,the growth of FeNi Prussian blue analogue(PBA)on GCS-O effectively introduces active sites and increases the nitrogen content within the carbonaceous *** resulting FeNi-PBA/GCS-O composite exhibits excellent glucose sensing performance with a broad linear range of 1 to 1300μmol·L^(-1).Meanwhile,it also achieves a high sensitivity of 2496μA·mmol^(-1)·L·cm^(-2),a limit of detection of 100nmol·L^(-1)(S/N=3),and commendable long-term *** relatively simple synthesis process,exceptional sensitivity,and satisfactory electrochemical sensing performance of FeNi-PBA/GCS-O open up new directions for biosensor applications.

关键词： Coordination polymer Carbon nanosheet Prussian blue analogue Surface reconstruction Glucose oxidation

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Skeletal interoception in osteoarthritis

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Bone Research 2024年第2期12卷 241-254页

作者： Dinglong Yang Jiawen xu Ke xu peng xu Department of Joint Surgery Honghui HospitalXi’an Jiaotong UniversityXi’an 710054China Department of Orthopedic Surgery and Orthopedic Research Institute West China HospitalSichuan UniversityChengdu 610041China

The interoception maintains proper physiological conditions and metabolic homeostasis by releasing regulatory signals after perceving changes in the internal state of the *** its various forms,skeletal interoception specifically regulates the metabolic homeostasis of ***(OA)is a complex joint disorder involving cartilage,subchondral bone,and *** subchondral bone undergoes continuous remodeling to adapt to dynamic joint *** findings highlight that skeletal interoception mediated by aberrant mechanical loads contributes to pathological remodeling of the subchondral bone,resulting in subchondral bone sclerosis in *** skeletal interoception is also a potential mechanism for chronic synovial inflammation in *** this review,we offer a general overview of interoception,specifically skeletal interoception,subchondral bone microenviroment and the aberrant subchondral *** also discuss the role of skeletal interoception in abnormal subchondral bone remodeling and synovial inflammation in OA,as well as the potential prospects and challenges in exploring novel OA therapies that target skeletal interoception.

关键词： homeostasis inflammation releasing

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Highly efficient capture of thorium ion by citric acid-modified chitosan gels from aqueous solution

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Chinese Chemical Letters 2024年第5期35卷 361-365页

作者： Linshan peng Qihang peng Tianxiang Jin Zhirong Liu Yong qian State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices East China University of TechnologyNanchang 330013China

A novel citric acid-modified chitosan gel(CSCA)was synthesized through a simple one-step process and was used to extract thorium ions from *** CSCA samples with varying chemical compositions were analyzed using SEM with mapping EDS,FT-IR,and static water contact angle measurements,and their adsorption behaviors were studied in *** results showed that the adsorption performance of CSCA improves with the increase of CA content in the *** possesses an impressive capacity for thorium adsorption of 279.8 mg/***,it showed an ultra-fast adsorption rate and reached equilibrium within 30 *** terms of recyclability,the CSCA still retained more than 86%of its initial adsorption capacity after 6 cycles of *** functional theory(DFT)analysis reveals that the good selectivity of this material towards thorium ions should be attributed to the high density of adsorption sites and strong interaction between carboxyl groups and thorium *** work could be beneficial in the design and synthesis of new polymer materials for extracting thorium.

关键词： Thorium Adsorption Citric acid Chitosan DFT calculation

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Further Results on Stability Analysis for Sampled-Data Systems via Refined Semi-Looped-Functional

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Journal of Systems Science & Complexity 2024年第1期37卷 318-328页

作者： SHENG Zhaoliang xu Shengyuan MA qian ZHANG Baoyong School of Automation Nanjing University of Science and TechnologyNanjing 210094China

This paper investigates the stability problem for sampled-data systems by adopting a refined semi-looped-functional,which is with the following two ***,the new functional term is with a new integral vectorη0,which contains sampling information of the systems and associates two commonly used ***,the vectorη0 is combined into various zero equations for processing the functional,especially where a new equation is derived fromη*** on the refined functional,further stability results for sampled-data systems are *** the effectiveness of the results is numerically verified through two examples at the end.

关键词： Integral vector sampled-data systems semi-looped-functional stability analysis.

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Accurate Analysis of Multi-Mode Interferometric Optical Fiber Sensor

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Photonic Sensors 2024年第1期14卷 48-58页

作者： Lijun LI Congying JIA qian MA Tianzong xu College of Electronic and Information Engineering Shandong University of Science and TechnologyQingdao 266590.China State Key Laboratory of Mining Disaster Prevention and Control Co-Founded by Shandong Province and the Ministry of Science and Technology Qingdao 266590China

In view of the problem that the sensing characteristics of the multi-mode interferometric fiber sensors cannot be accurately analyzed,an analysis method based on the fast Fourier transform(FFT)and inverse fast Fourier transform(IFFT)is proposed and demonstrated theoretically and *** suitabilities of the rectangular window function with the narrow main lobe(high spectrum resolution)and low side lobe(high main mode energy leakage)and the Hanning window function with the wide main lobe(low spectrum resolution)and high side lobe(high energy concentration)in this kind of sensor analysis are discussed,*** method can not only realize the sensing performance analysis of the various modes,but also overcome the inconsistency of the different interference wavelength(dip)sensing characteristics in the conventional analysis *** the same time,this method is also beneficial to solve the repetitive problem of such sensors.

关键词： Window function FFT optical fiber interferometric sensor analysis method

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Experimental distillation of tripartite quantum steering with an optimal local filtering operation

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Photonics Research 2024年第3期12卷 552-562页

作者： qian-XI ZHANG XIAO-xu FANG HE LU School of Physics State Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China Shenzhen Research Institute of Shandong University Shenzhen 518057China

Multipartite Einstein-Podolsky-Rosen(EPR)steering admits multipartite entanglement in the presence of uncharacterized verifiers,enabling practical applications in semi-device-independent *** applications generally require stronger steerability,while the unavoidable noise weakens steerability and consequently degrades the performance of quantum information ***,we propose the local filtering operation that can maximally distill genuine tripartite EPR steering from N copies of three-qubit generalized Greenberger-Horne-Zeilinger states,in the context of two semi-device-independent *** optimal filtering operation is determined by the maximization of assemblage *** and numerical results indicate the advantage of the proposed filtering operation when N is finite and the steerability of initial assemblages is ***,a proof-of-principle demonstration of two-copy distillation is realized with the optical *** advantage of the optimal local filtering operation is confirmed by the distilled assemblage in terms of higher assemblage fidelity with perfectly genuine tripartite steerable assemblages,as well as the greater violation of the inequality to witness genuine tripartite steerable *** results benefit the distillation of multipartite EPR steering in practice,where the number of copies of initial assemblages is generally finite.

关键词： filtering distillation optimal

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