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The potential mechanisms of skin wound healing mediated by tetrapeptides from sea cucumber

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FOOD BIOSCIENCE 2023年第3期53卷 2394-2405页

作者： zheng, Zhihong Sun, Na Lu, Zhiqiang zheng, Jingru Zhang, Simin Lin, Songyi Dalian Polytech Univ Natl Engn Res Ctr Seafood Sch Food Sci & Technol 1 Qinggongyuan Dalian 116034 Peoples R China Dalian Polytech Univ Collaborat Innovat Ctr Seafood Deep Proc Dalian 116034 Peoples R China

Numerous food-derived natural bioactive peptides have excellent skin wound healing potential. Herein, we reported the capacity of sea cucumber derived tetrapeptides VTPY and VLLY to promote wound healing. Our study revealed that the two peptides significantly contribute to the healing of skin wounds by promoting reepithelialization, collagen and lipid regeneration for skin appendage remodeling, and enhancing angiogenesis both in vitro and in vivo. VTPY and VLLY significantly accelerate the migration of keratinocytes to seal the wound surface, as well as facilitate collagen regeneration by promoting the phosphorylation of EKR and P-38. Meanwhile, VTPY and VLLY further enhance angiogenesis and lipid regeneration via upregulating expression of VEGF and eNOS, and triggering ERK/AKT signaling. VTPY works better than VLLY. These findings indicate that sea cucumber derived tetrapeptide VTPY and VLLY can serve as natural food source-derived candidate for promoting skin wound healing.

关键词： Sea cucumber Peptide Wound healing Re-epithelialization Angiogenesis

基于机器视觉的拆回旧电能表参数信息检测技术研究

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电测与仪表 2023年第9期60卷 171-176页

作者：王敏郑鹏郑州大学机械与动力工程学院郑州450001

针对拆回旧智能电能表的回收分类存在人工检定准确率不高、效率低下的问题,提出了一种基于机器视觉的参数信息检测方法,通过检测智能电能表的额定参数信息,完成电能表的分类回收工作。在以C#与Halcon为软件平台建立智能电能表图像检测... 详细信息

针对拆回旧智能电能表的回收分类存在人工检定准确率不高、效率低下的问题,提出了一种基于机器视觉的参数信息检测方法,通过检测智能电能表的额定参数信息,完成电能表的分类回收工作。在以C#与Halcon为软件平台建立智能电能表图像检测系统的基础上,采用Blob分析算法,对图像进行ROI(感兴趣区域)提取,采用直方图均衡化对提取后的图像进行处理,以增强背景与目标区域之间的对比度,获取质量较高的电能表图片,通过OTSU算法对Canny边缘检测算法进行改进,提高图像阈值范围的自适应性,获取更完整的图像外观轮廓,最后对图像进行字符分割处理,得到电能表的额定参数信息。经过实验验证,该方法能够准确检测识别电能表铭牌的额定参数信息,实验数据显示检测准确率达99.5%,平均每台电能表检测耗时0.62 s,很大程度上节省了电能表分类工作的检定时间,提升了工作的效率与准确性。

关键词：机器视觉智能电能表图像处理技术参数信息检测

Thermodynamic modeling of Cr-Al-C and Ni-Al-C systems for low-density steels

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Journal of Iron and Steel Research International 2020年第10期27卷 1190-1199页

作者： Wei-sen zheng Yan-lin He Xiao-gang Lu State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China School of Materials Science and Engineering Shanghai UniversityShanghai 200444China

The so-called low-density steels have generated a lot of interests with their high specific strength and ductility due to the addi-tion of the light element *** order to accelerate the low-density steel design,a thermodynamic database has been developedwithin the present author *** Al-containing systems,i.e.,Cr-Al-Cand Ni-Al-C,were modeled and optimirzed with CALPHAD approach based on the reliable binary *** Cr-Al-C,system,the Gibbs energy of Cr2AlC phasewas described by a temperature-dependent polynomial with the aid of the experimental data on the heat capacity,instead of estimating heat capacity from Ncumann-Kopp *** incongruent melting temperature of Cr2AlC is 1762 K with theinvariant reaction of liquid+Cr3C2+Al4C3→*** phase equilibria between Cr2AlC and binary phases were wellreproduced by using the present model *** Ni-Al-C system,the liquid,fec and bec phases have been optimizedto fit the carbon solubility in these three phases.A good agreement between the calculated and experimental data has beenobtained using the present description of Ni-Al-C *** reliable descriptions of the two ternary systems developedin the present work can be implemented into the thermodynamic database for low-density steels.

关键词： Cr-Al-C system Ni-Al-C system Thermodynamic model CALPHAD Low-density steel

Mesh Adaptation for Curing the Pathological Behaviors of an Upwind Scheme

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Communications in Computational Physics 2022年第2期31卷 626-644页

作者： Yifan Xia Jianjing zheng Jianfeng Zou Jifa Zhang Gaofeng Wang Yao zheng School of Aeronautics and Astronautics Zhejiang UniversityHangzhou 310027P.R.China Center for Hypergravity Experimental and Interdisciplinary Research Zhejiang UniversityHangzhou 310027P.R.China

In present paper,mesh adaptation is applied for curing the pathological behaviors of the enhanced time-accurate upwind scheme(Loh&Jorgenson,AIAAJ 2016).In the original ETAU(enhanced time-accurate upwind)scheme,a multidimensional dissipation model is required to cure the pathological *** multi-dimensional dissipation model will increase the global dissipation level reducing numerical *** present work,the metric-based mesh adaptation strategy provides an alternative way to cure the pathological behaviors of the shock *** Hessian matrix of flow variables is applied to construct the metric,which represents the curvature of the physical *** adapting operation can well refine the anisotropic meshes at the location with large *** numerical results show that the adaptation of mesh provides a possible way to cure the pathological behaviors of upwind schemes.

关键词： Metric tensor mesh adaptation finite volume scheme unstructured grid

Pulmonary contusion mimicking COVID-19:A case report

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World Journal of Clinical Cases 2020年第8期8卷 1554-1560页

作者： Li-Ru Chen zheng-Xin Chen Yang-Chun Liu Lei peng Ye Zhang Quan Xu Qing Lin Yun-Ming Tao Hao Wu Sui Yin Ye-Ji Hu Department of Thoracic Surgery Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Surgery Yongxin County People's HospitalJi’an 343400Jiangxi ProvinceChina

BACKGROUND Coronavirus disease 2019(COVID-19)is a major public health emergency with obvious characteristics of human-to-human transmission,and there are infective asymptomatic *** identification and proper management of patients with COVID-19 are *** in chest computed tomography(CT)can facilitate identifying newly infected ***,CT findings of some lung contusions are similar to those of COVID-19,as shown in the present *** SUMMARY A 46-year-old woman was admitted to hospital for backache and foot pain caused by a fall injury 1 d before *** was suspected of having COVID-19,since there was a confirmed COVID-19 case near her *** she had no fever,cough,chest tightness,difficult breathing,nausea,vomiting,or diarrhea,*** physical examination,the lower posterior chest of both sides showed dullness on percussion and moist rales at the end of inspiration on *** white blood cell count and lymphocyte count were 10.88×109/L and 1.04×109/L,*** performed on February 7,2020 revealed that both lungs were scattered with patchy ground-glass *** patient was diagnosed with pulmonary contusion with thoracic spinal fracture(T12),calcaneal fracture,and pelvic *** day 9 after conservative treatment,her condition was *** review of the chest CT,the previous shadows were significantly *** Differential diagnosis of lung contusion and COVID-19 must be *** conditions require effective prompt actions,especially COVID-19.

关键词： COVID-19 Pulmonary contusion Computed tomography Differential diagnosis Case report Ground-glass opacity

Accommodation of curtailed wind power by electric water heaters based on a new hybrid prediction approach

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Journal of Modern Power Systems and Clean Energy 2019年第3期7卷 525-537页

作者： Yang YU Zengqiang MI Xiaoming zheng Da CHANG State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBaoding071003China Hebei Key Laboratory of Distributed Energy Storage and Micro-grid North China Electric Power UniversityBaoding071003China

Wind power curtailment is of great importance with the increase of large-scale wind power connected to the grid. A new concept of redundant wind power accommodated by dispatching electric water heaters(EWHs) is developed in the paper. Precise predictions of wind power and EWHs load power are the basis for this work. A hybrid multi-kernel prediction approach integrating an adaptive fruit fly optimization algorithm(AFOA)and multi-kernel relevance vector machine(MKRVM) is proposed to deal with the sample distribution of multisource heterogeneous features uncovered by an energy entropy method, where AFOA is used to determine the kernel parameters in MKRVM adaptively and avoid the arbitrariness. For the large computation of the prediction approach, parallel computation based on the Hadoop cluster is used to accelerate the calculation. Then, an economic dispatching model for accommodating wind power is built taking into account the penalty of curtailed wind power and the operation cost of EWHs. The proposedscheme is implemented in an intelligent residential *** results show that the optimization performance of the hybrid prediction approach is superior to those of four usual optimization algorithms in this case. Regular or orderly scheduling of EWHs enables accommodation of superfluous wind power and reduces dispatch cost.

关键词： Wind power curtailment Electric water heaters(EWH) Dispatching model Relevance vector machine Prediction model

On the “spring predictability barrier” for strong El Nio events as derived from an intermediate coupled model ensemble prediction system

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Science China Earth Sciences 2017年第9期60卷 1614-1631页

作者： QI QianQian DUAN WanSuo zheng Fei TANG YouMin State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China University of Chinese Academy of Sciences Beijing 100049 China International Center for Climate and Environment Science Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China Second Institute of Oceanology State Oceanic Administration Hangzhou 310012 China

Using predictions for the sea surface temperature anomaly(SSTA) generated by an intermediate coupled model(ICM)ensemble prediction system(EPS), we first explore the "spring predictability barrier"(SPB) problem for the 2015/16 strong El Nio event from the perspective of error growth. By analyzing the growth tendency of the prediction errors for ensemble forecast members, we conclude that the prediction errors for the 2015/16 El Nio event tended to show a distinct season-dependent evolution, with prominent growth in spring and/or the beginning of the summer. This finding indicates that the predictions for the 2015/16 El Nio occurred a significant SPB phenomenon. We show that the SPB occurred in the 2015/16 El Nio predictions did not arise because of the uncertainties in the initial conditions but because of model errors. As such, the mean of ensemble forecast members filtered the effect of model errors and weakened the effect of the SPB, ultimately reducing the prediction errors for the 2015/16 El Nio event. By investigating the model errors represented by the tendency errors for the SSTA component,we demonstrate the prominent features of the tendency errors that often cause an SPB for the 2015/16 El Nio event and explain why the 2015/16 El Nio was under-predicted by the ICM EPS. Moreover, we reveal the typical feature of the tendency errors that cause not only a significant SPB but also an aggressively large prediction error. The feature is that the tendency errors present a zonal dipolar pattern with the west poles of positive anomalies in the equatorial western Pacific and the east poles of negative anomalies in the equatorial eastern Pacific. This tendency error bears great similarities with that of the most sensitive nonlinear forcing singular vector(NFSV)-tendency errors reported by Duan et al. and demonstrates the existence of an NFSV tendency error in realistic predictions. For other strong El Nio events, such as those that occurred in 1982/83 and 1997

关键词： 2015/16 strong El Nio event Spring predictability barrier Initial errors Model errors

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基于非挥发存储器的存内计算技术

物理学报 2022年第14期71卷 396-414页

作者：周正黄鹏康晋锋北京大学集成电路学院北京100871

通过在基本单元上集成存储和计算功能,存内计算技术能够显著降低数据搬运规模,被广泛认为是突破传统冯·诺依曼计算架构性能瓶颈的新型计算范式.非挥发存储器件兼具非易失特性和存算融合功能,是实现存内计算的良好功能器件.本文首先介... 详细信息

通过在基本单元上集成存储和计算功能,存内计算技术能够显著降低数据搬运规模,被广泛认为是突破传统冯·诺依曼计算架构性能瓶颈的新型计算范式.非挥发存储器件兼具非易失特性和存算融合功能,是实现存内计算的良好功能器件.本文首先介绍了存内计算范式的基本概念,包括技术背景和技术特征.然后综述了用于实现存内计算的非挥发存储器件及其性能特征,包含传统闪存器件和新型阻变存储器;进一步介绍了基于非挥发存储器件的存内计算实现方法,包括存内模拟运算和存内数字运算.之后综述了非挥发存内计算系统在深度学习硬件加速、类脑计算等领域的潜在应用.最后,对非挥发型存内计算技术的未来发展趋势进行了总结和展望.

关键词：存内计算非挥发存储器闪存阻变存储器

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Altering elastic-plastic mechanical response of a series of isostructural metal-organic complexes crystals

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Science China Chemistry 2022年

作者： zheng Tang Xiao-peng Sun Shu-Dong Wang Xue-Yang Ji Yun Li Zi-Shuo Yao Jun Tao Key Laboratory of Cluster Science of Ministry of Education School of Chemistry and Chemical Engineering Beijing Institute of Technology Henan Key Laboratory of Polyoxometalate Chemistry College of Chemistry and Chemical Engineering Henan University

The mechanically compliant single crystals have attracted massive attention. However, the related reports on the single crystals composed of metal-organic complexes remain scarce. In this study, we synthesized a series of isostructural single crystals of ZnII complexes that manifest mechanical bending in response to external stress. In these crystals, the mechanical responses can be shifted between elastic bending and plastic bending by the control of the intermolecular interactions through a rational structural modification in the substituent group of pyridine ligands. As the molecular reorientation corresponding to ligand variation elongates the interfacial distance between molecular slip planes, and the structural disorder of ligands disperses the interplanar intermolecular interactions, the shift from elastic bending to plastic bending of the metal-organic complex-based single crystal was realized. The different mechanical responses of single crystals were comprehensively investigated both experimentally and theoretically.

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