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Study of partial discharge characteristics at repetitive square voltages based on UHF method

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Science China(Technological Sciences) 2013年第1期56卷 262-270页

作者： WANG peng WU GuangNing GAO Bo LUO Yang CAO KaiJiang School of Electrical Engineering Southwest Jiaotong University

Due to overvoltage produced by inverter output,inverter-fed motor insulation systems often experience fast electrical aging process,especially when partial discharge(PD) is *** putting into use,the PD detection should be performed on inverter-fed motors at repetitive square voltages to avoid the PD caused insulation deterioration when the motors are collected to inverters having specific ***,unlike PD tests at AC/DC voltages proposed in IEC 60270,the PD detection at repetitive square voltages is much more complex because of serious interference generated by impulse *** solve the problem,ultra-high frequency(UHF) method seems recommendable for its preferable signal-to-noise ratio(SNR).The chief aim of this study is to investigate PD pulse and statistical characteristics of turn-to-turn insulation for inverter-fed traction motors.A square-shaped Archimedes antenna,specially designed for the PD detection at repetitive square voltages of fast rise times,was used to perform PD tests on turn-to-turn insulation *** and frequency analysis results indicate that energy component of generator disturbance and PD pulses are mainly distributed in the 0-0.5 GHz and 0.6-1.5 GHz range,*** on the results,suitable filter was designed for power disturbance ***,resorting to the sensor unit(*** and filter) and the PD test system,the PD statistical features at square voltages of different frequencies were *** results show that higher frequency will give rise,statistically,to PD of lower magnitudes distributing at smaller phases.A reasonable interpretation of this phenomenon was ***,according to the PD statistical features,some suggestions for the PD detection system design,generator parameter optimization and the PD pulse extracting were *** results of this work would be beneficial to the increase of the sensitivity when performing the PD detection on insulatio

关键词： inverter-fed motors insulation system partial discharge UHF square voltage antenna filter

Engineering immunosuppressive drug-resistant armored(IDRA)SARS-CoV-2 T cells for cell therapy

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Cellular & Molecular Immunology 2023年第11期20卷 1300-1312页

作者： Qi Chen Adeline Chia Shou Kit Hang Amy lim Wee Kun Koh Yanchun peng Fei Gao Jili Chen Zack Ho Lu-En Wai Kamini Kunasegaran Anthony Tanoto Tan Nina Le Bert Chiew Yee Loh Yun Shan Goh Laurent Renia Tao Dong Anantharaman Vathsala Antonio Bertoletti Emerging Infectious Disease Program Duke-NUS Medical SchoolSingaporeSingapore National University Centre for Organ Transplantation National University HospitalSingaporeSingapore MRC Human Immunology Unit MRC Weatherall Institute of Molecular MedicineRadcliffe Department of MedicineUniversity of OxfordOxfordUK Lion TCR Pte Ltd SingaporeSingapore A*STAR ID labs Agency for ScienceTechnology and ResearchSingaporeSingapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore Department of Medicine Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Singapore Immunology Network A*STARSingaporeSingapore

Solid organ transplant(SOT)recipients receive immunosuppressive drugs(ISDs)and are susceptible to developing severe ***,we analyze the Spike-specific T-cell response after 3 doses of mRNA vaccine in a group of SOT patients(n=136)treated with different *** demonstrate that a combination of a calcineurin inhibitor(CNI),mycophenolate mofetil(MMF),and prednisone(Pred)treatment regimen strongly suppressed the mRNA vaccine-induced Spike-specific cellular *** defects have clinical consequences because the magnitude of vaccine-induced Spike-specific T cells was directly proportional to the ability of SOT patients to rapidly clear SARS-CoV-2 after breakthrough *** then compensate for the T-cell defects induced by immunosuppressive treatment and to develop an alternative therapeutic strategy for SOT patients,we describe production of 6 distinct SARS-CoV-2 epitope-specific ISD-resistant T-cell receptor(TCR)-T cells engineered using the mRNA electroporation method with reactivity minimally affected by mutations occurring in Beta,Delta,Gamma,and Omicron *** strategy with transient expression characteristics marks an improvement in the immunotherapeutic field and provides an attractive and novel therapeutic possibility for immunosuppressed COVID-19 patients.

关键词： T cell therapy Transplantation SARS-CoV-2 Immunosuppressive drug resistant T cells

Emergency repair of blunt traumatic bronchus injury presenting with massive air leak

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Chinese Journal of Traumatology 2022年第6期25卷 392-394页

作者： Jun Sen Chuah Zhun Ming Raymond lim Ee peng Lee Jih Huei Tan Yuzaidi Mohamad Rizal Imran Alwi Trauma Surgery Unit Department of General SurgeryHospital Sultanah AminahMinistry of Health MalaysiaJohor BahruMalaysia

Blunt traumatic tracheobronchial injury is rare,but can be potentially *** accounts for only 0.5%-2%of all trauma *** may present with non-specific signs and symptoms,requiring a high index of suspicion with accurate diagnosis and prompt treatment.A 26-year-old female was brought into the emergency department after sustained a blunt trauma to the chest from a high impact motor vehicle *** presented with signs of respiratory distress and extensive subcutaneous emphysema from the chest up to the *** airway was secured and chest drain was inserted for right sided *** of the neck and thorax revealed a collapsed right middle lung lobe with a massive pneumothorax,raising the suspicion of a right middle lobe bronchus *** was confirmed by *** view of the difficulty in maintaining her ventilation and persistent pneumothorax with a massive air leak,immediate right thoracotomy via posterolateral approach was *** right middle lobar bronchus tear was *** were no intra-or post-operative *** made an uneventful *** was asymptomatic at her first month follow-up.A repeated chest X-ray showed expanded *** of the case including clinical presentation,imaging and management were discussed with an emphasis on the early uses of bronchoscopy in case of suspected blunt traumatic tracheobronchial injury.A review of the current literature of tracheobronchial injury management was presented.

关键词： Blunt chest trauma Bronchus injury Bronchoscopy Thoracotomy

Hexyl-pentynoic acid serves as a novel radiosensitizer for breast cancer by inhibiting UCHL3-dependent Rad51 deubiquitination

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Radiation Medicine and Protection 2023年第4期4卷 204-213页

作者： Zuchao Cai David lim Beidi Jia Guochao Liu Wenwen Ding Zhendong Wang Zhujun Tian Junxuan peng Fengmei Zhang Chao Dong Zhihui Feng Department of Occupational Health and Occupational Medicine School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Stomatology Hospital School of StomatologyZhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceCancer Center of Zhejiang UniversityHangzhou 310000China Translational Health Research Institute School of Health SciencesWestern Sydney UniversityCampbelltownNew South WalesAustralia College of Medicine and Public Health Flinders UniversityBedford ParkSouth AustraliaAustralia

Objective:To investigate the effects and underlying mechanism of 2-hexyl-4-pentynoic acid(HPTA),a derivative of valproic acid(VPA),on radiotherapy in breast ***:MCF7 cells and 7,12-dimethylbenz-[α]-anthracene(DMBA)-induced transformed human normal breast cells(MCF10A–DMBA cells)were irradiated with 8 Gy *** both cells there were four groups:control,valproic acid(VPA)/HPTA,IR,and VPA/HPTA+IR *** and clonogenic survival assays were performed to assess cell proliferation,and comet assay was performed to evaluate DNA *** expression ofγH2AX,53BP1,Rad51,and BRCA1 was examined via immunofluorescence and *** chase and ubiquitination experiments were conducted to determine Rad51 *** vivo experiments involved a rat model of DMBA-induced breast cancer,with four fractionated doses of 2 *** tissue pathological changes andγH2AX,Rad51,and UCHL3 expression levels were measured by hematoxylin-eosin staining,immunohistochemistry,and ***:Compared with the IR group,15μmol/L HPTA reduced the cell proliferation ability of irradiated MCF7 cells(t=2.16,P<0.05).The VPA/HPTA+IR group exhibited significantly increased DNA double-strand breaks relative to those in the IR group(VPA+IR ***,t=13.37,P<0.05;HPTA+IR ***,t=8.48,P<0.05).Immunofluorescence and immunoblotting experiments demonstrated that the VPA/HPTA+IR group displayed signifi-cantly increased cell foci formation,γH2AX and 53BP1 protein expression levels compared to the IR group[(γH2AX:VPA+IR ***,t=8.88,P<0.05;HPTA+IR ***,t=8.90,P<0.05),(53BP1,VPA+IR ***,t=5.73,P<0.05;HPTA+IR ***,t=6.40,P<0.05)].Further,Rad51 expression was downregulated(VPA+IR ***,t=3.12,P<0.05;HPTA+IR ***,t=2.70,P<0.05),and Rad51 inhibition effectively counteracted HPTA-induced *** detection further verified that HPTA inhibits Rad51 expression via UCHL3-dependent Rad51 *** vivo study results showed that 20 mg

关键词： 2-hexyl-4-pentynoic acid Radiosensitization UCHL3 Rad51 Homologous recombination Deubiquitination

Ribotrap Analysis of Proteins Associated with FHL3 3'Untranslated Region in Glioma Cells

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Chinese Medical Sciences Journal 2014年第2期29卷 78-84页

作者： Wei Han Qing Xia Bin Yin Xiao-zhong peng State Key Laboratory of Medical Molecular Biology Department of Biochemistry and Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100005 China State Key Laboratory of Proteomics Institute of Basic Medical Sciences National Center of Biomedical Analysis Beijing 100850 China

Objective To screen the proteins associated with four-and-a-half lim domains 3(FHL3) 3' untranslated region(3'UTR) in glioma cells. Methods Western blot was adopted to detect the regulatory effect of poly(C)-binding protein 2(PCBP2) on FHL3. Biotin pull-down and sliver staining were employed to screen and verify the candidate binding proteins of FHL3 3'UTR. Then liquid chromatography-tandem mass spectrometry(LC-MS/MS) and molecule annotation system were used to identify and analyze the candidate binding proteins. Immunoprecipitation was conducted to study the interaction between PCBP2 and polypyrimidine tract-binding protein 1(PTBP1), a binding protein identified by LC-MS/MS. Results PCBP2 could bind to FHL3 mRNA 3'UTR-A and inhibited the expression of FHL3 in T98 G glioms cells. 22 candidate binding proteins were identified. Among them, there were 11 RNA binding proteins, including PCBP2. PTBP1 associated with FHL3 mRNA 3'UTR and interacted with PCBP2 protein. Conclusion PCBP2 and PTBP1 can both associate with FHL3 mRNA 3'UTR through forming a protein complex.

关键词： FHL3 3'untranslated region poly(C)-binding protein 2 polypyrimidine tract-binding protein 1 liquid chromatography-tandem mass spectrometry

Fairyland: Wuyi Mountain

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Women of China 1999年第10期 52-53页

作者： JENNIFER lim

ASK where fairyland is on earth andsome people will say you need look nofurther than Wuyi Mountain. Located on theboarder of Fujian and Jiangxi provinces, WuyiMountain is famous for its unique landscapeand rich cultural background. A legend says that in remote antiquity thisarea was a place often stricken by *** lived a miserable life. peng Yi workednight and day, eating in the wind and sleepingin the dew. He rallied the people together andwith their hoes they opened the mountain,controlled the water and finally changed

关键词： Wuyi Mountain Fairyland

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弹载GNSS虚拟参考站差分定位技术研究

兵器装备工程学报 2024年第8期45卷 67-73页

作者：吴庆丰宋叶志闫正洲夏凤雨李静罗鹏周善石胡小工赵炽西华师范大学四川南充637002 中国科学院上海天文台上海200030 中国科学院大学北京100049

针对高动态目标定位的长基线实时解算需要,本研究采网络多基站融合技术,结合基准站与线性内插模型算法,生成虚拟参考站伪距观测值,并将虚拟参考站作为基准站与目标进行伪距差分解算,从而解算高动态目标的位置轨迹。通过静态目标与高动... 详细信息

针对高动态目标定位的长基线实时解算需要,本研究采网络多基站融合技术,结合基准站与线性内插模型算法,生成虚拟参考站伪距观测值,并将虚拟参考站作为基准站与目标进行伪距差分解算,从而解算高动态目标的位置轨迹。通过静态目标与高动态目标的实测数据验证,在有3个基准站的情况下,静态数据的定位精度达到0.399 m;而高动态目标在目标与基准站共视卫星个数不少于6颗的情况下,定位中误差不超过2.750 m;而与光学雷达、多测速雷达等其他外测设备的实测综合轨迹相比,两者之间位置差异的均方根值为6.390 m,基本满足高动态目标的定位需要。

关键词：网络伪距差分虚拟参考站技术弹道测量扩展卡尔曼滤波线性内插模型

普世与特殊——论希伯来智慧思想的两极结构和教育空间

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基督教文化学刊 2015年第2期34卷 91-118页

作者：林德平三一神学院(新加坡)

第二圣殿时期是礼崩乐坏的时代。随着北国以色列和南国犹大的相继亡国,以色列人沦为殖民,经历了希伯来文化传统与宗教体制崩坏离析的剧变。但是,第二圣殿时期也是犹大人社群致力整理传统和编篆经典的年代。~①以色列诸传统在这时期得以... 详细信息

第二圣殿时期是礼崩乐坏的时代。随着北国以色列和南国犹大的相继亡国,以色列人沦为殖民,经历了希伯来文化传统与宗教体制崩坏离析的剧变。但是,第二圣殿时期也是犹大人社群致力整理传统和编篆经典的年代。~①以色列诸传统在这时期得以沉淀和文字化,最后成为犹太教和基督教的经典——包括《箴言》、《传道书》和《约伯记》所代表的智慧传统。上世纪50年代,德国哲学家雅斯贝尔斯(Karl Jaspers)在《历史的起源与目标》中指出。

关键词： Hebrew Wisdom Axial Age Breakthroughs Horizon Nationalization of Wisdom sapiential practice

A novel mutation of lim2 causes autosomal dominant membranous cataract in a Chinese family

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International Journal of Ophthalmology(English edition) 2020年第10期13卷 1512-1520页

作者： Rui Pei peng-Fei Liang Wei Ye Ji Li Ji-Yuan Ma Jian Zhou Department of Ophthalmology Xijing HospitalFourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Otolaryngology Xijing HospitalFourth Military Medical UniversityXi'an 710032Shaanxi ProvinceChina

AIM:To identify mutations in the genes of a fourgeneration Chinese family with congenital membranous cataracts and investigate the morphologic changes and possible functional damage underlying the role of the mutant ***:Whole exome analysis of thirteen members of a four-generation pedigree affected with congenital membranous cataracts was performed;co-segregation analysis of identified variants was validated by Sanger *** members underwent detailed physical and complete eye *** physical changes caused by the mutation were analyzed in silico through homology *** lens fiber block from a patient was observed under a scanning electron microscope(SEM).Cell membrane proteins and cytoplasmic proteins from the human lenses donated by one patient with cataract in this family and from the dislocated lens resulted from the penetrating ocular trauma of a patient unrelated with this family were extracted,and the expression and localization of MP20 and Cx46 were detected by Western blot(WB)assay in these ***:A novel lim2 heterozygous mutation(c.388 C>T,p.R130 C)was identified with congenital membranous cataracts inherited by an autosomal dominant(AD)*** and amblyopia were observed in all patients of this family,and exotropia and long axial length were observed in most patients.A/B ultrasound scan and ultrasound biomicroscopy revealed obvious thin crystalline lenses from 1.7 to 2.7 mm in central thickness in all cataract *** bioinformatic analysis showed that the mutation was deleterious to the physiological function of lim2-encoded ***,by SEM,ultrastructure of the cataract nucleus showed that lens fiber cells(LFCs)remained morphologic characteristics of immature fiber cells,including flap cell surface with straight edges and lacking normal ball-and-socket joint boundaries,which implied that the differentiation of LFCs might be *** of MP20 and Cx46 in the cytoplasm was observe

关键词： lim2 MP20 congenital cataract missense mutation differentiation