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Application of radioactive iodine-125 microparticles in hepatocellular carcinoma with portal vein embolus

World Journal of Gastrointestinal Surgery 2024年第7期16卷 2023-2030页

作者： peng Meng Ji-peng Ma Xiao-Fei Huang kang-Le Zhang The Fourth Department of Oncology Yantai Hospital of Traditional Chinese MedicineYantai 264001Shandong ProvinceChina Department of Medical Services Yantai Hospital of Traditional Chinese MedicineYantai 264001Shandong ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Sun Yatsen UniversityGuangzhou 510062Guangdong ProvinceChina The Third Department of Oncology Yantai Hospital of Traditional Chinese MedicineYantai 264001Shandong ProvinceChina

BACKGROUND Radioactive iodine-125(125I)microparticle therapy is a new type of internal radiation therapy that has shown unique advantages in the treatment of malignant tumors,especially hepatocellular *** with hepatocellular carcinoma frequently experience portal vein embolism,which exacerbates the difficulty and complexity of treatment.125I particles,used in local radiotherapy,can directly act on tumor tissue and reduce damage to surrounding healthy *** retrospective analysis,this study discussed the efficacy and safety of radioactive 125I particles in portal vein embolization patients with hepatocellular carcinoma in order to provide more powerful evidence supporting clinical *** To investigate the effect of transcatheter arterial chemoembolization combined with portal vein 125I particle implantation in the treatment of primary liver cancer patients with portal vein tumor thrombus and its influence on liver *** The clinical data of 96 patients with primary liver cancer combined with portal vein tumor thrombus admitted to our hospital between January 2020 and December 2023 were retrospectively ***-two patients received treatment with transcatheter arterial chemoembolization and implantation of 125I particles in the portal vein(combination group),while 44 patients received treatment with transcatheter arterial chemoembolization alone(control group).The therapeutic effects on tumor lesions,primary liver cancer,and portal vein tumor embolisms were compared between the two *** in relevant laboratory indexes before and after treatment were *** t test was used to compare the measurement data between the two groups,and the χ^(2) test was used to compare the counting data between *** The tumor lesion response rate in the combination group(59.62%vs 38.64%)and the response rate of patients with primary liver cancer complicated with portal vein tumor thrombus(80.77%vs 59.09%)were signi

关键词： Radioactive iodine-125 Hepatocellular carcinoma Transcatheter arterial chemoembolization Portal vein embolus Retrospective study

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In^(3+)-doped Sr_(2)Fe_(1.5)Mo_(0.5)O_(6−δ)cathode with improved performance for an intermediate-temperature solid oxide fuel cell

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Nano Research 2024年第1期17卷 407-415页

作者： Yumei Ma Lijie Zhang kang Zhu Binze Zhang Ranran peng Changrong Xia Ling Huang State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources College of ChemistryXinjiang UniversityUrumqi 830046China Department of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China

Promoting the oxygen reduction reaction(ORR)is critical for commercialization of intermediate-temperature solid oxide fuel cells(IT-SOFCs),where Sr_(2)Fe_(1.5)Mo_(0.5)O_(6)−δ(SFM)is a promising cathode by working as a mixed ionic and electronic *** this work,doping of In^(3+)greatly increases the oxygen vacancy concentration and the content of adsorbed oxygen species in Sr_(2)Fe_(1.5)Mo_(0.5−x)InxO_(6−δ)(SFMInx),and thus effectively promotes the ORR *** a typical example,SFMIn_(0.1)reduces the polarization resistance(R_(p))from 0.089 to 0.046Ω∙cm^(2)at 800°C,which is superior to those doped with other metal *** addition,SFMIn0.1 increases the peak power density from 0.92 to 1.47 W∙cm^(−2)at 800°C with humidified H_(2)as the fuel,indicating that In3+doping at the Mo site can effectively improve the performance of SOFC cathode material.

关键词： solid oxide fuel cell cathode In3+doping oxygen reduction reaction(ORR) Sr_(2)Fe_(1.5)Mo_(0.5)O_(6-δ)

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Glucocorticoids affect the metabolism of bone marrow stromal cells and lead to osteonecrosis of the femoral head： a review

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Chinese Medical Journal 2012年第1期125卷 134-139页

作者： TAN Gang kang peng-de PEI Fu-xing Department of Orthopedic Surgery West China HospitalSichuan UniversityChengduSichuan 610041China

Objective To review the recent developments in the mechanisms of glucocorticoids induced osteonecrosis of femoral head （ONFH） and introduce a new theory of *** sources Both Chinese- and English-language literatures were searched using MEDLINE （1997-2011）,Pubmed （1997-2011 ） and the Index of Chinese-language Literature （1997-2011 ）.Study selection Data from published articles about mechanisms of glucocorticoids induced ONFH in recent domestic and foreign literature were *** extraction Data were mainly extracted from 61 articles which are listed in the reference section of this *** Glucocorticoids are steroid hormones secreted by the adrenal cortex that play a pivotal role in the regulation of a variety of developmental,metabolic and immune ***,high dose of exogenous glucocorticoids usage is the most common non-traumatic cause of ON *** can affect the metabolisms of osteoblasts,osteoclasts,bone marrow stromal cells and adipocytes which decrease osteoblasts formation but increase adipocytes formation and cause ONFH *** Glucocorticoids affect the differentiation of mesenchymal stem cells,through activating or inhibiting the related transcript regulators of osteogenesis and *** last,the size and volume of mesenchymal stem cells derived adipocytes will increase amazingly,but the osteoblasts will be decreased *** the meantime,the activity of the osteoclasts will be ***,these mechanisms work together and lead to ONFH.

关键词： glucocorticoids osteonecrosis of femoral head peroxisome proliferator-activated receptor-y Runx2 Dickkopf-1 bone marrow stromal cells

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Effect of slag composition on elements oxidation behavior of GH984G superalloy for electroslag remelting withdrawal process

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Journal of Iron and Steel Research International 2022年第5期29卷 761-771页

作者： Fu-bin Liu Jun-zhe Gao Hai-bo Cao Hua-bing Li Zhou-hua Jiang Xin Geng Cong-peng kang Kui Chen Rui-dong An School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819LiaoningChina Hefei Institutes of Physical Science Chinese Academy of SciencesHefei230031AnhuiChina

The composition of a slag system has been shown to be particularly important and influential for the new technology of electroslag remelting withdrawal *** oxidation of the GH984G alloy elements,in contact with different contents of CaF_(2)–CaO–Al_(2)O_(3)–MgO–TiO_(2)–SiO_(2)in various slag systems,has been investigated in the present study by performing slag–metal equilibrium experiments and ion and molecule coexistence theory *** results show that CaF_(2)and MgO have only a minor effect on the oxidation rates of Al and Ti in the GH984G ***,it was found that SiO_(2)would intensify the oxidation degree of Al and Ti,and Al was found to become easier oxidized than ***,CaO was found to reduce the activity of SiO_(2)and,thereby,also the oxidation degree of Al and ***,TiO_(2)was found to reduce the oxidation rate of Ti and instead increase the oxidation rate of ***,the effect of Al_(2)O_(3)on the oxidation of Al and Ti was observed to be opposite to that of TiO_(2).The calculated results were found to be in good agreement with experimental ***,viscosity experiments showed that CaO would rapidly increase the viscosity of the slag at low temperatures,and that the viscosity of the slag would increase with an increase in SiO_(2)content.

关键词： Electroslag remelting withdrawal Slag GH984G superalloy Oxidation rate Viscosity

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Stress Concentration Effect in Interface Between Conductor and Epoxy Resin in Coaxial Components of Power Equipment

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 412-420页

作者： Chuang Wang kang Lei Qing Sun Hui Li Jiawei Zhang Lang Zhao Zongren peng School of Electrical Engineering Xi’an University of TechnologyXi’an 710054China Xi’an Power Supply Company State Grid Shaanxi Electric Power CompanyXi’an 710032China State Key Laboratory of Electrical Insulation and Power Equipment Xi’an Jiaotong UniversityXi’an 710049China

The spacer used in gas insulated switchgear(GIS)plays a vital role in its safe *** mismatch of mechanical properties between conductor and insulating material in spacers results in stress concentration at the interface between *** a hydrostatic test,mechanical damages are often initiated from the *** this paper,the stress between aluminum conductors and epoxy resin is studied by using a simplified coaxial structure *** measurement system and finite element simulation are used to explore the generation of stress and strain during curing and *** real-time measurement of strain at the interface shows that the residual strain in the entire process is primarily generated during the cooling ***,the temperature and stress/strain distribution at the interface during the cooling stage are further studied,and combined with experiments and *** consistency between the finite element simulation and the experimental measurement results verifies the validity of the simulation method *** results show that the maximum of the first principal stress generated during the cooling stage of the production process is concentrated on the upper and lower edges of the interface which is critical to the impact of the production quality of the spacer.

关键词： Epoxy resin GIS interface stress/strain distribution

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Multiple Uplift and Exhumation of the Southeastern Tibetan Plateau:Evidence from Low-Temperature Thermochronology

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Acta Geologica Sinica(English Edition) 2024年第3期98卷 569-584页

作者： WU Limin peng Touping FAN Weiming ZHAO Guochun GAO Jianfeng DONG Xiaohan peng Shili MIN kang Tin Aung MYINT State Key Laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China Chinese Academy of Sciences Center for Excellence in Deep Earth Science Guangzhou 510640China University of Chinese Academy of Sciences Beijing 100049China Chinese Academy of Sciences Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100101China Department of Earth Sciences The University of Hong KongHong Kong 999077China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiGuangdong 519085China Department of Geology University of MandalayMandalay 05011Myanmar

Since the Cenozoic,the Tibetan Plateau has experienced large-scale uplift and outgrowth due to the India-Asia ***,the mechanism and timing of these tectonic processes still remain ***,using apatite fission track dating and inverse thermal modeling,we explore the mechanism of different phases of rapid cooling for different batholiths and intrusions in the southeastern Tibetan *** contrast to previous views,we find that the coeval granitic batholith exposed in the same tectonic zone experienced differential fast uplift in different sites,indicating that the present Tibetan Plateau was the result of differential uplift rather than the entire lithosphere uplift related to lithospheric collapse during Cenozoic *** addition,we also suggest that the 5-2 Ma mantle-related magmatism should be regarded as the critical trigger for the widely coeval cooling event in the southeastern Tibetan Plateau,because it led to the increase in atmospheric CO_(2)level and a hotter upper crust than before,which are efficient for suddenly fast rock weathering and ***,we propose that the current landform of the southeastern Tibetan Plateau was the combined influences of tectonic and climate.

关键词： apatite fission track rapid cooling differential uplift magmatism southeastern Tibetan Plateau

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下向进路充填采矿法深部矿岩破坏机理数值模拟研究

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黄金 2024年第8期45卷 58-63页

作者：邢超高铭阳邱洋洋余乐魁张亚鹏薛超彭康嵩县山金矿业有限公司山东黄金矿业(鑫汇)有限公司中南大学资源与安全工程学院

针对嵩县山金深部矿体采用下向进路充填采矿法开采矿岩破坏机理及地压显现技术问题,采用Rhino+Griddle+Flac 3D快速建模技术,对矿区下向进路开采1~8 a矿岩应力及位移变化规律进行研究。模拟结果表明:最小主应力随深度的增加而增加,靠近... 详细信息

针对嵩县山金深部矿体采用下向进路充填采矿法开采矿岩破坏机理及地压显现技术问题,采用Rhino+Griddle+Flac 3D快速建模技术,对矿区下向进路开采1~8 a矿岩应力及位移变化规律进行研究。模拟结果表明:最小主应力随深度的增加而增加,靠近底部较大;未开采采场起到了临时矿柱的作用,应力集中现象较明显,同时在采场附近的充填体中也形成应力卸压区;各中段的位移随开采时间的增加而不断增大,采场顶板的最大位移主要出现在顶板中间,在矿山不断向深部推进的过程中,最大位移值呈上升趋势。

关键词：深部开采下向进路充填采矿法矿岩破坏机理地压显现数值模拟

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Fracture behavior and mechanism of highly fragmented steel cylindrical shell under explosive loading

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Defence Technology（防务技术） 2024年第6期36卷 122-132页

作者： kang Wang peng Chen Xingyun Sun Yufeng Liu Jiayu Meng Xiaoyuan Li Xiongwei Zheng Chuan Xiao Xi'an Modern Chemistry Research Institute Xi'an 710065China Shanxi Jiangyang Chemical Company Limited Taiyuan 030051China Central Iron&Steel Research Institute Company Limited Beijing 100081China China Research and Development Academy of Machinery Equipment Beijing 100089China

An in-depth understanding of the fracture behavior and mechanism of metallic shells under internal explosive loading can help develop material designs for warheads and regulate the quantity and mass distribution of the fragments *** study investigated the fragmentation performance of a new high-carbon silicon-manganese(HCSiMn)steel cylindrical shell through fragment recovery *** with the conventional 45Cr steel shell,the number of small mass fragments produced by the HCSi Mn steel shell was significantly increased with a scale parameter of 0.57 g fitted by the Weibull distribution *** fragmentation process of the HCSi Mn shell exhibited more brittle tensile fracture characteristics,with the microcrack damage zone on the outer surface being the direct cause of its high *** the one hand,the doping of alloy elements resulted in grain refinement by forming metallographic structure of tempered sorbite,so that microscopic intergranular fracture reduces the characteristic mass of the fragments;on the other hand,the distribution of alloy carbides can exert a"pinning"effect on the substrate grains,causing more initial cracks to form and propagate along the brittle carbides,further improving the shell *** the killing power radius for light armored vehicles was slightly reduced by about 6%,the dense killing radius of HCSiMn steel projectile against personnel can be significantly increased by about 26%based on theoretical *** results provided an experimental basis for high fragmentation warhead design,and to some extent,revealed the correlation mechanism between metallographic structure and shell fragmentation.

关键词： Projectile fragmentation Fragment mass distribution Fracture mode Metallographic structure Damage power

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Nitrogen doped tin oxide nanostructured catalysts for selective electrochemical reduction of carbon dioxide to formate

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Journal of Energy Chemistry 2017年第5期26卷 825-829页

作者： Qiankun Li Zhuo Wang Miao Zhang pengfei Hou peng kang Technical Institute of Physics and Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences

Tin/tin oxide materials are key electrocatalysts for selective conversion of CO;to formate/formic *** we report a tin oxide material with nitrogen doping by using ammonia treatment at elevated temperature. The N doped material demonstrated enhanced electrocatalytic CO;reduction activity, showing high Faradaic efficiency（90%） for formate at -0.65 V vs. RHE with partial current density of 4 mA/cm;.The catalysis was contributed to increased electron negativity of N atom compared to O atom. Additionally, the N-doped catalyst demonstrates sulfur tolerance with retained formate selectivity. The analysis after electrolysis shows that the catalyst structure partially converts to metallic Sn, and thus the combined Sn/N-SnO;is the key for the active CO;catalysis.

关键词： CO2 reduction Electrocatalysis Formate Tin oxide Nitrogen doping

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Microseismic source location using the Log-Cosh function and distant sensor-removed P-wave arrival data

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Journal of Central South University 2022年第2期29卷 712-725页

作者： peng kang GUO Hong-yang SHANG Xue-yi School of Resources and Safety Engineering Central South UniversityChangsha 410083China State Key Laboratory of Coal Mine Disaster Dynamics and Control School of Resources and Safety EngineeringChongqing UniversityChongqing 400044China

Source location is the core foundation of microseismic *** date,commonly used location methods have usually been based on the ray-tracing travel-time technique,which generally adopts an L1 or L2 norm to establish the location objective ***,the L1 norm usually achieves low location accuracy,whereas the L2 norm is easily affected by large P-wave arrival-time picking *** addition,traditional location methods may be affected by the initial iteration point used to find a local optimum ***,the P-wave arrival-time data that have travelled long distances are usually poor in *** address these problems,this paper presents a microseismic source location method using the Log-Cosh function and distant sensor-removed P-wave arrival *** basic principles are as follows:First,the source location objective function is established using the Log-Cosh *** function has the stability of the L1 norm and location accuracy of the L2 ***,multiple initial points are generated randomly in the mining area,and the established Log-Cosh location objective function is used to obtain multiple corresponding location *** average value of the 50 location points with the largest data field potential values is treated as the initial location ***,the P-wave travel times from the initial location result to triggered sensors are calculated,and then the P-wave arrival data with travel times exceeding 0.2 s are ***,the aforementioned location steps are repeated with the denoised P-wave arrival dataset to obtain a high-precision location *** synthetic events and eight blasting events from the Yongshaba mine,China,were used to test the proposed *** of whether the P-wave arrival data with long travel times were eliminated,the location error of the proposed method was smaller than that of the L1/L2 norm and trigger-time-based location method(TT1/TT2 method).Furthermore,after eliminating the Pw

关键词： seismic source location Log-Cosh function data field theory location stability

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