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Anticancer potential of metabolic compounds from marine actinomycetes isolated from Lagos Lagoon sediment

Journal of Pharmaceutical Analysis 2019年第3期9卷 201-208页

作者： Olabisi Flora Davies-Bolorunduro Isaac Adeyemi Adeleye Moshood Olushola Akinleye peng george wang Department of Microbiology University of Lagos Akoka Lagos Nigeria Department of Pharmaceutical Chemistry University of Lagos Idi-Araba Lagos Nigeria Department of Chemistry Georgia State University Atlanta GA United States

Thirty-two actinomycetes strains were isolated from sediment samples from 12 different sites at Lagos Lagoon and identified using standard physiological and biochemical procedures as well as 16S rDNA gene sequence analysis. Secondary metabolites were extracted from the strains and their anticancer activity on the K562 (Human acute myelocytic leukemia), HeLa (cervical carcinoma), AGS (Human gastric), MCF- 7 (breast adenocarcinoma) and HL-60 (Human acute promyelocytic leukemia) cell lines was determined. The metabolic extracts exhibited cytotoxicity with IC50 values ranging from 0.030 mg/mL to 4.4 mg/mL. The Streptomyces bingchenggensis ULS14 extract was cytotoxic against all the cell lines tested. The bioactivity-guided extraction and purification of the metabolic extracts from this strain yielded two purified anticancer compounds: ULDF4 and ULDF5. The structures of the extracted compounds were determined using spectroscopic analyses, including electrospray ionization mass spectrophotometer and nuclear magnetic resonance (1 Dimensional and 2 Dimensional), and were shown to be structurally similar to staurosporine and kigamicin. The IC50 of ULDF4 and ULDF5 against the HeLa cell line was 0.034 mg/mL and 0.075 mg/mL, respectively. This study is the first to reveal the anticancer potential of actinomycetes from Lagos Lagoon, which could be exploited for therapeutic purposes.

关键词： Streptomyces bingchenggensis ULS14 Metabolic extracts Cytotoxicity Spectroscopy Kigamicin Staurosporine

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Recent progress in lantha-nide-catalyzed organic reactions in protic media

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Chinese Science Bulletin 2001年第20期46卷 1673-1681页

作者： LUO Sanzhong ZHANG Baolian XIAN Ming Adam Janczuk XIE Wenhua CHENG Jinpei peng george wang Department of Chemistry Nankai UniversityTianjin 300071China Department of Chemistry Wayne State UniversityDetroit MI 48202-3489USA

Lanthanide triflates are stable in water. It is possible for lanthanides to undergo many organic reactions in environmentally friendly solvents. This makes lanthanides very promising in the field of green chemistry. This review describes the recent development of the lanthanide-catalyzed organic reactions in protic solvents. Those reac-tions include Diels-Alder, Aldol, Allylation, acetalization, pericyclization, radical reactions as well as some newly-developed lanthnides-based catalysts.

关键词： green chemistry lanthanide triflate aqueous media organic syntheses.

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Gut microbiota have blood types as human

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Science Bulletin 2018年第20期63卷 1311-1313页

作者： Qizheng Wu Hui Zhong Yafei Zhai Yanjiong Jia Zhinan Yin Min Chen Hengwen Yang peng george wang The State Key Laboratory of Microbial Technology and National Glycoengineering Research Center Shandong University The First Affiliated Hospital Biomedical Translational Research Institute Guangdong Province Key Laboratory of Molecular Immunology and Antibody EngineeringJinan University

ABO blood group system was firstly recognized by Landsteiner in 1900[1].Since then,the antigens of the ABO system (A,B and H determinants,respectively)have been shown to encompass complex carbohydrate structures [2].A and B antigen were synthesized by the sequential action of glycosyltransferases,with A and B glycosyltransferases catalyzing the addition of N-acetylgalactosamine and D-galactose to precursor H antigen,respectively. Group O individuals lack such transferase enzymes and consequently continue to express the basic H structure only [3,4].It is determined that approximate 2million ABH glycan antigen sites are presented on each red blood cell [5].Additionally,the ABH antigens are widely expressed in other human ceils and tissues,including the sensory neurons,epithelium,the vascular endothelium and platelets [6].

关键词： Gut microbiota blood types

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Mechanism of Polysaccharide Synthesis:the Last Frontier on the Biosynthesis of Biopolymers

Mechanism of Polysaccharide Synthesis:the Last Frontier on t...

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2008年全国糖生物学学术会议

作者： peng george wang The Ohio State University Department of Biochemistry

Lipopolisaccharide(LPS),the major component of surface structures of Gram-negative bacteria,is closely associated with bacterial *** consists of lipid A,core oligosaccharide and

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Design and synthesis of O-GIcNAcase inhibitor

Design and synthesis of O-GIcNAcase inhibitor

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2011年全国药物化学学术会议——药物的源头创新

作者： peng george wang College of Pharmacy Nankai University

＜正＞Protein O-GlcNAcylation has been shown to play an important role in a number of biological processes,including regulation of the cell cycle,DNA transcription and translation,signal transduction and protein degradation.1,2 O-GlcNAcase（OGA） is responsible for the removal of O-linked-N-acetylglucosamine（O-GlcNAc） from serine or threonine residues,and thus plays a key

关键词： O-GlcNAcase inhibitor PUGNAc analogue

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A new strategy for high-throughput identification of human gut microbiota containing specific monosaccharide

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Science China(Life Sciences) 2019年第7期62卷 985-987页

作者： Qizheng Wu Fang Liu Yu Song Qingyun Meng Xunlian Zhang Huizi Li Jingyu Sun Hongqi Gao peng george wang Yun Kong Min Chen The State Key Laboratory of Microbial Technology and National Glycoengineering Research Center Shandong UniversityQingdao 266237China School of Journalism and Communication Shandong UniversityJinan 250100China Department of Chemistry Georgia State UniversityAtlantaGA 30303USA

Dear Editor,The human gastrointestinal tract is colonized by trillions of microorganisms,the majority of which cannot be cultured (Wu et al.,2018).Numerous glycans are expressed on the surface of gut microbiota that are characteristic of different strains,and the diversity of these glycans is partially attributed to variations in their monosaccharides.

关键词： Editor glycans monosaccharides

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Influence of Substrate Conformation on the Deglycosylation of Ribonuclease B by Recombinant Yeast Peptide:N-glycanase

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Acta Biochimica et Biophysica Sinica 2007年第1期39卷 8-14页

作者： Shengjun wang peng george wang and Qingsheng QI State Key Laboratory of Microbial Technology,Life Science Schooll,Shandong University,Jinan 250100,China State Key Laboratory of Microbial Technology Life Science SchoolShandongUniversityJinan 250100China

Peptide:N-glycanase has been thought to be responsible for proteasome-dependent degradationof misfolded glycoproteins translocated from the endoplasmic reticulum (ER) to the ***,theenzyme was supposed to be able to distinguish between native and non-native *** the presentstudy,a recombinant,yeast peptide:N-glycanase,Png lp, was expressed in Escherichia coli as inclusionbodies and was purified,refolded and *** results showed that the recombinant enzymehas a broad pH range adaptation,from pH 4.0 to pH 10.0,and has an optimum temperature of 30 ℃.This enzyme is a zinc *** activity was abolished with the addition of EDTA and notrestored by adding metal ***,the deglycosylation efficiency of recombinant Pnglpfrom *** was investigated with respect to the substrate conformation in *** ribonuclease B(RNase B) was denatured at 60-65 ℃ or by 40-60 mM dithiothreitol, indicated by its obvious structuralchange and sharpest activity change,its deglycosylation by Pnglp was most *** deglycosylationefficiency of RNase B by Pnglp was found to be related to its structural conformation and enzymaticactivity.

关键词： glycanase ribonuclease B glycoprotein deglycosylation circular dichroism

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Correlation between the rock mass properties and maximum horizontal stress:A case study of overcoring stress measurements

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 39-48页

作者： peng Li Meifeng Cai Shengjun Miao Yuan Li Yu wang Key Laboratory of Ministry of Education for Efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyXuzhou 221116China

Understanding the mechanical properties of the lithologies is crucial to accurately determine the horizontal stress *** investigate the correlation between the rock mass properties and maximum horizontal stress,the three-dimensional(3D)stress tensors at 89 measuring points determined using an improved overcoring technique in nine mines in China were adopted,a newly defined characteristic parameter C_(ERP)was proposed as an indicator for evaluating the structural properties of rock masses,and a fuzzy relation matrix was established using the information distribution *** results indicate that both the vertical stress and horizontal stress exhibit a good linear growth relationship with *** is no remarkable correlation between the elastic modulus,Poisson's ratio and depth,and the distribution of data points is scattered and ***,there is no obvious relationship between the rock quality designation(RQD)and *** maximum horizontal stress σ_(H) is a function of rock properties,showing a certain linear relationship with the C_(ERP)at the same *** addition,the overall change trend of σ_(H) determined by the established fuzzy identification method is to increase with the increase of C_(ERP).The fuzzy identification method also demonstrates a relatively detailed local relationship betweenσ_H and C_(ERP),and the predicted curve rises in a fluctuating way,which is in accord well with the measured stress data.

关键词： overcoring stress measurements elastic modulus Poisson's ratio rock quality designation maximum horizontal stress fuzzy identification

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Collaborative Trajectory Planning for Stereoscopic Agricultural Multi-UAVs Driven by the Aquila Optimizer

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Computers, Materials & Continua 2025年第1期82卷 1349-1376页

作者： Xinyu Liu Longfei wang Yuxin Ma peng Shao School of Computer and Information Engineering Jiangxi Agricultural UniversityNanchang330045China

Stereoscopic agriculture,as an advanced method of agricultural production,poses new challenges for multi-task trajectory planning of unmanned aerial vehicles(UAVs).To address the need for UAVs to perform multi-task trajectory planning in stereoscopic agriculture,a multi-task trajectory planning model and algorithm(IEP-AO)that synthesizes flight safety and flight efficiency is *** on the requirements of stereoscopic agricultural geomorphological features and operational characteristics,the multi-task trajectory planning model is ensured by constructing targeted constraints at five aspects,including the path,slope,altitude,corner,energy and obstacle threat,to improve the effectiveness of the trajectory planning *** combined with the path optimization algorithm,an Aquila optimizer(IEP-AO)based on the interference-enhanced combination model is proposed,which can help UAVs to improve the trajectory search capability in complex operation space and large-scale operation tasks,and jump out of the locally optimal trajectory path region timely,to generate the optimal trajectory planning plan that can adapt to the diversity of the tasks and the flight ***,four simulated flights with different operation scales and different scene constraints were conducted under the constructed real 3Dimension scene,and the experimental results can show that the proposedmulti-task trajectory planning method canmeet themulti-task requirements in stereoscopic agriculture and improve the mission execution efficiency and agricultural production effect of UAV.

关键词： Stereoscopic agriculture unmanned aerial vehicle multi-task interference model Aquila optimizer

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Boosting bidirectional sulfur conversion enabled by introducing boron-doped atoms and phosphorus vacancies in Ni2P for lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 760-769页

作者： Lin peng Yu Bai Hang Li Meixiu Qu Zhenhua wang Kening Sun Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Beijing Key Laboratory of Chemical Power Source and Green Catalysis School of Chemistry and Chemical Engineering Beijing Institute of Technology

Lithium-sulfur （Li-S） batteries have gained great attention due to the high theoretical energy density and low cost,yet their further commercialization has been obstructed by the notorious shuttle effect and sluggish redox ***,we supply a strategy to optimize the electron structure of Ni2P by concurrently introducing B-doped atoms and P vacancies in Ni2P （Vp-B-Ni2P）,thereby enhancing the bidirectional sulfur *** study indicates that the simultaneous introduction of B-doped atoms and P vacancies in Ni2P causes the redistribution of electron around Ni atoms,bringing about the upward shift of d-band center of Ni atoms and effective d-p orbital hybridization between Ni atoms and sulfur species,thus strengthening the chemical anchoring for lithium polysulfides （LiPSs） as well as expediting the bidirectional conversion kinetics of sulfur ***,theoretical calculations reveal that the incorporation of B-doped atoms and P vacancies in Ni2P selectively promotes Li2S dissolution and nucleation ***,the Li-S batteries with Vp-B-Ni2P-separators present outstanding rate ability of 777 m A h g-1at 5 C and high areal capacity of 8.03 mA h cm-2under E/S of 5μL mg-1and sulfur loading of 7.20 mg *** work elucidates that introducing heteroatom and vacancy in metal phosphide collaboratively regulates the electron structure to accelerate bidirectional sulfur conversion.

关键词： Lithium sulfur batteries

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