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Shrinkage estimation analysis of correlated binary data with a diverging number of parameters

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Science China Mathematics 2013年第2期56卷 359-377页

作者： xu peirong FU WenJiang ZHU LiXing School of Finance and Statistics East China Normal University Department of Epidemiology and Biostatistics Michigan State University Department of Mathematics Hong Kong Baptist University

For analyzing correlated binary data with high-dimensional covariates,we,in this paper,propose a two-stage shrinkage ***,we construct a weighted least-squares(WLS) type function using a special weighting scheme on the non-conservative vector field of the generalized estimating equations(GEE) ***,we define a penalized WLS in the spirit of the adaptive LASSO for simultaneous variable selection and parameter *** proposed procedure enjoys the oracle properties in high-dimensional framework where the number of parameters grows to infinity with the number of ***,we prove the consistency of the sandwich formula of the covariance matrix even when the working correlation matrix is *** the selection of tuning parameter,we develop a consistent penalized quadratic form(PQF) function *** performance of the proposed method is assessed through a comparison with the existing methods and through an application to a crossover trial in a pain relief study.

关键词： correlated binary data variable selection diverging number of parameters adaptive LASSO GEE oracle properties sandwich covariance formula penalized quadratic form function

Geochemical characteristics of Cretaceous basaltic rocks in South China and constraints on Pacific plate subduction

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Science China Earth Sciences 2005年第12期48卷 2104-2117页

作者： CHEN Weifeng CHEN peirong xu Xisheng ZHANG Min The State Key Laboratory of Mineral Deposit Research Department of Earth Sciences Nanjing University Nanjing 210093 China The State Key Laboratory of Mineral Deposit Research Department of Earth Sciences Nanjing University Nanjing 210093 China The State Key Laboratory of Mineral Deposit Research Department of Earth Sciences Nanjing University Nanjing 210093 China The State Key Laboratory of Mineral Deposit Research Department of Earth Sciences Nanjing University Nanjing 210093 China

Middle-Late Cretaceous Basaltic rocks (85―110 Ma) are distributed in the contemporaneous downfaulted red basins and volcanic-sedimentary basins in South China (including Hunan, Jiangxi, Guangdong, Fujian, Zhejiang provinces). They are geographically divided into two groups delimited by Wuyishan Range, namely the west area basaltic rocks (WABs) distributing over the west of Wuyishan Range and the east area basaltic rocks (EABs) distributing over the east of Wuyishan Range, and observed having distinct geochemical and isotopic characters. WABs are characterized by relatively low in K2O (0.44%―3.17%), alkalis (K2O+Na2O= 3.27%―6.80%) and Al2O3 (13.08%―16.75%) contents, but high in MgO (5.13%―8.78%) and TiO2 (1.12%―3.35%) contents. WABs are similar to ocean-island basalts (OIB) or intraplate basalts on trace elements and isotopes: no negative Nb and Ta anomalies, relatively low ∑REE (74.66 μg/g―287.72 μg/g) and LaN/YbN (4.49―22.10), low (87Sr/86Sr)i (average ratio is 0.704679), high εNd(t) (?1.81―8.00). In contrast, EABs display relatively high in K2O (0.55%―4.86%), alkalis (K2O+Na2O=2.95%―7.55%) and Al2O3 (15.80%―21.10%) contents, but low in MgO (2.63%―6.28%) and TiO2 (1.19%―1.86%) contents, strong negative Nb and Ta anomalies, enrichment in LILE (K, Rb, Ba and Th), relatively high ΣREE (79.68 μg/g―327.61 μg/g) and LaN/YbN (5.25―26.37), high (87Sr/86Sr)i (average ratio is 0.707658) and negative εNd(t) (?8.50― ?1.22), similar to that of IAB (island arc basalts) or CAB (continental arc basalts). Accordingly, WABs were probably generated under continental rifting tectonic setting related to asthenosphere upwelling, and hence their source was characterized by mixing between EMⅡ with DM. Source of EABs may be enriched lithoshperic mantle which had ever undergone the metasomatism of fluid/melt derived from the subducted Pacific *** indicates that subduction of a paleo-Pacific plate (Kula) beneath the Eurasian continent had ever occurred during the late Mesozoic period,

关键词： basalt, imprint of subducted plate, rifting, Cretaceous basins, South China.

Feedback LSTM Network Based on Attention for Image Description Generator

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Computers, Materials & Continua 2019年第5期59卷 575-589页

作者： Zhaowei Qu Bingyu Cao Xiaoru Wang Fu Li peirong xu Luhan Zhang Beijing Key Laboratory of Network System and Network Culture Beijing University of Posts and TelecommunicationsBeijing100876China Department of Electrical and Computer Engineering Portland States UniversityPortlandOR 97207-0751USA

Images are complex multimedia data which contain rich semantic *** of current image description generator algorithms only generate plain description,with the lack of distinction between primary and secondary object,leading to insufficient high-level semantic and accuracy under public evaluation *** major issue is the lack of effective network on high-level semantic sentences generation,which contains detailed description for motion and state of the principal *** address the issue,this paper proposes the Attention-based Feedback Long Short-Term Memory Network(AFLN).Based on existing codec framework,there are two independent sub tasks in our method:attention-based feedback LSTM network during decoding and the Convolutional Block Attention Module(CBAM)in the coding ***,we propose an attentionbased network to feedback the features corresponding to the generated word from the previous LSTM decoding *** implement feedback guidance through the related field mapping algorithm,which quantifies the correlation between previous word and latter word,so that the main object can be tracked with highlighted detailed ***,we exploit the attention idea and apply a lightweight and general module called CBAM after the last layer of VGG 16 pretraining network,which can enhance the expression of image coding features by combining channel and spatial dimension attention maps with negligible *** experiments on COCO dataset validate the superiority of our network over the state-of-the-art *** scores and actual effects are *** BLEU 4 score increases from 0.291 to 0.301 while the CIDEr score rising from 0.912 to 0.952.

关键词： Image description generator feedback LSTM network attention CBAM

Constant light in early life induces fear-related behavior in chickens with suppressed melatonin secretion and disrupted hippocampal expression of clock-and BDNF-associated genes

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Journal of Animal Science and Biotechnology 2022年第6期13卷 1799-1809页

作者： Yang Yang Wei Cong Jie Liu Mindie Zhao peirong xu Wanwan Han Deyun Wang Ruqian Zhao MOE Joint International Research Laboratory of Animal Health&Food Safety Institute of ImmunologyNanjing Agricultural UniversityNanjing 210095People’s Republic of China Key Laboratory of Animal Physiology&Biochemistry College of Veterinary MedicineNanjing Agricultural UniversityNanjing 210095People’s Republic of China Institute of Traditional Chinese Veterinary Medicine College of Veterinary MedicineNanjing Agricultural UniversityNanjing 210095People’s Republic of China

Background: Light management plays an important role in the growth and behavior of broiler chickens. Constant light in early post hatch stage has been a common practice in broiler industry for improving growth performance,while whether and how constant light in early life affects the behavior of broiler chickens is rarely ***: In this study, newly hatched chicks were kept in either constant(24 L:0 D, LL) or(12 L:12 D, LD) photoperiod for 7 d and then maintained in 12 L:12 D thereafter until 21 days of age. Constant light increased the average daily feed intake but not the body weight, which led to higher feed conversion ratio. Chickens in LL group exhibited fear-related behaviors, which was associated with higher corticosterone, lower melatonin and 5-HT levels. Concurrently, constant light exposure increased the mRNA expression of clock-related genes and suppressed the expression of antioxidative genes in the hippocampus. Moreover, brain derived neurotrophic factor/extracel ular signal-regulated kinase(BDNF/ERK) pathway was suppressed in the hippocampus of chickens exposed to constant light in the first week post ***: These findings indicate that constant light exposure in early life suppress melatonin secretion and disrupts hippocampal expression of genes involved in circadian clock and BDNF/ERK pathway, thereby contributing to fear-related behaviors in the chicken.

关键词： BDNF/ERK Constant light Fear-related behavior Hippocampus

Macrophage membrane-biomimetic adhesive polycaprolactone nanocamptothecin for improving cancer-targeting efficiency and impairing metastasis

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Bioactive Materials 2023年第2期20卷 449-462页

作者： Kangkang Ying Yifeng Zhu Jianqin Wan Chenyue Zhan Yuchen Wang Binbin Xie peirong xu Hongming Pan Hangxiang Wang The First Affiliated Hospital NHC Key Laboratory of Combined Multi-Organ TransplantationZhejiang University School of MedicineHangzhouZhejiang Province310003PR China Jinan Microecological Biomedicine Shandong Laboratory JinanShandong Province250117PR China Department of Hepatobiliary Surgery The First Affiliated HospitalWenzhou Medical UniversityWenzhouZhejiang Province325000PR China Department of Medical Oncology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouZhejiang Province310016PR China Department of Chemical Engineering Zhejiang UniversityHangzhouZhejiang Province310027PR China

The recent remarkable success and safety of mRNA lipid nanoparticle technology for producing severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccines has stimulated intensive efforts to expand nanoparticle strategies to treat various *** synthetic nanoparticles have been developed for pharmaceutical delivery and cancer ***,only a limited number of nanotherapies have enter clinical trials or are clinically *** administered nanotherapies are likely to be sequestered by host mononuclear phagocyte system(MPS),resulting in suboptimal pharmacokinetics and insufficient drug concentrations in *** drug-delivery formulations have emerged as an alternative approach to evade the MPS and show potential to improve drug therapeutic *** we developed a biodegradable polymer-conjugated camptothecin prodrug encapsulated in the plasma membrane of lipopolysaccharide-stimulated *** conjugation revived the parent camptothecin agent(e.g.,7-ethyl-10-hydroxy-camptothecin),enabling lipid nanoparticle ***,macrophage membrane cloaking transformed the nonadhesive lipid nanoparticles into bioadhesive nanocamptothecin,increasing the cellular uptake and tumor-tropic effects of this biomimetic *** tested in a preclinical murine model of breast cancer,macrophage-camouflaged nanocamptothecin exhibited a higher level of tumor accumulation than uncoated ***,intravenous administration of the therapy effectively suppressed tumor growth and the metastatic burden without causing systematic *** study describes a combinatorial strategy that uses polymeric prodrug design and cell membrane cloaking to achieve therapeutics with high efficacy and low *** approach might also be generally applicable to formulate other therapeutic candidates that are not compatible or miscible with biomimetic delivery carriers.

关键词： Polymer prodrug Macrophage membrane Cancer nanomedicine Antimetastasis Nanocamptothecin

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梅州市林下经济发展动力与对策探讨

林业建设 2021年第3期 48-52页

作者：许培容广东省岭南综合勘察设计院广东广州510500

梅州市资源丰富、自然条件优越,林下经济发展前景广阔,目前已初具规模,但缺乏长远规划、缺乏营销平台,而且品牌竞争力不强、科技支撑力度不够,需要科学制定规划、优化林下经济结构、建设高标准示范园(基地)、建立交流合作平台、加强市... 详细信息

梅州市资源丰富、自然条件优越,林下经济发展前景广阔,目前已初具规模,但缺乏长远规划、缺乏营销平台,而且品牌竞争力不强、科技支撑力度不够,需要科学制定规划、优化林下经济结构、建设高标准示范园(基地)、建立交流合作平台、加强市场流通体系建设,走集约化、规模化、标准化、产业化发展之路。

关键词：林下经济发展动力对策梅州市

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核干细胞因子在宫颈鳞癌中的表达及意义

华中师范大学学报（自然科学版） 2009年第2期43卷 281-283页

作者：范天黎席宇许培荣鲁照明刘红涛郑州大学基础医学院郑州450001 郑州大学生物工程系郑州450001

采用免疫组织化学方法,分析了57例宫颈鳞癌组织、39例癌旁不典型增生组织及57例正常宫颈黏膜组织中核干细胞因子(Nucleostemin,NS)蛋白的表达。结果显示:NS蛋白在正常宫颈黏膜组织、癌旁不典型增生组织及宫颈鳞癌组织中表达的阳性率依... 详细信息

采用免疫组织化学方法,分析了57例宫颈鳞癌组织、39例癌旁不典型增生组织及57例正常宫颈黏膜组织中核干细胞因子(Nucleostemin,NS)蛋白的表达。结果显示:NS蛋白在正常宫颈黏膜组织、癌旁不典型增生组织及宫颈鳞癌组织中表达的阳性率依次升高,分别为15.8%、41.0%及71.9%,组间比较有显著性差异(X^2=39.015,P0.05),而与肿瘤分期、淋巴结转移和肿瘤分化具有明显的相关性(P<0.05),提示NS在宫颈鳞癌中的高表达可能与宫颈鳞癌的发生、发展密切相关,NS蛋白检测有望成为新的诊断和治疗宫颈鳞癌的重要指标。

关键词：核干细胞因子宫颈鳞癌免疫组织化学

中文版癌症患者功能评估-认知功能量表在胃肠肿瘤患者中的信效度检验和最佳界值研究

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军事护理 2023年第5期40卷 75-78页

作者：徐培镕张焱孙倩男王勇王道荣扬州大学护理学院公共卫生学院江苏扬州225009 扬州大学临床医学院普外科江苏扬州225003

目的验证中文版癌症患者功能评估-认知功能量表(functional assessment of cancer therapy-cognitive function FACT-Cog)在胃肠肿瘤人群中的信效度,并探讨其最佳界值。方法采用随机抽样方法选取311位胃肠肿瘤患者进行调查,评价问卷... 详细信息

目的验证中文版癌症患者功能评估-认知功能量表(functional assessment of cancer therapy-cognitive function FACT-Cog)在胃肠肿瘤人群中的信效度,并探讨其最佳界值。方法采用随机抽样方法选取311位胃肠肿瘤患者进行调查,评价问卷的信效度,应用受试者工作特性曲线(receiver operating characteristic curve, ROC)以确定量表的最佳界值。结果中文版FACT-Cog量表的Cronbach’s α系数为0.876,4个维度的Cronbach’s α系数分别为0.851、0.946、0.838和0.969,重测信度为0.975;探索性因子分析共提取4个公因子,累积方差贡献率为76.515%;验证性因子结果显示模型拟合良好;效标效度与蒙特利尔认知评估量表呈正相关(r=0.291);量表最佳界值为75分,此时ROC曲线下面积为0.967、敏感度为84.6%、特异度为90.7%。结论中文版FACT-Cog量表在我国胃肠肿瘤患者人群中具有较好的信效度,推荐最佳界值为75分,可用于评价我国胃肠肿瘤患者的认知功能。

关键词：认知功能胃肠肿瘤信度效度临界值

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一种基于鞅差散度的纵向数据降维方法

应用概率统计 2023年第1期39卷 132-158页

作者：汪红霞房丽云卜士杰许佩蓉南京审计大学统计与数据科学学院南京211815 上海师范大学数理学院上海200233 上海交通大学数学科学学院上海200240

变量间的相关性和同一个体多次观测之间的相关性是纵向数据集两大固有特点,这两种相关性包含纵向数据的许多重要信息.本文借鉴矩阵值数据的降维思想,利用这两种相关性对纵向数据进行降维,提出一种基于鞅差散度的充分维数折叠降维方法.... 详细信息

变量间的相关性和同一个体多次观测之间的相关性是纵向数据集两大固有特点,这两种相关性包含纵向数据的许多重要信息.本文借鉴矩阵值数据的降维思想,利用这两种相关性对纵向数据进行降维,提出一种基于鞅差散度的充分维数折叠降维方法.理论上,该降维准则在总体形式下能找到中心均值维数折叠子空间,实现时间和变量两个维度的同时降维,基于其样本形式得到的中心均值维数折叠子空间的估计具有√n相合性.算法上,通过引入Kronecker乘积假定,将降维过程转化为带约束的低维优化问题,从而可以用成熟的非线性优化算法快速求解.进一步地,本文提出一种相合的BIC准则自适应地确定结构维数.相较于文献中的降维方法,数值模拟表明所提方法不仅能快速实现,而且在中心均值维数折叠子空间的估计和结构维数的确定上有更高的准确度.最后,本文通过原发性胆汁性肝硬化临床数据的实证分析验证了所提方法的有效性.

关键词：纵向数据鞅差散度充分性降维维数折叠中心均值子空间