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Fantastic voyage: The journey of NLRP3 inflammasome activation

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Genes & Diseases 2024年第2期11卷 819-829页

作者： Xiangyong que Sihao Zheng Qibin Song Huadong pei Pingfeng Zhang Cancer Center Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Department of Oncology Georgetown Lombardi Comprehensive Cancer CenterGeorgetown University Medical CenterWashingtonDC 20057USA

NLRP3 inflammasome,an intracellular multiprotein complex,can be activated by a range of pathogenic microbes or endogenous hazardous *** activation results in the release of cytokines such as IL-1β and IL-18,as well as Gasdermin D which eventually causes *** activation of NLRP3 inflammasome is under strict control and regulation by numerous pathways and *** excessive activation can lead to a persistent inflammatory response,which is linked to the onset and progression of severe *** studies have revealed that the subcellular localization of NLRP3 changes significantly during the activation *** this review,we review the current understanding of the molecular mechanism of NLRP3 inflammasome activation,focusing on the subcellular localization of NLRP3 and the associated regulatory *** aim to provide a comprehensive understanding of the dynamic transportation,activation,and degradation processes of NLRP3.

关键词： Inflammasome activation Innate immunity NLRP3 NLRP3 inflammasome Subcellular localization

Endodontic management of the maxillary first molars with two root canals: A case report and review of the literature

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World Journal of Clinical Cases 2019年第1期7卷 79-88页

作者： Jie Liu Ke-Hua que Zuo-Hui Xiao wen wen Department of Endodontics College of Stomatology Tianjin Medical University Department of Geriatric Dentistry National Engineering Laboratory for Digital and Material Technology of Stomatology Laboratory of Biomedical Materials Peking University School and Hospital of Stomatology Department of Stomatology Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital

BACKGROUND The complex anatomy of the maxillary first molars has always been a major challenge for complete root canal treatment in endodontic therapy. Here, we present two cases of maxillary first molars, each with only two root canals, which have been rarely reported. We also perform a literature review of maxillary first molar *** SUMMARY The two patients were referred to the hospital after 1) finding a cavity in their tooth with a color change and, 2) a toothache during mastication, *** of these cases were diagnosed as apical periodontitis by X-ray imaging and cone beam computed tomography(CBCT). Non-surgical endodontic therapy was performed with the assistance of a dental operating microscope(DOM). CBCT showed rare but accurate images of both patients, each with two root canals and two roots in their maxillary first molars. Both roots were located in the buccal in the palatal direction, and each root had only one clear root canal. In addition,each maxillary first molar in both patients was symmetrical to that on the opposing side with only two separate root canals. Non-surgical endodontic therapy was performed with the assistance of a DOM. Finally, the teeth were restored using composite resin and the patients were satisfied with the *** Making full use of CBCT and DOM would contribute to helping dentists make correct diagnoses and successfully treat teeth with rare root canal morphologies.

关键词： Root canal anatomy Maxillary first molar Cone beam computed tomography Dental operating microscope Endodontic therapy Case report

The transcription of iodothyronine deiodinase genes is regulated by thyroid hormone receptor in the Pacific oyster Crassostrea gigas

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Journal of Oceanology and Limnology 2019年第4期37卷 1317-1323页

作者： HUANG wen XU Fei LI Li que Huayong ZHANG Guofan Key Laboratory of Experimental Marine Biology Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China School of Marine Sciences Guangxi University Nanning 530004 China University of Chinese Academy of Sciences Beijing 100049 China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and Technology Qingdao 266237 China Center for Ocean Mega-Science Chinese Academy of Sciences Qingdao 266071 China

Thyroid hormones (THs) are indispensable for each phyla in Chordata, while their functions in the non-chordate invertebrates are indistinct. Studies on the TH system in non-chordate invertebrates are important for understanding the evolution of TH system and may be applied in aquaculture or biofouling control at the same time. Iodothyronine deiodinases are keys to studying the TH system, as they are critical enzymes in maintaining TH homeostasis by catalyzing the initiation and termination of the effects of thyroid hormone in vertebrates. Here, we report the primary physiological effects of T4, the outer ring deiodinase activity, and a similar transcription regulation of two oyster deiodinases by TH receptor (CgTR) in an invertebrate, Pacific oyster Crassostrea gigas. L-thyroxine (T4) may have an important physiological function in the oyster, suggested by the growth retardation effect of excessive T4 in umbo larvae stage. The outer ring deiodinase activity transforming T4 to T3 (3, 3', 5-triiodothyronine) was then detected in the Pacific oyster in vivo, which may be conducted by two oyster deiodinases (CgDx and CgDy). Transcription regulation of CgTR onto these two deiodinase genes was also verified by electrophoretic mobility shift assay and dual luciferase reporter assay in mammalian cells. These results contribute to a better understanding of the evolution of the TH system.

关键词： iodothyronine deiodinase mollusk thyroid hormone (TH) TH responsive elements

Two new oplopane sesquiterpenes from Artemisia gmelinii Web. ex Stechm.

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Chinese Chemical Letters 2014年第8期25卷 1153-1156页

作者： wen-Zhi Zeng que sheng Qing-Ying Zhang Hong Liang State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Health Science Center Department of Chemistry Teachers College for Nationalities Qinghai Normal University

Two new oplopane sesquiterpenes, gmelinin A（1） and gmelinin B（2）, were isolated from Artemisia gmelinii Web. ex Stechm. Their structures were established by spectroscopic techniques（mainly 1D and2 D NMR） and app... 详细信息

关键词： Ololopane Artemisia gmelinii Web. ex Stechm. Gmelinin A Gmelinin B

基于多节点样条理论的漏磁数据去冗余压缩算法

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上海交通大学学报 2005年第4期39卷 539-543页

作者：金涛阙沛文上海交通大学信息检测技术与仪器系上海200030

为解决管道漏磁缺陷检测中采样数据的去冗余压缩问题,在利用小波去噪的基础上,根据多节点样条理论具有插值过程无需解方程组、逼近误差小、基函数有界支集的性质,通过构造一个对称的、局部支集的、拉格朗日型基函数,从而设计出一种能快... 详细信息

为解决管道漏磁缺陷检测中采样数据的去冗余压缩问题,在利用小波去噪的基础上,根据多节点样条理论具有插值过程无需解方程组、逼近误差小、基函数有界支集的性质,通过构造一个对称的、局部支集的、拉格朗日型基函数,从而设计出一种能快速、高效地逼近原检测数据的去冗余压缩新算法,以提高管道漏磁在线检测数据压缩的实时性.用实验室检测到的漏磁数据对该算法进行了验证.结果表明,该算法具有很好的实时性及较高的数据压缩率.

关键词：漏磁检测数据压缩多样条小波分析

De novo transcriptome sequencing reveals candidate genes involved in orange shell coloration of bay scallop Argopecten irradians

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Journal of Oceanology and Limnology 2018年第4期36卷 1408-1416页

作者： TENG wen CONG Rihao que Huayong ZHANG Guofan Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China University of Chinese Academy of Sciences Beijing 100049 China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and Technology Qingdao 266071 China National & Local Joint Engineering Laboratory of Ecological Mariculture Qingdao 266000 China

Molluscan shell color has received persistent attention for its distinctive diversity and complexity. In the present study, six transcriptome libraries obtained from two developmental stages, pre-pigmentation and post-pigmentation, were used for paired-end sequencing in the bay scallop Argopecten irradians. In total, 289 839 646 paired-end reads were assembled into 70 929 transcripts. Using BLASTX and BLASTN, 30 896 unigenes were successfully annotated against the SWISS-PROT, NR, and KOG database. Gene ontology annotation and Kyoto Encyclopedia of Genes and Genomes classification identified numbers of unigenes involved in biomineralization and pigmentation. Digital gene expression analysis revealed that melanin, trace metal elements and porphyrins are potentially involved in shell coloration of A. irradians.

关键词： molluscs shell coloration differentially expressed genes gene ontology

用于管道漏磁数据的小波域自适应及小波系数去噪算法

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上海交通大学学报 2006年第1期40卷 103-107页

作者：韩文花阙沛文上海交通大学自动检测研究所上海200030

基于漏磁检测是油气管道在线检测中应用最广泛的无损检测技术,提出了一种去除漏磁数据中无缝管道噪声(SPN)和系统噪声的新算法.首先利用将小波变换和自适应滤波技术相结合而提出的新型小波域自适应滤波方法去除漏磁数据中的SPN,然后再... 详细信息

基于漏磁检测是油气管道在线检测中应用最广泛的无损检测技术,提出了一种去除漏磁数据中无缝管道噪声(SPN)和系统噪声的新算法.首先利用将小波变换和自适应滤波技术相结合而提出的新型小波域自适应滤波方法去除漏磁数据中的SPN,然后再利用小波系数去噪方法去除小波域自适应SPN消除系统输出漏磁数据中的系统噪声.实测漏磁数据所得结果表明,该算法具有良好的去噪效果,极大地提高了漏磁数据中缺陷信号的可检测性.

关键词：漏磁数据小波变换自适应滤波无缝管道噪声小波系数去噪系统噪声

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基于遗传优化算法的二维漏磁缺陷重构

中国石油大学学报（自然科学版） 2006年第1期30卷 138-141页

作者：韩文花阙沛文上海交通大学自动检测研究所上海200030

信号逆问题,即从测量信号中恢复出缺陷轮廓及其参数,是漏磁无损评估中的一个重要课题。提出了一种基于遗传算法的逆算法,用于从漏磁信号中重构二维缺陷。在该算法中,径向基函数(RBF)神经网络用作前向模型,遗传算法用于求解逆问题中的优... 详细信息

信号逆问题,即从测量信号中恢复出缺陷轮廓及其参数,是漏磁无损评估中的一个重要课题。提出了一种基于遗传算法的逆算法,用于从漏磁信号中重构二维缺陷。在该算法中,径向基函数(RBF)神经网络用作前向模型,遗传算法用于求解逆问题中的优化问题,其优点是能够避免基于梯度下降法的迭代逆算法中可能遇到的局部最小问题,并能得到逆问题的全局最优解。实验结果验证了所提出的逆算法的有效性。

关键词：逆问题径向基函数神经网络遗传算法漏磁检测

去除SPN的小波域自适应FIR滤波修正算法

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哈尔滨工业大学学报 2007年第9期39卷 1473-1477页

作者：韩文花阙沛文上海交通大学自动检测研究所

漏磁检测(MFL)是油气管道在线检测中应用非常成熟的一种无损检测技术.漏磁检测数据通常被无缝管道噪声所污染,而无缝管道噪声在某些情况下可能完全掩没来自某一类型缺陷的漏磁信号,因而极大地降低了管道缺陷的可检测性.本文对小波变换... 详细信息

漏磁检测(MFL)是油气管道在线检测中应用非常成熟的一种无损检测技术.漏磁检测数据通常被无缝管道噪声所污染,而无缝管道噪声在某些情况下可能完全掩没来自某一类型缺陷的漏磁信号,因而极大地降低了管道缺陷的可检测性.本文对小波变换域自适应有限冲激响应(FIR)滤波算法进行修正,提出一种可有效去除漏磁数据中无缝管道噪声(SPN)的修正算法.该算法利用无缝管道噪声和漏磁信号的不同相关特性,可有效去除漏磁数据中相关度高的漏磁信号,从而提高漏磁数据中相关度较小的缺陷信号的可检测性.该修正算法用于实测漏磁数据,所得结果说明该算法具有良好的去噪效果,从而提高了漏磁数据中缺陷信号的可检测性.

关键词：无损检测漏磁信号离散小波变换自适应FIR滤波无缝管道噪声