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Potential preservative mechanisms of cardiac rehabilitation pathways on endothelial function in coronary heart disease

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Science China(Life Sciences) 2025年第1期68卷 158-175页

作者： Wen-tao Sun Jian-Yong Du Jia wang Yi-Long wang Er-Dan Dong Research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital(Qingdao Municipal Hospital)Schoolof Health and Life SciencesUniversityof Health and Rehabilitation SciencesQingdao 266071China Department of Cardiology and Instituteof Vascular Medicine Peking University Third HospitalTheInstituteofCardiovascular SciencesPeking UniversityState Key Laboratoryof Vascular Homeostasisand RemodelingPeking UniversityBeijing 100191China

Cardiac rehabilitation,a comprehensive exercise-based lifestyle and medical management,is effective in decreasing morbidity and improving life quality in patients with coronary heart *** function,an irreplaceable indicator in coronary heart disease progression,is measured by various methods in traditional cardiac rehabilitation pathways,including medicinal treatment,aerobic training,and smoking ***,studies on the effect of some emerging cardiac rehabilitation programs on endothelial function are *** article briefly reviewed the endothelium-beneficial effects of different cardiac rehabilitation pathways,including exercise training,lifestyle modification and psychological intervention in patients with coronary heart disease,and related experimental models,and summarized both uncovered and potential cellular and molecular mechanisms of the beneficial roles of various cardiac rehabilitation pathways on endothelial *** exercise training and some lifestyle interventions,the enhanced bioavailability of nitric oxide,increased circulating endothelial progenitor cells(EPCs),and decreased oxidative stress are major contributors to preventing endothelial dysfunction in coronary heart ***,the preservation of endothelial-dependent hyperpolarizing factors and inflammatory suppression play *** the one hand,to develop more endothelium-protective rehabilitation methods in coronary heart disease,adequately designed and sized randomized multicenter clinical trials should be advanced using standardized cardiac rehabilitation programs and existing assessment *** the other hand,additional studies using suitable experimental models are warranted to elucidate the relationship between some new interventions and endothelial protection in both macro-and microvasculature.

关键词： cardiac rehabilitation coronary heart disease endothelial function

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Chattering-Free Fault-Tolerant Cluster Control and Fault Direction Identification for HIL UAV Swarm With Pre-Specified Performance

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IEEE/CAA Journal of Automatica Sinica 2025年第1期12卷 183-197页

作者： pei-Ming Liu Xiang-Gui Guo Jian-Liang wang Daniel Coutinho Lihua Xie the Beijing Engineering Research Center of Industrial Spectrum Imaging School of Automation and Electrical Engineering University of Science and Technology Beijing the Shunde Graduate School of University of Science and Technology Beijing IEEE Autonomous Intelligent Systems Department Hangzhou Innovation Institute of Beihang University the Department of Automation and Systems Universidade Federal de Santa Catarina the School of Electrical and Electronic Engineering Nanyang Technological University

In this paper, the problem of pre-specified performance fault-tolerant cluster consensus control and fault direction identification is solved for the human-in-the-loop(HIL) swarm unmanned aerial vehicles(UAVs) in the presence of possible nonidentical and unknown direction faults(NUDFs) in the yaw *** control strategy begins with the design of a pre-specified performance event-triggered observer for each individual *** observers estimate the outputs of the human controlled UAVs, and simultaneously achieve the distributed design of actual control signals as well as cluster consensus of the observer *** is worth mentioning that these observers require neither the high-order derivatives of the human controlled UAVs' output nor a priori knowledge of the initial conditions. The fault-tolerant controller realizes the pre-specified performance output regulation through error transformation and the Nussbaum function. It should be pointed out that there are no chattering caused by the jump of the Nussbaum function when a reverse fault occurs. In addition, to provide a basis for further solving the problem of physical malfunctions, a fault direction identification algorithm is proposed to accurately identify whether a reverse fault has occurred. Simulation results verify the effectiveness of the proposed control and fault direction identification strategies when the reverse faults occur.

关键词： Chattering-free cluster consensus fault direction identification human-in-the-loop (HIL) nonidentical and unknown direction faults (NUDFs) pre-specified performance swarm unmanned aerial vehicles (UAVs)

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How do Notch Shape and Boundary Conditions Affect the Hydro-Mechanical Behavior of Fractured Geomaterials?Findings via the Darcy-Brinkman-Biot Approach

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Journal of Earth Science 2025年第1期36卷 351-356页

作者： Yi-Xiang wang Xiao-pei Guo Ling Xu Shi-Feng Lu Department of Civil Engineering School of Human Settlements and Civil EngineeringXi'an Jiaotong UniversityXi'an 710049China China Construction Eighth Engineering Division Co. Ltd.Southwest BranchChengdu 610041China

0 INTRODUCTION Natural geomaterials,including soils and rocks,are invariably exposed to intricate stress conditions,in addition to water pressure,in various engineering contexts such as foundation treatment,mining,and *** geomaterials frequently contain numerous fractures,which significantly influence hydrological dynamics as water permeates through them,leading to processes like expansion and bifurcation(Shu et al.,2023;Tran and Jha,2021;Lei et al.,2017;wang et al.,2015).

关键词： bifurcation invar mining

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Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo Min Song Lulu An Xiao Huang Qian Zhang Chenhao Zhang tao Shen Shuang wang Deli wang Key Laboratory of Material Chemistry for Energy Conversion and Storage(Huazhong University of Science and Technology)Ministry of Education School of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiChina

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds (IMCs)(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction (ORR) and hydrogen evolution reaction (HER) with mass activity of 1.21 A mgPt-1(at 0.9 V) and5.70 A mgPt-1(at an overpotential of 100 mV),***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Synergistic effect Intermetallics Single atomic sites Oxygen reduction reaction Hydrogen evolution reaction

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Synthesis and high frequency structure simulator electromagnetic simulation of hollow NC@CeO_(2)nanospheres for broad absorption bandwidth

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International Journal of Minerals,Metallurgy and Materials 2025年第3期32卷 678-688页

作者： Shuhao Yang peiyan Zhao Xianyong Lu Xiaoyuan Hao Yufan Wu Huiya wang tao Zhou Guangsheng wang Hangzhou International Innovation Institute Beihang UniversityHangzhou 311115China School of Chemistry Beihang UniversityBeijing 100191China School of Materials Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018China School of Chemistry and Chemical Engineering Lingnan Normal UniversityZhanjiang 524048China

Recent progress in microwave absorption materials stimulates the extensive exploration of rare earth oxide ***,we report the synthesis of a hollow sphere-based carbon material compounded with rare earth *** N-doped carbon nano-spheres loaded ceria composites(H-NC@CeO_(2))were designed and prepared by the template method,combined with in-situ coating,pyrolysis and chemical *** controlling the loading content of H-NC@CeO_(2)and adjusting the impedance matching of the material,the H-NC@CeO_(2)/PS(polystyrene)composite exhibited a minimum reflection loss(RL)of-50.8 dB and an effective absorption band-width(EAB)of 4.64 GHz at a filler ratio of 20wt%and a thickness of 2 *** accordance with measured electromagnetic parameters,simulations using the high frequency structure simulator(HFSS)software were conducted to investigate the impact of the honeycomb structure on the electromagnetic wave performance of H-NC@CeO_(2)/*** calculating the surface electric field and the material’s bulk loss density,the mechanism of electromagnetic loss for the honeycomb structure was elaborated.A method for structural design and man-ufacturing of broadband absorbing devices was proposed and a broadband absorber with an EAB of 11.9 GHz was *** study presents an innovative approach to designing advanced electromagnetic(EM)wave absorbing materials with broad absorption band-widths.

关键词： rare earth oxides carbon matrix composites hollow structure electromagnetic simulation

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Three-dimensional internal multiple elimination in complex structures using Marchenko autofocusing theory

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Petroleum Science 2025年第1期22卷 222-233页

作者： pei-Nan Bao Ying Shi Xin-Min Shang Hong-Xian Liang Wei-Hong wang School of Earth Sciences Northeast Petroleum University Geophysical Research Institute of Shengli Oilfield Sinopec

Internal multiples are commonly present in seismic data due to variations in velocity or density of subsurface media. They can reduce the signal-to-noise ratio of seismic data and degrade the quality of the image. With the development of seismic exploration into deep and ultradeep events, especially those from complex targets in the western region of China, the internal multiple eliminations become increasingly challenging. Currently, three-dimensional(3D) seismic data are primarily used for oil and gas target recognition and drilling. Effectively eliminating internal multiples in 3D seismic data of complex structures and mitigating their adverse effects is crucial for enhancing the success rate of drilling. In this study, we propose an internal multiple prediction algorithm for 3D seismic data in complex structures using the Marchenko autofocusing theory. This method can predict the accurate internal multiples of time difference without an accurate velocity model and the implementation process mainly consists of several steps. Firstly, simulating direct waves with a 3D macroscopic velocity ***, using direct waves and 3D full seismic acquisition records to obtain the upgoing and downgoing Green's functions between the virtual source point and surface. Thirdly, constructing internal multiples of the relevant layers by upgoing and downgoing Green's functions. Finally, utilizing the adaptive matching subtraction method to remove predicted internal multiples from the original data to obtain seismic records without multiples. Compared with the two-dimensional(2D) Marchenko algorithm, the performance of the 3D Marchenko algorithm for internal multiple prediction has been significantly enhanced, resulting in higher computational accuracy. Numerical simulation test results indicate that our proposed method can effectively eliminate internal multiples in 3D seismic data,thereby exhibiting important theoretical and industrial application value.

关键词： Marchenko Internal multiple elimination Autofocusing Three-dimensional seismic data

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Model Predictive Control Scheduling Strategy for Hydrogen-doped Integrated Energy System Considering Ladder Carbon Trading

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Journal of Thermal Science 2025年第02期 337-351页

作者： JI Zhishi ZHANG Hanqing wang pei School of engineering Southern Methodist University Lyle College of Electrical and Power Engineering Hohai University Engineering Research Center of Renewable Power Generation Technologies of Ministry of Education Hohai University

To achieve low-carbon economic operation of hydrogen-doped integrated energy systems while mitigating the stochastic impact of new energy outputs on the system,the coordinated operation mode of hydrogen-doped gas turbines and electrolyzers is focused on,as well as a hybrid energy storage scheme involving both hydrogen and heat storage and an optimized scheduling model for integrated energy systems encompassing electricity-hydrogen-heat-cooling conversions is established.A model predictive control strategy based on deep learning prediction and feedback is proposed,and the effectiveness and superiority of the proposed strategy are demonstrated using error penalty ***,the introduction of hydrogen energy exchange and ladder carbon trading is shown to effectively guide the low-carbon economic operation of hydrogen-doped integrated energy systems across multiple typical scenarios.A sensitivity analysis is conducted based on this framework,revealing that increases in the hydrogen doping ratio of turbines and the carbon base price led to higher system operation costs but effectively reduce carbon emissions.

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An electrically activable nanochip to intensify gas-ionic-immunotherapy

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Science Bulletin 2025年第3期70卷 390-406页

作者： Gang wang Jingrui Li Shumin Sun Yuqi Yang Zhihui Han Zifan pei Liang Cheng Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China

Excess intracellular H_(2)S induces destructive mitochondrial toxicity,while overload of Zn^(2+)results in cell pyroptosis and potentiates the tumor immunogenicity for ***,the precise delivery of both therapeutics remains a great ***,an electrically activable ZnS nanochip for the controlled release of H_(2)S and Zn^(2+)was developed for enhanced gas-ionic-immunotherapy(GIIT).Under an electric field,a locality with particularly high concentrations of H_(2)S and Zn^(2+)was established by the voltage-controlled degradation of the ZnS nanoparticles(NPs).Consequently,the ZnS nanochip-mediated gas-ionic therapy(GIT)resulted in mitochondrial membrane potential depolarization,energy generation inhibition,and oxidative stress imbalance in tumor ***,the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes(cGAS-STING)signaling pathway was activated due to the mitochondrial ***,the released Zn^(2+)resulted in the increase of the intracellular Zn levels and cell pyroptosis,which enhanced the immunogenicity via the release of damage-associated molecular patterns(DAMPs).In vitro and in vivo studies revealed that the ZnS nanochip-based GIT effectively eliminated the tumors under an electric field and mobilized the cytotoxic T lymphocytes for *** combination withαCTLA-4 further promoted the adaptive immune response and inhibited tumor metastasis and long-term tumor *** work presented an electrically activable ZnS nanochip for combined immunotherapy,which might inspire the development of electric stimulation therapy.

关键词： H_(2)S gas therapy lonic interference therapy Electrically controll eddelivery Cell pyroptosis CGAS-STING pathway

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Generalized Tur′an number for edge blow-up of paths and cycles

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Acta Mathematica Sinica,English Series 2025年

作者： Yuan pei wang Li Ying KANG Department of Mathematics Shanghai University Newtouch Center for Mathematics of Shanghai University

Given a graph H and an integer p≥2,the edge blow-up graph Hp+1of H is the graph obtained by replacing each edge in H with a clique of order p+1,where the new vertices of the cliques are all *** generalized Tur′an number ex（n,Km,F） denote the maximum number of copies of Kmin an n-vertex F-free *** Ctand Ptdenote the cycle and path with t vertices,*** this paper,we obtain the generalized Tur′an numbers ex(n,Km,Pp+1_t),ex(n,Km,Cp+1_t)and characterize the unique graph for Pp+1_tand Cp+1_trespectively,when t≥3,p≥m≥3 and n is sufficiently large.

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Efficacy and safety of combined Kahook Dual Blade goniotomy with phacoemulsification in Chinese patients with primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 268-274页

作者： Lin Fu Jiang-tao Lou Yue Guo pei-Juan wang Rong-Rong Le Shu-Xia Xu Guo-Xing Li Yuan-Bo Liang National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325003Zhejiang ProvinceChina

AIM:To report the one-year surgical outcome Kahook Dual Blade goniotomy combined with phacoemulsification(KDB-Phaco)in Chinese patients with primary open angle glaucoma(POAG).METHODS:This is a retrospective study included 43 eyes of 28 Chinese POAG patients with cataract who accepted KDB-Phaco and followed-up for *** pressure(IOP),glaucoma medications and surgical complications were *** 1 and success 2 was defined as 5-21 mm Hg and 5-18 mm Hg,and success plus was determined if additional criteria of IOP reduction≥20%from baseline was reached.A corrected IOP by adding 3 mm Hg for each medication was used to do correlation ***’s proportional hazards regression model was used to test the hazard ratio for factors associated with surgical ***:After a 12-month follow up,the IOP decreased from 28.1±6.3 to 13.8±3.0 mm Hg(47.92%reduction,P<0.001),and the medications used decreased from 2.0(1.0)to 0.0(0.0)(95%reduction,P<0.001).The mean IOP of all postoperative visits were lower than preoperative IOP(all P<0.001),so as the number of glaucoma medications(all P<0.001).Complete success 1 and qualified success 1 were 87.80%and 100.00%*** complete success 1 plus and qualified success 1 plus were 85.37%and 97.56%,*** 82.93%and 90.24%of patients got complete success 2 and qualified success 2 while 80.49%and 87.80%of patients satisfied complete success 2 plus and qualified success 2 ***(r=-0.511,P=0.001)and visual acuity(VA;r=-0.321,P=0.041)were negatively correlated with postoperative corrected IOP at 12mo,while anterior chamber depth(r=0.432,P=0.005),mean deviation(r=0.617,P<0.001)and visual field index(r=0.524,P<0.001)were positively correlated with *** VA(OR=33.092,P=0.004)and MD(OR=1.481,P=0.018)were hazard factors associated with failure based on qualified success as 18 mm *** main complications of KDB were hyphema(9.30%),IOP spike(11.63%)and peripheral anterior synechia(6.98%).CONCLUSI

关键词： Kahook Dual Blade goniotomy primary open angle glaucoma success rate risk factors

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