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Magnetic resonance imaging-based artificial intelligence model in rectal cancer

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World Journal of Gastroenterology 2021年第18期27卷 2122-2130页

作者： pei-pei wang Chao-Lin Deng Bin Wu Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Rectal magnetic resonance imaging(MRI)is the preferred method for the diagnosis of rectal cancer as recommended by the *** MRI can accurately evaluate the tumor location,tumor stage,invasion depth,extramural vascular invasion,and circumferential resection *** summarize the progress of research on the use of artificial intelligence(AI)in rectal cancer in recent ***,represented by machine learning,is being increasingly used in the medical *** application of AI models based on high-resolution MRI in rectal cancer has been increasingly *** addition to staging the diagnosis and localizing radiotherapy,an increasing number of studies have reported that AI models based on high-resolution MRI can be used to predict the response to chemotherapy and prognosis of patients.

关键词： Artificial intelligence Deep learning Colorectal cancer Magnetic resonance imaging Radiomics

Screening of a Composite Microbial System and Its Characteristics of Wheat Straw Degradation

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Agricultural Sciences in China 2011年第10期10卷 1586-1594页

作者： LI pei-pei wang Xiao-juan YUAN Xu-feng wang Xiao-fen CAO Yan-zuan CUI Zong-jun College of Agronomy and Biotechnology China Agricultural University Beijing 100193 P.R.China

To accelerate the decomposition of wheat straw directly returned to soil, we constructed a microbial system （ADS-3） from agricultural soil containing rotting straw residues using a 40-wk limited cultivation. To assess its potential use for accelerating straw decomposing, the decomposing characteristics and the microbial composition of ADS-3 were analyzed. The results indicated that it could degrade wheat straw and filter paper by 63.8 and 80%, respectively, during 15 d of incubation. Straw hemicellulose degraded dramatically 51.2% during the first 3 d, decreasing up to 73.7% by the end of incubation. Cellulose showed sustained degradation reaching 53.3% in 15 d. Peak values of xylanase and cellulase activities appeared at 3 and 11 d, with 1.32 and 0.15 U mL-1, respectively. Estimated pH averaged 6.4-7.6 during the degradation process, which approximated acidity and alkalinity of normal soils. The microbial composition of ADS-3 was stable based on denaturing gradient gel electrophoresis （DGGE） analysis. By using bacterial 16S rRNA and fungal 26S rRNA gene clone library analysis, 20 bacterial clones and 7 fungal clones were detected. Closest identified relatives of bacteria represented by Bacillus fusiformis, Cytophaga sp., uncultured Clostridiales bacterium, Ruminobacillus xylanolyticum, Clostridium hydroxybenzoicum, and uncultured proteobacterium and the fungi were mainly identified as related to Pichia sp. and uncultured fungus.

关键词： wheat straw degradation composite microbial system cellulose hemicelulose cellulase xylanase microbial composition

Risk factors for perioperative complications in laparoscopic surgeries of retrorectal cystic lesions

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World Journal of Gastrointestinal Surgery 2021年第12期13卷 1685-1695页

作者： pei-pei wang Chen Lin Jiao-Lin Zhou Kai-Wen Xu Hui-Zhong Qiu Bin Wu Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

BACKGROUNDThe incidence of retrorectal lesions is low, and no consensus has been reachedregarding the most optimal surgical approach. Laparoscopic approach has theadvantage of minimally invasive. The risk factors influencing perioperativecomplications of laparoscopic surgery are rarely *** investigate the risk factors for perioperative complications in laparoscopicsurgeries of retrorectal cystic *** retrospectively reviewed the medical records of patients who underwentlaparoscopic excision of retrorectal cystic lesions between August 2012 and May2020 at our hospital. All surgeries were performed in the general surgerydepartment. Patients were divided into groups based on the lesion location anddiameter. We analysed the risk factors like type 2 diabetes mellitus, hypertension,the history of abdominal surgery, previous treatment, clinical manifestation,operation duration, blood loss, perioperative complications, and readmission ratewithin 90 d *** perioperative complications occurred in seven patients. Prophylactictransverse colostomy was performed in four patients with suspected rectal *** patients underwent puncture drainage due to postoperative pelvic *** patient underwent debridement in the operating room due to incisioninfection. The massive-lesion group had a significantly longer surgery duration,higher blood loss, higher incidence of perioperative complications, and higherreadmission rate within 90 d (P < 0.05). Univariate analysis, multivariate analysis,and logistic regression showed that lesion diameter was an independent riskfactor for the development of perioperative complications in patients whounderwent laparoscopic excision of retrorectal cystic *** diameter of the lesion is an independent risk factor for perioperative complicationsin patients who undergo laparoscopic excision of retrorectal cystic *** location of the lesion was not a determining factor of the

关键词： Laparoscopic excision Retrorectal cystic lesions Minimally invasive Risk factors Perioperative complications

Innovative integration of lung ultrasound and wearable monitoring for predicting pulmonary complications in colorectal surgery:A prospective study

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2649-2661页

作者： Chen Lin pei-pei wang Zi-Yan wang Guo-Ru Lan Kai-Wen Xu Chun-Hua Yu Bin Wu Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China School of Medicine Tsinghua UniversityBeijing 100084China Department of Anesthesiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Clinical Laboratory Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

BACKGROUND Postoperative pulmonary complications(PPCs)are common in patients who undergo colorectal *** have focused on how to accurately diagnose and reduce the incidence of *** ultrasound has been proven to be useful in preoperative monitoring and postoperative care after cardiopulmonary ***,lung ultrasound has not been studied in abdominal surgeries and has not been used with wearable devices to evaluate the influence of postoperative ambulation on the incidence of *** To investigate the relationship between lung ultrasound scores,PPCs,and postoperative physical activity levels in patients who underwent colorectal *** In this prospective observational study conducted from November 1,2019 to August 1,2020,patients who underwent colorectal surgery underwent daily bedside ultrasonography from the day before surgery to postoperative day(POD)*** ultrasound scores and PPCs were recorded and analyzed to investigate their *** bracelets measured the daily movement distance for 5 days post-surgery,and the correlation between postoperative activity levels and lung ultrasound scores was *** Thirteen cases of PPCs was observed in the cohort of 101 *** mean(standard deviation)peak lung ultrasound score was 5.32(2.52).Patients with a lung ultrasound score of≥6 constituted the high-risk ***-risk lung ultrasound scores were associated with an increased incidence of PPCs after colorectal surgery(logistic regression coefficient,1.715;odds ratio,5.556).Postoperative movement distance was negatively associated with the lung ultrasound scores[Spearman’s rank correlation coefficient(r),-0.356,P<0.05].CONCLUSION Lung ultrasound effectively evaluates pulmonary condition post-colorectal *** ambulation and respiratory exercises in the initial two PODs will reduce PPCs and optimize postoperative care in patients undergoing colorectal surgery.

关键词： Colorectal cancer Pulmonary complications Lung ultrasound Wearable devices Respiratory exercises

A Dandy-Walker malformation associated with ganglioglioma

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Chinese Medical Journal 2019年第20期132卷 2495-2497页

作者： Lei-Ming wang Meng Zhang pei-pei wang Xin-Gang Zhou Yue-Shan Piao De-Hong Lu Department of Pathology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Radiology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Pathology Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

To the Editor: The Dandy-Walker malformation (DWM) is a rare congenital malformation involving the posterior fossa. Diagnosis of the DWM is based on a series of characteristic neuroimaging findings, which include complete or partial agenesis of the cerebellar vermis, cystic dilatation of the fourth ventricle, and enlarged posterior fossa.[1] Several malformation syndromes and cytogenetic abnormalities have been associated with the DWM. However, the co-existence of the DWM and neoplasms is rare.[2] There are rare reports of the co-existence of the DWM and ganglioglioma.

关键词： malformation neoplasms glioma

All-sky Guide Star Catalog for CSST

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Research in Astronomy and Astrophysics 2024年第4期24卷 35-59页

作者： Hui-Mei Feng Zi-Huang Cao Man I Lam Ran Li Hao Tian Da-Yi Yin Yuan-Yu Yang Xin Zhang Dong-Wei Fan Yi-Qiao Dong Xin-Feng Li Wei wang Long Li Hugh RAJones Yi-Han Tao Jia-Lu Nie pei-pei wang Mao-Yuan Liu He-jun Yang Chao Liu Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of ChineseAcademy of Sciences Beijing 100049China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai200083China Technology and Engineering Center for Space Utilization.Chinese Academy of Sciences Beijing 100094China Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Centre for Astrophysics University of HertfordshireHatfieldUK Beijing University of Technology Beijing 100124China

The China Space Station Telescope(CSST)is a two-meter space telescope with multiple back-end *** Fine Guidance Sensor(FGS)is an essential subsystem of the CSST Precision Image Stability System to ensure the required absolute pointing accuracy and line-of-sight *** this study,we construct the Main Guide Star Catalog for *** accomplish this,we utilize the information about the FGS and object information from the Gaia Data Release *** provide an FGS instrument magnitude and exclude variables,binaries,and high proper motion stars from the catalog to ensure uniform FGS guidance ***,we generate a HEALPix index,which provides a hierarchical tessellation of the celestial sphere,and employ the Voronoi algorithm to achieve a homogeneous distribution of stars across the *** distribution ensures adequate coverage and sampling of the *** performance of the CSST guide star catalog was assessed by simulating the field of view of the FGS according to the CSST mock survey strategy *** analysis of the results indicates that this catalog provides adequate coverage and *** catalog's performance meets the FGS requirements,ensuring the functioning of the FGS and its guidance capabilities.

关键词： catalogs astrometry instrumentation:detectors

Interhemispheric cistern lipoma associated with malformations of cortical development, hypogenesis of the corpus callosum, and abnormal vasculature

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Chinese Medical Journal 2020年第1期133卷 117-119页

作者： Lei-Ming wang Meng Zhang pei-pei wang Li-Feng Wei Yue-Shan Piao Li Chen De-Hong Lu Department of Pathology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Radiology Xuanwu HospitalCapital Medical UniversityBeijing 100053China

To the Editor:Intracranial lipomas(ICLs)are very rare congenital malformative lesions accounting for about 0.1%to 1.7%of all intracranial tumors.[1,2]Herein we describe a rare case of a lipoma affecting the cerebral interhemispheric cisterns in association with malformations of cortical development(MCD),hypogenesis of the corpus callosum,and abnormal vasculature.

关键词： congenital cerebral rare

面孔表情及注视方向对面孔加工特异性的影响——基于知觉负荷理论的视角

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心理科学进展 2018年第6期26卷 984-993页

作者：张凯莉周霈王沛上海师范大学心理学系上海200234

知觉负荷理论认为,当前任务知觉负荷的高低决定了选择性注意过程中的资源分配状况。面孔加工具有特异性,不论知觉负荷的高低,作为干扰刺激的面孔都能得到一定程度的加工。不过面孔的表情和面孔的注视方向可能会受到知觉负荷的影响。其中... 详细信息

知觉负荷理论认为,当前任务知觉负荷的高低决定了选择性注意过程中的资源分配状况。面孔加工具有特异性,不论知觉负荷的高低,作为干扰刺激的面孔都能得到一定程度的加工。不过面孔的表情和面孔的注视方向可能会受到知觉负荷的影响。其中,面孔的负性情绪相比正性和中性情绪,较少受知觉负荷的影响;正性和中性情绪相比负性情绪,更易受到知觉负荷的影响。面孔直视的注视方向不需要主观注意,较少受知觉负荷的影响;非直视的注视方向则容易受到知觉负荷的影响。今后可将研究范围拓展到种族、性别、年龄等范畴,探讨不同知觉负荷条件对于这些面孔信息的影响。

关键词：面孔加工知觉负荷注意资源面孔表情注视方向

Identifying medication regularity of traditional Chinese medicine and potential pharmacological mechanism of Jiedu Sangen decoction in colorectal cancer treatment by data mining and network pharmacology

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Gastroenterology & Hepatology Research 2023年第3期5卷 12-28页

作者： Xin-Ru Jia Xiang-Chang Ying Yu-Wei Xia Li-Hui Qian Lei-Tao Sun pei-pei wang The First School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053China Department of Medical Oncology The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou 310006China Institute of Zhejiang Chinese Medical Culture Zhejiang Chinese Medical UniversityHangzhou 310053China Academy of Chinese Medical Science Zhejiang Chinese Medical UniversityHangzhou 310053China Zhejiang Cancer Hospital Hangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhou 310022China

Objective:Colorectal cancer(CRC)is one of the most common malignancies in the world,and traditional Chinese medicine(TCM)is widely used in its treatment in ***,the medication rules of TCM for CRC treatment remain ***,data mining combined with network pharmacology was utilized to establish treatment principles and ***:The CRC cases treated at Zhejiang Provincial Hospital of Chinese Medicine from January 1,2016 to October 31,2021 were analyzed using data mining ***-Q/TOF-MS analysis was performed to identify the chemical composition of Jiedu Sangen decoction(JSD).Network pharmacology was used to reveal the therapeutic mechanism of ***:A total of 312 cases 2,998 prescriptions that met the inclusion criteria used 343 kinds of traditional Chinese *** nature of the herbs used in treatment was mainly warm and *** taste was mainly sweet,bitter,and *** meridian tropisms were mainly the spleen meridian,followed by lung and stomach *** and replenishing herbs were the most frequently used in ***-frequency herbs were classified into 11 categories by cluster analysis,and 42 association rules were obtained by association rule *** with complex network analysis,3 core prescriptions for clinical CRC treatment were *** Sangen decoction contains 64 chemical ingredients,out of which 31 active ingredients were identified,including polydatin,caffeic acid,and glutamic acid,along with 130 potential targets such as AKT1,SRC,and *** Sangen decoction may play a role in regulating inflammation,immunity,metabolism,and hormones in the development of CRC via pathways such as the relaxin signaling pathway,IL-17 signaling pathway,prolactin signaling pathway,and T cell receptor signaling ***:This study summarizes the treatment and medication principles for clinical CRC treatment,promoting the inheritance and development of the traditional Chinese medica

关键词： data mining network pharmacology traditional Chinese medicine colorectal cancer Jiedu Sangen decoction