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Xinfuli Granule improves post-myocardial infarction ventricular remodelingand myocardial fibrosis in rats by regulating TGF-β/Smads signaling pathway

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Journal of Geriatric Cardiology 2017年第5期14卷 301-307页

作者： Jie MA Zhi-Yuan LI Xiao-Peng LIANG Cai-Xia GUO pei-pei lu Li-Hong MA Department of Traditional Chinese Medicine State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College Beij'ing China

Recent clinical and experimental studies have confirmed the effects of Xinfuli Granule (XG), a compound Chinese medicine in the prevention and treatment of heart failure (HF). This study aimed to investigate the effects and the mechanisms of XG on ventricular reconstruction in rats with acute myocardial infarction (AMI).MethodsSprague-Dawley rats were subjected to left anterior descending branch ligation. The rats that survived 24 h were randomly assigned to five groups: medium-dose of XG group (MI+XGM), high-dose of XG group (MI+XGH), carvedilol group (MI+C), medium-dose of XG + carvedilol group (MI+C+XGM). Fourteen rats underwent identical surgical procedures without artery ligation, serving as sham controls. At 28 days, left ventricular weight to body weight (LVW/BW) and heart weight to body weight (HW/BW) were calculated; left ventricular ejection fraction (LVEF), left ventricular shortening fraction (LVFS), left ventricular internal diameter at systole (LVIDS) were measured by ultrasound; HE staining, Masson staining, and Sirius red staining were used to assess the myocardial pathological and physiological changes as well as myocardial fibrosis area and non-infarct zone I/III collagen ratio. Expression of Smad3 were detected and analyzed by Western blot, immunohistochemistry and immunofluorescence. P-Smad3, Smad2 and Smad7 in the TGF-β/Smads signaling pathway were also analyzed by Western *** LVIDS (P luding Smad3, P-Smad3 and Smad2 protein were decreased, while the expression of Smad7 increased in both XG and carvedilol treatment groups as compared to those of the MI group (all P luorescence furth

关键词： Acute myocardial infarction Myocardial fibrosis TGF-β/Smads signaling pathway Ventricular remodeling Wnt/β-cateninsignaling pathway Xinfuli Granule

Complement use of Chinese herbal medicine after percutaneous coronary intervention: a prospective observational study

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Journal of Geriatric Cardiology 2022年第9期19卷 696-704页

作者： Si-Yu YAN Wei-Xian YANG pei-pei lu Xuan-Tong GUO Cai-Xia GUO Yan-Ni SU Li-Hong MA Chinese Academy of Medical Sciences&Peking Union Medical College Fuwai Hospital Xicheng DistrictBeijingChina

BACKGROUND Chinese herbal medicine is widely used as a complement or alternative treatment in coronary artery disease(CAD)patients after percutaneous coronary intervention(PCI)in *** compared the incidence of the major adverse cardi-ovascular event(MACE)of CAD patients with or without the complement use of Chinese herbal medicine after *** In this prospective,observational study that was conducted from September 2016 to August 2019 in Fuwai Hospital(China),we followed up consecutive patients who received PCI treatment for two *** was defined as the composite all-cause mortality,revascularization,and myocardial infarction(MI)and was compared between those using(integrative medicine group)or those not using Chinese herbal medicine as an additional treatment to standard Western medicine,with unadjusted(Kaplan-Meier curves)and risk-adjusted(multivariable Cox regression)*** A total of 5942 patients after PCI were enrolled in this study,and 5453 patients were included in the final analysis(4189[76.8%]male;mean age:61.9±9.9%years).During the follow-ups,2932(53.8%)patients used only Western medicine while 2521(46.2%)patients had used Chinese herbal medicine as an additional treatment to standard Western *** in the integrative medicine group(IM group)were older than the Western medicine group(WM group),had more females and less pre-vious *** incidence of MACE was 15.3%(449/2932)in WM group and 11.54%(291/2521)in IM *** regression ana-lysis showed that cumulative incidence of MACE was 27%lower in patients of the IM group than those in WM group(hazard ra-tio=0.73;95%CI:0.63-0.85;PluSIONS For CAD patients after PCI treatment,complement use of Chinese herbal medicine is associated with a lower 2-year MACE *** prospective studies are warranted to provide higher levels of benefit evidence in these pa-tients.

关键词： herbal prospective coronary

Qishen capsule safely boosts cardiac function and angiogenesis via the MEK/ERK pathway in a rat myocardial infarction model

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Journal of Geriatric Cardiology 2019年第10期16卷 764-774页

作者： Cai-Xia GUO Zhi-Yuan LI Jin-Bang NIU Shuan-Cheng FAN Si-Yu YAN pei-pei lu Yan-Ni SU Li-Hong MA State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Shanghai Kai Bao Pharmaceutical Co. LtdShanghaiChina

Background Qishen(QS) capsules, a Traditional Chinese Medicine, has been widely used to treat coronary heart disease in China. However, evidence of its effectiveness remains unclear. Methods To explore whether QS has cardioprotective efficacy and/or promotes angiogenesis after myocardial infarction (MI), we performed experiments in a preclinical rat MI model. One month after left anterior descending coronary artery ligation, the rats received either QS solution (0.4 g/kg/day) or the same volume of saline by intragastric injection for four weeks. Results Echocardiographic and hemodynamic analyses demonstrated relatively preserved cardiac function in MI rats administered QS. Indeed, QS treatment was associated with reduced infarct scar size and heart weight index, and these beneficial effects were responsible for enhancing angiogenesis. Mechanistically, QS treatment increased phosphorylation of protein kinase B (Akt) and downregulated phosphorylation of mitogen-activated protein kinase/extracellular-regulated kinase (MEK/ERK). Conclusions QS therapy can improve the cardiac function of rats after MI by an underlying mechanism involving increased angiogenesis, at least partially via activation of the Akt signaling pathway and inhibition of MEK/ERK phosphorylation.

关键词： Angiogenesis Cardioprotective efficacy Qishen capsule

Xinfuli improves cardiac function, histopathological changes and attenuate cardiomyocyte apoptosis in rats with doxorubicin-induced cardiotoxicity

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Journal of Geriatric Cardiology 2016年第12期13卷 968-972页

作者： pei-pei lu Jie MA Xiao-Peng LIANG Cai-Xia GUO Yan-Kun YANG Kun-Qi YANG Qi-Ming SHEN Li-Hong MA Xian-Liang ZHOU Department of Traditional Chinese Medicine State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Cardiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular D&eases Chinese Acad-emy of Medical Sciences and Peking Union Medical College Beijing China

Background Xinfuli Granule （XG）, a compound Chinese herbal medicine, has been effectively used in China for the treatment of heart failure for more than fifty years. This study aimed to investigate the effects and the underlying mechanisms of Xinfuli in rats with dox- orubicin-induced cardiotoxicity. Methods Sprague-Dawley rats were treated with intraperitoneal injection of Doxorubicin （DOX, 2.5 mg/kg per week） for six weeks, and then randomly divided into four groups which received intragastrically administration of normal saline （control group） or different dosage of XG （0.675 g/kg per day, 1.35 g/kg per day, and 2.7g/kg per day, respectively） for six weeks. Transtho- racic echocardiography was performed to evaluate the left ventricular fractional shortening （LVFS） and left ventricular ejection fraction （LVEF） before and after the XG treatment and histopathologic changes were also examined. Myocardial cell apoptosis was detected by TUNEL staining. The expression of related genes and proteins were analyzed using immunohistochemical staining. Results Compared to those in the control group, rats in XG treated groups showed significantly improved cardiac function and milder cardiac histopathological changes, lower cardiomyocyte apoptosis index, higher expression of Bcl-2 and lower expression of Bax. Conclusions Administration of XG improves cardiac function and histopathological changes in rats with doxorubicin-induced cardiotoxicity. These effects are associated with inhibition of cardiomyocyte apoptosis, perhaps via regulation of Bcl-2 and Bax protein expression.

关键词： Apoptosis Doxorubicin Heart failure Herbal medicine

Twenty-four-hour ambulatory blood pressure changes in older patients with essential hypertension receiving monotherapy or dual combination antihypertensive drug therapy

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Journal of Geriatric Cardiology 2019年第4期16卷 354-361页

作者： pei-pei lu Xu MENG Ying ZHANG Yan-Qi LI Shu WANG Li-Sheng LIU Wen WANG Yu-Ling LI Yu-Qing ZHANG Ai-Hua HU Xian-Liang ZHOU Li-Hong MA Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina Clinical Trial and Research Center Beijing Hypertension League InstituteChinese Hypertension LeagueBeijingChina Xinjiekou Community Health Service Center BeijingChina Department of Traditional Chinese Medicine Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Objective To evaluate the differences in 24-hour ambulatory blood pressure (BP) in older patients with hypertension treated with the five major classes of antihypertensive drugs,as monotherapy or dual combination therapy,to improve daytime and nighttime BP control. Methods We enrolled 1920 Chinese community-dwelling outpatients aged ≥ 60 years and compared ambulatory BP values and ambulatory BP control (24-hour BP lusions Antihypertensive monotherapy and dual combination drug therapy provided different ambulatory BP control and nighttime BP dip patterns. BB-based regimens provided lower daytime BP,whereas diuretic-based therapies provided lower nighttime BP,compared with other antihypertensive regimens.

关键词： Aging Ambulatory blood pressure monitoring Antihypertensive drugs Beta-blockers Diuretics

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差分速度调制分子离子激光光谱技术

物理学报 1999年第5期48卷 834-839页

作者：杨晓华陈扬骎蔡佩佩卢晶晶王荣军华东师范大学物理系国家教育部华东师范大学量子光学开放实验室

从理论上分析了速度调制激光光谱技术的技术特点及谱线线型，并在实验上采用差分速度调制激光光谱技术在可见光波段测量得到Ｎ＋２，ＣＯ＋的光谱信号．

关键词：分子光谱离子光谱速度调速激光光谱

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棉花枯萎病菌新生理型菌株的分子鉴定

植物病理学报 2018年第2期48卷 145-153页

作者：郭庆港王培培鹿秀云董丽红赵卫松张晓云李社增马平河北省农林科学院植物保护研究所河北省农业有害生物综合防治工程技术研究中心农业部华北北部作物有害生物综合治理重点实验室保定071000

Fusarium oxysporum ***(Fov)已报道有8个生理小种和一个澳大利亚生理型,在我国只报道有3、7、8号小种。前期研究发现,我国还有一个与3、7、8号小种具有较大遗传差异的Fov新生理型。本研究通过对3、7、8号小种和新生理型菌株的翻译延伸... 详细信息

Fusarium oxysporum ***(Fov)已报道有8个生理小种和一个澳大利亚生理型,在我国只报道有3、7、8号小种。前期研究发现,我国还有一个与3、7、8号小种具有较大遗传差异的Fov新生理型。本研究通过对3、7、8号小种和新生理型菌株的翻译延伸因子(EF-1α)基因序列比对分析,发现该新生理型菌株具有特异性碱基序列。根据这些特异性碱基序列,设计了一对针对新生理型菌株的特异性引物,并证明该引物可以特异性检测Fov新生理型菌株。利用该引物对采自河北省主要植棉区的77株Fov菌株进行筛选,鉴定出2株潜在的新生理型菌株。从这2个Fov菌株中克隆出EF-1α和β-tubulin基因序列,通过构建系统发育树,证明这2个Fov菌株为新生理型菌株,而且与澳大利亚生理型菌株具有较近的亲缘关系。本研究建立的分子检测方法可用于棉花枯萎病菌新生理型菌株的鉴定。

关键词：尖孢镰孢菌特异性分子检测遗传多样性

CFD simulation of bubbling and collapsing characteristics in a gas-solid fluidized bed

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Petroleum Science 2009年第1期6卷 69-75页

作者： pei pei Zhang Kai lu Erwei Wen Dongsheng State Key Laboratory of Heavy Oil Processing China University of Petroleum Beijing 102249 China School of Engineering and Materials Science Queen Mary University of London Mile End Road London UK E1 4NS

Computational Fluid Dynamics （CFD） has become an alternative method to experiments for understanding the fluid dynamics of multiphase flow. A two-fluid model, which contains additional terms in both the gas- and solid-phase momentum equations, is used to investigate the fluidization quality in a fluidized bed. A case study for quartz sand with a density of 2,660 kg/m^3 and a diameter of 500 μm, whose physical property is similar to a new kind of catalyst for producing clean fuels through the residue fluid catalytic cracking process, is simulated in a two-dimensional fluidized bed with 0.57 m width and 1.00 m height. Transient bubbling and collapsing characteristics are numerically investigated in the platform of CFX 4.4 by integrating user-defined Fortran subroutines. The results show that the fluidization and collapse process is in fair agreement with the classical theory of Geldart B classification, but the collapse time is affected by bubbles at the interface between the dense phase and freeboard.

关键词： Fluidized bed CFD simulation bubbling and collapsing behaviors

IDENTIFYING INFluENTIAL SPREADERS IN ARTIFICIAL COMPLEX NETWORKS

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Journal of Systems Science & Complexity 2014年第4期27卷 650-665页

作者： WANG pei TIAN Chengeng lu Jun-an School of Mathematics and Information Sciences Henan University School of Mathematics and Statistics Wuhan University

A long-term common belief in complex networks is that,the most connected nodes are the most efficient ***,recent investigations on real-world complex networks show that the most influential spreaders are those with the highest fc-shell *** is well-known that,many real-world complex networks have scale free(SF),small world(SW) properties,therefore,identification of influential spreaders in general artificial SF,SW as well as random networks will be more *** research finds that,for artificial ER and SW networks,degree is more reliable than fc-shell in predicting the outcome of ***,for artificial SF networks,fc-shell is remarkably reliable than degree and betweeness,which indicate that the four recently investigated real-world networks[Kitsak M,Gallos L K,Havlin S,Liljeros F,Muchnik L,Stanley H E,Makse H A,Identification of influential spreaders in complex networks,***.,2010,6:888-893.]are more similar to scale free ***,the investigations also indicate us an optimal dissemination strategy in networks with scale free *** is,starting from moderate-degree-nodes will be ok and even more economical,since one can derive roughly similar outcome with starting from hubs.

关键词： Complex network influential spreader k-shell scale free small world.