检索结果-南通市图书馆

TAX1BP1 and FIP200 orchestrate non-canonical autophagy of p62 aggregates for mouse neural stem cell maintenance

Zoological Research 2024年第4期45卷 937-950页

作者： Yi-Fu Zhu Rong-Hua Yu Shuai Zhou pei-pei tang Rui Zhang Yu-Xin Wu Ran Xu Jia-Ming Wei Ying-Ying Wang Jia-Li Zhang Meng-Ke Li Xiao-Jing Shi Yu-Wei Zhang Guang-Zhi Liu Rick FThorne Xu Dong Zhang Mian Wu Song Chen School of Life Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China Translational Research Institute of Henan Provincial People’s Hospital and People'’s Hospital of Zhengzhou University Tianjian Laboratory of Advanced Biomedical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan 450053China Institute of Medicinal Biotechnology Jiangsu College of NursingHuai’anJiangsu 223300China Laboratory Animal Center Academy of Medical ScienceZhengzhou UniversityZhengzhouHenan 450052China Henan Key Laboratory of Stem cell Differentiation and Modification Henan Provincial People’s HospitalHenan UniversityZhengzhouHenan 450053China School of Biomedical Sciences and Pharmacy The University of NewcastleNSW 2308Australia

Autophagy plays a pivotal role in diverse biological processes,including the maintenance and differentiation of neural stem cells(NSCs).Interestingly,while complete deletion of Fip200 severely impairs NSC maintenance and differentiation,inhibiting canonical autophagy via deletion of core genes,such as Atg5,Atg16l1,and Atg7,or blockade of canonical interactions between FIP200 and ATG13(designated as FIP200-4A mutant or FIP200 KI)does not produce comparable detrimental *** highlights the likely critical involvement of the non-canonical functions of FIP200,the mechanisms of which have remained ***,utilizing genetic mouse models,we demonstrated that FIP200 mediates non-canonical autophagic degradation of p62/sequestome1,primarily via TAX1BP1 in *** deletion of Tax1bp1 in fip200hGFAP conditional knock-in(cKI)mice led to NSC deficiency,resembling the fip200hGFAP conditional knockout(cKO)mouse ***,reintroducing wild-type TAX1BP1 not only restored the maintenance of NSCs derived from tax1bp1-knockout fip200hGFAP cKI mice but also led to a marked reduction in p62 aggregate ***,a TAX1BP1 mutant incapable of binding to FIP200 or NBR1/p62 failed to achieve this ***,conditional deletion of Tax1bp1 in fip200hGFAP cKO mice exacerbated NSC deficiency and p62 aggregate accumulation compared to fip200hGFAP cKO ***,these findings illustrate the essential role of the FIP200-TAX1BP1 axis in mediating the non-canonical autophagic degradation of p62 aggregates towards NSC maintenance and function,presenting novel therapeutic targets for neurodegenerative diseases.

关键词： Non-canonical autophagy TAX1BP1 FIP200 p62 Aggregates Neural stem cell

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

甜菜粉与亚硝酸钠复合对中式香肠品质的影响

引用

食品工业科技 2017年第1期38卷 269-272,327页

作者：朱培培唐宏刚肖朝耿陈黎洪陆胜民南京农业大学食品科技学院江苏南京210095 浙江省农业科学院食品科学研究所浙江杭州310021

研究甜菜粉对中式香肠品质的影响,以期达到替代或部分替代亚硝酸钠目的。采用甜菜粉(0、0.5%、1.0%)与亚硝酸钠(0、50、100 mg/kg)正交组合添加于中式香肠中,分别于第2、7、14 d测定亚硝酸盐残留量、色泽(L*、a*、b*)、亚硝基肌红蛋白(N... 详细信息

研究甜菜粉对中式香肠品质的影响,以期达到替代或部分替代亚硝酸钠目的。采用甜菜粉(0、0.5%、1.0%)与亚硝酸钠(0、50、100 mg/kg)正交组合添加于中式香肠中,分别于第2、7、14 d测定亚硝酸盐残留量、色泽(L*、a*、b*)、亚硝基肌红蛋白(NOMb)含量、脂质氧化(TBARS)、质构(TPA)及酸度等指标。结果表明:各甜菜粉添加组的亚硝酸盐残留量显著低于100 mg/kg亚硝酸钠添加组的和国标规定(p0.05)。综合亚硝酸盐残留量、色泽、NOMb、TBARS等指标,最优的组合为0.5%甜菜粉与50 mg/kg亚硝酸钠复合组。由此可见:甜菜粉可以替代部分亚硝酸钠添加于中式香肠中。

关键词：甜菜粉中式香肠亚硝酸钠亚硝酸盐残留品质

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sulfur-driven methylmercury production in paddies continues following soil oxidation

引用

Journal of Environmental Sciences 2022年第9期34卷 166-174页

作者： Wenli tang Chao tang pei Lei School of the Environment State Key Laboratory of Pollution Control and Resource ReuseNanjing UniversityNanjing 210023China School of Environment Nanjing Normal UniversityNanjing 210023China

Methylmercury(MeHg) production in paddy soils and its accumulation in rice raise global concerns since rice consumption has been identified as an important pathway of human exposure to MeHg. Sulfur(S) amendment via fertilization has been reported to facilitate Hg methylation in paddy soils under anaerobic conditions, while the dynamic of S-amendment induced MeHg production in soils with increasing redox potential remains unclear. This critical gap hinders a comprehensive understanding of Hg biogeochemistry in rice paddy system which is characterized by the fluctuation of redox potential. Here, we conducted soil incubation experiments to explore MeHg production in slow-oxidizing paddy soils amended with different species of S and doses of sulfate. Results show that the elevated redox potential(1) increased MeHg concentrations by 10.9%-35.2%, which were mainly attributed to the re-oxidation of other S species to sulfate and thus the elevated abundance of sulfatereducing bacteria, and(2) increased MeHg phytoavailability by up to 75% due to the reductions in acid volatile sulfide(AVS) that strongly binds MeHg in soils. Results obtained from this study call for attention to the increased MeHg production and phytoavailability in paddy soils under elevated redox potentials due to water management, which might aggravate the MeHg production induced by S fertilization and thus enhance MeHg accumulation in rice.

关键词： Mercury Sulfur Availability Mercury methylation Rice

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sequential auto-reclosing strategy for hybrid HVDC breakers in VSC-based DC grids

引用

Journal of Modern Power Systems and Clean Energy 2019年第3期7卷 633-643页

作者： Xiangyu pei Guangfu tang Shengmei ZHANG China Electric Power Research Institute Beijing100192China Global Energy Interconnection Research Institute Co.Ltd. Beijing102209China North China Electric Power University Beijing102206China

The use of overhead lines for power transmission in the future high-voltage and large-capacity voltagesource converter(VSC)-based direct current(DC) grid will significantly increase the probability of temporary *** eliminate potential adverse impacts such as erroneous protection, line-insulation failure, and even damage to power electronic devices resulting from a DC breaker reclosing operation with the traditional sequential autoreclosing strategy, a new sequential auto-reclosing strat-egy for hybrid HVDC breakers(HHBs) in VSC-based DC grids is proposed. This strategy is based on the step-by-step operation of the transfer branch in the HHB. As a result,du/dt resulting from the HHB reclosing operation is greatly reduced, and therefore those potential negative impacts can be eliminated. Several other advantages are also *** feasibility and validity of the proposed strategy are verified in a four-terminal annular VSC-based DC grid electromagnetic transient model.

关键词： Overhead line Voltage-sourced converter(VSC)-based direct current grid Temporary fault Hybrid HVDC breaker(HHB) Auto-reclosing strategy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Statistical inference for multivariate longitudinal data with irregular auto-correlated error process

引用

Science China Mathematics 2020年第10期63卷 2117-2136页

作者： Youquan pei Yiming tang Tao Huang School of Economics Shandong UniversityJinan 250100China School of Statistics and Management Shanghai University of Finance and EconomicsShanghai 200433China

Multivariate longitudinal data arise frequently in a variety of applications,where multiple outcomes are measured repeatedly from the same *** this paper,we first propose a two-stage weighted least square estimation procedure for the regression coefficients when the random error follows an irregular autoregressive(AR)process,and establish asymptotic normality properties for the resulting *** then apply the smoothly clipped absolute deviation(SCAD)variable selection approach to determine the order of the AR error *** further propose a test statistic to check whether multiple responses are correlated at the same observation time,and derive the asymptotic distribution of the proposed test *** simulated examples and real data analysis are presented to illustrate the finite-sample performance of the proposed method.

关键词： multivariate longitudinal data autoregressive error two-stage weighted least square hypothesis testing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Systematic Review on Wearable Lower Extremity Robotic Exoskeletons for Assisted Locomotion

引用

Journal of Bionic Engineering 2023年第2期20卷 436-469页

作者： Shuang Qiu Zhongcai pei Chen Wang Zhiyong tang School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China

Lower extremity robotic exoskeletons(LEEX)can not only improve the ability of the human body but also provide healing treatment for people with lower extremity *** are a wide range of application needs and development prospects in the military,industry,medical treatment,consumption and other felds,which has aroused widespread concern in *** paper attempts to review LEEX technical ***,the history of LEEX is briefy ***,based on existing research,LEEX is classifed according to auxiliary body parts,structural forms,functions and felds,and typical LEEX prototypes and products are ***,the latest key technologies are analyzed and summarized,and the research contents,such as bionic structure and driving characteristics,human–robot interaction(HRI)and intentawareness,intelligent control strategy,and evaluation method of power-assisted walking efciency,are described in ***,existing LEEX problems and challenges are analyzed,a future development trend is proposed,and a multidisciplinary development direction of the key technology is provided.

关键词： Lower extremity robotic exoskeletons Bionic robot Classifcation method Human-robot interaction Biomechatronic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Air Injector on the Performance of an Air-lift for Conveying River Sand

引用

Chinese Journal of Mechanical Engineering 2010年第1期23卷 122-128页

作者： tang Chuanlin HU Dong pei Jianghong YANG Lin College of Mechanical Engineering Hunan University of Technology Zhuzhou 412008 China Department of Mechanical Engineering Chongqing Jiaotong University Chongqing 400044 China

An air-lift has been more recently applied in the dredging, deep-seated beach placer mining and underground mining engineering. However, the influence and mechanism of various parameters on the air-lift performance are not quite clear, especially the influence of flow pattern on lifting efficiency. Focusing on the problems mentioned above, the key part of the air-lift （namely, the air injector） was proposed aimed to reduce friction loss in the inner pipe according to improving flow field performance, thus increase the lifting efficiency. The study of relative factors of the performance of an air-lift is performed and the river sand is used as simulation of underground ore bed. The total lifting height of the experimental system is 3 m, the water flux, mass flow of solid particles, concentration of particles and lifting efficiency are measured under the same submergence ratios by changing the air injector, which is divided into nine specifications of air injection in this research. The experimental results indicate that the optimal air flow rate corresponding to excellent performance of the air-lift can be obtained in the range of 35-40 m3/h. The air injection method has a great effect on the performance of the air-lift, the air injector with three nozzles is better than that in the case of one or two nozzles. Further more, the air injection angle and arrangement of air injection pipes also have great effect on the performance of an air-lift. The proposed research results have guiding significance for engineering application.

关键词： air-lift submergence ratio air flow rate air injector lifting efficiency

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Double Penalized Variable Selection Procedure for Partially Linear Models with Longitudinal Data

引用

Acta Mathematica Sinica,English Series 2014年第11期30卷 1963-1976页

作者： pei Xin ZHAO An Min tang Nian Sheng tang College of Mathematics and Statistics Hechi University Department of Statistics Yunnan University

Based on the double penalized estimation method,a new variable selection procedure is proposed for partially linear models with longitudinal *** proposed procedure can avoid the effects of the nonparametric estimator on the variable selection for the parameters *** some regularity conditions,the rate of convergence and asymptotic normality of the resulting estimators are *** addition,to improve efficiency for regression coefficients,the estimation of the working covariance matrix is involved in the proposed iterative *** simulation studies are carried out to demonstrate that the proposed method performs well.

关键词： Partially linear model variable selection penalized estimation longitudinal data

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of surfactants on the combined toxicity of TiO_2 nanoparticles and cadmium to Escherichia coli

引用

Journal of Environmental Sciences 2018年第12期30卷 126-133页

作者： Mei Li Jianchuan pei Xiaomeng tang Xiaoli Guo School of Environmental and Resource Sciences Zhejiang A & F University

The combined ecological toxicity of TiO2 nanoparticles（nano-TiO2） and heavy metals has been paid more attention. As the common pollutants in water environment, surfactants could affect the properties of nanoparticles and heavy metals, and thus further influence the combined toxicity of nano-TiO2 and heavy metals. In this study, the effects of sodium dodecyl benzene sulfonate（SDBS） and Tween 80 on the single and combined toxicities of Cd2＋ and nano-TiO2 to Escherichia coli（E. coli） were examined, and the underlying influence mechanism was further discussed. The results showed both SDBS and Tween 80 enhanced the toxicity of Cd2＋ to E. coli in varying degrees. The reaction of SDBS and Cd2＋ could increase the outer membrane permeability and the bioavailability of Cd, while Tween 80 itself could enhance the outer membrane permeability. The combined toxicity of nano-TiO2 and Cd2＋ to E. coli in absence of surfactant was antagonistic because of the adsorption of Cd2＋ to nanoTiO2 particles. However, in the presence of SDBS, both SDBS and nano-TiO2 influenced the toxicity of Cd2＋ , and also SDBS could adsorb to nano-TiO2 by binding to Cd2＋ . The combined toxicity was reduced at Cd2＋ lower than 4 mg/L and enhanced at Cd2＋ higher than 4 mg/L under multiple interactions. Tween 80 enhanced the combined toxicity of nano-TiO2 and Cd2＋ by increasing the outer membrane permeability. Our study firstly elucidated the effects of surfactants on the combined toxicity of nano-TiO2 and Cd2＋ to bacteria, and the underlying influencing mechanism was proposed.

关键词： Nano-TiO2 Heavy metal Surfactant Combined toxicity Bacteria

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

NYFR output pulse radar signal TOA analysis using extended Fourier transform and its TOA estimation

引用

Journal of Systems Engineering and Electronics 2017年第2期28卷 212-223页

作者： Zhaoyang Qiu pei Wang Jun Zhu Bin tang School of Electronic Engineering University of Electronic Science and Technology of China Chengdu 611731 China

Nyquist folding receiver (NYFR) is a typical wideband analog-to-information architecture. Focusing on the non-cooperative receiving, the pulse radar signal intercepted by the NYFR in time domain is analyzed. The NYFR outputs under different input conditions are investigated based on the extended Fourier transform (EFT) and the sampling theorem. Combining with the characteristic of the NYFR output in time domain, a new time of arrival (TOA) estimation method based on the energy envelope and the wavelet transform is proposed. The proposed estimation method can be adapted for the non-cooperative situation. It has no requirement for prior information to determine the threshold and is not necessary to transform the signal into baseband. Simulation results prove the correctness of the NYFR output expressions and show the efficacy of the proposed estimation method. © 2017 Beijing Institute of Aerospace Information.

关键词： Fourier transforms Radar Time domain analysis Wavelet transforms

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：