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Protein & Cell 2011年第9期2卷 764-771页

作者： Wen-Zhong Liu Ru-jia Yan Wei jing Hai-Qing Gong pei-ji liang School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Correlated firings among neurons have been extensively investigated;however,previous studies on retinal ganglion cell(RGC)population activities were mainly based on analyzing the correlated activities between the entire spike *** the present study,the correlation properties were explored based on burst-like activities and solitary spikes *** results indicate that:(1)burst-like activities were more correlated with other neurons’activities;(2)burst-like spikes correlated with their neighboring neurons represented a smaller receptive field than that of correlated solitary *** results suggest that correlated burst-like spikes should be more efficient in signal transmission,and could encode more detailed spatial information.

关键词： correlated firing burst-like spikes solitary spikes correlation index receptive field

Stimulus discrimination via responses of retinal ganglion cells and dopamine-dependent modulation

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Neuroscience Bulletin 2013年第5期29卷 621-632页

作者： Hao Li pei-ji liang School of Biomedical Engineering Shanghai Jiao Tong University

Neighboring retinal ganglion cells（RGCs）fire with a high degree of *** has been increasingly realized that visual perception of the environment relies on neuronal population activity to encode and transmit the information contained in *** how neuronal population activity contributes to visual information processing is essential for understanding the mechanisms of visual *** we simultaneously recorded spike discharges from groups of RGCs in bullfrog retina in response to visual patterns（checkerboard,horizontal grating,and full-field illumination）using a multi-electrode array *** determine the role of synchronous activity mediated by gap junctions,we measured the correct classification rates of single cells＇firing patterns as well as the synchronization patterns of multiple *** found that,under normal conditions,RGC population activity exhibited distinct response features with exposure to different stimulus patterns and had a higher rate of correct stimulus discrimination than the activity of single ***（1μmol/L）application did not significantly change the performance of single neuron activity,but enhanced the synchronization of the RGC population activity and decreased the rate of correct stimulus pattern *** findings suggest that the synchronous activity of RGCs plays an important role in the information coding of different types of visual patterns,and a dopamine-induced increase in synchronous activity weakens the population performance in pattern discrimination,indicating the potential role of the dopaminergic pathway in modulating the population coding process.

关键词： retinal ganglion cells synchronous activity dopamine information coding

GABA_A Receptor Activity Suppresses the Transition from Interictal to Ictal Epileptiform Discharges in Juvenile Mouse Hippocampus

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Neuroscience Bulletin 2018年第6期34卷 1007-1016页

作者： Yan-Yan Chang Xin-Wei Gong Hai-Qing Gong pei-ji liang Pu-Ming Zhang Qin-Chi Lu Department of Neurology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University School of Biomedical Engineering Shanghai Jiao Tong University

Exploring the transition from inter-ictal to ictal epileptiform discharges(IDs) and how GABAAreceptormediated action affects the onset of IDs will enrich our understanding of epileptogenesis and epilepsy *** used Mg2+-free artificial cerebrospinal fluid(ACSF) to induce epileptiform discharges in juvenile mouse hippocampal slices and used a micro-electrode array to record the discharges. After the slices were exposed to Mg2+-free ACSF for 10 min–20 min, synchronous recurrent seizurelike events were recorded across the slices, and each event evolved from inter-ictal epileptiform discharges(IIDs) to pre-ictal epileptiform discharges(PIDs), and then to *** the transition from IIDs to PIDs, the duration of discharges increased and the inter-discharge interval decreased. After adding 3 lmol/L of the GABAAreceptor agonist muscimol, PIDs and IDs disappeared, and IIDs remained. Further, the application of 10 lmol/L muscimol abolished all the epileptiform discharges. When the GABAAreceptor antagonist bicuculline was applied at 10 lmol/L, IIDs and PIDs disappeared, and IDs remained at decreased intervals. These results indicated that there are dynamic changes in the hippocampal network preceding the onset of IDs, and GABAAreceptor activity suppresses the transition from IIDs to IDs in juvenile mouse hippocampus.

关键词： Epileptiform discharge Gamma-aminobutyric acid Bicuculline Muscimol Micro-electrode array Hippocampal slice

Possible mechanisms for response dynamics of ON-OFF RGCs

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Possible mechanisms for response dynamics of ON-OFF RGCs

中国神经科学学会第十届全国学术会议

作者： Lei XIAO pei-ji liang School of Biomedical Engineering Shanghai Jiao Tong University

Objective Stimulus duration is an important feature of visual *** activities of ON-OFF retinal ganglion cells(RGCs) can be modulated by forgoing stimulus,i.e.,ON-response characteristics,including response latency and firing rate,are modulated by different light-OFF intervals and vice ***(DA) is an important neuromodulator,while y-amino-butyric acid(GABA) and glycine are inhibitory *** this study,we studied the effects of DA,GABA,and glycine on the response dynamics of bullfrog ON-OFF RGCs to different stimulus *** RGCs’ firing activities were recorded using multi-electrode *** stimulation protocols were applied:(1) Stimulation with different light-ON durations,in which light-ON stimuli with duration of 1s,5 s and 9 s which were presented randomly in each trial and separated by 1-s full-filed light-OFF *** experiment contained 30 trials.(2) Stimulation with different light-OFF intervals,in which hght-OFF intervals of 1 s,5s and 9 s were separated by full-filed 1-s light-ON *** pharmacological experiments,DA(10 μM),PTX(20 μM),strychnine(STR,20 μM) were applied with the Ringer’s ***(1) The stimulus-duration-dependent response latency change was only significantly attenuated during DA application.(2) All the drugs significantly increased the firing rates of RGCs,but they did not obviously influence the stimulus-duration-dependent firing rate *** DA-related activity participated in the stimulus-duration-dependent latency change,and DA-,GABA-,and glycine-related activities may not direcdy involve in stimulus-duration-dependent firing rate change.

关键词： retinal ganglion cells response dynamics stimulus duration dopamine

Possible roles of electrical synapse in temporal information processing: A computational study

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Journal of Biomedical Science and Engineering 2008年第1期1卷 27-36页

作者： Xu-Long Wang Xiao-Dong jiang pei-ji liang Department of Biomedical Engineering Shanghai Jiao Tong University

Temporal information processing in the range of tens to hundreds of milliseconds is critical in many forms of sensory and motor tasks. However, little has been known about the neural mechanisms of temporal information processing. Experimental observations indicate that sensory neurons of the nervous system do not show selective response to temporal properties of external stimuli. On the other hand, temporal selective neurons in the cortex have been reported in many species. Thus, processes which realize the temporal-to-spatial transformation of neuronal activities might be required for temporal information processing. In the present study, we propose a computational model to explore possible roles of electrical synapses in processing the duration of external stimuli. Firstly, we construct a small-scale network with neurons interconnected by electrical synapses in addition to chemical synapses. Basic properties of this small-scale neural network in processing duration information are analyzed. Secondly, a large-scale neural network which is more biologically realistic is further explored. Our results suggest that neural networks with electrical synapses functioning together with chemical synapses can effectively work for the temporal-to-spatial transformation of neuronal activities, and the spatially distributed sequential neural activities can potentially represent temporal information.

关键词： model neural network electrical synapse temporal information processing

A modified model accounting for the intrinsic firing behaviors of retinal ganglion cells

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A modified model accounting for the intrinsic firing behavio...

中国神经科学学会第十届全国学术会议

作者： Lei WANG pei-ji liang Yi-Hong QIU School of Biomedical Engineering Shanghai Jiao Tong University

Objective Ganghon cells in the retina have been observed to exhibit a diversity of firing behaviors,however,the specific mechanisms,especially the intrinsic part that participates in the generation of these firing behaviors is still *** present study is to explore how the firing behaviors of retinal ganghon cells（RGCs） would be modulated or influenced by different intrinsic ionic *** A computational model is thus employed,which is modified from two previously reported models of salamander RGCs,and the model contains a sodium channel,a delayed-rectifier potassium channel,a calcium channel,a A-type potassium channel,a calcium-dependent potassium channel,and a leak *** The simulation results demonstrate that the modified model possesses prominent features:in addition to generate the typical spikes and adapting firings similar with those in the two original models,it can also produce some other firing patterns that the two models failed to do,e.g.,tonic activity and phasic *** The ionic model we modified has eminent characteristics in mimicking the typical firing behaviors of RGCs,meanwhile,the model can also be used as a good basis for simulating some other firing patterns intrinsically exhibited by RGCs.

关键词： computational model retinal ganglion cell adaptation tonic firing phasic firing

Spatiotemporal dynamics of high-K^+-induced epileptiform discharges in hippocampal slice and the effects of valproate

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Neuroscience Bulletin 2013年第1期29卷 28-36页

作者： jian-Sheng Liu jing-Bo Li Xin-Wei Gong Hai-Qing Gong Pu-Ming Zhang pei-ji liang Qin-Chi Lu Department of Neurology Renji Hospital School of Medicine Shanghai Jiao Tong University Department of Biomedical Engineering Shanghai Jiao Tong University

The epileptic seizure is a dynamic process involving a rapid transition from normal activity to a state of hypersynchronous neuronal discharges. Here we investigated the network properties of epileptiform discharges in hippocampal slices in the presence of high K ＋ concentration （8.5 mmol/L） in the bath, and the effects of the anti-epileptic drug valproate （VPA） on epileptiform discharges, using a microelectrode array. We demonstrated that epileptiform discharges were predominantly initiated from the stratum pyramidale layer of CA3a-b and propagated bi-directionally to CA1 and CA3c. Disconnection of CA3 from CA1 abolished the discharges in CA1 without disrupting the initiation of discharges in CA3. Further pharmacological experiments showed that VPA at a clinically relevant concentration （100 μmol/L） suppressed the propagation speed but not the rate or duration of high-K＋-induced discharges. Our findings suggest that pacemakers exist in the CA3a-b region for the generation of epileptiform discharges in the hippocampus. VPA reduces the conduction of such discharges in the network by reducing the propagation speed.

关键词： epileptiform discharges hippocampal slices microelectrode array valproate

Contribution of the GABAergic pathway（s） to the correlated activities of chicken retinal ganglion cells

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Contribution of the GABAergic pathway（s） to the correlated...

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Xue LIU,Yi ZHOU,pei-ji liang Department of Biomedical Engineering,Shanghai jiao Tong University,Shanghai 200240,China

＜正＞In the present study,the spatiotemporal pattern of chicken retinal ganglion cells’ firing activity in response to full-field white light stimulation was ***-correlation analysis showed that ganglion cells of sustained subtype fired in precise synchrony with their adjacent neurons of the same subtype（delay lag within 2 ms,narrow correlation）. On the other hand,the activities of neighboring ganglion cells of transient subtype were correlated with distributed time lags（10-30 ms,medium correlation）.Pharmacological studies demonstrated that the intensity of the medium correlations could be strengthened when exogenous GABA was applied,and attenuated when GABA receptors were blocked by ***,the GABAergic modulation on the narrow correlations was not *** results suggest that in the chicken retina,GABAergic pathway（s） are likely involved in the formation of medium correlations between ganglion *** might fire at a lower rate but with higher level of synchronization to improve the efficiency of information transmission,with the mechanism involving the GABAergic inhibitory input.

关键词： multi-unit recording population activity excitatory inhibition

Caffeine induced Ca2+ release in carp retinal horizontal cells

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Caffeine induced Ca2+ release in carp retinal horizontal cel...

第九届全国钙信号和细胞功能研讨会

作者： Ting Lv,Hai-Qing Gong,and pei-ji liang Department of Biomedical Engineering,Shanghai jiao Tong University,Shanghai 200240,China

＜正＞Calcium is a ubiquitous intracellular messenger that regulates numerous cellular processes,calcium release from the endoplasmic reticulum（ER）is one of the main mechanisms of intracellular calcium *** was found in carp retina that type I horizontal cells（H 1 HCs）contained ryanodine-sensitive intracellular calcium store In the present study,the temporal characteristics of calcium signal initiated by ER calcium release were investigated in freshly isolated carp H 1 HCs using fluo-3-based calcium imaging *** application of caffeine,a ryanodine receptor

关键词： Cell=carp retinal horizontal cell Method=calcium imaging Topic=ER calcium release

Visual pattern recognition based on spatio-temporal patterns of retinal ganglion cells’ activities

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Visual pattern recognition based on spatio-temporal patterns...

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Wei jiNG Hai-Qing GONG pei-ji liang~* Department of Biomedical Engineering Shanghai jiao Tong University Shanghai 200240 China

＜正＞Neural information is processed based on integrated activities of relevant *** the present study,the spike activities of bullfrog population retinal ganglion cells in response to three different visual patterns（vertical gratings, horizontal gratings,and pseudo-random binary checker-board） were recorded using multi-electrode array.A measurement of subsequence distribution discrepancy（MSDD） was applied to identify the spatio-temporal patterns of retina ganglion cells’ activities in response to different stimulation *** results showed that the population activity patterns were different under different stimulus patterns although the firing rates were similar,and such differences could be consistently detected in repeated experimental ***,the stimulation pattern can be discriminated according to the spatio-temporal patterns of the neuronal activities using the MSDD algorithm.

关键词： multi-unit recording population activity multiple spike train analysis pattern recognition