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International Journal of Minerals,Metallurgy and Materials 2015年第9期22卷 933-941页

作者： pei Li Jun Li Qing-ge Meng Wen-bin hu Chun-fu Kuang School of Material Science and Engineer Shanghai Jiao Tong University Research Institute of Baoshan Iron and Steel Co. Ltd School of Material Science and Engineer University of Science and Technology Beijing

Three low-carbon dual-phase （DP） steels with almost constant martensite contents of 20vo1% were produced by intercritical annealing at different heating rates and soaking temperatures. Microstructures prepared at low temperature （1043 K, FH1） with fast-heating （300 K/s） show banded ferrite/martensite structure, whereas those soaked at high temperature （1103 K, FH2） with fast heating reveal blocky martensite uniformly distributed in the fine-grained ferrite matrix. Their mechanical properties were tested under tensile conditions and compared to a slow-heated （5 K/s） reference material （SH0）. The tensile tests indicate that for a given martensite volume fraction, the yield strength and total elongation values are noticeably affected by the refinement of ferrite grains and the martensite morphology. Metallographic observations reveal the formation of microvoids at the ferrite/martensite interface in the SH0 and FH2 samples, whereas microvoids nucleate via the fracture of banded martensite particles in the FH1 specimen. In addition, analyses of the work-hardening behaviors of the DP microstructures using the differential Crussard-Jaoul technique demonstrate two stages of work hardening for all samples.

关键词： high-strength steel martensite ferrite heating microstructure tensile properties grain refinement

Comparative analysis of protein kinases and associated domains between Ascomycota and Basidiomycota

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Journal of Integrative Agriculture 2019年第1期18卷 96-107页

作者： pei Guo-liang GUO Jun WANG Qin-hu KANG Zhen-sheng State Key Laboratory of Crop Stress Biology for Arid Areas College of Plant ProtectionNorthwest A&F University

Protein kinases play an important role in every aspect of cellular *** this study,we systemically identified protein kinases from the predicted proteomes of 59 representative fungi from Ascomycota and *** analysis revealed that fungi from Ascomycota and Basidiomycota differed in the number and variety of protein *** groups of protein kinases,such as calmodulin/calcium regulated kinases(CMGC) and those with the highest group percentages are the most prevalent protein kinases among all fungal species *** contrast,the STE group(homologs of the yeast STE7,STE11 and STE20 genes),was more abundant in Basidiomycetes than in ***,the distribution of some protein kinase families appeared to be *** tyrosine kinase-like(TKL) group had a higher protein kinase density in Agaricomycotina *** addition,the distribution of accessory domains,which could have functional implications,demonstrated that usage bias varied between the two *** component analysis revealed a divergence between the main functional domains and associated domains in *** study provides novel insights into the variety and expansion of fungal protein kinases between Ascomycota and Basidiomycota.

关键词： protein kinases associated domains Ascomycota Basidiomycota

Recent advances in efficient computation of deep convolutional neural networks

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Frontiers of Information Technology & Electronic Engineering 2018年第1期19卷 64-77页

作者： Jian CHENG pei-song WANG Gang LI Qing-hao hu Han-qing LU National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China

Deep neural networks have evolved remarkably over the past few years and they are currently the fundamental tools of many intelligent *** the same time,the computational complexity and resource consumption of these networks continue to *** poses a significant challenge to the deployment of such networks,especially in real-time applications or on resource-limited ***,network acceleration has become a hot topic within the deep learning *** for hardware implementation of deep neural networks,a batch of accelerators based on a field-programmable gate array(FPGA) or an application-specific integrated circuit(ASIC)have been proposed in recent *** this paper,we provide a comprehensive survey of recent advances in network acceleration,compression,and accelerator design from both algorithm and hardware points of ***,we provide a thorough analysis of each of the following topics:network pruning,low-rank approximation,network quantization,teacher–student networks,compact network design,and hardware ***,we introduce and discuss a few possible future directions.

关键词： Deep neural networks Acceleration Compression Hardware accelerator

Synthesis of Novel 3-Aryl Isoindolinone Derivatives

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Chemical Research in Chinese Universities 2013年第3期29卷 487-494页

作者： hu Chen-ming ZHENG Lian-you pei Ya-zhong BAI Xu Center for Combinatorial Chemistry and Drug Discovery College of Chemistry and School of Pharmaceutical Sciences Jilin University Changchun 130021 P. R. China

A library of novel 3-aryl isoindolinone derivatives with aromatic amino acid derivative fragments was designed and synthesized. Two synthetic routes were employed to construct 3-aryl isoindolinone ring system for diff... 详细信息

关键词： Molecular library 3-Aryl isoindolinone Aromatic amino acid derivative

Some basic aspects of polymer nanocomposites: A critical review

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Nano Materials Science 2019年第1期1卷 2-30页

作者： Shaoyun Fu Zheng Sun pei huang Yuanqing Li Ning hu College of Aerospace Engineering Chongqing University

Polymer nanocomposites have been investigated for about three decades. To get deep insights into the modifying effects of various nanofillers on mechanical and physical properties of polymer nanocomposites, the three basic aspects of processing, characterization and properties are critically reviewed in this paper. Nanofillers can be classified into three major types of two-dimensional (2D) layered, one-dimensional (1D) fibrous and zerodimensional (0D) spherical ones and this review thus discusses in detail the processing, characterization and properties of the three types of polymer nanocomposites. It starts with an introduction of various nanoscale fillers such as two-dimensional (2D) nano-clay, graphene and MXene, one dimensional (1D) carbon nanofibers and nanotubes, zero dimensional (0D) silica nanoparticles and ZnO quantum dots as well as nanofiller-polymer interfaces. The processing of these polymer nanocomposites using different methods and the characterization of nanofillers and polymer nanocomposites using various techniques are described. Finally, the mechanical and physical properties of these polymer nanocomposites are discussed by considering the effects of nanofiller type, dispersion and contents;also, interface properties show significant effects on the mechanical properties of polymer nanocomposites and are discussed in some details.

关键词： Polymer nanocomposite Nanofiller Processing Characterization Mechanical and physical properties

Prognostics based on the generalized diffusion process with parameters updated by a sequential Bayesian method

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Science China(Information Sciences) 2022年第6期65卷 172-188页

作者： Hong pei Xiaosheng SI Changhua hu Jianxun ZHANG Dangbo DU Zhenan PANG Shengfei ZHANG School of Missile Engineering Rocket Force University of Engineering School of Mechanical Engineering Xi'an Jiaotong University

The realistic degradation process for the engineering equipment is generally stochastic and complicated owing to the uncertain operational condition and multiple functional loading, exhibiting the absolute nonlinear distinction. Such a nonlinear degradation process is widely modeled as a generalized diffusion process. When utilizing the generalized diffusion process-based model, certain model parameters are considered as the random variables to characterize the unit-to-unit discrepancies. Hence, the estimation of these kinds of parameters usually resorts to the Bayesian method. However, owing to the complex pattern of the model parameters in the generalized diffusion process, computing the Bayesian updated parameters requires plenty of repeated calculation and integration operations once the new degradation monitoring information is available. This will inevitably lower the computing efficiency and real-time performance. Toward this end, this paper presents an adaptive prognostic method based on the generalized diffusion process to determine the remaining useful life(RUL) of degraded equipment. First, a generalized diffusion process-based degradation modeling framework is constructed to describe the health performance of stochastic degraded equipment under complex conditions. Then, we utilize the maximum likelihood estimation(MLE) method to estimate the initial model parameters by analyzing the historical degradation information. Furthermore, a sequential Bayesian method is proposed to recursively update the stochastic model parameters in the generalized diffusion process for particular equipment in service. Unlike the existing studies utilizing the Bayesian method,the primary contrast in the presented method lies in that there is no need to implement the calculation process with complicated integration repeatedly utilizing the whole degradation information obtained before the current time. Particularly, the current measured information is incorporated into the esti

关键词： generalized diffusion process stochastic model parameters remaining useful life maximum likelihood estimation sequential Bayesian methods

Gold-catalyzed ketene dual functionalization and mechanistic insights:divergent synthesis of indenes and benzo[d]oxepines

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Science China Chemistry 2021年第5期64卷 778-787页

作者： Ming Bao Jinzhou Chen Chao pei Sujie Zhang Jinping Lei Wenhao hu Xinfang Xu Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China

An unprecedented gold-catalyzed ketene C=O/C=C bifunctionalization method has been *** studies and density function theory(DFT)calculations indicate that the reaction is initiated by gold-catalyzed Wolff rearrangement of diazoketone to form the ketene intermediate,followed by intermolecular nucleophilic addition and terminated with two divergent cyclization processes via enol *** the case with alcohols as the nucleophiles,the reaction goes through a C-5-endodig carbocyclization to give the indene products;whereas,O-7-endo-dig cyclization occurs dominantly when indoles/pyrroles are used as the nucleophiles,delivering the 7-membered benzo[d]*** comparison with the well-documented cycloaddition and nucleophilic addition reactions,this cascade reaction features a novel reaction pattern for the ketene dual functionalization through addition with nucleophile and electrophile in sequence.

关键词： metal carbene ketene dual functionalization Wolff rearrangement gold catalysis indene benzo[d]oxepine

Cellular and molecular overview of gestational diabetes mellitus:Is it predictable and preventable?

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World Journal of Diabetes 2023年第11期14卷 1693-1709页

作者： pei-Qi Lim Yen-Ju Lai pei-Ying Ling Kuo-hu Chen Department of Obstetrics and Gynecology Taiwan Adventist HospitalTaipei 105TaiwanChina School of Medicine George Washington UniversityWashingtonDC 20052United States Department of Obstetrics and Gynecology Taipei Tzu-Chi General HospitalTaipei 231TaiwanChina

BACKGROUND In contrast to overt diabetes mellitus(DM),gestational DM(GDM)is defined as impaired glucose tolerance induced by pregnancy,which may arise from exaggerated physiologic changes in glucose *** prevalence is reported to be as high as 20%among pregnancies depending on the screening method,gestational age,and the population *** and fetal effects of uncontrolled GDM include stillbirth,macrosomia,neonatal diabetes,birth trauma,and subsequent postpartum ***,it is essential to find the potential target population and associated predictive and preventive measures for future intensive peripartum *** To review studies that explored the cellular and molecular mechanisms of GDM as well as predictive measures and prevention *** The search was performed in the Medline and PubMed databases using the terms“gestational diabetes mellitus,”“overt diabetes mellitus,”and“insulin resistance.”In the literature,only full-text articles were considered for inclusion(237 articles).Furthermore,articles published before 1997 and duplicate articles were *** a final review by two experts,all studies(1997-2023)included in the review met the search terms and search strategy(identification from the database,screening of the studies,selection of potential articles,and final inclusion).RESULTS Finally,a total of 79 articles were collected for *** risk factors for GDM included maternal obesity or overweight,pre-existing DM,and polycystic ovary *** pathophysiology of GDM involves genetic variants responsible for insulin secretion and glycemic control,pancreaticβcell depletion or dysfunction,aggravated insulin resistance due to failure in the plasma membrane translocation of glucose transporter 4,and the effects of chronic,low-grade ***,many antepartum measurements including adipokines(leptin),body mass ratio(waist circumference and waist-to-hip ratio),and biomarkers(microRNA in extra

关键词： Gestational diabetes mellitus Overt diabetes mellitus Insulin resistance Diabetes mellitus

Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi hu Rui Wang Hanyue Zhang Xiou Wang Sijia Zhou Bo Ma Yan Luan Xin Wang Xinlin Chen Zhichao Zhang Qianyan Kang Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell ***,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development ***,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo *** this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in ***,we used SOX2 and PAX6 immunostaining to identify retinal progenitor *** then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,***-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between ***,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,*** timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant *** study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina *** findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells

Effects of Different Substrates on Microstructures and Mechanical Properties of a Bulk Nanocrystalline Structure Pure Iron Prepared by Aluminothermic Reaction Casting

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Journal of Iron and Steel Research International 2015年第4期22卷 324-329页

作者： Xiao-juan ZHEN pei-qing LA Cui-ling LI Su-lei hu State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metals Lanzhou University of Technology

A simple method was developed to produce the nanocrystalline pure iron by aluminothermic reaction cast- ing. The mierostructure of the iron was investigated by optical microseope （OM）, transmission electron microscope （TEM）, electron probe micro-analyzer （EPMA）, scanning electron microscope （SEM） and X-ray diffraction （XRD）. The mechanical performances of nanoerystalline pure iron were tested. It is found that the pure iron consists of nanoerystalline ferrite. For different substrates of eopper and glass, the average grain size of the ferrite was 38 and 35 nm, respectively, which is larger on copper substrate than that on glass. The hardness, compressive strength, tensile strength, and total elongation are 167 and 137 HB, 400 and 500 MPa, 243 and 185 MPa, 16% and 10% on copper substrate and glass suhstrate, respectively. The hardness, tensile strength and total elongation are all larger on copper substrate than those on glass substrate, while the eompressive strength is lower. The large supercooling in the product solidification provides the condition for high nucleation rate and thus leads to nano-grained austenite and final nano-grained ferrite transformed from those small austenite grains.

关键词： nanocrystalline aluminothermic reaction casting pure iron substrate microstructure mechanical property