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Protein nanoparticles as potent delivery vehicles for polycytosine RNA-binding protein one

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World Journal of Diabetes 2025年第1期16卷 222-225页

作者： Zi-Yu Zhao pei-Li luo Xia Guo Zheng-Wei Huang State Key Laboratory of Bioactive Molecules and Druggability Assessment Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative DrugsCollege of PharmacyJinan UniversityGuangzhou 511436Guangdong ProvinceChina

Ma et al recently reported in the World Journal of Diabetes that ferroptosis occurs in osteoblasts under high glucose conditions,reflecting diabetes *** condition could be protected by the upregulation of the gene encoding polycytosine RNA-binding protein 1(PCBP1).Additionally,Ma et al used a lentivirus infection system to express *** the authors’method of administration can be improved in terms of stability and cost,we propose delivering PCBP1 to treat type 2 diabetic osteoporosis by encapsulating it in protein ***,PCBP1 is small and ***,intravenous injection can help deliver PCBP1 across the mucosa while avoiding acid and enzyme-catalyzed ***,incorporating PCBP1 into nanoparticles prevents its interaction with water or oxygen and protects PCBP1’s structure and ***,the safety of the protein materials and the industrialization techniques for large-scale production of protein nanoparticles must be comprehensively investigated before clinical application.

关键词： Polycytosine RNA-binding protein 1 Protein nanoparticle Osteoblast Ferroptosis Diabetes

Betaine combined with traditional Chinese medicine ointment to treat skin wounds in microbially infected diabetic mice

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World Journal of Diabetes 2025年第1期16卷 104-120页

作者： Wen-Yan Xu Yuan-Yuan Dai Shi-Xian Yang Hao Chen Yan-Qiang Huang pei-pei luo Zhong-Heng Wei Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Guangxi Clinical Medical Research Center for Hepatobiliary Diseases Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Pathology Wannan Medical CollegeWuhu 241002Anhui ProvinceChina Guangxi Zhuang Autonomous Region Engineering Research Center of Clinical Prevention and Control Technology and Leading Drug for Microorganisms with Drug Resistance in Border Ethnic Areas Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Gastroenterology Wujin People’s Hospital Affiliated to Jiangsu UniversityChangzhou 213004Jiangsu ProvinceChina

BACKGROUND Skin wounds are highly common in diabetic patients,and with increasing types of pathogenic bacteria and antibiotic resistance,wounds and infections in diabetic patients are difficult to treat and *** To explore the effects of betaine ointment(BO)in promoting the healing of skin wounds and reducing the inflammation and apoptosis of skin cells in microbially infected diabetic *** By detecting the minimum inhibitory concentrations(MICs)of betaine and plant monomer components such as psoralen,we prepared BO with betaine as the main ingredient,blended it with traditional Chinese medicines such as gromwell root and psoralen,and evaluated its antibacterial effects and safety in vitro and in *** skin infection wound models of ordinary mice and diabetic mice were constructed,and the OTC drugs mupirocin ointment and Zicao ointment were used as controls to evaluate the antibacterial effects in vivo and the anti-inflammatory and anti-apoptotic effects of *** The MICs of betaine against microorganisms such as Staphylococcus aureus(***),Candida albicans and Cryptococcus neoformans ranged from 4 to 32μg/*** root and psoralea,both of which contain antimicrobial components,mixed to prepare BO with MICs ranging from 16 to 64μg/mL,which is 32-256 times lower than those of Zicao ointment,although the MIC is greater than that of *** 15 days of treatment with BO for USA300-infected ordinary mice,the wound scab removal rates were 83.3%,while those of mupirocin ointment and Zicao ointment were 66.7%and 0%,respectively,and the differences were statistically *** diabetic mice,the wound scab removal rate of BO and mupirolacin ointment was 80.0%,but BO reduced wound inflammation and the apoptosis of skin cells and facilitated wound *** The ointment prepared by mixing betaine and traditional Chinese medicine can effectively inhibit common skin microorganisms and has a strong effect on the skin wounds of sensit

关键词： Betaine ointment Staphylococcus aureus Drug resistance Skin infection Diabetes mellitus

Inter-domain routing and wavelength assignment based on source routing in ASON

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High Technology Letters 2007年第3期13卷 317-321页

作者：黄善国 Yu Song Lee Meng luo pei Gu Wanyi Key Laboratory of Optical Communication and Lightwave Technologies Ministry of Education Beijing University of Posts and Telecommunications Beijing 100876 P.R. China

The inter-domain and intra-domain routings are treated jointly with dynamically distributed algorithms in automatically switched optical networks （ASON） based on source routing. The proposed algorithms are discussed through numerical calculations. The routing loops can be avoided efficiently and the inter-domain signaling complexity is reduced significantly. The performance of the blocking probability is also improved.

关键词： ASON distributed routing inter-domain routing RWA source routing

Mechanistic research:Selenium regulates virulence factors,reducing adhesion ability and inflammatory damage of Helicobacter pylori

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World Journal of Gastroenterology 2024年第1期30卷 91-107页

作者： Chun Qin Gan-Rong Huang Ai-Xing Guan Wen-Ting Zhou Hao Chen pei-pei luo Xian-Ke luo Yan-Qiang Huang Zan-Song Huang Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Digestive Diseases Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Pathology Wannan Medical CollegeWuhu 241002Anhui ProvinceChina Department of Gastroenterology Wujin People’s Hospital affiliated to Jiangsu UniversityChangzhou 213004Jiangsu ProvinceChina Department of Gastroenterology Guangzhou Liwan District People's HospitalGuangzhou 510370Guangdong ProvinceChina

BACKGROUND The pathogenicity of Helicobacter pylori is dependent on factors including the environment and the *** selenium is closely related to pathogenicity as an environmental factor,the specific correlation between them remains *** To investigate how selenium acts on virulence factors and reduces their *** *** strains were induced by sodium *** expression of cytotoxin-associated protein A(CagA)and vacuolating cytotoxin gene A(VacA)was determined by quantitative PCR and Western *** was used to analyze CagA,CagM,CagE,Cag1,Cag3,and CagT.C57BL/6A mice were infected with the attenuated strains subjected to sodium selenite induction,and *** colonization,inflammatory reactions,and the cell adhesion ability of *** were *** CagA and VacA expression was upregulated at first and then downregulated in the *** strains after sodium selenite *** expression was significantly and steadily downregulated after the 5th cycle(10 d).Transcriptome analysis revealed that sodium selenite altered the levels affect *** virulence factors such as CagA,CagM,CagE,Cag1,Cag3,and *** these factors,CagM and CagE expression was continuously downregulated and further downregulated after 2 h of induction with sodium ***,CagT expression was upregulated before the 3rd cycle(6 d)and significantly downregulated after the 5th ***1 and Cag3 expression was upregulated and downregulated,respectively,but no significant change was observed by the 5th cycle.C57BL/6A mice were infected with the attenuated strains subjected to sodium selenite *** extent of *** colonization in the stomach increased;however,sodium selenite also induced a mild inflammatory reaction in the gastric mucosa of ***-infected mice,and the cell adhesion ability of *** was significantly *** These results demonstrate that *** displayed virulence attenuation after

关键词： Helicobacter pylori Sodium selenite Virulence factors Adherence Inflammation

Chemical derivatization strategies for enhancing the HPLC analytical performance of natural active triterpenoids

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Journal of Pharmaceutical Analysis 2024年第3期14卷 295-307页

作者： Xiao-Feng Huang Ying Xue Li Yong Tian-Tian Wang pei luo Lin-Sen Qing Chengdu Institute of Biology Chinese Academy of SciencesChengdu610041China State Key Laboratory for Quality Research in Chinese Medicines Macao University of Science and TechnologyMacaoChina Sichuan Center for Disease Control and Prevention Chengdu610041China University of Chinese Academy of Sciences Beijing100049China

Triterpenoids widely exist in nature,displaying a variety of pharmacological *** triterpenoids in different matrices,especially in biological samples holds great ***-performance liquid chromatography(HPLC)has become the predominant method for triterpenoids analysis due to its exceptional analytical ***,due to the structural similarities among botanical samples,achieving effective separation of each triterpenoid proves challenging,necessitating significant improvements in analytical ***,triterpenoids are characterized by a lack of ultraviolet(UV)absorption groups and chromophores,along with low ionization efficiency in mass ***,routine HPLC analysis suffers from poor *** derivatization emerges as an indispensable technique in HPLC analysis to enhance its *** the structural characteristics of triterpenoids,various derivatization reagents such as acid chlorides,rhodamines,isocyanates,sulfonic esters,and amines have been employed for the derivatization analysis of *** review comprehensively summarized the research progress made in derivatization strategies for HPLC detection of ***,the limitations and challenges encountered in previous studies are discussed,and future research directions are proposed to develop more effective derivatization methods.

关键词： Triterpenoid HPLC Derivatization Quantification

Epigenetic regulation in cardiovascular disease:mechanisms and advances in clinical trials

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2368-2395页

作者： Yuncong Shi Huanji Zhang Suli Huang Li Yin Feng Wang pei luo Hui Huang The Eighth Affiliated Hospital Sun Yat-sen UniversityNo.3025Shennan Middle RdFutian District518033 ShenzhenChina Shenzhen Center for Disease Control and Prevention 518055 ShenzhenChina State Key Laboratory of Chinese Materia Medica Quality Research Macao University of Science and Technology999078 MacaoChina

Epigenetics is closely related to cardiovascular ***-wide linkage and association analyses and candidate gene approaches illustrate the multigenic complexity of cardiovascular *** epigenetic mechanisms,such as DNA methylation,histone modification,and noncoding RNA,which are of importance for cardiovascular disease development and *** epigenetic key enzymes,especially the DNA methyltransferases,histone methyltransferases,histone acetylases,histone deacetylases and their regulated target genes,could represent an attractive new route for the diagnosis and treatment of cardiovascular ***,we summarize the knowledge on epigenetic history and essential regulatory mechanisms in cardiovascular ***,we discuss the preclinical studies and drugs that are targeted these epigenetic key enzymes for cardiovascular diseases ***,we conclude the clinical trials that are going to target some of these processes.

关键词： cardiovascular clinical diagnosis

Mid-infrared dual-comb spectroscopy with electro-optic modulators

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Light(Science & Applications) 2017年第1期6卷 450-457页

作者： Ming Yan pei-Ling luo Kana Iwakuni Guy Millot Theodor W Hänsch Nathalie Picqué Max-Planck-Institut für Quantenoptik 85748 GarchingGermany Fakultät für Physik Ludwig-Maximilians-Universität München80799 MünchenGermany Laboratoire Interdisciplinaire Carnot de Bourgogne UMR 6303 CNRS-Univ.Bourgogne Franche-ComtéF-21078 DijonFrance Institut des Sciences Moléculaires d’Orsay(ISMO) CNRSUniv.Paris-SudUniversitéParis-SaclayF-91405 OrsayFrance

Absorption spectroscopy of fundamental ro-vibrational transitions in the mid-infrared region provides a powerful tool for studying the structure and dynamics of molecules in the gas phase and for sensitive and quantitative gas *** frequency combs permit novel approaches to perform broadband molecular *** dual-comb spectroscopy without moving parts can achieve particularly high speed,sensitivity and ***,achieving Doppler-limited resolution in the mid-infrared still requires overcoming instrumental *** we demonstrate a new approach based on difference-frequency generation of frequency-agile near-infrared frequency combs that are produced using electro-optic *** combs have a remarkably flat intensity distribution,and their positions and line spacings can be freely selected by simply dialing a *** the proposed technique,we record,in the 3-μm region,Doppler-limited absorption spectra with resolved comb lines within milliseconds,and precise molecular line parameters are *** technique holds promise for fast and sensitive time-resolved studies of,for example,trace gases.

关键词： Fourier transform spectroscopy frequency comb mid-infrared molecular spectroscopy

Two sandwich-type uranyl-containing polytungstates catalyze aerobic synthesis of benzimidazoles

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Rare Metals 2024年第3期43卷 1316-1322页

作者： Yu-Feng Liu Qi-Long Hu Xue-Jiao Chen Ke Li pei luo Guo-Ping Yang School of Chemistry and Material Science Jiangxi Province Key Laboratory of Synthetic ChemistryJiangxi Key Laboratory for Mass Spectrometry and InstrumentationEast China University of TechnologyNanchang330013China School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen518055China

Diversified synthetic strategies are extremely important for the structural diversity of uranium-containing polyoxometalates(U-POMs)and their functional ***,two sandwich-type U-POMs were reported,which are Na_(5.6)K_(6.4)[(UO_(2))(H_(2)O)(TeW_(9)O_(33))]_(2)·21H_(2)O(UTeW_(9))and Na_(8.9)K_(2.7)H_(1.19)[K_(0.79)(UO_(2))_(2.21)(PW_(9)O_(34))_(2)]·12H_(2)O(UPW_9)using in-situ strategy and lacunary precursor strategy,***_9 shows a typical Keggin-typeopen or half-sandwich configuration.

关键词： configuration expansion sandwich

Fiber Bragg Grating Strain Sensing Detecting Multi-Crack Damages under Vibrating Status

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Optics and Photonics Journal 2017年第8期7卷 7-13页

作者： pei luo National Engineering Laboratory for Fiber Optic Sensing Technology Wuhan University of Technology Wuhan China

The multi-crack damages modal of simple supported beam has been build, at the vibrating status, the multi-damage detecting method of simple supported beam measured by fiber Bragg grating strain sensing array has been studied. From 0 hz to 200 hz, using exciter vibrating simple supported beam, with different damages, resonant frequency of simple supported beam has changed. So, when the damage appears in simple supported beam, the local rigidity will decrease, the resonant frequency of simple supported beam will be affected, the damage status of simple supported beam have been determined by this. The experimental result indicates that the resonant frequency of simple supported beam has changed when there is no damage, one damage, two damages, three damages on simple supported beam. According to this, the fiber Bragg grating strain sensing array can detect multi-crack damage of simple supported beam under vibrating status.

关键词： Vibration Fiber Bragg Grating Strain Sensing Array Simple Supported Beam Damage Detection Resonant Frequency